DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and Myo9a

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_599162.2 Gene:Myo9a / 171296 RGDID:621395 Length:2626 Species:Rattus norvegicus


Alignment Length:3015 Identity:696/3015 - (23%)
Similarity:1095/3015 - (36%) Gaps:990/3015 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 PIPGEIQEVHRAAQVIVVQALIKGKMRIVRFHLEPW--------QRGGGGSVTPSPAQSP-SLAL 73
            |||.  ::...||:||  .:||.      |.||:..        :..||.....:|...| ...:
  Rat    33 PIPA--RKNSTAAEVI--DSLIN------RLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMM 87

  Fly    74 LSPHVLRRQRPASLEDFEDL---PNLSAK-HPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHP 134
            |.|.:....| .|.||:..|   .||... |.....|.||..:.|     :|:.          .
  Rat    88 LWPRMALENR-LSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEER-----RRMM----------E 136

  Fly   135 QTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYK 199
            :.|..||.:           ...:|:..|.||:|.:||.|||.|:....|||:.||||||:||:|
  Rat   137 RGFLPQPQQ-----------KDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIAINPFK 190

  Fly   200 MFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQ 261
            ..| .|..:..|.|....||.|.||::|:...|:.|:   ...|.:|||||||||||:||..::.
  Rat   191 FLP-IYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIH 254

  Fly   262 YLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEV-YFKSGAIVGAKITQ 325
            :|.|:...|.::.  :.:.||.|.|:|||||||:||.|:|||||||:::| |.::|.::||.:.:
  Rat   255 HLTALSQKGFASG--VEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEK 317

  Fly   326 YLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQ---------------- 374
            |||||||:|.|...||||||||.||.|.||.||..:.|.:.::|.:|||                
  Rat   318 YLLEKSRLVYQEHNERNYHVFYYLLAGASEEERLAFHLKQPEEYHFLNQITKKPLRQSWDDYCYD 382

  Fly   375 GATDC--ASG---RVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVE 434
            ...||  ..|   |.|:|.||.||:::|.....|..|..:|:|:|||||:.:.::..|  .:.::
  Rat   383 SEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNISYKKKTYR--DDSID 445

  Fly   435 VGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWL 499
            :.:...:...:.||.:..:.|..||.:|.|....|:|..|..:.:|:..|::.||:||:.||:|:
  Rat   446 ICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWI 510

  Fly   500 VSRINSIV--QKGGTHDAHRISI--LDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQA 560
            |.|||..:  .|....|...:||  ||||||||...|||||.|||:|||.||.|||:|:|||||.
  Rat   511 VFRINHALLNSKDLEKDTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQE 575

  Fly   561 EYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYAR 625
            ||..|.:.|..:.:.||...|:|::|||.|:.||||:|||||:||:.:.|:|..:.|..:.....
  Rat   576 EYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEENSYIEF 640

  Fly   626 PRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELT------------- 677
            |.:....|.:.||||:|.|.|..|.:||.|.:|.|::.||.|||...|..:|             
  Rat   641 PAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSRNAFVSGMTGIDPVAVFRWAVL 705

  Fly   678 ----KQLRAQRDAGK-----------TLP------------------------------------ 691
                :.:.|.|:|||           |.|                                    
  Rat   706 RAFFRAVVAFREAGKRHIQRKSGHDDTTPCTILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSIT 770

  Fly   692 -----------KGSN-------------------------------------GRFVT-------- 700
                       :|.|                                     |.|..        
  Rat   771 RKNPRTPLSDLQGMNTLNEKNQHDTFDIAWNVRTGIRQSRLPTNNTSLLDKDGIFANSASSKLLE 835

  Fly   701 ------------------------------------------------MKPRTPTVAARFADSLQ 717
                                                            .|.:.|:::|:|..||.
  Rat   836 RAHGILTRNKNFRSKPVLPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQVSLS 900

  Fly   718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
            :|::::.:..|:||:||:.|.||..||.....||:||||.|||:|::|||.||..:..||.||..
  Rat   901 KLMETLDQAEPYFVKCIRSNAEKLPLRFSDALVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSH 965

  Fly   783 Y-----RHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLRE--------ALHR- 833
            :     :|::||.......:|::           .:...:||:|.|.|||:|        .||: 
  Rat   966 FHVLLPQHIIPSKFNIQDFFRKI-----------NINPDNYQVGKTMVFLKEHERQHLQDLLHQE 1019

  Fly   834 --------------ALESGRTERLRRAAVSVQRHVRGMLVRRQLAR---------RQAAATRLQA 875
                          .|...:...||:|:|.:||..|..|.::|:..         ..:||:.|||
  Rat  1020 VLRRIILLQRWFRVLLSRQQFLHLRQASVIIQRFWRNYLNQKQVRNAAVEKDAFIMASAASLLQA 1084

