DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo10A and LOC100537594

DIOPT Version :9

Sequence 1:	NP_001036269.2	Gene:	Myo10A / 32028	FlyBaseID:	FBgn0263705	Length:	3145	Species:	Drosophila melanogaster
Sequence 2:	XP_021325145.1	Gene:	LOC100537594 / 100537594	-ID:	-	Length:	1085	Species:	Danio rerio

Alignment Length:	904	Identity:	287/904 - (31%)
Similarity:	444/904 - (49%)	Gaps:	125/904 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 VIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILI 193
            |..:..:.|.:.|.:          ...:|||.::..|:|.|:|:||:.||...:|||::|...:
Zfish    69 VTVKEDEVFPMNPPK----------FDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCV 123

  Fly   194 AVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKTES 255
            .|||||..| .|...|...|.|:.....|||:|:|...|:..:.:.   |.|:|:||||:|||.:
Zfish   124 TVNPYKWLP-VYDAVVVAGYRGKKRIEAPPHIFSISDNAYQFMLTDRENQSVLITGESGAGKTVN 187

  Fly   256 TKLVMQYLAAV---------VPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEV 311
            ||.|:||.|.|         .|..|.....:.:||:.|.|||||:|||:|.||||||||||::.:
Zfish   188 TKRVIQYFATVGAMSGAKKQEPVAGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRI 252

  Fly   312 YFKS-GAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEA-----DKYF 370
            :|.| |.:..|.|..|||||||:..|...||:||:||:|:.|      .|..||||     :.|.
Zfish   253 HFGSTGKLASADIETYLLEKSRVTFQLSAERSYHIFYQLMTG------HKPELLEALLITTNPYD 311

  Fly   371 Y--LNQG--------------ATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNV 419
            |  ::||              |||.            |:.:||.:..|:..|.::..||:|.|::
Zfish   312 YPMISQGEITVKSINDVEEFIATDT------------AIDILGFTADEKIAIYKLTGAVMHHGSM 364

  Fly   420 YFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALD 482
            .|.::|.....|  |.||...     .|:|:.:::..:.:||.....:...|.:.....:.|..:
Zfish   365 KFKQKQREEQAEPDGTEVADK-----IAYLMGLNSADMLKALCYPRVKVGNEMVTKGQTVPQVNN 424

  Fly   483 ARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANEN 545
            |..|..|::|..:|.|:|.|||.::.   |....:  |.:|||.|||....||.||||||:.||.
Zfish   425 AVSALCKSVYEKMFLWMVIRINEMLD---TKQPRQFFIGVLDIAGFEIFDYNSLEQLCINFTNEK 486

  Fly   546 LQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFL 610
            ||.:||.|:|.|||.||.:|.:||..:.:..:|.....|.:||:||..:|::|..||:|||.||.
Zfish   487 LQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFK 551

  Fly   611 EKCHYNHALSELYA----RPRIGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSR 669
            .|.|..| |.:..|    :|..|..|  |.:.||||.|.|.:.|:||||:|.|...|::|...|.
Zfish   552 NKLHDQH-LGKCSAFQKPKPAKGKAEAHFSLVHYAGTVDYNIVGWLDKNKDPLNDSVVQLYQKSS 615

  Fly   670 LPLVGELTKQ---LRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFV 731
            :.|:..|...   ..|:...||...|...|.|       .||:|.|.::|.:|:.::...||.||
Zfish   616 VKLLSFLYASHAAAEAEGGGGKKGGKKKGGSF-------QTVSALFRENLGKLMTNLRSTHPHFV 673

  Fly   732 RCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTP 796
            ||:.||:.|....|:...|:.|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.:..| .
Zfish   674 RCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASVIPEG-Q 737

  Fly   797 YRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRR 861
            :.:..:|..:.:....|:...|:.|.|:||.:..|...||..|.|:|.......|...||.::|:
Zfish   738 FIDNKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLATLVTMTQALCRGFVMRK 802

  Fly   862 QLAR---RQAAATRLQ---------ARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRS 914
            :..:   |:.|...:|         ..|...:...:.:.|.|.|.|.:.:         .....:
Zfish   803 EFVKMMERREAIYSIQYNIRSFMNVKHWPWMKLYFKIKPLLKSAETEKEM---------AAMKEN 858

  Fly   915 DHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAEL-----------AFIYSKLQ 962
            ..:.:::..:|..:.:|..|...::|:......|.:.:|.           ..|.||:|
Zfish   859 FEKMKEDLTKALAKKKELEEKMVSLLQEKNDLQLQVASESENLSDAEERCEGLIKSKIQ 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc	156..836	CDD:214580	257/726 (35%)
		MYSc_Myo15	169..828	CDD:276838	251/705 (36%)
		MyTH4	1014..1171	CDD:295320
		MyTH4	2704..2810	CDD:279165
		B41	2823..3033	CDD:214604
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
LOC100537594	XP_021325145.1	Myosin_N	34..72	CDD:308391	1/2 (50%)
		MYSc_class_II	99..769	CDD:276951	251/705 (36%)
		SMC_N	849..>1081	CDD:330553	10/78 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000