DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo-1

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_492053.1 Gene:myo-1 / 172471 WormBaseID:WBGene00002348 Length:1938 Species:Caenorhabditis elegans


Alignment Length:2682 Identity:572/2682 - (21%)
Similarity:970/2682 - (36%) Gaps:858/2682 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 LRRQRPASLEDFEDLPNLSAKHPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHPQTFALQPGE 143
            |:|.|...|.| :..|..|.|:..:|.:....::    .|:|........||        :..|.
 Worm    14 LKRSREQQLAD-QSRPYDSKKNVWIPDAEEGYIE----GVIKGPGPKADTVI--------VTAGG 65

  Fly   144 GSLRARQDLGS-------SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMF 201
            ..:..::|:..       ...|||:.|..|::||:|||||.||...||||::|...:.:||||..
 Worm    66 KDVTLKKDIVQEVNPPKFEKTEDMSNLTFLNDASVLWNLRSRYAAMLIYTYSGLFCVVINPYKRL 130

  Fly   202 PDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYL 263
            | .|...||:.:.|:....:||||||:...|:..:   ...|.::|:||||:||||:||.|:.|.
 Worm   131 P-IYTDSVARMFMGKRRTEMPPHLFAVSDQAYRYMLQDHENQSMLITGESGAGKTENTKKVICYF 194

  Fly   264 AAVVPGGGSASAVITE---------QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAI 318
            |.|   |.|..|.:.|         ||::..|:|||||||:|.||:|||||||::.::| |.|.:
 Worm   195 ATV---GASQKAALKEGEKEVTLEDQIVQTNPVLEAFGNAKTVRNNNSSRFGKFIRIHFNKHGTL 256

  Fly   319 VGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE--ADKYFYLNQGATDCAS 381
            ....|..|||||||::.||||||.||:||::........|.:. ||.  ...|:::.| |.....
 Worm   257 ASCDIEHYLLEKSRVIRQAPGERCYHIFYQIYSDFKPQLRDEL-LLNHPISNYWFVAQ-AELLID 319

  Fly   382 GRVDWESLQ---GAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKW 443
            |..|.|..|   .|..||..|..|:....|:::|.:|:||:.|.:|.   .:|..|.....|.:.
 Worm   320 GIDDTEEFQLTDEAFDVLKFSPTEKMDCYRLMSAHMHMGNMKFKQRP---REEQAEPDGQDEAER 381

  Fly   444 AAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQ 508
            |.::..|..|...:||.|...:...|.:.....:||...|..|.||.|||.:|:|||.:.|..:.
 Worm   382 ACNMYGIDVDQFLKALVSPRVKVGTEWVSKGQNVDQVHWAIGAMAKGLYARVFHWLVKKCNLTLD 446

  Fly   509 KGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLA 573
            :.|....:.|.:|||.|||....||||||.||:.||.||.:||.|:|.|||.|||||.::||.:.
 Worm   447 QKGIDRDYFIGVLDIAGFEIFDFNSFEQLWINFVNEKLQQFFNHHMFVLEQEEYAREGIQWTFID 511

  Fly   574 WDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARP-----RIGAQE 632
            :..:|.....|.:||:||..:||:|...|:|||::..:|....| .....:.:|     :.|...
 Worm   512 FGLDLQACIELIEKPLGIISMLDEECIVPKATDMTLAQKLTDQHLGKHPNFEKPKPPKGKQGEAH 576

  Fly   633 FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELL-ASSRLPLVGELTKQLRAQRD------AGKTL 690
            |.:.||||.|.|.|..:|:||:|.|...|:.:: ||.:..|:.|:.:....|.:      ||...
 Worm   577 FAMRHYAGTVRYNVLNWLEKNKDPLNDTVVSVMKASKKNDLLVEIWQDYTTQEEAAAAAKAGGGR 641

  Fly   691 PKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLR 755
            ..|.:|.|:       ||:..:.:||.:|:..:.:.||.|:|||.||::|.:..:|...||.||.
 Worm   642 KGGKSGSFM-------TVSMMYRESLNKLMTMLHKTHPHFIRCIIPNEKKQSGMIDAALVLNQLT 699

  Fly   756 YLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCR-ALLEAM-PRTGVEGPDY 818
            ..|:|:.|:|.::|:|.|.:...||:||. :|.:..|:.:...:.|. |:|:|: .:..:....:
 Worm   700 CNGVLEGIRICRKGFPNRTQHPDFVQRYA-ILAAKEAKSSDDMKTCAGAILQALINQKQLNDEQF 763

