Protein Alignment Myo10A and didum

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_061498899.1
• Gene: didum / 1277086
• VectorBaseID: AGAMI1_009889
• Length: 1868
• Species: Anopheles gambiae
• Alignment Length: 1641
• Identity: 443/1641 - (26%)
• Similarity: 685/1641 - (41%)
• Gaps: 378/1641 - (23%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||..:|:||.:|: |:..|||:.|.:|:|:|||...| .||.::.:.|.|..:|
Mosquito    69 GQNDLTALSYLHEPDVLYNLEVRFCDRQAIYTYCGIVLVAINPYAELP-LYGPDLIRAYRGHAMG 132

  Fly   220 SLPPHLFAIGAAAHAALPSPQV---VVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            .|.||:||:...|:|.|...:.   :::|||||:|||.|.|..|:|.|||  ||..:...|.:::
Mosquito   133 ELEPHIFAVSEEAYAKLEREKCDISIIVSGESGAGKTVSAKYAMRYFAAV--GGSESETQIEKKV 195

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYF---KSGAIVGAKITQYLLEKSRIVTQAPGERNY 343
            |.::|::||.|||:|.||||||||||:.::.|   .|.|:.|..:..|||||||:..||||||||
Mosquito   196 LASSPIMEAIGNAKTTRNDNSSRFGKFTKLLFLNNHSMALTGGTMQTYLLEKSRVCFQAPGERNY 260

  Fly   344 HVFYELLGGLSETERSKYGLL---EADKYFYLNQGAT---DCASGRVDWESLQGAMQVLGVSEGE 402
            |:||:|..|     |.::..|   ..||:.:||||.:   ...|.|..:|...||::.||..:.|
Mosquito   261 HIFYQLCAG-----REQWPELMLDHQDKFHFLNQGQSPNISKLSDRDQFEDTLGALKTLGFDDAE 320

  Fly   403 REGIVRVLAAVLHLGNVYFHRRQLRH----GQEGVEVGS-DAEIKWAAHLLHISADGLHRALTSR 462
            ...|::|:|:|||||||.|:.||...    ..|...:.| |..:..|..:|.:....|.:.|.:|
Mosquito   321 IGDIMKVVASVLHLGNVVFNHRQKSQTSEVDSEACSIASNDLHLNVACDILQLDRGELRKWLVTR 385

  Fly   463 TTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFE 527
            ..|:..:.:..|:....|...|||.||.:||.||..:|.:||..:......:...|.:|||:|||
Mosquito   386 QIESMNDSVLIPMNKQTAEATRDALAKHIYAELFQHIVQKINRNLAGSKKQNCCFIGVLDIYGFE 450

  Fly   528 DLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGIC 592
            ....|||||.|||||||.||..||:|||||||.:|.||.:||..:.:.||.|.|.|:..| :||.
Mosquito   451 TFDINSFEQFCINYANEKLQQQFNQHVFKLEQEQYLREGIEWKMIDFYDNQPCIDLIESK-LGIL 514

  Fly   593 HLLDDESNFPRATDLSF----LEKC-HYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDK 652
            .|||:|...||.:|.|:    :||| .|.|     :.|||.|...|.:.|::..|.|...|||:|
Mosquito   515 DLLDEECRMPRGSDDSWVGKLMEKCGKYPH-----FDRPRFGTSAFLIKHFSDTVQYESRGFLEK 574

  Fly   653 NRDALRGDVLELLASSRLPLVGELTKQLRAQRDAG-----KTLPKG---------------SNGR 697
            |||.:..:::.:|.:|.:.|...|   :.||.:.|     ||.|..               ...:
Mosquito   575 NRDTVSRELVSVLKASGMRLCQRL---MVAQEEGGGDGDAKTAPAAGVKIMVSAARTQSVDKKKK 636

  Fly   698 FVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDT 762
            .:|.|.:..||.::|.:||.||:.::....|.:|||||||.:|...:.:.|.::||||..|:|:|
Mosquito   637 PMTQKQQRKTVGSQFRESLTQLITTLHNTTPHYVRCIKPNDDKAPFKWEAPKIVQQLRACGVLET 701

  Fly   763 IQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPD-YQLGATRVF 826
            ::|...|:|.|.:::.|.||||.|...........:..|..::    |..:...| |:||.|::|
Mosquito   702 VRISAAGFPSRWKYEDFYERYRLLCKRAQIVDWHVKATCTNIV----RNWLLDEDKYRLGNTQIF 762

  Fly   827 LREALHRALESGRTE-----------------------RLRRAAVSVQRHVRGMLVRRQL--ARR 866
            .|......||..|::                       ||::.|:.:|||.||||.|::.  .|:
Mosquito   763 FRAGQVAYLEQVRSDTRKKHIIVVQSLIRRFVCRRRYLRLKQTALGLQRHARGMLARKRADNLRK 827

