Protein Alignment Myo10A and Myh7

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_542766.1
• Gene: Myh7 / 140781
• MGIID: 2155600
• Length: 1935
• Species: Mus musculus
• Alignment Length: 2223
• Identity: 532/2223 - (23%)
• Similarity: 873/2223 - (39%)
• Gaps: 588/2223 - (26%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Mouse    87 IEDMAMLTFLHEPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLP-VYNAEVVAAYRGKKRSEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAV-----------VPGGGS 272
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|.:           .||.|:
Mouse   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDRSKKDQTPGKGT 215

  Fly   273 ASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQ 336
                :.:||::|.|.|||||||:|.||||||||||::.::| .:|.:..|.|..|||||||::.|
Mouse   216 ----LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQ 276

  Fly   337 APGERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQGATDCASGRVDWESL---QGAMQVL 396
            ...||:||:||::|.. .:.|.....|:..:.|.|  ::||.|..|| ..|.|.|   ..|..||
Mouse   277 LKAERDYHIFYQILSN-KKPELLDMLLITNNPYDYAFISQGETTVAS-IDDSEELMATDSAFDVL 339

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTS 461
            |.:..|:..|.::..|::|.||:.|.::|   .:|..|.....|...:|:|:.:::..|.:.|..
Mouse   340 GFTPEEKNSIYKLTGAIMHFGNMKFKQKQ---REEQAEPDGTEEADKSAYLMGLNSADLLKGLCH 401

  Fly   462 RTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGF 526
            ...:...|.:.....:.|...|..|.||::|..:|||:|:|||:.::...... :.|.:|||.||
Mouse   402 PRVKVGNEYVTKGQNVQQVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQ-YFIGVLDIAGF 465

  Fly   527 EDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGI 591
            |....|||||||||:.||.||.:||.|:|.|||.||.:|.:|||.:.:..:|.....|.:||:||
Mouse   466 EIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQACIDLIEKPMGI 530

  Fly   592 CHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWYCVDGFLD 651
            ..:|::|..||:|||::|..|.:.|| ..|..:.:||  .|.||  |.:.||||.|.|.:.|:|.
Mouse   531 MSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFSLVHYAGTVDYNILGWLQ 595

  Fly   652 KNRDALRGDVLELLASSRLPLVGELTKQLR---AQRDAGK-TLPKGSNGRFVTMKPRTPTVAARF 712
            ||:|.|...|:.|...|.|.|:..|.....   |..|.|| ...|||:.:         ||:|..
Mouse   596 KNKDPLNETVVGLYQKSSLKLLSNLFANYAGADAPADKGKGKAKKGSSFQ---------TVSALH 651

  Fly   713 ADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQ 777
            .::|.:|:.::...||.|||||.||:.|....||.|.|:.|||..|:|:.|:|.::|:|.|:.:.
Mouse   652 RENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYG 716

  Fly   778 HFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRT 840
            .|.:|||.|.|:.:..|  ...|:....||.::   .::...|:.|.|:||.:..|...||..|.
Mouse   717 DFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSL---DIDHNQYKFGHTKVFFKAGLLGLLEEMRD 778

  Fly   841 ERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERLRKGA 893
            |||.|....:|...||:|.|   ::|..|:.:...:|         ..|...:...:.:.|.|.|
Mouse   779 ERLSRIITRIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKNWPWMKLYFKIKPLLKSA 843

  Fly   894 LTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIY 958
            .|.:.:...::...||:.                 |.|..||::..||...:|.|....:|
Mouse   844 ETEKEMATMKEEFGRVKD-----------------ALEKSEARRKELEEKMVSLLQEKNDL---- 887

  Fly   959 SKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPL 1023
             :||                         ||..:|....:..:...:..|.::|:.:.:.:|..|
Mouse   888 -QLQ-------------------------VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMTERL 926

  Fly  1024 LTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVH 1088
                       :|                    :|::.|:....|    |.|.||     |::
Mouse   927 -----------ED--------------------EEEMNAELTAKK----RKLEDE-----CSE-- 949

  Fly  1089 GLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGA 1153
                                            |.|.:||      ..|.|.::.:::
Mouse   950 --------------------------------LKRDIDD------LELTLAKVEKEK-------- 968

  Fly  1154 VGAGACRSFVPAWLEWRAWTRGCD-MALPLTLPDEASQTV---AVDSWTSCEEAAALAVSSLGVA 1214
               .|..:.|....|..|   |.| :.:.||...:|.|..   |:|...:.|:    .|::|..|
Mouse   969 ---HATENKVKNLTEEMA---GLDEIIVKLTKEKKALQEAHQQALDDLQAEED----KVNTLTKA 1023

  Fly  1215 SRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVP 1279
            .    :.|:  ||:.|..|     .|..||::       |.||.|     |:..|...:|.
Mouse  1024 K----VKLE--QQVDDLEG-----SLEQEKKV-------RMDLER-----AKRKLEGDLKL---- 1061

  Fly  1280 PPAPPTSSGKEDVPRERRSSRELLSRS----SALNERYFEREPSPGPGQGSSTGQAKSRSKSLDD 1340
                 |.....|:..:::...|.|.:.    :|||.| .|.|.:.|........:.::|.:.|::
Mouse  1062 -----TQESIMDLENDKQQLDERLKKKDFELNALNAR-IEDEQALGSQLQKKLKELQARIEELEE 1120

