DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and Myh11

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_006521906.1 Gene:Myh11 / 17880 MGIID:102643 Length:1979 Species:Mus musculus


Alignment Length:1965 Identity:507/1965 - (25%)
Similarity:829/1965 - (42%) Gaps:374/1965 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||..|..|:|||:|.|||.||..|||||::|...:.|||||..| .|..::...|.|:...
Mouse    85 SKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKYLP-IYSEKIVDMYKGKKRH 148

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLA------------AVVPG 269
            .:|||::||...|:.::   ...|.::.:||||:||||:||.|:||||            ::..|
Mouse   149 EMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDSSITQG 213

  Fly   270 GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRI 333
            ...|...:.:|:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.
Mouse   214 PSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRA 278

  Fly   334 VTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQV 395
            :.||..||.:|:||.||.|..|..:|...|...:.|.:|:.|.....:.:.|   .|:|: ||.:
Mouse   279 IRQARDERTFHIFYYLLAGAKEKMKSDLLLESFNSYTFLSNGFVPIPAAQDDEMFQETLE-AMSI 342

  Fly   396 LGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRA-L 459
            :|.:|.|:..|::|:::||.|||:.|.:.:   ..:...:..:...:...||:.|:.....|| |
Mouse   343 MGFNEEEQLAILKVVSSVLQLGNIVFKKER---NTDQASMPDNTAAQKVCHLVGINVTDFTRAIL 404

  Fly   460 TSRTTEAR--AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILD 522
            |.|....|  .::..|.   :||..|.:|.|||.|..||.|::||:|..:.|.....|..:.|||
Mouse   405 TPRIKVGRDVVQKAQTK---EQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFLGILD 466

  Fly   523 IFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK 586
            |.|||....||||||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|:.:
Mouse   467 IAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIER 531

  Fly   587 --KPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVD 647
              .|.|:..|||:|..||:|||.||:||..........:.:|:  ....||.:.||||:|.|...
Mouse   532 PNNPPGVLALLDEECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKDKTEFSIIHYAGKVDYNAS 596

  Fly   648 GFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG---------KTLPKGSNGRFVTMKP 703
            .:|.||.|.|..:|..||.:|....|.:|.|.:  .|..|         .:||..|.    |.|.
Mouse   597 AWLTKNMDPLNDNVTSLLNASSDKFVADLWKDV--DRIVGLDQMAKMTESSLPSASK----TKKG 655

  Fly   704 RTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQR 768
            ...||...:.:.|.:|:.::....|.|||||.||.||.:.::|...||:|||..|:|:.|:|.::
Mouse   656 MFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQ 720

  Fly   769 GYPVRLRFQHFVERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALH 832
            |:|.|:.||.|.:||..|..:.:.:| ...::.|..:::|:.   ::...|::|.:::|.|..:.
Mouse   721 GFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALE---LDPNLYRIGQSKIFFRTGVL 782

  Fly   833 RALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQ 897
            ..||..|..::....::.|...||.|.|:...:||...|.::..   ||....|.:||.      
Mouse   783 AHLEEERDLKITDVIMAFQAMCRGYLARKAFTKRQQQLTAMKVI---QRNCAAYLKLRN------ 838

  Fly   898 RLWRGRQARRRVQQLRSDHRRRQEAR---EAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYS 959
              |:..:...:|:.|....|:.:|.:   |..|:.:|.::..:..|:..:..:..:..|...:..
Mouse   839 --WQWWRLFTKVKPLLQVTRQEEEMQAKEEEMQKIKERQQKAETELKELEQKHTQLAEEKTLLQE 901

  Fly   960 KLQGWSPPHGDRHLVKV--------LGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRR 1016
            :||..:..:.:...::|        |..:.....:.::..||.||              :||..|
Mouse   902 QLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQ--------------QLQAER 952

  Fly  1017 EPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILV 1081
            :.:...:|        |.::.|            :..|.|::||..:.:..:| ..:.|.|:|||
Mouse   953 KKMAQQML--------DLEEQL------------EEEEAARQKLQLEKVTAEA-KIKKLEDDILV 996

  Fly  1082 Q-------------LCNQVHGLPPNSGE----ATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEA 1129
            .             |..:|..|..|..|    |..|.:|..      :..:..|:..:|...:|.
Mouse   997 MDDQNSKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKS------KHESMISELEVRLKKEEK 1055

  Fly  1130 PESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAV 1194
            .......|.|:|              .|....|.....:.:|  :..::.:.|...:|..|    
Mouse  1056 SRQELEKLKRKL--------------EGDASDFHEQIADLQA--QIAELKMQLAKKEEELQ---- 1100

