Protein Alignment Myo10A and nmy-3

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_501620.2
• Gene: nmy-3 / 177750
• WormBaseID: WBGene00012437
• Length: 1464
• Species: Caenorhabditis elegans
• Alignment Length: 940
• Identity: 273/940 - (29%)
• Similarity: 449/940 - (47%)
• Gaps: 149/940 - (15%)

  Fly    74 LSPHVLRRQRPASLED-FEDLPN---------------------------LSAKHPALPSSRLRR 110
            |.|::||..:...:|: .|||.|                           ...:.......|:.:
 Worm     9 LEPNILRHLQTKKVEERIEDLNNQIWIEDDLYGYRMVTVIDEGLSDLLVGFRDEQGFFEKKRIEK 73

  Fly   111 LKCRYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNL 175
            .||..|.:                                   ::..||:..|...:.|::|..|
 Worm    74 TKCEVPSL-----------------------------------NNYSEDLCTLTQPNAATVLNAL 103

  Fly   176 RLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGA-AAHAALPS- 238
            ::||...:|:||.|...:.:||::..| .|..||.:.|  :....||||::::.. |.|..|..
 Worm   104 KIRYTSNVIHTFCGLFCVVINPWRNIP-IYSDEVKQLY--QLQNDLPPHVYSVAQNAFHGILKGG 165

  Fly   239 -PQVVVISGESGSGKTESTKLVMQY-LAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDN 301
             .|.::|:||||:||||:||.::.: |::.|........|:|..:     ||||.|||||..|.|
 Worm   166 RNQSILITGESGAGKTENTKKIIDFILSSSVSNNTIGDCVVTSGV-----LLEAMGNARTTHNSN 225

  Fly   302 SSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLL- 364
            ||||||::.:.| ::..::||||..|||||||:|.|:.|:||:|:||::|....:.....:..|
 Worm   226 SSRFGKFIRIEFDENSKLIGAKIECYLLEKSRVVFQSDGDRNFHIFYQMLSNYFDNPHKSFLKLS 290

  Fly   365 -EADKYFYLNQGAT---DCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQ 425
             :.::|.||....:   |..:.::..|    |...:|:||.|:..|.::|:|||.:|::.|..|
 Worm   291 KKVNEYKYLRNDDSMIDDAETAKMTDE----AFTRIGLSEEEKIWIFQILSAVLWIGDIKFGER- 350

  Fly   426 LRHGQEGVEVG---SDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAF 487
                 .|::|.   |..|:...|.||.:.:..|..|||..|.:...:.:.....:.:.|.:..|.
 Worm   351 -----SGLDVSFVESMQEVDNIAELLEMKSSKLVDALTQPTIKVHDKLIRKNQNLAKTLSSASAM 410

  Fly   488 AKALYAGLFNWLVSRINSIVQKGGTHDAHRIS----ILDIFGFEDLAENSFEQLCINYANENLQL 548
            ||.||..||.|:|.|.|.......|....|:|    :|||.|||.:.:|||||.||||.||.||.
 Worm   411 AKILYERLFGWIVKRCNDAFSVDDTESTCRLSRFIAVLDIAGFEIIEKNSFEQFCINYTNEKLQQ 475

  Fly   549 YFNKHVFKLEQAEYARERLEWTPLAWDDNL-PVIHLLAKKPVGICHLLDDESNFPRATDLSFLEK 612
            :||..:|..||::|..|.::||.:.:.::| |.|.|: :||:||...|::|...|..::.|.|||
 Worm   476 FFNHFMFAKEQSDYLEEGIKWTQVNFANHLQPTIDLI-EKPMGILSFLEEECVVPNGSEKSLLEK 539

  Fly   613 CHYNHALSELYARPR-----IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPL 672
            ...|.:....:.:.:     ...:.|.|.||||:|.|.:||:||||||.:...||::|:.|..||
 Worm   540 LCSNLSNDSSFKKSKQTQKCSTIRHFYVQHYAGEVHYNIDGWLDKNRDNVETSVLDILSQSTHPL 604

  Fly   673 VGEL-----TKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVR 732
            :..|     ...|:.:|..            :|    ..||:..:.:.||.||.::......|:|
 Worm   605 LKLLFPPVPVNNLKTRRGT------------IT----NSTVSFLYKNQLQCLLDTLNSSSAHFIR 653

  Fly   733 CIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPS-PLARGTP 796
            |:..|.||...::|.|.||.||:..|:|:.|:|.:.|||.||....|:|||..|:.: ..::|..
 Worm   654 CVVSNYEKLPGKIDAPLVLAQLKCNGVLEGIRICREGYPSRLSHSEFIERYSLLMKNKEQSKGAS 718

  Fly   797 YRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRR 861
            .:|.|..:.:   ...|....|.:|.|::|.:..:...||:.|...:....:.:|.::|.:.:::
 Worm   719 EKEKCTLICQ---DAQVRKERYAVGKTKLFCKVGVISELETKRNNYISSFIILIQANIRYLNIQK 780

  Fly   862 QLARRQ---AAATRLQARWR-----GQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRR 918
            .|..|:   .|...:|...|     .|....|...|.:|.:...|      .:.|:::|.::..:
 Worm   781 DLIERRKKLEAVVTIQDNVRQFAELSQWPWYRIYHLTRGLIPRNR------DKERIEELENEKLK 839

  Fly   919 RQEAREAAQRAREAREAKQAVLERSQLSYL 948
            .:|..:..:...|     :|:.|..:||.|
 Worm   840 LEEEIQEMEIKNE-----EALKENLKLSML 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	233/687 (34%)
		PTZ00121	<828..>943	CDD:173412	21/122 (17%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
nmy-3	NP_501620.2	MYSc_class_II	97..747	CDD:276951	233/687 (34%)
		SMC_prok_B	848..>1463	CDD:274008	6/22 (27%)