  Fly   819 QLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQAR------- 876
            ::|.|:||.:..:...:|..|.::|.:.....|     ..:|...|...|.|.|.|..       
 Worm   764 RIGHTKVFFKAGVVAHIEDLRDDKLNQIITGFQ-----SAIRWYTATADAGARRKQLNSYIILQR 823

  Fly   877 ----WRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQ 937
                |...|....:  |..|.|..| |..|:.|...::..........||:: |:.||:::|...
 Worm   824 NIRSWCVLRTWDWF--LLFGKLRPQ-LKCGKMAEEMIKMAEEQKVLEAEAKK-AESARKSQEEAY 884

  Fly   938 AVL--ERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFG 1000
            |.|  |||:                            |::.|....| .|:|::  |.|      
 Worm   885 AKLSAERSK----------------------------LLEALELTQG-GSAAIE--EKL------ 912

  Fly  1001 KFSSVYCNGLRLQPRREPITAPL------LTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEK 1059
                     .||...|:.:...|      |:....::.|.:..        |....:.:|..|:.
 Worm   913 ---------TRLNSARQEVEKSLNDANDRLSEHEEKNADLEKQ--------RRKAQQEVENLKKS 960

  Fly  1060 LLA-DYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMR 1123
            :.| |..:.|:|..:..::       ||:|.|.                                
 Worm   961 IEAVDGNLAKSLEEKAAKE-------NQIHSLQ-------------------------------- 986

  Fly  1124 FVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEA 1188
                                                                             
 Worm   987 ----------------------------------------------------------------- 986

  Fly  1189 SQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAP 1253
                  |...|.:|       ::|..::...|:.::.:||.|        ||.||:       |.
 Worm   987 ------DEMNSQDE-------TIGKINKEKKLLEENNRQLVD--------DLQAEE-------AK 1023

  Fly  1254 RSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREP 1318
            ::...|...|..:|                 ....:|.|.||:|...|     :..::|..|   
 Worm  1024 QAQANRLRGKLEQT-----------------LDEMEEAVEREKRIRAE-----TEKSKRKVE--- 1063

  Fly  1319 SPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCD---SQEPLHTLGLSESRLNDRYHSAERLA 1380
                      |:.|...:::|:|.|   :.:.||..   .:..:|.||:   |:.|....|.||.
 Worm  1064 ----------GELKGAQETIDELSA---IKLETDASLKKKEADIHALGV---RIEDEQALANRLT 1112

  Fly  1381 PVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPS 1445
            ...|:...|..:.:                   |:.|:..:|.:.:|.:.|              
 Worm  1113 RQSKENAQRIIEIE-------------------DELEHERQSRSKADRARA-------------- 1144

  Fly  1446 QASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQEN--EAESEI----DDLDDYINDI 1504
               ::.:.||:     |:..|||.:....:         :|:|  :.:|||    .|||:     
 Worm  1145 ---ELQRELDE-----LNERLDEQNKQLEI---------QQDNNKKKDSEIIKFRRDLDE----- 1187

  Fly  1505 FQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLT 1569
                      :.:.::||:|.|        :.:..|:.|.:.:..|.:.:....|...:|:    
 Worm  1188 ----------KNMANEDQMAMI--------RRKNNDQISALTNTLDALQKSKAKIEKEKGV---- 1230

  Fly  1570 SKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLL 1634
                                         |..|.:...|...|:.:....|..:|:..:||   :
 Worm  1231 -----------------------------LQKELDDINAQVDQETKSRVEQERLAKQYEIQ---V 1263

  Fly  1635 AQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPP 1699
            |:   ||..:.:|:.......||..                     |:....|.|          
 Worm  1264 AE---LQQKVDEQSRQIGEYTSTKG---------------------RLSNDNSDL---------- 1294

  Fly  1700 PPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRK 1764
                        .:...|....|....||||                        ||..:..:.|
 Worm  1295 ------------ARQVEELEIHLATINRAKT------------------------AFSSQLVEAK 1323

  Fly  1765 TTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTT 1829
            ...:.:.|                       |.:||......   :..:|.:....||       
 Worm  1324 KAAEDELH-----------------------ERQEFHAACKN---LEHELDQCHELLE------- 1355

  Fly  1830 SAVNNRDRDRETQDVGQPMQSVVTTKLA--KKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAG 1892
            ..:|.:|      |: |...|.:.::::  |..:|      ..|.||..:|....|:::.:|...
 Worm  1356 EQINGKD------DI-QRQLSRINSEISQWKARYE------GEGLVGSEELEELKRKQMNRVMDL 1407

