DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and nmy-2

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	NP_492186.3	Gene:	nmy-2 / 172562	WormBaseID:	WBGene00003777	Length:	2003	Species:	Caenorhabditis elegans

Alignment Length:	2299	Identity:	550/2299 - (23%)
Similarity:	900/2299 - (39%)	Gaps:	620/2299 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            |||::|..|:|||:|.||:.||...|.||::|...:.:||||..| .|...:|:|:..:....:|
Worm    89 EDMSMLTCLNEASVLHNLKQRYFSNLYYTYSGLFCVVINPYKRIP-IYTDTIAEQFKCKKRKEMP 152

  Fly   223 PHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAV------------VPGGGS 272
            ||:||:...|:.::   ...|.::.:||||:||||:||.|:||||.|            |....|
Worm   153 PHIFAVADEAYRSMLQERDDQSILCTGESGAGKTENTKKVIQYLAYVANRSMVKNRKTSVDLDTS 217

  Fly   273 ASAV---ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKS-GAIVGAKITQYLLEKSRI 333
            .:.:   :.||:|:|.|:||||||::|.:|||||||||::.|:|.| |.|.||.|..|||||||:
Worm   218 TNRIMGQLEEQLLQANPILEAFGNSKTVKNDNSSRFGKFIRVHFDSTGCISGANIEFYLLEKSRV 282

  Fly   334 VTQAPGERNYHVFYELLGGLSETERSKYGLLE--ADKYFYLNQGATDCA---SGRVDWESLQGAM 393
            :.|||.||::|:||:||.|||:.:|..| |||  ..||.:::.|.:..|   .|....|:| .||
Worm   283 LKQAPNERSFHIFYQLLKGLSKVQREHY-LLEDSLSKYKFVSNGDSKLAGVDDGAEMKETL-NAM 345

  Fly   394 QVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRA 458
            .::|:::.|..||:||::||:..||:.|......:.|  ..:.:||..:..|.||.::...|.||
Worm   346 SIMGLNDEEIGGILRVVSAVMLFGNLEFSHENKNNDQ--AVLLNDAVAQKIASLLGVNVTELMRA 408

  Fly   459 LTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDI 523
            ......:.:.:.:|....:||...:..|.|||.|..||.|||.|:|..:.:........|.||||
Worm   409 FLKPKIKVQRDLVHRAQSVDQVNFSVGAIAKASYERLFRWLVHRLNKSLDRTRQQSVSFIGILDI 473

  Fly   524 FGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNL-PVIHLLAKK 587
            .|||....||||||||||.||.||..||..:|..||.||..|.|||..|.:..|| |.|.|: .|
Worm   474 AGFEIFETNSFEQLCINYTNEKLQQLFNNTMFVREQQEYLDEGLEWKFLDFGLNLQPTIDLI-DK 537

  Fly   588 PVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQ-EFGVTHYAGQVWYCVDGFLD 651
            |:||...|||...||:..|.||:::.:..|:....|..|.|.:: :|.|.||||:|.|..:|:..
Worm   538 PMGIMSTLDDVCLFPQGNDQSFVQRLNNTHSQHPKYVVPEIRSRSDFAVVHYAGRVDYQSEGWRV 602

  Fly   652 KNRDALRGDVLELLASSRLPLVGELTKQLR---AQRDAGKTLPKGSNGRFVTMKPRTPTVAARFA 713
            ||.|.|..:|:::|.:|:..|:.::.|.:.   :...|..|...|..|..|..|....||:..:.
Worm   603 KNMDPLNENVIDVLKTSKESLIVDMWKDIADVCSLSAADSTSDTGVFGSRVPKKGMFRTVSQLYK 667

  Fly   714 DSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQH 778
            :.|.:|:.::...:|.|||||.||.||....::...||.|||..|:|:.|:|.::|:|.||.||.
Worm   668 EQLARLMSTLNNTNPHFVRCIIPNHEKKHGVLNAHLVLDQLRCNGVLEGIRICRQGFPTRLPFQE 732

  Fly   779 FVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERL 843
            |.:||..|| :|......:.:...|:...:....|:...:::|.:::|.|..:....|..|.::|
Worm   733 FRQRYEKLL-APDVNPAGFMDGKNAVYRIVQYLEVDANLFRIGQSKIFFRSGVIAEFEEMRDQKL 796

