Protein Alignment Myo10A and Myh1

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_109604.1
• Gene: Myh1 / 17879
• MGIID: 1339711
• Length: 1942
• Species: Mus musculus
• Alignment Length: 2209
• Identity: 490/2209 - (22%)
• Similarity: 835/2209 - (37%)
• Gaps: 607/2209 - (27%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Mouse    88 IEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRQEA 151

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG---------GSAS 274
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|.:...|         |...
Mouse   152 PPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEATSGKMQ 216

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||:.|.|||||||||:|.||||||||||::.::| .:|.:..|.|..|||||||:..|..
Mouse   217 GTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLK 281

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCASGRVDWESL---QGAM 393
            .||:||:||:::      ...|..|:|       ...|.:::||.....| ..|.|.|   ..|:
Mouse   282 AERSYHIFYQIM------SNKKPDLIEMLLITTNPYDYAFVSQGEITVPS-IDDQEELMATDSAI 339

  Fly   394 QVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLH 456
            .:||.:..||..|.::..||:|.||:.|.::|.....|  |.||...     ||:|.::::..|.
Mouse   340 DILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADK-----AAYLQNLNSADLL 399

  Fly   457 RALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--IS 519
            :||.....:...|.:.....:.|..::..|.|||:|..:|.|:|:|||   |:..|....:  |.
Mouse   400 KALCYPRVKVGNEYVTKGQTVQQVYNSVGALAKAVYEKMFLWMVTRIN---QQLDTKQPRQYFIG 461

  Fly   520 ILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLL 584
            :|||.|||....||.||||||:.||.||.:||.|:|.|||.||.:|.:||..:.:..:|.....|
Mouse   462 VLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIEL 526

  Fly   585 AKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWY 644
            .:||:||..:|::|..||:|||.||..|.:..| ..|..:.:|:  .|..|  |.:.||||.|.|
Mouse   527 IEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKVEAHFSLVHYAGTVDY 591

  Fly   645 CVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDA------GKTLPKGSNGRFVTMKP 703
            .:.|:||||:|.|...|:.|...|.:..:..|.....|..:|      ||...|.....|
Mouse   592 NIAGWLDKNKDPLNETVVGLYQKSSMKTLAYLFSGAAAAAEAESGGGGGKKGAKKKGSSF----- 651

  Fly   704 RTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQR 768
              .||:|.|.::|.:|:.::...||.|||||.||:.|....|:...||.|||..|:|:.|:|.::
Mouse   652 --QTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRK 714

  Fly   769 GYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHR 833
            |:|.|:.:..|.:||:.|..|.:..| .:.:..:|..:.:....::...|:.|.|:||.:..|..
Mouse   715 GFPSRILYADFKQRYKVLNASAIPEG-QFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLG 778

  Fly   834 ALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRY 886
            .||..|.::|.:.....|...||.|.|   :::..|:.:...:|         ..|...:...:.
Mouse   779 LLEEMRDDKLAQLITRTQAMCRGYLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKI 843

  Fly   887 ERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIP 951
            :.|.|.|.|.:.:                ...::|..:|.:...:| |||:..||...::.:...
Mouse   844 KPLLKSAETEKEM----------------ANMKEEFEKAKENLAKA-EAKRKELEEKMVALMQEK 891

  Fly   952 AELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRR 1016
            .:|     :||                 |.....|.....|...|....|        ::|:.:.
Mouse   892 NDL-----QLQ-----------------VQSEADSLADAEERCDQLIKTK--------IQLEAKI 926

  Fly  1017 EPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILV 1081
            :.:|        .|.:|.::..|......|...|:..|..|:....:..:.|....:...:..:.
Mouse   927 KEVT--------ERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 983

  Fly  1082 QLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDD-EAPE-SLRPLLLRQLLRQ 1144
            .|..::.||.....:.|:             ...|..:...:.:|| :|.| .:..|...::..:
Mouse   984 NLTEEMAGLDETIAKLTK-------------EKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE 1035

  Fly  1145 QGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVS 1209
            |......|::                                |..:.:.:|    .|.|......
Mouse  1036 QQVDDLEGSL--------------------------------EQEKKIRMD----LERAKRKLEG 1064

  Fly  1210 SLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVK 1274
            .|.:|......|.:|.|||.:.         :.:||                  |..:.|...:
Mouse  1065 DLKLAQESTMDVENDKQQLDEK---------LKKKE------------------FEMSNLQSKI- 1101

  Fly  1275 RPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSR---SK 1336
                           ||   |:....:|..:...|..|..|.|......:.|.....|.|   |:
Mouse  1102 ---------------ED---EQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSR 1148

  Fly  1337 SLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQ---HAGR 1398
            .|:::                        ..||.:...:......:.|.....:||.:   ....
Mouse  1149 ELEEI------------------------SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEAT 1189

  Fly  1399 RSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRV--RVPSQASDVDQFLDDLFSPV 1461
            ..|.|:..:...|:||            ..:|......:::||  ::..:.|::...:|||.|.:
Mouse  1190 LQHEATAATLRKKHAD------------SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNM 1242

