|
Fly 18 PIPGEIQEVHRAAQVIVVQALIKGKMRIVRFHLEPW--------QRGGGGSVTPSPAQSP-SLAL 73
|||. ::...||:|| .:||. |.||:.. :..||.....:|...| ...:
Rat 33 PIPA--RKNSTAAEVI--DSLIN------RLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMM 87
Fly 74 LSPHVLRRQRPASLEDFEDL---PNLSAK-HPALPSSRLRRLKCRYPQVVKRLSTLCSDVIARHP 134
|.|.:....| .|.||:..| .||... |.....|.||..:.| :|:. .
Rat 88 LWPRMALENR-LSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEER-----RRMM----------E 136
Fly 135 QTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYK 199
:.|..||.: ...:|:..|.||:|.:||.|||.|:....|||:.||||||:||:|
Rat 137 RGFLPQPQQ-----------KDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIAINPFK 190
Fly 200 MFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQ 261
..| .|..:..|.|....||.|.||::|:...|:.|: ...|.:|||||||||||:||..::.
Rat 191 FLP-IYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIH 254
Fly 262 YLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEV-YFKSGAIVGAKITQ 325
:|.|:...|.::. :.:.||.|.|:|||||||:||.|:|||||||:::| |.::|.::||.:.:
Rat 255 HLTALSQKGFASG--VEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEK 317
Fly 326 YLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQ---------------- 374
|||||||:|.|...||||||||.||.|.||.||..:.|.:.::|.:|||
Rat 318 YLLEKSRLVYQEHNERNYHVFYYLLAGASEEERLAFHLKQPEEYHFLNQITKKPLRQSWDDYCYD 382
Fly 375 GATDC--ASG---RVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVE 434
...|| ..| |.|:|.||.||:::|.....|..|..:|:|:|||||:.:.::..| .:.::
Rat 383 SEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNISYKKKTYR--DDSID 445
Fly 435 VGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWL 499
:.:...:...:.||.:..:.|..||.:|.|....|:|..|..:.:|:..|::.||:||:.||:|:
Rat 446 ICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWI 510
Fly 500 VSRINSIV--QKGGTHDAHRISI--LDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQA 560
|.|||..: .|....|...:|| ||||||||...|||||.|||:|||.||.|||:|:|||||.
Rat 511 VFRINHALLNSKDLEKDTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQE 575
Fly 561 EYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYAR 625
||..|.:.|..:.:.||...|:|::|||.|:.||||:|||||:||:.:.|:|..:.|..:.....
Rat 576 EYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEENSYIEF 640
Fly 626 PRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELT------------- 677
|.:....|.:.||||:|.|.|..|.:||.|.:|.|::.||.|||...|..:|
Rat 641 PAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSRNAFVSGMTGIDPVAVFRWAVL 705
Fly 678 ----KQLRAQRDAGK-----------TLP------------------------------------ 691
:.:.|.|:||| |.|
Rat 706 RAFFRAVVAFREAGKRHIQRKSGHDDTTPCTILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSIT 770
Fly 692 -----------KGSN-------------------------------------GRFVT-------- 700
:|.| |.|..
Rat 771 RKNPRTPLSDLQGMNTLNEKNQHDTFDIAWNVRTGIRQSRLPTNNTSLLDKDGIFANSASSKLLE 835
Fly 701 ------------------------------------------------MKPRTPTVAARFADSLQ 717
.|.:.|:::|:|..||.
Rat 836 RAHGILTRNKNFRSKPVLPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQVSLS 900
Fly 718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
:|::::.:..|:||:||:.|.||..||.....||:||||.|||:|::|||.||..:..||.||..