  Fly   844 RRAAVSVQRHVRGMLVRRQLARR--QAAATRLQAR----WRGQRAQQRY---------------- 886
            .....|.|...||.|.||.:.||  |..|.::..|    |...|..|.:
Worm   797 SALIESFQAQCRGWLGRRVMVRRREQEVAIKILQRNGLAWMRLREWQWWRLLTKVKPLLEVTNKD 861

  Fly   887 ----ERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEA-------------REAAQRAREARE 934
                ||.::..:||::|       ||.:...||::::.|.             .|:::||....|
Worm   862 ELIAEREQELKVTAEKL-------RRSEVFISDYKQQMEKMDEERLVLKTRLDAESSERAEIFEE 919

  Fly   935 AKQAVLERSQL--------SYLDIPAELAFIYSKLQGWSPPHGD--RHL-----------VKVLG 978
            ..:....|.:|        ..|:|..:.|   .|....|....:  |||           .|:|.
Worm   920 RSRMAARRDELEGILEEVSKRLEIEEQKA---KKADSESRKLTEMVRHLEENLEDEERSRQKLLL 981

  Fly   979 TVPGPPSSAVQLP------EDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDA 1037
            ......|...:|.      ||.|    .|.|.   ....|:.|.|.:::.|:.. ..|.:....|
Worm   982 EKNSIESRLKELEAQGLELEDSG----NKLSK---EKKALEERCEDLSSRLIDE-VERSKQLVKA 1038

  Fly  1038 LAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQ 1102
            .|..:..:...||: ||..|::.      |.|.::|...:                    |:|.:
Worm  1039 KARLEATVAEINDE-LEKEKQQR------HNAETARRAAE--------------------TQLRE 1076

  Fly  1103 LLGQCLCCFQPSAAFSKYLMRFVDDEAPESLR---PLLLRQLLRQQGGGTSSGAVGAGACRSFVP 1164
            ....||...:.:...:..|||...:.:..|:|   .|..||.|.::
Worm  1077 EQESCLEKTRKAEELTNQLMRKESELSQISIRNDEELAARQQLERE------------------- 1122

  Fly  1165 AWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLT 1229
             ..|.||..            |:|.:.      |:.|:||                     :|..
Worm  1123 -IREIRAQL------------DDAIEE------TNKEKAA---------------------RQKA 1147

  Fly  1230 DSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPR 1294
            :....|...:|.:.|:          :|..|..|   |.|...:|.......|......:|.|
Worm  1148 EKARRDMAEELESYKQ----------ELEESNDK---TVLHSQLKAKRDEEYAHLQKQLEETV-- 1197

  Fly  1295 ERRSSRELLSRSSALNERYFE----------REPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPV 1349
              :||.|::....|.|::..|          |       |..|..:|||.::|.::....::..:
Worm  1198 --KSSEEVVEEMKAQNQKKIEELNETIDQLKR-------QKISADKAKSSAESDNENFRAELSNI 1253

  Fly  1350 PT------------DCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHA 1402
            .:            :....|..|.:...:|.|:|      .:|.:.|     ......:.:::.:
Worm  1254 ASARLEAEKKRKAAETSLMEKDHKMREMQSNLDD------LMAKLSK-----MNNELESIQKAKS 1307

  Fly  1403 ASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPV--LDGS 1465
            |....:|:.....|....:.|.:::.||..      ||.|. :..:.:.|..:||...|  .|.:
Worm  1308 ADETLNSNLLKKNASLDMQLSELTEASEED------RRTRA-TLNNKIRQLEEDLAVAVEARDDA 1365

  Fly  1466 LD-------ELSDARSLAASIRGGSYEQENE--------------AESE---------------- 1493
            ||       |:.:.:||.|..|....|:..|              ||.|
Worm  1366 LDAQEKIEKEVKEVKSLLAEARKKLDEENREVMEELRKKKEKELSAEKERADMAEQARDKAERAK 1430

  Fly  1494 ---IDDLDDYINDIFQPIPLVQNLE-KLTSKDQLAAIIKGGGVASKPEE-------RDEESEIED 1547
               |.:.:|...::...:...:.:| |:...||..|..:...:.::.|.       ||.|::...
Worm  1431 KKAIQEAEDVQKELTDVVAATREMERKMRKFDQQLAEERNNTLLAQQERDMAHQMLRDAETKALV 1495