  Fly   867 QAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDH--------------R 917
            ..||..:|...||...::||.::|...|..|...||..|||:.:....::              |
Mosquito   828 NRAAIIIQRYTRGWLQRKRYVQIRTAVLGLQTRARGFMARRKFRAALDNYKATEVQRFCRGYLAR 892

  Fly   918 RRQEAR-------EAAQRAREAREA------------------------------KQAVLERSQL 945
            ||..||       :||.|...||.|                              :..||.:...
Mosquito   893 RRYRARLDHIIKCQAAVRRFLARRAFKKLKAEARTVAHIQKMYKGLENKIIELQQRHDVLSKENA 957

  Fly   946 SYLDIPAELAFIYSKLQGWSPPHG------------DRHLVKVLGTVPGPPSSAVQLPEDLGQFS 998
            :......|:..:..||.|.....|            |..|:..:..:.|.....:||.|:
Mosquito   958 ALKKQNVEVVEMRQKLDGMKRLEGELKLLQLQLVQKDEKLMLSIRQLEGERDEKMQLLEE----- 1017

  Fly   999 FGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLAD 1063
                          :.|.|.      .||..||...|:...|.:.:...:....:|.|:....||
Mosquito  1018 --------------KQREEE------ERARERDAFEQELAKVRREVTEITAVTQIEQARLVSQAD 1062

  Fly  1064 YIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDE 1128
            .....|...|.::|:.:::  |:...|   ..|..||.:::.........|.:.|.......:|.
Mosquito  1063 TEEIHAAYQRTVKDKDVLE--NENVAL---RQEVRRLQRIMADSHELKTHSRSVSNASSTNEEDY 1122

  Fly  1129 APESLRPLL-LRQL----LRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEA 1188
            ...|.|..| :|:.    .....||...|:.|.|:.||
Mosquito  1123 GYTSGRNTLDIRRASPHPYEGDAGGAGGGSAGRGSHRS--------------------------- 1160

  Fly  1189 SQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAP 1253
                          ......|:..|:|   |:|...|:...:            ||.      .|
Mosquito  1161 --------------GGGSVGSNYSVSS---TIVASHGESRRE------------EKR------HP 1190

  Fly  1254 RSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKED----VPRERRSSRELLSRSSALNERYF 1314
            ..|..|     ...|.|||:.....|..:....|.::|    :.|.|:...|..|:|..|.:...
Mosquito  1191 FVDYER-----VYRTPPDAIGMLKDPSDSTVGESPEKDQTAIILRMRKLFEEEKSKSEQLRKELA 1250

  Fly  1315 EREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERL 1379
            ..:              ||.:.|.:|.:...               .|.:...:|...|:.....
Mosquito  1251 RLK--------------KSSTFSTEDSIRAS---------------ELEVENEKLRQDYNLLRNS 1286

  Fly  1380 APVGKDTGPRYQKSQHAG-------RRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASH 1437
            ...|.::  |...:|:..       ||....|.         ||..|.:|.::....:..:.|..
Mosquito  1287 IKRGVES--REMDAQYGALQEELKRRREECISL---------KAVLAQQSQSLRSLGQTANGAET 1340

  Fly  1438 VRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYIN 1502
            ..|:..                   :|.|.|...|:.|.          ..:.|||:..:.|..|
Mosquito  1341 SLRIHD-------------------EGELMEAFQAQKLV----------NRQLESELRAITDANN 1376

  Fly  1503 DIFQPIPLVQN---LEKL-TSKDQLAAIIKGGGVASKPEERDEESEIE----------------- 1546
            :     .||:|   ::.| |...:|.||::     ...|:..||.::|
Mosquito  1377 E-----TLVENNRIIDGLRTENGELQAILQ-----QHVEQVGEEVDLETVRQNEQYLRHELRKST 1431

  Fly  1547 ----DLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQ-LPGETESG 1606
                :|.:.:|||     :|:..:.|.....|:..:|..|..||...:...|.::. :..:|:|.
Mosquito  1432 AAYVELQEQLNEL-----LAKNNELLKKNNILSNRLRDHGLNDSILMNDEFHSMVAVVKKQTQSS 1491

  Fly  1607 PAL--YQQQVQRAFLQ 1620
            ..:  |:|:.:...:|
Mosquito  1492 QGILKYRQEDESKIMQ 1507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	265/702 (38%)
		PTZ00121	<828..>943	CDD:173412	44/190 (23%)
		MyTH4	1014..1171	CDD:470587	34/161 (21%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	7/66 (11%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
didum	XP_061498899.1	None