Rat 901 KLMETLDQAEPYFVKCIRSNAEKLPLRFSDALVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSH 965
Fly 783 Y-----RHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLRE--------ALHR- 833
: :|::||.......:|:: .:...:||:|.|.|||:| .||:
Rat 966 FHVLLPQHIIPSKFNIQDFFRKI-----------NINPDNYQVGKTMVFLKEHERQHLQDLLHQE 1019
Fly 834 --------------ALESGRTERLRRAAVSVQRHVRGMLVRRQLAR---------RQAAATRLQA 875
.|...:...||:|:|.:||..|..|.::|:.. ..:||:.|||
Rat 1020 VLRRIILLQRWFRVLLSRQQFLHLRQASVIIQRFWRNYLNQKQVRNAAVEKDAFIMASAASLLQA 1084
Fly 876 RWRGQRAQQRYERLRKGALTAQRLWRGRQARRR------VQQLRSDHRRRQEARE---------A 925
.||....:|||..||..|:..|:.|| ...||| :|.....:|:.::.:| :
Rat 1085 SWRAHLERQRYLELRAAAVIIQQRWR-ELCRRRHRAATCIQSRWRGYRQSKKYKEQRNKIILLQS 1148
Fly 926 AQRAREAREAKQAVLERSQLSYLDIPAELAFIYS----KLQGWSPPH-GDRHLVKVLGTVPGPPS 985
..|...||:..:| |:..:|....:...||.|.: ::||..|.. .||.. :
Rat 1149 IYRGFRARQRYKA-LKEERLKETKLEHGLAQIKTCGPLEIQGSDPSEWEDRSF-----------A 1201
Fly 986 SAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSND 1050
:.|:..|: |..: |.:..::|.:|.| ..:.|.|
Rat 1202 NRVKAIEE-------------CKSV--------IESNRISRESSMD------------FSKESPD 1233
Fly 1051 KALEGAKEK----LLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCF 1111
|..|..:.: |..|.||.: |.:.|..|..:..|.... |:.|:.:|
Rat 1234 KQQERGRSQSGTDLQGDVIVRQ-------RPKSLEDLHQKKVGRAKR--ESRRMREL-------- 1281
Fly 1112 QPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGC 1176
::|..||..|.:|.| ||.|.. |.|.|:...
Rat 1282 ---------------EQAIFSLELLKVRSL-----GGMSPS---------------EERRWSTEL 1311
Fly 1177 ---DMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVM 1238
.:..|...||..|...:::..| |:| ...|:..:|:||||:....|
Rat 1312 MPEGLQSPQGTPDSESSQGSLELLT-CDE---------NQKSKPESLILDDGELKISS------- 1359
Fly 1239 DLIAEKELCPA-FPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSREL 1302
|: |..|:.| |....
Rat 1360 ---------PSTFTNPKFD-----------------------------------------SQNNA 1374
Fly 1303 LSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSES 1367
||.||..:..: .|:|:|:.....::.:.::.|.....|: .|.||
Rat 1375 LSASSETSSTF--------SGKGASSDSEHLKNGTAEEKLVYSSQPI--TCKSQ----------- 1418
Fly 1368 RLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAP 1432
|.|.:.|:.. |.:....| :...::|:..|||
Rat 1419 -LRDSFVSSSL---------PTFFYIPH---------------------QEPLKTSSQLDTS--- 1449
Fly 1433 SLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDL 1497
::|.::|.:.:.:...| :||...:||....| |.....|...|
Rat 1450 -----IQRNKLPERETTLKTTL----------TLDINREARKCQFS---GQVTPLNPDSS----- 1491
Fly 1498 DDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVA 1562
..:::.||||. .:.|:|.::.:.::..:.:.::.:...:.
Rat 1492 ----------CTVLKKLEKLN---------------IEKEKRQKQLQQQNEKEMMEQIRQQTDIL 1531
Fly 1563 EGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQ--QQVQRAFLQSAMAQ 1625
| ||..|........|::: || .|:.|| |:|:|.
Rat 1532 E-------KERKAFKTIEQSRTEAS----LL------------APSFYQSRQKVERP-------- 1565
Fly 1626 NLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLV 1690
|||.|...|.:....:..:.|:|.
Rat 1566 -----------------------------------------SSLHIQNTPSKGEAGVLGSPSALA 1589
Fly 1691 VMESLQPPPPPPPPPMPPPLECK-DPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFF 1754
..:|.....||...|:....|.| .|.::|...: ..||.|:| |:.|
Rat 1590 TKDSPSIHLPPKDRPVTLFFERKGSPCQSRTVKE---LTKTERMG--------------TQHD-- 1635
Fly 1755 AFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESP-------------- 1805
|.....:.|.| :.:|.:.|.:.......|...|:|.......:..:.:|
Rat 1636 AACRLSNNRNT--EREHFKSTHSYSHRSDDPSREGSSRPIFFTPKDNVITPLVHSGNPQVHKQDE 1698
Fly 1806 -------TPPPMSGQLMRSSIRLETTTTTTTSAVNNR------DRDRETQDVGQPMQSVVTTKLA 1857
..|....|:.|.:.:.:.....|.|....| :.|.|..|....::.:::...|
Rat 1699 PAWKSKLAGPGQREQVARPAHKKKARMARTRSDFLTRGTFADGEGDTEEDDYDDIIEPLLSLDQA 1763
Fly 1858 KKSFEIGADRPPPGSVGKLKLS-SEM-RQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQ 1920
..| |:| |..|:|:...| ||| .||...| .|| |:| .|.|.|
Rat 1764 SHS-ELG----PVSSLGQASHSDSEMTSQRFSSV-------------DEQ---ARL---HKAMSQ 1804
Fly 1921 QQLGGLFASVSGGNSGPGGVVDSHATVRTQIERM----EGKLSPPPAPPSGGWPGVLLPPAPS-- 1979
.::..| .|....|...:|.|..:| :|| .|......:.|||.
