Protein Alignment Myo10A and LOC100495968

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_002935256.2
• Gene: LOC100495968 / 100495968
• XenbaseID: XB-GENE-29082907
• Length: 1941
• Species: Xenopus tropicalis
• Alignment Length: 2160
• Identity: 517/2160 - (23%)
• Similarity: 865/2160 - (40%)
• Gaps: 507/2160 - (23%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|:|.|:|:||:.||...:|||::|...|.|||||..| .|..||...|.|:.....
 Frog    88 IEDMAMMTHLNEPSVLFNLKERYAAWMIYTYSGLFCITVNPYKWLP-VYNPEVVAGYRGKKRVEA 151

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG---------GSAS 274
            |||:|:|...|:.::.:.   |.|:|:||||:|||.:||.|:||.|.|...|         .:..
 Frog   152 PPHIFSISDNAYQSMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAAIGDAGKKKQADNNLK 216

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||::|.|||||||||:|.||||||||||::.::| .:|.:..|.|..|||||||:..|..
 Frog   217 GTLEDQIIQANPLLEAFGNAKTLRNDNSSRFGKFIRIHFGTTGKLSSADIETYLLEKSRVTFQLS 281

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFY--LNQGATDCASGRVDWE----SLQGAMQVLG 397
            .||:||:||::|.. ...|..:..||..:.|.|  ::||.....|  :|.|    :.:.|::|||
 Frog   282 AERSYHIFYQILTN-KIPELIEMLLLTTNPYDYPTISQGELKVKS--IDDEDEFMATESAIEVLG 343

  Fly   398 VSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLHRALT 460
            .:..||..|.::..||:|.||:.|.::|.....|  |.||...     .::|:.:::..|.:||.
 Frog   344 FNAEERVSIYKMTGAVMHHGNMKFKQKQREEQAEPDGTEVADK-----ISYLMGLNSADLLKALC 403

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDI 523
            ....:...|.:.....:.|..::..|..|::|..||.|:|:|||   |:..|....:  |.:|||
 Frog   404 YPRVKVGNEFVTKSQTVPQVCNSVGALCKSVYEKLFLWMVTRIN---QQLDTKQPRQFFIGVLDI 465

  Fly   524 FGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKP 588
            .|||....||.||||||:.||.||.:||.|:|..||.||.:|.:||..:.:..:|.....|.:||
 Frog   466 AGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVQEQEEYKKEGIEWEFIDFGMDLAACIELIEKP 530

  Fly   589 VGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRIG----AQEFGVTHYAGQVWYCVDG 648
            :||..:|::|..||:||:.||..|.:..| ...:.:.:|:.|    ...|.:.||||.|.|.:.|
 Frog   531 MGIFSILEEECMFPKATETSFKNKLYEQHLGKCKNFEKPKPGKGKAEAHFSLVHYAGIVDYNISG 595

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPR---TPTVAA 710
            :||||:|.|...|::|...|.:.|:..|.... |..|:|........|:    |.:   ..||:|
 Frog   596 WLDKNKDPLNDSVVQLYQKSSVKLLSFLYSSY-ASADSGSDSSSKGGGK----KKKGSSFQTVSA 655

  Fly   711 RFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLR 775
            .|.::|.:|:.::...||.||||:.||:.|....||...::.|||..|:|:.|:|..:|:|.|::
 Frog   656 VFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGIMDNYLIIHQLRCNGVLEGIRICTKGFPSRIQ 720

  Fly   776 FQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRT 840
            :..|.:||:.|..|.:..| .:.:..:|..:.:....|:...|:.|.|:||.:..|...||..|.
 Frog   721 YGDFKQRYKILNASAIPDG-QFIDSKKAAEKLLGSIDVDHNQYRFGHTKVFFKAGLLGTLEEMRD 784

  Fly   841 ERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERLRKGA 893
            |.|......:|.:.||.|:|   :::..|:.|...:|         ..|...:...:.:.|.|.|
 Frog   785 EMLAHVITRIQSYCRGYLMRIEFKKMNSRREALFVIQYNLRSFMNVKHWPWMKLYFKIKPLLKSA 849

  Fly   894 LTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVL--ERSQLSYLDIPAE--- 953
                      :..:.:..::.::.:.:||.|.|:..::..|.|..||  |::.| .|...||
 Frog   850 ----------ETEKEMANIKEEYEKIKEALEKAEARKKELEEKMVVLLQEKNDL-MLQAQAESET 903

  Fly   954 LAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREP 1018
            ||....:.:.         |:|                        ||        ::|:.:.:.
 Frog   904 LADAEERCES---------LIK------------------------GK--------IQLESKIKE 927

  Fly  1019 ITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQL 1083
            :|        .|.:|.:::.|......|...|:..|..|:....:..:.|....:...:..:..|
 Frog   928 MT--------ERLEDEEESNAELSAKKRKLEDECSELKKDIDELEITLSKVEKEKHATENKVKNL 984

  Fly  1084 CNQVHGLPPNSGEATR----LWQLLGQCLCCFQP--------SAAFSKYLMRFVDD-----EAPE 1131
            ...:..|..|..:.|:    |.:...|.|...|.        |.|.|| |.:.|||     |..:
 Frog   985 TEDMAALDDNISKVTKEKKSLQEAHQQTLDDLQTEEDKVNTLSKAKSK-LEQQVDDLEGSLEQEK 1048

  Fly  1132 SLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDS 1196
            .|| |.|.:..|:                      ||       ||:.|        :|...:|.
 Frog  1049 KLR-LDLERTKRK----------------------LE-------CDLKL--------TQETVLDF 1075

