DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh2

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001034634.2 Gene:Myh2 / 17882 MGIID:1339710 Length:1942 Species:Mus musculus


Alignment Length:2199 Identity:490/2199 - (22%)
Similarity:839/2199 - (38%) Gaps:593/2199 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Mouse    88 IEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNPEVVAAYRGKKRQEA 151

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG---------GSAS 274
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|.:...|         |...
Mouse   152 PPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKEEATSGKMQ 216

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||:.|.|||||||||:|.||||||||||::.::| .:|.:..|.|..|||||||:..|..
Mouse   217 GTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLK 281

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLE-----ADKYFY--LNQGATDCASGRVDWESL---QGAM 393
            .||:||:||::      |...|..|:|     .:.|.|  ::||....|| ..|.|.|   ..|:
Mouse   282 AERSYHIFYQI------TSNKKPELIEMLLITTNPYDYPFVSQGEISVAS-IDDQEELMATDSAI 339

  Fly   394 QVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLH 456
            .:||.:..|:..|.::..||:|.||:.|.::|.....|  |.||...     ||:|..:::..|.
Mouse   340 DILGFTNDEKVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADK-----AAYLQGLNSADLL 399

  Fly   457 RALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--IS 519
            :||.....:...|.:.....::|..:|..|.|||:|..:|.|:|:|||   |:..|....:  |.
Mouse   400 KALCYPRVKVGNEYVTKGQTVEQVTNAVGALAKAMYEKMFLWMVTRIN---QQLDTKQPRQYFIG 461

  Fly   520 ILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLL 584
            :|||.|||....||.||||||:.||.||.:||.|:|.|||.||.:|.:|||.:.:..:|.....|
Mouse   462 VLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIEL 526

  Fly   585 AKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRI--GAQE--FGVTHYAGQVWY 644
            .:||:||..:|::|..||:|||.||..|.:..| ..|..:.:|::  |..|  |.:.||||.|.|
Mouse   527 IEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSANFQKPKVVKGKAEAHFSLIHYAGTVDY 591

  Fly   645 CVDGFLDKNRDALRGDVLELLASSRLPLVGEL---TKQLRAQRDAGKTLPKGSNGRFVTMKPRTP 706
            .:.|:||||:|.|...|:.|...|.:..:..|   .:...|:..:|....||:..:..:.:    
Mouse   592 NITGWLDKNKDPLNETVVGLYQKSSVKTLAYLFSGAQTAEAEASSGGAAKKGAKKKGSSFQ---- 652

  Fly   707 TVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYP 771
            ||:|.|.::|.:|:.::...||.|||||.||:.|....|:...||.|||..|:|:.|:|.::|:|
Mouse   653 TVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFP 717

  Fly   772 VRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALE 836
            .|:.:..|.:||:.|..|.:..| .|.:..:|..:.:....::...|:.|.|:||.:..|...||
Mouse   718 SRILYADFKQRYKVLNASAIPEG-QYIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLE 781

  Fly   837 SGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERL 889
            ..|.::|.:.....|...||.|.|   :::..|:.:...:|         ..|...:...:.:.|
Mouse   782 EMRDDKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNIRAFMNVKHWPWMKLFFKIKPL 846

  Fly   890 RKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAEL 954
            .|.|.|.:.:   ...:...|:.:.|..:              .|||:..||...:|.|...   
Mouse   847 LKSAETEKEM---ATMKEEFQKTKDDLAK--------------SEAKRKELEEKMVSLLKEK--- 891

  Fly   955 AFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPI 1019
                                                                 |.|:||.:.|  
Mouse   892 -----------------------------------------------------NDLQLQVQAE-- 901

  Fly  1020 TAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGA--KEKLLADYIVHKALSSRGLRDEILVQ 1082
             |..|..|..|    .|.|...|:.|.....:..|.|  :|::.|:....|    |.|.||    
Mouse   902 -AEGLADAEER----CDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK----RKLEDE---- 953

  Fly  1083 LCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDD--------EAPESLRPLLLR 1139
             |::                                  |.:.:||        |..:......::
Mouse   954 -CSE----------------------------------LKKDIDDLELTLAKVEKEKHATENKVK 983

  Fly  1140 QLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAA 1204
            .|..:.          ||...:......|.:|    ...|...||.|..::...|::.|..:   
Mouse   984 NLTEEM----------AGLDETIAKLTKEKKA----LQEAHQQTLDDLQAEEDKVNTLTKAK--- 1031

  Fly  1205 ALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTL 1269
                           :.|:  ||:.|..|     .|..||:|       |.||.|:..|.     
Mouse  1032 ---------------IKLE--QQVDDLEG-----SLEQEKKL-------RMDLERAKRKL----- 1062

  Fly  1270 PDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSR 1334
                               :.|:...:.|..::.:....|:||..::|          ...:..:
Mouse  1063 -------------------EGDLKLAQESIMDIENEKQQLDERLKKKE----------FEMSNLQ 1098