  Fly  1893 HSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERME-- 1955
            ....|....|             .:.|::..|.|.|......|.    ||.|.||...:|:.:  
 Worm  1408 QEALSAAQNK-------------VISLEKAKGKLLAETEDARSD----VDRHLTVIASLEKKQRA 1455

  Fly  1956 -GKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTS 2019
             .|:       ...|...:......:.|                       |.|      |.|.:
 Worm  1456 FDKI-------VDDWKRKVDDIQKEIDA-----------------------TTR------DSRNT 1484

  Fly  2020 SSQVVK---------EHVPAFIQRQERDTFG-AVR--QQQMISSHHLHLEDHSASSSPAVAAWEQ 2072
            |::|.|         |.:...  |:|...|. .:|  .:|:......:.|.|.     :|...||
 Worm  1485 STEVFKLRSSMDNLSEQIETL--RRENKIFSQEIRDINEQITQGGRTYQEVHK-----SVRRLEQ 1542

  Fly  2073 AERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESHK 2137
            .:.|...:...:....:..||...|.::|.....|    |.|||.:|:|     .:.|..|::|:
 Worm  1543 EKDELQHALDEAEAALEAEESKVLRLQIEVQQIRS----EIEKRIQEKE-----EEFENTRKNHQ 1598

  Fly  2138 VYQPAPPRVIQASMDTTGGHRRE--DRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSMHM 2200
                .....||||::|....:.|  .....|.|....:....:|..|....|...:::..|.:. 
 Worm  1599 ----RALESIQASLETEAKSKAELARAKKKLETDINQLEIALDHANKANVDAQKNLKKLFDQVK- 1658

  Fly  2201 TTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGP 2265
                                       .|.|             :|..:.|.|:|:.:.:.....
 Worm  1659 ---------------------------ELQG-------------QVDDEQRRREEIRENYLAAEK 1683

  Fly  2266 PVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRA 2330
            .:|:.|..::.|..        ||...:|       |...:.::. :....|.....||...:.|
 Worm  1684 RLAIALSESEDLAH--------RIEASDK-------HKKQLEIEQ-AELKSSNTELIGNNAALSA 1732

  Fly  2331 LVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLARRDAD-YLIVVQAISFGEIQ 2394
            : ||.:                                .:.:.:||.:.| ||        .|::
 Worm  1733 M-KRKV--------------------------------ENEVQIARNELDEYL--------NELK 1756

  Fly  2395 SAVTLPRPAA-----LQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAA 2454
            ::....|.||     |...:|..:..|:|..|.              |||               
 Worm  1757 ASEERARKAAADADRLAEEVRQEQEHAVHVDRQ--------------RKS--------------- 1792

  Fly  2455 QTLNVPLERLESRQAHAQRN--EHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQ 2517
              |.:..:.|:::...|:|.  :.|....::..::::..|...|.:|::.|:..:.:.:|:::.:
 Worm  1793 --LELNAKELQAKIDDAERAMIQFGAKALAKVEDRVRSLEAELHSEQRRHQESIKGYTKQERRAR 1855

  Fly  2518 QLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQ 2582
            :|:..:||...|.|..|:..::|.|:...|:|                          |:...|:
 Worm  1856 ELQFQVEEDKKAFDRLQENVEKLQQKIRVQKR--------------------------QIEEAEE 1894

  Fly  2583 MLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRNDQLRDADRHHERHQSA 2647
            :..|                            :::|:..:|.|:::           ..||.:.|
 Worm  1895 VATQ----------------------------NLSKFRQIQLALEN-----------AEERAEVA 1920

  Fly  2648 ANRSYAELVKWQGHAIR 2664
            .|    .||:.:|..:|
 Worm  1921 EN----SLVRMRGQVVR 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 257/712 (36%)
MYSc_Myo15 169..828 CDD:276838 252/691 (36%)
MyTH4 1014..1171 CDD:295320 15/163 (9%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myo-1NP_492053.1 Myosin_N 33..71 CDD:280832 7/49 (14%)
Myosin_head 86..773 CDD:278492 257/703 (37%)
MYSc_class_II 98..773 CDD:276951 252/691 (36%)
Myosin_tail_1 854..1918 CDD:279860 275/1783 (15%)
P-loop_NTPase <863..>1071 CDD:304359 61/429 (14%)
DUF2213 <1074..1224 CDD:303028 41/228 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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