  Fly  1341 LLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASH 1405
            .|..:..       ::..:..|....||  :....:|||...|..|..:.:.::..
Mouse  1121 ELEAERT-------ARAKVEKLRSDLSR--ELEEISERLEEAGGATSVQIEMNKKR--------- 1167

  Fly  1406 GSHSSKYADKAEY-ATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDEL 1469
                     :||: ..|......|.:..:.|:.:|:....|.|.             |...:|.|
Mouse  1168 ---------EAEFQKMRRDLEEATLQHEATAAALRKKHADSVAE-------------LGEQIDNL 1210

  Fly  1470 SDARSLAASIRGGSYEQENEAESEID-DLDDYINDIFQPIPLVQNLEKL--TSKDQLAAIIKGGG 1531
            ...:.        ..|:|   :||.. :|||..:::.|.|....||||:  |.:||:
Mouse  1211 QRVKQ--------KLEKE---KSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM-------- 1256

  Fly  1532 VASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQL 1596
                   .:..|:.|:....:|:             |||:.....:..|..|...:..:.|:.||
Mouse  1257 -------NEHRSKAEETQRSVND-------------LTSQRAKLQTENGELSRQLDEKEALISQL 1301

  Fly  1597 MQLPGETESGPALYQQQV--------QRAFLQSAMAQNLQ--------IQQQLLAQNQA---LQT 1642
            .:       |...|.||:        :....::|:|..||        :::|...:.:|   ||.
Mouse  1302 TR-------GKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQR 1359

  Fly  1643 LLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMP 1707
            :||:..:..|...:.....|  |..:..:.....:...|::....::..:.:
Mouse  1360 VLSKANSEVAQWRTKYETDA--IQRTEELEEAKKKLAQRLQDAEEAVEAVNA------------- 1409

  Fly  1708 PPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTE-EDFFAFKMRQHQRKTTPQAQH 1771
               :|....:|:|                         :.|.| ||......|
Mouse  1410 ---KCSSLEKTKH-------------------------RLQNEIEDLMVDVER------------ 1434

  Fly  1772 HQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRS-SIRL--------ETTTTT 1827
                ||..........|.......||::...||.:....|.:..|| |..|        |:....
Mouse  1435 ----SNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHL 1495

  Fly  1828 TTSAVNNRDRDRE----TQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSE------- 1881
            .|....|::...|    |:.:|...:|:...:..:|..|          ..||:|.|.
Mouse  1496 ETFKRENKNLQEEISDLTEQLGSTGKSIHELEKIRKQLE----------AEKLELQSALEEAEAS 1550

  Fly  1882 --------MRQRLE--QVTAGHSVRSTVSTKSEQRAPAKLEDTRKL-MLQQQLGGLFASVSGGNS 1935
                    :|.:||  |:.|  .:...::.|.|:...||....|.: .||..|
Mouse  1551 LEHEEGKILRAQLEFNQIKA--EIERKLAEKDEEMEQAKRNHLRMVDSLQTSL------------ 1601

  Fly  1936 GPGGVVDSHATVRTQI----ERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPA 1996
                  |:....|.:.    ::|||.|:......|                     ....||..|
Mouse  1602 ------DAETRSRNEALRVKKKMEGDLNEMEIQLS---------------------HANRMAAEA 1639

  Fly  1997 PPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQ------ERDTFGAV----------RQ 2045
            ...........:..:.:.|....::..:||:: |.::|:      |.:...||          .:
Mouse  1640 QKQVKSLQSLLKDTQIQLDDAVRANDDLKENI-AIVERRNNLLQAELEELRAVVEQTERSRKLAE 1703

  Fly  2046 QQMISSHH----LHLEDHS-----------------------------------ASSSPAVAAWE 2071
            |::|.:..    ||.::.|                                   |.:..|:.| |
Mouse  1704 QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMA-E 1767

  Fly  2072 QAERERSRSRSRSRDREDYSESV------WDRAEVEGPASGSGSEKEREKRERERERLYEIRQVE 2130
            :.::|:..|....|.:::..:::      .|.||......|....::.|.|.||.|...|..| :
Mouse  1768 ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQ-K 1831

  Fly  2131 RERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGL----------ATFRTHMAQKYEHERKRKS 2185
            |..||.|..:.:..|:.:.:..|     .|||...|          ...:.:..|..|.|.:..:
Mouse  1832 RNAESVKGMRKSERRIKELTYQT-----EEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANT 1891

  Fly  2186 SASS--GMREELD 2196
            :.|.  .::.|||
Mouse  1892 NLSKFRKVQHELD 1904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	256/689 (37%)
		PTZ00121	<828..>943	CDD:173412	29/126 (23%)
		MyTH4	1014..1171	CDD:470587	20/156 (13%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	17/69 (25%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myh7	NP_542766.1	COG5022	37..1432	CDD:227355	435/1674 (26%)
		MYSc_class_II	99..766	CDD:276951	256/689 (37%)
		Actin-binding	655..677		10/21 (48%)
		Actin-binding	757..771		5/13 (38%)
		SMC_prok_B	1173..1930	CDD:274008	158/909 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1915..1935