Protein Alignment Myo10A and Mhc

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_061510840.1
• Gene: Mhc / 1279567
• VectorBaseID: AGAMI1_010506
• Length: 1964
• Species: Anopheles gambiae
• Alignment Length: 2263
• Identity: 532/2263 - (23%)
• Similarity: 873/2263 - (38%)
• Gaps: 560/2263 - (24%)

  Fly   136 TFALQPGEGSLRARQDLGS-------SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILI 193
            |.|| ||..:...::||.|       ...|||:.|..|::||:|.|||.||...||||::|...:
Mosquito    62 TVAL-PGGETKDFKKDLVSQVNPPKYEKCEDMSNLTYLNDASVLHNLRQRYYAKLIYTYSGLFCV 125

  Fly   194 AVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTES 255
            .:||||.:| .|....||.|.|:....:||||||:...|:..:   ...|.::|:||||:||||:
Mosquito   126 VINPYKRYP-LYTNRCAKMYRGKRRNEVPPHLFAVSDGAYVNMLTNHENQSMLITGESGAGKTEN 189

  Fly   256 TKLVMQYLAAVVPGG-----GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK- 314
            ||.|:.|.|.:...|     ......:.:|:::..|:|||||||:|.||||||||||::.::|.
Mosquito   190 TKKVIAYFATIGASGKKDENAEKKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFTG 254

  Fly   315 SGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGL-----LEADKYFY--L 372
            ||.:.||.|..|||||:|:::|...||:||:||:::.|      |..||     |..|.|.|  :
Mosquito   255 SGKLAGADIETYLLEKARVISQQTLERSYHIFYQIMSG------SVKGLKEMCFLSNDIYDYNSV 313

  Fly   373 NQGATDCASGRVDWESL--QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHR--RQLRHGQEGV 433
            :||.....:.....|.|  ..|..|||.::.|::.|.|:.:||:|:|.:.|.:  |:.:...:|.
Mosquito   314 SQGKITIPNVDDGEECLLTDEAFNVLGFTQEEKDNIYRITSAVMHMGRMQFKQKGREEQAEADGT 378

  Fly   434 EVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNW 498
            |.|..     .|.||.:..|.|::.|.....:...|.:......||..::..|..|.::..||.|
Mosquito   379 EDGDR-----VAKLLGVGTDDLYKNLLKPRIKVGNEFVTKGQNKDQVTNSVGALCKGIFDRLFKW 438

  Fly   499 LVSRINSIV---QKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQA 560
            ||.:.|..:   ||    .|..|.:|||.|||....|.|||||||:.||.||.:||.|:|.|||.
Mosquito   439 LVKKCNETLDTKQK----RAQFIGVLDIAGFEIFDFNGFEQLCINFTNEKLQQFFNHHMFVLEQE 499

  Fly   561 EYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYA 624
            ||.:|.:.|..:.:..:|.....|.:||:||..:|::||.||:|||.:|.||...|| ..|..:.
Mosquito   500 EYKKEGINWAFIDFGMDLLACVELIEKPMGILSILEEESMFPKATDQTFAEKLMTNHLGKSAPFM 564

  Fly   625 RPR-----IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQR 684
            :||     |.|..|.:.||||.|.|.:.|:|:||:|.|...|::........|:.|:......|
Mosquito   565 KPRPPKPGIPAGHFAIGHYAGVVSYNITGWLEKNKDPLNDTVVDQFKKGSNALMVEIFADHPGQ- 628

  Fly   685 DAGKTLPKGSNGR----FVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRM 745
            .|.....||..|:    |.       ||::.:.:.|..|:.::....|.|||||.||:.|.|..:
Mosquito   629 SADPAAAKGGRGKKGAGFA-------TVSSSYKEQLNNLMTTLKSTQPHFVRCIIPNEMKTAGVV 686

  Fly   746 DMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPL------ARGTPYRELCRAL 804
            |...|:.||...|:|:.|:|.::|:|.|:.:..|..||:.|.|..:      ..|   |::.:.:
Mosquito   687 DAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKLRYKILNPKAVDGLDVEKEG---RKIAQLI 748