  Fly  1462 -----LDGSL--------DELSDARS-----------LAASIRGGSYEQENEAESEIDDLDDYIN 1502
                 ..|:|        |::|:.::           |.|. ||....:..|...::|:.|..::
Mouse  1243 EVISKSKGNLEKMCRTLEDQVSELKTKEEEQQRLINELTAQ-RGRLQTESGEYSRQLDEKDSLVS 1306

  Fly  1503 DIFQ-PIPLVQNLEKLTSKDQLAAIIKGGGVASKP------------EERDEESE---------- 1544
            .:.: .....|.:|:|  |.||...||.....:..            |:.:||.|
Mouse  1307 QLSRGKQAFTQQIEEL--KRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMS 1369

  Fly  1545 --------------------IEDLDDYINELFEPIPVAE-----------GLDKLTSK-----EH 1573
                                .|:|::...:|.:.:..||           .|:|...:     |.
Mouse  1370 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVED 1434

  Fly  1574 LAVSIRGGGSTDSNGA-----------DPLLHQLMQLPGETESGPALYQQQ----------VQRA 1617
            |.:.:.     .:|.|           |.:|.:..|...||.:.....|::          ::.|
Mouse  1435 LMIDVE-----RTNAACAALDKKQRNFDKILAEWKQKYEETHAELEASQKESRSLSTELFKIKNA 1494

  Fly  1618 F------LQSAMAQNLQIQQQL------LAQN----QALQTLLSQ--------QAAAAAANNSTS 1658
            :      |::...:|..:||::      :|:.    ..|:.:..|        |||...|..|..
Mouse  1495 YEESLDHLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQIEQEKSELQAALEEAEASLE 1559

  Fly  1659 PPPAPPILSSLSISPPPPQSPMRM--------KATRSSLVVMESLQPPPPPPPPPMPPPLECKDP 1715
            ......:...|.::....:...::        :..|:.:.|:||:|..
Mouse  1560 HEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHIRVVESMQST----------------- 1607

  Fly  1716 SETRHFLDPYGRAK--TVRIGKWRWPPPQDEPQFQTEEDFFAFKMR-QHQRKTTPQAQHHQMTSN 1777
                  ||...|::  .:|:.|            :.|.|....::: .|..:...:|..:...:.
Mouse  1608 ------LDAEIRSRNDAIRLKK------------KMEGDLNEMEIQLNHSNRMAAEALRNYRNTQ 1654

  Fly  1778 G-----------------------GMMESGPGARGASATAIEWEE----FEIESPTPPPMSGQLM 1815
            |                       .|:|     |.|:....|.||    .|....:......:|:
Mouse  1655 GILKDTQLHLDDALRGQEDLKEQLAMVE-----RRANLLQAEIEELRATLEQTERSRKIAEQELL 1714

  Fly  1816 RSSIRLETTTTTTTSAVNNRDR-DRETQDVGQPMQSVV-----TTKLAKKSFEIGADRPPPGSVG 1874
            .:|.|::...|..||.:|.:.: :.:...:...|:.:|     ..:.|||:....|
Mouse  1715 DASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAA--------- 1770

  Fly  1875 KLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDT-----RKLMLQQQLGGLFASVSGGN 1934
              .::.|:::  ||.|:.|.          :|....||.|     .:|...:||     ::.||
Mouse  1771 --MMAEELKK--EQDTSAHL----------ERMKKNLEQTVKDLQHRLDEAEQL-----ALKGG- 1815

  Fly  1935 SGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPP 1999
                         :.||:::|
Mouse  1816 -------------KKQIQKLE-------------------------------------------- 1823

  Fly  2000 APQSPPTARSPEPEPDYRTSSSQVVKEHVPAF--IQRQERDTFGAVRQQQMISSHHLHLEDHSAS 2062
                   ||..|.|.:.....    |.:|.|.  :::.||.......|.:....:.|.|:|....
Mouse  1824 -------ARVRELEGEVENEQ----KRNVEAIKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDK 1877

  Fly  2063 SSPAVAAW----EQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK-RERERE 2121
            ....|.|:    |:||.:.:.:.::.|..:...|...:||::        :|.:..| |.:.||
Mouse  1878 LQSKVKAYKRQAEEAEEQSNVNLAKFRKIQHELEEAEERADI--------AESQVNKLRVKSRE 1933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	249/696 (36%)
		PTZ00121	<828..>943	CDD:173412	25/126 (20%)
		MyTH4	1014..1171	CDD:470587	21/158 (13%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	11/66 (17%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myh1	NP_109604.1	Myosin_N	33..77	CDD:460670
		MYSc_Myh1_mammals	100..773	CDD:276875	249/696 (36%)
		Actin-binding. /evidence=ECO:0000250	662..684		10/21 (48%)
		Actin-binding. /evidence=ECO:0000250	764..778		5/13 (38%)
		Myosin_tail_1	853..1930	CDD:460256	216/1415 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1156..1175		3/18 (17%)