  Fly   876 RWRGQRAQQRYERLRKGALTAQRLWRGRQARRR------VQQLRSDHRRRQEARE---------A 925
            .||....:|||..||..|:..|:.|| ...|||      :|.....:|:.::.:|         :
  Rat  1085 SWRAHLERQRYLELRAAAVIIQQRWR-ELCRRRHRAATCIQSRWRGYRQSKKYKEQRNKIILLQS 1148

  Fly   926 AQRAREAREAKQAVLERSQLSYLDIPAELAFIYS----KLQGWSPPH-GDRHLVKVLGTVPGPPS 985
            ..|...||:..:| |:..:|....:...||.|.:    ::||..|.. .||..           :
  Rat  1149 IYRGFRARQRYKA-LKEERLKETKLEHGLAQIKTCGPLEIQGSDPSEWEDRSF-----------A 1201

  Fly   986 SAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSND 1050
            :.|:..|:             |..:        |.:..::|.:|.|            ..:.|.|
  Rat  1202 NRVKAIEE-------------CKSV--------IESNRISRESSMD------------FSKESPD 1233

  Fly  1051 KALEGAKEK----LLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCF 1111
            |..|..:.:    |..|.||.:       |.:.|..|..:..|....  |:.|:.:|        
  Rat  1234 KQQERGRSQSGTDLQGDVIVRQ-------RPKSLEDLHQKKVGRAKR--ESRRMREL-------- 1281

  Fly  1112 QPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGC 1176
                           ::|..||..|.:|.|     ||.|..               |.|.|:...
  Rat  1282 ---------------EQAIFSLELLKVRSL-----GGMSPS---------------EERRWSTEL 1311

  Fly  1177 ---DMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVM 1238
               .:..|...||..|...:::..| |:|         ...|:..:|:||||:....|       
  Rat  1312 MPEGLQSPQGTPDSESSQGSLELLT-CDE---------NQKSKPESLILDDGELKISS------- 1359

  Fly  1239 DLIAEKELCPA-FPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSREL 1302
                     |: |..|:.|                                         |....
  Rat  1360 ---------PSTFTNPKFD-----------------------------------------SQNNA 1374

  Fly  1303 LSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSES 1367
            ||.||..:..:        .|:|:|:.....::.:.::.|.....|:  .|.||           
  Rat  1375 LSASSETSSTF--------SGKGASSDSEHLKNGTAEEKLVYSSQPI--TCKSQ----------- 1418

  Fly  1368 RLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAP 1432
             |.|.:.|:..         |.:....|                     :...::|:..|||   
  Rat  1419 -LRDSFVSSSL---------PTFFYIPH---------------------QEPLKTSSQLDTS--- 1449

  Fly  1433 SLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDL 1497
                 ::|.::|.:.:.:...|          :||...:||....|   |.....|...|     
  Rat  1450 -----IQRNKLPERETTLKTTL----------TLDINREARKCQFS---GQVTPLNPDSS----- 1491

  Fly  1498 DDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVA 1562
                      ..:::.||||.               .:.|:|.::.:.::..:.:.::.:...:.
  Rat  1492 ----------CTVLKKLEKLN---------------IEKEKRQKQLQQQNEKEMMEQIRQQTDIL 1531

  Fly  1563 EGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQ--QQVQRAFLQSAMAQ 1625
            |       ||..|........|:::    ||            .|:.||  |:|:|.        
  Rat  1532 E-------KERKAFKTIEQSRTEAS----LL------------APSFYQSRQKVERP-------- 1565

  Fly  1626 NLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLV 1690
                                                     |||.|...|.:....:..:.|:|.
  Rat  1566 -----------------------------------------SSLHIQNTPSKGEAGVLGSPSALA 1589

  Fly  1691 VMESLQPPPPPPPPPMPPPLECK-DPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFF 1754
            ..:|.....||...|:....|.| .|.::|...:   ..||.|:|              |:.|  
  Rat  1590 TKDSPSIHLPPKDRPVTLFFERKGSPCQSRTVKE---LTKTERMG--------------TQHD-- 1635

  Fly  1755 AFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAI------------------------ 1795
            |.....:.|.|  :.:|.:.|.:.......|...|:|....                        
  Rat  1636 AACRLSNNRNT--EREHFKSTHSYSHRSDDPSREGSSRPIFFTPKDNVITPLVHSGNPQVHKQDE 1698

  Fly  1796 -EWEEFEIESPTPPPMSGQLMRSSIRLETTTT--TTTSAVNNRDRDRETQDVGQPMQSVVTTKLA 1857
             .|:. ::..|....::....:...|:..|.:  .|.....:.:.|.|..|....::.:::...|
  Rat  1699 PAWKS-KLAGPGQREVARPAHKKKARMARTRSDFLTRGTFADGEGDTEEDDYDDIIEPLLSLDQA 1762

  Fly  1858 KKSFEIGADRPPPGSVGKLKLS-SEM-RQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQ 1920
            ..| |:|    |..|:|:...| ||| .||...|             .||   |:|   .|.|.|
  Rat  1763 SHS-ELG----PVSSLGQASHSDSEMTSQRFSSV-------------DEQ---ARL---HKAMSQ 1803