  Fly   805 LEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAA 869
            :||:   |:....|:||.|:||.|..:...:|..|.|||.:....:|...||.|.|::..:.|..
Mosquito   749 IEAV---GLNADQYRLGMTKVFFRAGVLGQMEEFRDERLSKIMSWMQAWCRGYLSRKEFKKMQEQ 810

  Fly   870 ATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREARE 934
            ...|:.   .||..::|.:||..|.  .:||      ::|:.|.:..|...:..:..::|.:|:|
Mosquito   811 RVSLEI---VQRNLRKYLKLRTWAW--WKLW------QKVKPLLNVSRVEDQIAKLEEKATKAQE 864

  Fly   935 A--KQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQF 997
            |  |:..|.:          ||..:.|||..        ....:|.::.|...:..:..|...:.
Mosquito   865 AYEKEEKLRK----------ELEALNSKLLA--------EKTALLDSLSGEKGALQEYQEKAAKL 911

  Fly   998 SFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQ--------------DALAVFKLILRWS 1048
            :..|      |.|..|.|  .....|.....:|:|.||              ||..:...|.:..
Mosquito   912 TAQK------NDLENQLR--DTQERLAQEEDARNQLFQTKKKLEQEIGSQKKDAEDLELQIQKIE 968

  Fly  1049 NDKALEGAKEKLLADYIVH------KALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQC 1107
            .|||.:..:.:.|.|.|.|      |....:.::.|:..:...::...........::...|.|.
Mosquito   969 QDKASKDHQIRNLNDEIAHQDELINKLNKEKKMQGEVNQKTAEELQAAEDKVNHLNKVKAKLEQT 1033

  Fly  1108 LCCFQPSAAFSKYLMRFVDDEAPESL-RPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRA 1171
            |                  ||..:|| |...||            |.|
Mosquito  1034 L------------------DELEDSLEREKKLR------------GDV----------------- 1051

  Fly  1172 WTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDY 1236
                          ::|.:.|..|                                      |..
Mosquito  1052 --------------EKAKRKVEGD--------------------------------------LKL 1064

  Fly  1237 VMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKED----VPRERR 1297
            ..:.:|             ||.|:..:..:|.|....:..|:       |:..||    |.:.::
Mosquito  1065 TQEAVA-------------DLERNKKELEQTVLRKDKEISAL-------SAKLEDEQSLVGKLQK 1109

  Fly  1298 SSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTL 1362
            ..:||.:|...|.|..          :.....:||:..:..|  ||.::.      :..|.|...
Mosquito  1110 QIKELQARIEELEEEV----------EAERQARAKAEKQRAD--LARELE------ELGERLEEA 1156

  Fly  1363 GLSES---RLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSA 1424
            |.:.|   .||.: ..|| ||.:.:|.  .....||.|..::...  .|:...|:.||...:.:.
Mosquito  1157 GGATSAQIELNKK-REAE-LAKLRRDL--EEANIQHEGTLANLRK--KHNDAVAEMAEQVDQLNK 1215

  Fly  1425 MSDTSE--APSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQE 1487
            :...:|  ..::.:.:...|.                     :.|:||..::....|........
Mosquito  1216 LKTKAEHDRANMYNELNNTRT---------------------ACDQLSREKAAQEKIAKQLQHTL 1259

  Fly  1488 NEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYI 1552
            ||.:|::|:.:..:||..            .||.:|:.           |..|...::||.:..:
Mosquito  1260 NEVQSKLDETNRTLNDFD------------ASKKKLSI-----------ENSDLLRQLEDAESQV 1301

  Fly  1553 NELFE-PIPVAEGLD------------------KLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQ 1598
            ::|.: .|.:.:.|:                  |..:.||...::|.....::.|...:..||.:
Mosquito  1302 SQLSKIKISLTQQLEDTKRLADEEARERATLLGKFRNLEHDLDNLREQVEEEAEGKGDIQRQLSK 1366