  Fly  1335 SKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERL--APVGKDTGPRYQKSQHAG 1397
            ||..|:...|        ...|:.:..|......|.:.. .|||.  |...|......::.:...
Mouse  1099 SKIEDEQAIG--------IQLQKKIKELQARIEELEEEI-EAERASRAKAEKQRSDLSRELEEIS 1154

  Fly  1398 RRSHAASHGSHSSKYADKAEYATRSSAMSDTSEA----PSLASHVRRVRVPSQASDVDQFLDDLF 1458
            .|...|...:.:....:|...|.......|..||    .:.|:.:|:....|.| ::.:.:|:| 
Mouse  1155 ERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVA-ELGEQIDNL- 1217

  Fly  1459 SPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKL--TSKD 1521
                              ..::....::::|.:.|||||...:..:.:   ...||||:  |.:|
Mouse  1218 ------------------QRVKQKLEKEKSEMKMEIDDLASNVETVSK---AKGNLEKMCRTLED 1261

  Fly  1522 QLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDS 1586
            |::.:        |.:|.:::..|.||                           .:.||...|:|
Mouse  1262 QVSEL--------KSKEEEQQRLINDL---------------------------TTQRGRLQTES 1291

  Fly  1587 NGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQN---QALQT------ 1642
            ......|.:...|..:...|...:.||::..        ..|:::::.|:|   .|||:      
Mouse  1292 GEFSRQLDEKEALVSQLSRGKQAFTQQIEEL--------KRQLEEEVKAKNALAHALQSSRHDCD 1348

  Fly  1643 LLSQ------------QAAAAAANNST----SPPPAPPILSSLSISPPPPQSPMRMKATRSSLVV 1691
            ||.:            |.|.:.||:..    :......|..:..:.....:...|::|....:..
Mouse  1349 LLREQYEEEQESKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEA 1413

  Fly  1692 MESLQPPPPPPPPPMPPPLECKDPSETRH---------------------FLDPYGRAKTVRIGK 1735
            :.:                :|....:|:.                     .||...|.....:.:
Mouse  1414 VNA----------------KCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAE 1462

  Fly  1736 WRWPPPQDEPQFQ----------TEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMME----SGPG 1786
            |:....:...:.:          ||    .|||:....::..|.:..:..:.....|    :...
Mouse  1463 WKQKYEETHAELEASQKEARSLGTE----LFKMKNAYEESLDQLETLKRENKNLQQEISDLTEQI 1523

  Fly  1787 ARGAS--------ATAIEWEEFEIESPTPPPMS------GQLMRSSIRLETTTTTTTSAVNNRDR 1837
            |.|..        ...:|.|:.|:::......:      |:::|..:.|....:.....:..:|.
Mouse  1524 AEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDE 1588

  Fly  1838 D-----RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRS 1897
            :     |....|.:.|||.:..::..::..|...:...|.:.::::......|:    |..::|:
Mouse  1589 EIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHSNRM----AAEALRN 1649

  Fly  1898 TVSTKSEQRAPAKLEDTRKLM---------LQQQLGGLFASVSGGNSGPGGVVDSHAT-VRTQIE 1952
            ..:|:      ..|:||:..:         |::||               .:|:..|. ::.:||
Mouse  1650 YRNTQ------GILKDTQLHLDDALRGQEDLKEQL---------------AMVERRANLLQAEIE 1693

  Fly  1953 RMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPE-PEPDY 2016
            .:...|.                                             .|.||.: .|.:.
Mouse  1694 ELRATLE---------------------------------------------QTERSRKIAEQEL 1713

  Fly  2017 RTSSSQVVKEHVP---------------AFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPA 2066
            ..:|.:|...|..               :.||.:..|.....|..:         |....:.:.|
Mouse  1714 LDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE---------EKAKKAITDA 1769

  Fly  2067 VAAWEQAERERSRSRSRSRDREDYSESVWD---RAEVEGPASGSGSEKEREKRERERERLYEIRQ 2128
            ....|:.::|:..|....|.:::..::|.|   |.:.....:..|.:|:.:|.|.      .:|:
Mouse  1770 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEA------RVRE 1828

  Fly  2129 VERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERK 2182
            :|.|.||.:          :.:.:...|.|:.:|.....|::|      |.:||
Mouse  1829 LEGEVESEQ----------KRNAEAVKGLRKHERRVKELTYQT------EEDRK 1866

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 259/713 (36%)
MYSc_Myo15 169..828 CDD:276838 252/693 (36%)
MyTH4 1014..1171 CDD:295320 27/166 (16%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh2NP_001034634.2 Myosin_N 36..73 CDD:280832
Myosin_head 88..773 CDD:278492 258/705 (37%)
Motor_domain 100..773 CDD:277568 252/693 (36%)
Myosin_tail_1 853..1930 CDD:279860 215/1413 (15%)
RILP-like 968..1101 CDD:304877 33/212 (16%)
MIT_CorA-like <1302..>1414 CDD:294313 19/119 (16%)
DUF342 <1673..1770 CDD:302792 20/165 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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