Protein Alignment Myo10A and Myo1b

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_038938878.1
• Gene: Myo1b / 117057
• RGDID: 70994
• Length: 1147
• Species: Rattus norvegicus
• Alignment Length: 843
• Identity: 309/843 - (36%)
• Similarity: 465/843 - (55%)
• Gaps: 76/843 - (9%)

  Fly   148 ARQDLGSS------GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYG 206
            |::::.||      ||.|..||:.|:|.:.:.||:.|:|...|||:.||::|:||||:..| .|.
  Rat     2 AKKEVKSSLLDNMIGVGDTVLLEPLNEETFIDNLKKRFDHNEIYTYIGSVVISVNPYRSLP-IYS 65

  Fly   207 LEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVP 268
            .|..:.|..|....|.||:||:...|:.:|   ...|.::|:||||:||||::||||.|:|||.
  Rat    66 PEKVEDYRNRNFYELSPHIFALSDEAYRSLRDQDKDQCILITGESGAGKTEASKLVMSYVAAVC- 129

  Fly   269 GGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSR 332
            |.|:....:.||:|::.|:|||||||:|.|||||||||||:::.|. .|..:|..|:.|||||||
  Rat   130 GKGAEVNQVKEQLLQSTPVLEAFGNAKTVRNDNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSR 194

  Fly   333 IVTQAPGERNYHVFYELLGGLSE---------TERSKYGL-LEAD--KYFYLN------QGATDC 379
            :|.|..||||:||||:||.|.||         :|...:.| ||.|  :|.||:      .|..|.
  Rat   195 VVKQPRGERNFHVFYQLLSGASEELLRKSMGASEELLHKLKLERDFSRYNYLSLDSAKVNGVDDA 259

  Fly   380 ASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWA 444
            |:.|    :::.|||::|.|:.|.|.::.|:||||.|||:.|......:|.:..::....|:|..
  Rat   260 ANFR----TVRNAMQIVGFSDPEAESVLEVVAAVLKLGNIEFKPESRMNGLDESKIKDKNELKEI 320

  Fly   445 AHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQK 509
            ..|..|....|.||.:.||.||:.|::.|.|.:.||..||||.||.||:.||:|||:|||..: |
  Rat   321 CELTSIDQVVLERAFSFRTVEAKQEKVSTTLNVAQAYYARDALAKNLYSRLFSWLVNRINESI-K 384

  Fly   510 GGTHDAHRI-SILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLA 573
            ..|....:: .:|||:|||...:|||||..|||.||.||..|.:...|.||.||.||.:|||.:.
  Rat   385 AQTKVRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTLKEEQEEYIREDIEWTHID 449

  Fly   574 WDDNLPVIHLLAKKPVGICHLLDDESNFP-RATDLSFLEKCH-----YNHALSELYARPR----- 627
            :.:|..:..|:.....||..:||:|...| ..||.:||||.:     :.|..|.:....|
  Rat   450 YFNNAIICDLIENNTNGILAMLDEECLRPGTVTDETFLEKLNQVCATHQHFESRMSKCSRFLNDT 514

  Fly   628 -IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLP 691
             :....|.:.||||:|.|.|:||:|||.|.|..|:.:.:..:...|:..|             .|
  Rat   515 TLPHSCFRIQHYAGKVLYQVEGFVDKNNDLLYRDLSQAMWKAGHALIKSL-------------FP 566

  Fly   692 KGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRY 756
            :|:..: |.:| |.||..::|..|:..|::::...:|.::||||||.:|.|.......|..|:||
  Rat   567 EGNPAK-VNLK-RPPTAGSQFKASVATLMKNLQTKNPNYIRCIKPNDKKAAHIFSESLVCHQIRY 629

  Fly   757 LGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQ 819
            ||:|:.:::|:.||..|..::..:|||:.|...  |..:| |.|.....|...:.   :...:|.
  Rat   630 LGLLENVRVRRAGYAFRQAYEPCLERYKMLCKQTWPHWKG-PARSGVEVLFNELE---IPVEEYS 690

  Fly   820 LGATRVFLR--EALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRA 882
            .|.:::|:|  ..|.: ||..|.:||...|..:|:..||...|......:.:...:.|.:|....
  Rat   691 FGRSKIFIRNPRTLFQ-LEDLRKQRLEDLATLIQKIYRGWKCRTHFLLMKRSQVVIAAWYRRYAQ 754

  Fly   883 QQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQL 945
            |:||::::..||..|...||.:||:.:::|:  |::|  .:|||..........||..||.:|
  Rat   755 QKRYQQIKSSALVIQSYIRGWKARKILRELK--HQKR--CKEAATTIAAYWHGTQARKERRRL 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	264/695 (38%)
		PTZ00121	<828..>943	CDD:173412	33/116 (28%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
Myo1b	XP_038938878.1	MYSc_Myo1	29..699	CDD:276829	264/695 (38%)
		IQ	760..782	CDD:197470	7/21 (33%)
		Myosin_TH1	952..1129	CDD:461801