  Fly  1599 LPGETESGPALYQQQ-VQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPA 1662
            ...|.:...:.|:.: |.||             ::|....:.||..|::               |
Mosquito  1367 ANAEAQLWRSKYESEGVARA-------------EELEEAKRKLQARLAE---------------A 1403

  Fly  1663 PPILSSLSISPPPPQSPMRMKATRSSLVV-MESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYG 1726
            ...:.||:      |..:.::.|:..|.. :|.||             ||....|...:..:...
Mosquito  1404 EETIESLN------QKCIALEKTKQRLATEVEDLQ-------------LEVDRASSIANAAEKKQ 1449

  Fly  1727 RAKTVRIGKWR---------WPPPQDEPQFQTEEDF---FAFKMRQHQRKTTPQAQHHQMTSNGG 1779
            :|....||:|:         ....|.|.:..:.|.|   .|::..|.|.:...:...:.......
Mosquito  1450 KAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQEQLEAVRRENKNLADEVKD 1514

  Fly  1780 MMES-GPGARGAS----------------ATAIEWEEFEIESPTPPPMSGQLMRSSIR------- 1820
            :::. |.|.|...                ..|:|..|..:|......:..||..|.:|
Mosquito  1515 LLDQIGEGGRNIHEIEKSRKRLEAEKDELQAALEEAEAALEQEENKVLRAQLELSQVRQEIDRRI 1579

  Fly  1821 ------LETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAK--KSFEIGADRPPPGSVGKLK 1877
                  .|.|......|:::.....|.:..|:.....:..||..  ...||..|.....:....|
Mosquito  1580 QEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADINELEIALDHANKANAEAQK 1644

  Fly  1878 LSSEMRQRL--------EQVTAGHSVRSTVSTKSEQRAPA---KLEDTRKLMLQQQLGGLFA--S 1929
            .....:|:|        |:..|....|..:.. ||:||.|   :||::|.|:.|...|...|  .
Mosquito  1645 NIKRYQQQLKDVQSALEEEQRARDDAREQLGI-SERRANALQNELEESRTLLEQADRGRRQAEQE 1708

  Fly  1930 VSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP 1994
            :|..:.....|...:|::.....::|.:|.
Mosquito  1709 LSDAHEQLNEVSAQNASIAAAKRKLESELQ----------------------------------- 1738

  Fly  1995 PAPPPAPQSPPTARSPEPE--PDYRTSSSQVVKEHVPA------------FIQRQERDTFGAVRQ 2045
                       |..|...|  .:.:.|..:..|..|.|            ..|.||:     :|:
Mosquito  1739 -----------TLHSDLDELLNEAKNSEEKAKKAMVDAARLADELRAEQDHAQTQEK-----LRK 1787

  Fly  2046 --QQMISSHHLHLEDHSASS----SPAVAAWEQAERE-RSRSRSRSRDREDYSESVWDRAEVEGP 2103
              :|.|....:.|::..:::    ..|:...||..|| .|...|..|...|..::: .::|....
Mosquito  1788 ALEQQIKELQVRLDEAESNALKGGKKAIQKLEQRVRELESELDSEQRRHADAQKNL-RKSERRIK 1851

  Fly  2104 ASGSGSEKEREKRERERERLYEI--------RQVERERESHKVYQPAPPRVIQASMDTTGGHRRE 2160
            .....||::|:..||.::.:.::        ||:| |.|.......|..|..|..::     ..|
Mosquito  1852 ELTFQSEEDRKNHERMQDLVDKLQQKIKTYKRQIE-EAEEIAALNLAKFRKAQQELE-----EAE 1910

  Fly  2161 DRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVP 2213
            :|    |......|.|:..:..|..|...|          .:|.|...|:.:|
Mosquito  1911 ER----ADIAEQAATKFRTKGGRAGSVQRG----------ASPAPQRQPSAMP 1949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	250/697 (36%)
		PTZ00121	<828..>943	CDD:173412	30/116 (26%)
		MyTH4	1014..1171	CDD:470587	30/177 (17%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	5/66 (8%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Mhc	XP_061510840.1	None