DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and MYO3B

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_011508956.1 Gene:MYO3B / 140469 HGNCID:15576 Length:1386 Species:Homo sapiens


Alignment Length:1196 Identity:379/1196 - (31%)
Similarity:572/1196 - (47%) Gaps:228/1196 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDWAEGDLVWFDPGMGHPI----------PGEIQEVHRAAQV---IVVQALIKG-KMRIVRFHL- 50
            ::..:||...||.   ||:          |..:....:..:.   .:.|.|||. :.|....|| 
Human   236 IELGDGDPPLFDM---HPVKTLFKIPRNPPPTLLHPEKWCEEFNHFISQCLIKDFERRPSVTHLL 297

  Fly    51 -EPWQRGGGGSVTPSPAQSPSLALLSPHVLRRQRPASLEDFEDLPNLSAKHP-ALPSSRLRRLKC 113
             .|:.:|..|.|.               .|::|....|:|        .||. .:..:|..|:..
Human   298 DHPFIKGVHGKVL---------------FLQKQLAKVLQD--------QKHQNPVAKTRHERMHT 339

  Fly   114 RYPQVVKRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLR 178
            |.|..|:.....|.:                             :|:..|:.|.|.:::..|:.|
Human   340 RRPYHVEDAEKYCLE-----------------------------DDLVNLEVLDEDTIIHQLQKR 375

  Fly   179 YDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAH---AALPSPQ 240
            |...||||:.|.||||:||::.. ..|..:.::.|.|....|.|||:||...||:   ..|...|
Human   376 YADLLIYTYVGDILIALNPFQNL-SIYSPQFSRLYHGVKRASNPPHIFASADAAYQCMVTLSKDQ 439

  Fly   241 VVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRF 305
            .:|||||||||||||..|::|:|..:   |.:.:..:.|:||:...|:|||||:.||.|||||||
Human   440 CIVISGESGSGKTESAHLIVQHLTFL---GKANNQTLREKILQVNSLVEAFGNSCTAINDNSSRF 501

  Fly   306 GKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETER-SKYGLLE--- 365
            |||||:.| .:|.::||:|::|||||||::.||..|:|:|:||.:..||...:: |.:.|.|   
Human   502 GKYLEMMFTPTGVVMGARISEYLLEKSRVIKQAAREKNFHIFYYIYAGLHHQKKLSDFRLPEEKP 566

  Fly   366 ----ADKYFYLNQGATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQL 426
                ||:...:....|...|.|..:|::|...:::|.::.|...:.|:||.:|::||:.|.....
Human   567 PRYIADETGRVMHDITSKESYRRQFEAIQHCFRIIGFTDKEVHSVYRILAGILNIGNIEFAAISS 631

  Fly   427 RHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKAL 491
            :|..:..||.:...::.||.:|.||.:.|..||||.....|.|.:.....:|:|.|.|||.:|||
Human   632 QHQTDKSEVPNAEALQNAASVLCISPEELQEALTSHCVVTRGETIIRANTVDRAADVRDAMSKAL 696

  Fly   492 YAGLFNWLVSRINSIVQK--------GGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQL 548
            |..||:|:|:|||:::|.        ||.:    :.||||||||:...|||||||||.|||.:|.
Human   697 YGRLFSWIVNRINTLLQPDENICSAGGGMN----VGILDIFGFENFQRNSFEQLCINIANEQIQY 757

  Fly   549 YFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEK- 612
            |||:|||.|||.||..|.::..|:.::||.|::.:..:||:|:..|||:||.||:|||.:.::| 
Human   758 YFNQHVFALEQMEYQNEGIDAVPVEYEDNRPLLDMFLQKPLGLLALLDEESRFPQATDQTLVDKF 822

  Fly   613 -----CHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPL 672
                 |.|       :.||:.....||:.||||:|.|...|.|:||||.|..||:.:|.:|...|
Human   823 EDNLRCKY-------FWRPKGVELCFGIQHYAGKVLYDASGVLEKNRDTLPADVVVVLRTSENKL 880

  Fly   673 VGE-----LTK-----QLRAQ-RDAGKTLPKG-SNGRF------------VTMKPRTPTVAARFA 713
            :.:     |||     |.||: ..|..:||.. |.|:.            .|...:..|||:.|.
Human   881 LQQLFSIPLTKTGNLAQTRARITVASSSLPPHFSAGKAKVDTLEVIRHPEETTNMKRQTVASYFR 945

  Fly   714 DSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQH 778
            .||..||..|....|.||||||||.::.||:.....||.|||..|:|:|:.||::||..|:.|:.
Human   946 YSLMDLLSKMVVGQPHFVRCIKPNDDREALQFSRERVLAQLRSTGILETVSIRRQGYSHRILFEE 1010

  Fly   779 FVERYRHLL----PSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGR 839
            ||:||.:|.    .:|||.    :|.|.|:||   ::.::  .:.||.|:|||:           
Human  1011 FVKRYYYLAFTAHQTPLAS----KESCVAILE---KSRLD--HWVLGKTKVFLK----------- 1055

  Fly   840 TERLRRAAVSVQRHVR--GMLVRRQLARRQAAATRLQARWRGQRAQQRYERLR----KGALTAQR 898
                       ..||.  .:|:|..:.|    ...|||..:|....:||:|:|    |||:..|.
Human  1056 -----------YYHVEQLNLLLREVIGR----VVVLQAYTKGWLGARRYKRVREKREKGAIAIQS 1105

  Fly   899 LWRGRQARRRVQQLRSDHRRRQEA--REAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKL 961
            .|||..|||:.:::  .:||.:.|  .:|...:.::......|...::.|            :::
Human  1106 AWRGYDARRKFKKI--SNRRNESAAHNQAGDTSNQSSGPHSPVAAGTRGS------------AEV 1156

  Fly   962 QGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRL----------QPRR 1016
            |..|.| ||..:::  |:|.....|..:......|.|....:....||...          .||:
Human  1157 QDCSEP-GDHKVLR--GSVHRRSHSQAESNNGRTQTSSNSPAVTEKNGSHSCDIQTRAREEHPRQ 1218

  Fly  1017 E----PITAPLLTRA-ASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLR 1076
            |    .|....:.|| ..|....|.:.....:....:|..::.|.  .||:..|.|.|...:|| 
Human  1219 EKQEWAIARGRICRAILGRHSQAQSSPKGCDIFAGHANKHSVSGT--DLLSSRICHPAPDQQGL- 1280

  Fly  1077 DEILVQLCNQVHGLPPNSGEATRLWQ 1102
                     .:.|.|...|....|.|
Human  1281 ---------SLWGAPQKPGSENGLAQ 1297

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 286/733 (39%)
MYSc_Myo15 169..828 CDD:276838 281/712 (39%)
MyTH4 1014..1171 CDD:295320 22/94 (23%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
MYO3BXP_011508956.1 STKc_myosinIIIB_N 13..303 CDD:270808 15/69 (22%)
S_TKc 36..302 CDD:214567 15/68 (22%)
MYSc 355..1062 CDD:214580 288/752 (38%)
MYSc_Myo3 366..1055 CDD:276830 281/712 (39%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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