  Fly  1548 LDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQ 1612
            |.   |||.|...:.:.|:|  .|..|.:.|....||                 :.::|..:|:.
Worm  1496 LS---NELSEKKDIVDQLEK--DKRTLKLEIDNLAST-----------------KDDAGKNVYEL 1538

  Fly  1613 QVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQ 1677
            :..:..|...::   :.:||::....|||  |:..|.:....|
Worm  1539 EKTKRRLDEELS---RAEQQIIELEDALQ--LADDARSRVEVN---------------------- 1576

  Fly  1678 SPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQ 1742
                |:|.||..
Worm  1577 ----MQAMRSEF----------------------------------------------------- 1584

  Fly  1743 DEPQFQT-EEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPT 1806
             |.|..: |||       :..||....::...:|..   :||...||.|:....:..|.:|...|
Worm  1585 -ERQLASREED-------EDDRKKGLTSKIRNLTEE---LESEQRARQAAIANKKKIESQISELT 1638

  Fly  1807 P---------PPMSGQLMRSSI---RLETTTTTTTSAVNN-----RD---RDRETQDVGQPMQSV 1851
            .         ..:|.||.::.:   .|:...|...:|:.:     ||   |.|.::|
Worm  1639 EKNEASLRQIEDLSRQLRKAQLGWKDLQLDVTEARAAMEDALAGQRDAEKRARASED-------- 1695

  Fly  1852 VTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVR-STVSTKSEQRAPAKLEDTR 1915
               ::.:.:.:|.|     .|..|.|..:|..:.:|:|:   |:| |:.|.:.::|..||:.|
Worm  1696 ---EIKRLTADIQA-----VSSSKRKAEAERDELIEEVS---SLRASSFSNEEKRRLEAKVID-- 1747

  Fly  1916 KLMLQQQLGGLFASVSGGNSGPGGVVDSHATV-----------RTQIERMEGKLSPPPAPPSGGW 1969
               |:.||                  |..|:.           :.|:|:|...|
Worm  1748 ---LEDQL------------------DEEASANELAQEKVRKSQQQLEQMTADL----------- 1780

  Fly  1970 PGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQR 2034
                                                   :.|.....||.|.::..|.....:::
Worm  1781 ---------------------------------------AMERSVCERTESDKIALERANRDLKQ 1806

  Fly  2035 Q----ERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVW 2095
            |    |......:|.|..::      |...:|....::..||.:..:.|:..|...:....:.:.
Worm  1807 QLQDAENTAVARLRTQINVA------EAKVSSLEQQLSLEEQDKMRQGRTLRRMETKMAEMQQML 1865

  Fly  2096 DRAEVEGPASGSGSEKEREKRERERERLYEIR------QVERERESHKVYQPAPPRVIQASMDTT 2154
            :..:.:|       |..|:..:|:..|:.::|      :.||:|.::|:............::.|
Worm  1866 EEEKRQG-------ESNRQAVDRQNARIRQLRTQLEDTEAERDRLTNKLKDERRRAEEMTDLNET 1923

  Fly  2155 GGH------RRED---RTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPA 2210
            ...      :||.   ||.||...|         |.:|..|.:|..|:|.....:|
Worm  1924 LSRDVSLLKQRETTARRTPGLIGHR---------ESRRFGSNTSLARDEFRGSALT--------- 1970

  Fly  2211 PVPPPSSTSPGLGVVSGVLMGSGS 2234
                 :..||.....|.:..|:||
Worm  1971 -----NEMSPSDRPASRLTSGTGS 1989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	267/706 (38%)
		MYSc_Myo15	169..828	CDD:276838	260/687 (38%)
		MyTH4	1014..1171	CDD:295320	28/159 (18%)
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
nmy-2	NP_492186.3	MYSc	81..793	CDD:214580	268/710 (38%)
		MYSc_class_II	100..781	CDD:276951	260/687 (38%)
		Myosin_tail_1	858..1934	CDD:279860	245/1443 (17%)
		ATP-synt_B	<1104..1195	CDD:304375	26/162 (16%)
		CDC37_N	<1317..1396	CDD:296150	20/85 (24%)
		Orbi_VP5	1599..>1865	CDD:279272	61/366 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910