  Fly  1197 WTSCEEAAA------LAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRS 1255
            ....::|..      ..:|.|  .|:     ::|.|.|:.......       |||     ..|:
 Frog  1076 ENDKQQAEERLKKKDYEISQL--LSK-----IEDEQALSSQLQKKI-------KEL-----QART 1121

  Fly  1256 DLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSP 1320
            :.|....:..||....|.|:.|:                   .:|||...|..|.|
 Frog  1122 EELEEEIEAERTVRAKAEKQRAL-------------------ITRELEEISERLEE--------- 1158

  Fly  1321 GPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLH-TLGLSESRLNDRYHSAERLAPVGK 1384
               .|.:|......:|..::    :...:..|.:.....| |:.     .|.|...|:.:|.:|:
 Frog  1159 ---AGGATAVQIEMNKKREN----EFQKMRRDLEEANLRHETIA-----CNLRKKHADTVAELGE 1211

  Fly  1385 --DTGPRY------QKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSD-TSEAPS------- 1433
              |...|.      :||:........||:..::||.  ||.:...:..:.| .|||.:
 Frog  1212 QLDNLQRIKQKLEKEKSELKMEIDDFASNLDNTSKL--KANFEKLNHVLEDQLSEAKAKGEEQQR 1274

  Fly  1434 ----LASHVRRV-----RVPSQASDVDQFLDDLFS---------PVLDGSLDELSDAR-SLAASI 1479
                |.:|..|:     .:..|..:.:..:..|..         ..|...|:|.:.|: :||.::
 Frog  1275 LLNDLTTHKARLLSENGELSRQGEEKESLISQLSRGKQAFIQQIEELKRQLEEETKAKNALAHAV 1339

  Fly  1480 RGG---------SYEQENEAESEID-DLDDYINDIFQ--------PIPLVQNLEKLTSK------ 1520
            :..         .:|:|.||:||:. .|....|::.|        .|...:.||:...|
 Frog  1340 QSARHDCDLLREQFEEEQEAKSELQRSLSKANNEVSQWRNKYETDAIQRTEELEEAKKKLAQHLQ 1404

  Fly  1521 ---DQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSK-EHLAVSIR-- 1579
               ||:||:........|.::| .:||::||   :.::......|..|||.... :.:.|..:
 Frog  1405 EAEDQVAAVNSKCASLEKTKQR-LQSEVDDL---MIDVERSNNAAAALDKKQRNFDKVLVEWKQK 1465

  Fly  1580 -GGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLL--------- 1634
             |.|..:...|   |.:...|..|.......|::.::  ..::...:|..:||::.
 Frog  1466 YGEGQAELEAA---LKECRSLSTEIFKMRNAYEEALE--LTETLKRENKNLQQEITDLTEHIGES 1525

  Fly  1635 ---------AQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLV 1690
                     |:.|..|.....|||...|..|........:...|.::  ..:|.|..|.......
 Frog  1526 GKSINELDKARKQVEQQKNEMQAALEEAEGSLEHEETKFLRIQLELN--QVKSEMDKKIAEKDEE 1588

  Fly  1691 VMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFA 1755
            : |.|:.........:...|:    ||.|      .|.:.:|:.|            :.|.|...
 Frog  1589 I-EQLKRNNQRATDTLQTTLD----SEIR------SRNEALRLKK------------KMEGDLNE 1630

  Fly  1756 FKMRQHQ-----RKTTPQAQHHQMTSNGGMMESGPGARGAS-----------ATAIEWEEFEIES 1804
            .:::.:|     .:...|.::.|..:...:::.....|..|           .||::..|.| |.
 Frog  1631 LEIQLNQANRQAAEAQKQLRNVQTQNKDTLLQLDNKERIESDLKEQIAVLERRTALQLAEIE-EI 1694

  Fly  1805 PTPPPM--------SGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVV--------- 1852
            .....|        ..:|..||.||:...:..||..|:  :.:...||.| :||.|
 Frog  1695 RAALEMLDRSCKVAEQELADSSERLQLLRSHNTSLTNS--KKKLESDVSQ-LQSEVEESIQEARN 1756

  Fly  1853 TTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRA---PAKLEDT 1914
            |.:.|||:....|           .::.|:::  ||.|:.|.||  :....||..   ..:|::.
 Frog  1757 TEEKAKKAITDAA-----------LMAEELKK--EQDTSAHLVR--MKKNLEQTVKDLQHRLDEA 1806

  Fly  1915 RKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPS 1979
            .:|.|:           ||..       ....:.|::..:|.:|
 Frog  1807 EQLALK-----------GGKK-------QLQKLETRVRELENEL--------------------- 1832

  Fly  1980 VPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEH---VPAFIQRQERDTFG 2041
                                           |.|......:.:.|:::   :.....:.|.|...
 Frog  1833 -------------------------------ENEQKRGVEAVKGVRKYERRMKELTYQNEEDRKN 1866

  Fly  2042 AVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSR------SRSRDREDYSESVWDRAEV 2100
            .:|.|.::....|.::   |....|..|.|||....:|.|      ..:.:|.|.::|..::  :
 Frog  1867 VLRLQDLVDKLQLKVK---AYKRQAEEAEEQANAHMARYRKMQHELGEAEERADIADSQVNK--L 1926

  Fly  2101 EGPASGSGSEKEREK 2115
            ...:...||:|:.|:
 Frog  1927 RAKSRDIGSKKDSEE 1941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	246/689 (36%)
		PTZ00121	<828..>943	CDD:173412	27/128 (21%)
		MyTH4	1014..1171	CDD:470587	33/173 (19%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	10/72 (14%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
LOC100495968	XP_002935256.2	Myosin_N	33..77	CDD:460670
		MYSc_class_II	100..772	CDD:276951	246/689 (36%)
		Myosin_tail_1	852..1929	CDD:460256	244/1354 (18%)