  Fly  1921 QQLGGLFASVSGGNSGPGGVVDSHATVRTQIERM----EGKLSPPPAPPSGGWPGVLLPPAPS-- 1979
            .::..|          .|....|...:|.|..:|    :||        .|......:.|||.  
  Rat  1804 GEITKL----------AGRQKSSDLDIRPQRAKMRFWAKGK--------QGEKKTTRVKPAPQSE 1850

  Fly  1980 -----VPAPPPPIRPPS----MAPPAPPPAPQSPPTAR-----SPEPEP---------------- 2014
                 ..:...|:.|.|    ...|.||.:|:.|.:.|     :.||.|                
  Rat  1851 VSSLFAGSDVTPVHPFSDELTQYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRGVKISSVALD 1915

  Fly  2015 --DYRTSSSQVVK-----EHVPAFIQRQ---------ERDTF------GAVRQ--QQMISSHH-- 2053
              .::..|.|::.     :.:..|:.::         ::||.      .|:::  |.:.||:.  
  Rat  1916 SMHWQNDSVQIIASANDLKSMDEFLLKKMNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSSYSSA 1980

  Fly  2054 LHLED-HSASSSPAVAAWEQAERERSRSRSRSRDREDYSES---VW--------DRAEVEGPASG 2106
            |.::| .|.......|.:||...:..|...|     |::||   ||        |....|.....
  Rat  1981 LAMDDGKSIRYKDLYALFEQILEKTMRFEQR-----DWNESPVRVWVNTFKVFLDEYMNEFKTLD 2040

  Fly  2107 SGSEK----EREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRRE-----DR 2162
            |.:.|    ||:||.::...|.|      |...|..      :..|.|:.|...:...     ||
  Rat  2041 STAPKVLKTERKKRRKKETDLVE------EHNGHMF------KATQYSIPTYCEYCSSLIWIMDR 2093

  Fly  2163 TG--GLATFRTH----------MAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPP 2215
            ..  .|..:..|          .::||:.|   .||...|:  ||..:   |.....||..|...
  Rat  2094 ASVCKLCKYACHKKCCLKTTAKCSKKYDPE---LSSRQFGV--ELSRL---TSEDRAVPLVVEKL 2150

  Fly  2216 SSTSPGLGV-VSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGD 2279
            .:.....|: ..|:...|||        .|::       ||:.|..:.....|.||.....|:..
  Rat  2151 INYIEMHGLYTEGIYRKSGS--------TNKI-------KELRQGLDTDAESVNLDDYNIHVIAS 2200

  Fly  2280 VFGVTPCLRITP------------------QEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGG 2326
            ||  ...||..|                  ||:...:..::.   .:|.||..:.|         
  Rat  2201 VF--KQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYS---VIDQLSRTHLS--------- 2251

  Fly  2327 QVRALVKRHLVDMA--RDWPLYFARLFAVQGAPLY---PDV-----SIMGVSHSGLYLARRDADY 2381
            .:..|: .|||.:|  .|.....|...|:..||..   ||.     |:..:|.:...:.      
  Rat  2252 TLERLI-FHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVE------ 2309

  Fly  2382 LIVVQAIS-----FGEIQSAVTLPRPAALQLNL-RNGKHLALHAARAAAIQSMVTTFVQEFRKSQ 2440
            ||||:.::     ..:|.|.......|..:|:| |......|.|.|          |:...|.|.
  Rat  2310 LIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMKPVLIAVR----------FMSITRSSV 2364

  Fly  2441 SKASTLSSGARAAAQT---------LNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHH 2496
            |....|..|:.....:         .:||.|.|.|..|      ...|...:|...:||.|    
  Rat  2365 SGKGRLHRGSHPNPSSPVIVRLPSMSDVPEETLTSETA------MDTDVTDQQQAAMQQEE---- 2419

  Fly  2497 LQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFL--KQQSYLHS 2559
                :...:|.::.|:::::...|..:.|...:.|...:.:..:|.....:...:  :::|...|
  Rat  2420 ----KVLTEQIENLQKEKEELTFEMLVLEPRASDDEALESEASIGTADSLENLNMDPEERSLALS 2480

  Fly  2560 ARKSNAGQQPSSLTNGQVHHQEQML 2584
            :.|:....:|||....|:..|...|
  Rat  2481 SLKAAGKSEPSSKFRKQLRKQPDSL 2505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 294/904 (33%)
MYSc_Myo15 169..828 CDD:276838 285/860 (33%)
MyTH4 1014..1171 CDD:295320 29/160 (18%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
Myo9aNP_599162.2 Actin-binding. /evidence=ECO:0000250 908..919 5/10 (50%)
Neck or regulatory domain. /evidence=ECO:0000250 1022..1163 36/142 (25%)
Tail. /evidence=ECO:0000250 1164..2589 331/1829 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1221..1276 16/75 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1397 12/85 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1562..1602 12/88 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1618..1673 15/75 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1689..1726 3/37 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1765..1784 9/23 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1872..1907 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2365..2385 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2449..2527 11/57 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2552..2614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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