DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and hum-8

DIOPT Version :10

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001294574.1 Gene:hum-8 / 176872 WormBaseID:WBGene00002041 Length:1279 Species:Caenorhabditis elegans


Alignment Length:1067 Identity:319/1067 - (29%)
Similarity:492/1067 - (46%) Gaps:204/1067 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 ARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQ 212
            |.:|.....|||...|..|:||:||.|:||||..|.||::..:|||::|||:.....|.|:..|:
 Worm   122 ACEDDSRRHVEDNCQLMHLNEATLLNNIRLRYQNGKIYSYVANILISINPYQTIDGFYSLQKIKE 186

  Fly   213 YAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSAS 274
            |.|:.||...||:|||...::..:   ...|.:::|||||:|||||.|.|::||.   ...||.:
 Worm   187 YRGKSLGQKEPHIFAIADKSYREMIRHRKSQSIIVSGESGAGKTESQKAVLRYLC---ENWGSGA 248

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..|.:::||..|:|||||||:|.||:|||||||:::::| .:|.:.|..::.||||.|||..||.
 Worm   249 GEIQKRLLETNPILEAFGNAKTLRNNNSSRFGKFVQIHFADTGNVAGGYVSHYLLETSRICRQAA 313

  Fly   339 GERNYHVFYELLGGLSETERSKY-GLLEADKYFYLNQG----ATDCASGRV-------------- 384
            ||||||:||:|:.| |..|..|: .|.:.:::.||.:|    .|..:||..              
 Worm   314 GERNYHIFYQLIAG-SSPELFKFLALGQPNQFNYLKRGFIGFFTHPSSGTTSKIPKNRLSDPKFT 377

  Fly   385 ---------DWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEV--GSD 438
                     |::.|:.|:::.|:||.|...|...:||:||||||.| ...|...:.|.:|  ||:
 Worm   378 QDSMVDDFSDFQRLEYALKLTGLSEQEIHFIWTTIAAILHLGNVEF-EESLDDSRGGCKVFNGSE 441

  Fly   439 AEIKWAAHLLHISADGLHRALTSR---TTE--ARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498
            .::..||.||.:....|...|.:|   ||:  ||...:..||...:|...|||.:||:|:.||:|
 Worm   442 QDLIQAARLLGLETMELKMGLCARIMQTTKGGARGTLIRVPLKPHEACSGRDALSKAIYSKLFDW 506

  Fly   499 LVSRINSIV--QKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAE 561
            ||||||..:  :|    ..:.:.:||:.|||..|:|||||.|||:.||.||.:||:.:.:.||..
 Worm   507 LVSRINDSIPFEK----STNFVGVLDVAGFEFYAKNSFEQFCINFCNEKLQNFFNQRILREEQEL 567

  Fly   562 YARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARP 626
            |.:|.|....:.:.||...|.|...|..|:..|||:|:.||.:...||.::.|..:........|
 Worm   568 YEKEGLNVRKIEFIDNQDCIELFELKGNGLFDLLDEEAKFPTSNYKSFTKRAHEENRKHFRLDTP 632

  Fly   627 RIGA----------QEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLR 681
            |...          :...:.||||.|.|....|::||.|.|...:..|:..|.:.|:..|.    
 Worm   633 RKSKVKSHRELRDDEGLLIRHYAGSVCYETKHFVEKNDDLLHNSLQILIEQSTIRLLVSLF---- 693

  Fly   682 AQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMD 746
                       ||.......|.:..:|.|:|.:.|..||..:......||||||||.:......|
 Worm   694 -----------GSTAYPTKSKLKALSVGAKFKNQLSTLLIKLESTGTHFVRCIKPNNQMIPFEFD 747

  Fly   747 MPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRT 811
            ...:|.||:..||...:::.|.|:|.|..|......|:..||..|::..| |..|:.|..|:   
 Worm   748 GSAILSQLQCAGMTSVLKLMQDGFPSRTGFGDLYACYQKKLPPKLSKLDP-RMFCKCLFRAL--- 808

  Fly   812 GVEGPDYQLGATRVFLR----------------------EALHRALESGRTERLRRAAVSVQRHV 854
            |::..|:|.|.|:||.|                      :.::..|...|.::.:.|..||    
 Worm   809 GLDQHDFQFGLTKVFFRAGKFAEFDQMMKQDPETMTSLIQKVNEWLVGARWKQSQYAVWSV---- 869

  Fly   855 RGMLVRRQLARRQAAATRLQARWRGQRAQQRYER----LRKGALTAQ----------RLWRGRQA 905
              :.::.::|.|.|..||||:..||...:||:.|    .||.....:          ||....:|
 Worm   870 --IKLKNKIAWRSAQVTRLQSIARGYLTRQRFSRQIALYRKSVALLKNSKEIEKILFRLNEHSRA 932

  Fly   906 R----------------------------------------RRVQQLRSDHRRRQ---------- 920
            :                                        :||..:.:|.:::|          
 Worm   933 KYTSSAHSTIRDLEKLVSHIKLTTSANDHFEKAENAYEHYVKRVDSMIADLKKQQKSDELAEIER 997

  Fly   921 -------------EAREAAQRAREAR---EAKQAVLERSQLSYL--DIPAELAFIYSKLQGWSPP 967
                         ||::.|:|.||.:   |.:|...::...:||  :|.........|.|.....
 Worm   998 KRRESEEKERLEIEAKKEAERQREIKRKLEEQQQNAQKEHENYLISEIHKAAEETEKKRQNEEKE 1062

  Fly   968 HGDRHLVKVLGTVPGPP--SSAVQLPEDLGQFSF--GKFSSVYCNGLRLQPRREPITAPL---LT 1025
            ..|:.:...|....|..  ||.:::....|..:|  ||:....|:...|   |:.|...:   |.
 Worm  1063 KLDKMVSNRLAEADGVALISSKMEIEPSSGSATFRDGKYDVGGCSFAYL---RDTINTSMDINLL 1124

  Fly  1026 RAASRDQDFQDALAVFKLILRWSNDKA 1052
            :|.  :::|:..|.::.   .|.:..|
 Worm  1125 KAC--EEEFRRRLRIYN---EWKSRNA 1146

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc_Myo15 169..828 CDD:276838 252/709 (36%)
PTZ00121 <828..>943 CDD:173412 35/216 (16%)
MyTH4 1014..1171 CDD:470587 8/42 (19%)
Ubl1_cv_Nsp3_N-like 1178..>1245 CDD:475130
MyTH4 2704..2810 CDD:459939
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
hum-8NP_001294574.1 MYSc_Myo6 143..825 CDD:276833 252/709 (36%)
CBD_MYO6-like 836..987 CDD:409646 25/156 (16%)
tolA_full 983..>1076 CDD:274303 16/92 (17%)
MyUb_Myo6 1099..1139 CDD:439319 10/44 (23%)
Myosin-VI_CBD 1180..1276 CDD:465157
Blue background indicates that the domain is not in the aligned region.

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