  Fly  1195 DSWTSCEEAAALAVSSLGVASRGWTLV--------LDDGQQLTDSCGLDYVMDLIAEK---ELCP 1248
                     ||||.....:|.:...|.        :.|.|:..||   :......|||   :|..
Mouse  1101 ---------AALARLDEEIAQKNNALKKIRELEGHISDLQEDLDS---ERAARNKAEKQKRDLGE 1153

  Fly  1249 AFPAPRSDL------------LRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRE 1301
            ...|.:::|            ||:..:...|.|..|:..        .|.|.:..|...|:...:
Mouse  1154 ELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDE--------ETRSHEAQVQEMRQKHTQ 1210

  Fly  1302 LLSRSSALNERY-------------FEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDC 1353
            .:...:...|::             .|:|.:...|:....||||...:.....|...:..:.:.|
Mouse  1211 AVEELTEQLEQFKRAKANLDKSKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEVQLQDLQSKC 1275

  Fly  1354 DSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGR-RSHAASHGSHSSKYADKAE 1417
            ...|      .:.:.|:|:.|..:.  .|...||...:....|.: ....||.||......:..:
Mouse  1276 SDGE------RARAELSDKVHKLQN--EVESVTGMLNEAEGKAIKLAKDVASLGSQLQDTQELLQ 1332

  Fly  1418 YATR-------------------SSAMSDTSEA-PSLASHVRRVRVPSQASDVDQFLDDLFSPVL 1462
            ..||                   ...:.:..|| .:|..||..:.:  |.||..:.|.|..|   
Mouse  1333 EETRQKLNVSTKLRQLEDERNSLQDQLDEEMEAKQNLERHVSTLNI--QLSDSKKKLQDFAS--- 1392

  Fly  1463 DGSLDELSDARS-LAASIRGGS--YEQENEAESEID--------DLDDYINDIFQPIPLVQNLEK 1516
              :::.:.:.:. |...:.|.|  ||::..|..:::        :|||.:.|:.....||.||||
Mouse  1393 --TIEVMEEGKKRLQKEMEGLSQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEK 1455

  Fly  1517 LTSK-DQLAAIIKGGGVASK---------PEERDEESEIEDLDDYINELFE---------PIPVA 1562
            ...| |||.|..|  .::||         .|.|::|::...|...:.|..|         .:..|
Mouse  1456 KQKKFDQLLAEEK--NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKA 1518

  Fly  1563 EGLDKLTSKEHLAVSI----RGGGSTDSNGADPLLHQLMQLPGE---TESGPALYQQQVQ----- 1615
            |..|.::||:.:..::    :...:.::. .:.:..||.:|..|   ||......:..:|     
Mouse  1519 EMEDLVSSKDDVGKNVHELEKSKRALETQ-MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582

  Fly  1616 -RAFLQSAMAQN----LQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPP 1675
             ...||:...||    .|:|:||......|:....|:|.||||.......     |..|.:    
Mouse  1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD-----LKDLEL---- 1638

  Fly  1676 PQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKD---------PSETRHFL---DPYGRA 1728
             |:...:|....::..:..||             .:.||         .|....|.   :...:|
Mouse  1639 -QADSAIKGREEAIKQLRKLQ-------------AQMKDFQRELDDARASRDEIFATSKENEKKA 1689

  Fly  1729 KTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSN---GGMMESGPGARGA 1790
            |::           :....|.:||..|.:..:.|.....:....::.|:   ...::.......|
Mouse  1690 KSL-----------EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNTLQDEKRRLEA 1743

  Fly  1791 SATAIEWEEFEIESPTPPPMSGQLMRSSIRL-----ETTTTTTTSAVNNRDR---DRETQDVGQP 1847
            ....:| ||.|.|......||.::.:::::.     |..|..:|:..|...|   :|:.:::...
Mouse  1744 RIAQLE-EELEEEQGNMEAMSDRVRKATLQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807

  Fly  1848 MQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKL- 1911
            :|.|.....||....:.|            |.:::.|..|||.. .:.....:|||.::...|| 
Mouse  1808 LQEVEGAVKAKLKSTVAA------------LEAKIAQLEEQVEQ-EAREKQAATKSLKQKDKKLK 1859

  Fly  1912 ------EDTRKLMLQ 1920
                  ||.||:..|
Mouse  1860 EVLLQVEDERKMAEQ 1874

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 267/716 (37%)
MYSc_Myo15 169..828 CDD:276838 259/695 (37%)
MyTH4 1014..1171 CDD:295320 30/173 (17%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myh11XP_006521906.1 Myosin_N 33..71 CDD:367160
MYSc_class_II 99..778 CDD:276951 259/695 (37%)
Myosin_tail_1 855..1935 CDD:366712 220/1167 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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