Rat 1805 GEITKL----------AGRQKSSDLDIRPQRAKMRFWAKGK--------QGEKKTTRVKPAPQSE 1851
Fly 1980 -----VPAPPPPIRPPS----MAPPAPPPAPQSPPTAR-----SPEPEP---------------- 2014
..:...|:.|.| ...|.||.:|:.|.:.| :.||.|
Rat 1852 VSSLFAGSDVTPVHPFSDELTQYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRGVKISSVALD 1916
Fly 2015 --DYRTSSSQVVK-----EHVPAFIQRQ---------ERDTF------GAVRQ--QQMISSHH-- 2053
.::..|.|::. :.:..|:.:: ::||. .|::: |.:.||:.
Rat 1917 SMHWQNDSVQIIASANDLKSMDEFLLKKMNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSSYSSA 1981
Fly 2054 LHLED-HSASSSPAVAAWEQAERERSRSRSRSRDREDYSES---VW--------DRAEVEGPASG 2106
|.::| .|.......|.:||...:..|...| |::|| || |....|.....
Rat 1982 LAMDDGKSIRYKDLYALFEQILEKTMRFEQR-----DWNESPVRVWVNTFKVFLDEYMNEFKTLD 2041
Fly 2107 SGSEK----EREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRRE-----DR 2162
|.:.| ||:||.::...|.| |...|.. :..|.|:.|...:... ||
Rat 2042 STAPKVLKTERKKRRKKETDLVE------EHNGHMF------KATQYSIPTYCEYCSSLIWIMDR 2094
Fly 2163 TG--GLATFRTH----------MAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPP 2215
.. .|..:..| .::||:.| .||...|: ||..: |.....||..|...
Rat 2095 ASVCKLCKYACHKKCCLKTTAKCSKKYDPE---LSSRQFGV--ELSRL---TSEDRAVPLVVEKL 2151
Fly 2216 SSTSPGLGV-VSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGD 2279
.:.....|: ..|:...||| .|:: ||:.|..:.....|.||.....|:..
Rat 2152 INYIEMHGLYTEGIYRKSGS--------TNKI-------KELRQGLDTDAESVNLDDYNIHVIAS 2201
Fly 2280 VFGVTPCLRITP------------------QEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGG 2326
|| ...||..| ||:...:..::. .:|.||..:.|
Rat 2202 VF--KQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYS---VIDQLSRTHLS--------- 2252
Fly 2327 QVRALVKRHLVDMA--RDWPLYFARLFAVQGAPLY---PDV-----SIMGVSHSGLYLARRDADY 2381
.:..|: .|||.:| .|.....|...|:..||.. ||. |:..:|.:...:.
Rat 2253 TLERLI-FHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVE------ 2310
Fly 2382 LIVVQAIS-----FGEIQSAVTLPRPAALQLNL-RNGKHLALHAARAAAIQSMVTTFVQEFRKSQ 2440
||||:.:: ..:|.|.......|..:|:| |......|.|.| |:...|.|.
Rat 2311 LIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMKPVLIAVR----------FMSITRSSV 2365
Fly 2441 SKASTLSSGARAAAQT---------LNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHH 2496
|....|..|:.....: .:||.|.|.|..| ...|...:|...:||.|
Rat 2366 SGKGRLHRGSHPNPSSPVIVRLPSMSDVPEETLTSETA------MDTDVTDQQQAAMQQEE---- 2420
Fly 2497 LQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFL--KQQSYLHS 2559
:...:|.::.|:::::...|..:.|...:.|...:.:..:|.....:...: :::|...|
Rat 2421 ----KVLTEQIENLQKEKEELTFEMLVLEPRASDDEALESEASIGTADSLENLNMDPEERSLALS 2481
Fly 2560 ARKSNAGQQPSSLTNGQVHHQEQML 2584
:.|:....:|||....|:..|...|
Rat 2482 SLKAAGKSEPSSKFRKQLRKQPDSL 2506
| 
