Protein Alignment Myo10A and myh4l

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_031747897.1
• Gene: myh4l / 100495638
• XenbaseID: XB-GENE-29082771
• Length: 1938
• Species: Xenopus tropicalis
• Alignment Length: 2210
• Identity: 496/2210 - (22%)
• Similarity: 879/2210 - (39%)
• Gaps: 573/2210 - (25%)

  Fly   143 EGSLRARQDLGSS-----------------GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGS 190
            :|.:..:.|.|::                 .:|||.::..|:|||:|:||:.||...:|||::|.
 Frog    56 DGKVTVKTDAGNNVTVKDSQIYPQNPPKYDKIEDMAMMTHLNEASVLYNLKERYAAWMIYTYSGL 120

  Fly   191 ILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGK 252
            ..:.|||||..| .|..||...|.|:.....|||:|:|...|:.|:.:.   |.|:|:||||:||
 Frog   121 FCVTVNPYKWLP-VYNPEVVAGYRGKKRVEAPPHIFSISDNAYQAMLTDRENQSVLITGESGAGK 184

  Fly   253 TESTKLVMQYLAAVVPGG----------GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGK 307
            |.:||.|:||.|.:...|          .|....:.:||::|.|||||||||:|.||||||||||
 Frog   185 TVNTKRVIQYFATIAAVGDAGKKKETTSSSLQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGK 249

  Fly   308 YLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYF- 370
            ::.::| .:|.:..|.|..|||||||:..|...||:||:||:::.. .:.|..:..|:..:.|.
 Frog   250 FIRIHFGTTGKLSSADIETYLLEKSRVTFQLSAERSYHIFYQMMTN-KKPEIIEMCLITTNPYDF 313

  Fly   371 -YLNQG-----ATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQL 426
             :::||     :.|      |.|.|   ..|:.:||.::.|:.||.::..||:|..|:.|.::|
 Frog   314 PFISQGEIVVKSID------DQEELMATDSAIDILGFNQDEKVGIYKLTGAVMHHSNMKFKQKQ- 371

  Fly   427 RHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKAL 491
              .:|..|.....:....|:|:.:::..|.:||.....:...|.:.....:.|..:|..|..|::
 Frog   372 --REEQAEPDGTEDADKIAYLMGLNSADLLKALCYPRVKVGNEFVTKGQTVGQVNNAVGALCKSV 434

  Fly   492 YAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHV 554
            |..||.|:|:|||   |:..|....:  |.:|||.|||....||.||||||:.||.||.:||.|:
 Frog   435 YEKLFLWMVTRIN---QQLDTKQPRQFFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHM 496

  Fly   555 FKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-A 618
            |.|||.||.:|.::|..:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| .
 Frog   497 FVLEQEEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLG 561

  Fly   619 LSELYARPRIG----AQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL-TK 678
            ..:.:.:|:.|    ...|.:.||||.|.|.:.|:||||:|.|...|::|...|.:.|:..| :.
 Frog   562 KCKNFEKPKPGKGKAEAHFSLGHYAGTVDYNISGWLDKNKDPLNESVVQLYQKSSVKLLSFLYSS 626

  Fly   679 QLRAQRDA---GKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEK 740
            ...|..||   |....|||:.:         ||:|.|.::|.:|:.::...||.||||:.||:.|
 Frog   627 YAAADADAGGKGGKKKKGSSFQ---------TVSALFRENLNKLMTNLRSTHPHFVRCLIPNESK 682

  Fly   741 HALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALL 805
            ....|:...::.|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.:..| .:.:..:|..
 Frog   683 TPGIMENHLIIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPDG-QFIDSKKASE 746

  Fly   806 EAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR----RQLARR 866
            :.:....|:...|:.|.|:||.:..|...||..|.|:|.:.....|...||.|:|    :.:.||
 Frog   747 KLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQALCRGFLMRVEFKKMMERR 811

  Fly   867 QAAAT---RLQA-----RWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAR 923
            :|..|   .|::     .|...:...:.:.|.|.|          :..:.:|.::.:..:.::|.
 Frog   812 EAIYTIQYNLRSFMNVKHWPWMKLYFKIKPLLKSA----------ETEKEMQNMKEEFEKTKDAL 866

  Fly   924 EAAQRAREAREAKQAVL--ERSQLSYLDIPAE---LAFIYSKLQGWSPPHGDRHLVKVLGTVPGP 983
            ..|:..::..|.|..||  |::.|| |.:..|   ||....:.:|         |:||
 Frog   867 AKAEARKKELEEKMVVLLQEKNDLS-LQVQTESETLADSEERCEG---------LIKV------- 914

  Fly   984 PSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRRE---PITA---PLLTRAASRDQDFQD-ALAVF 1041
               .:||...:.:.:           .||:...|   .:||   .|....:...:|..| .|.:.
 Frog   915 ---KIQLESKIKEIT-----------ERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLA 965

  Fly  1042 KLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQ 1106
            |:            .|||...:..|........:.||.:.:|..:...|
 Frog   966 KV------------EKEKHATENKVKNLTEEMAVLDENISKLTKEKKAL---------------- 1002

  Fly  1107 CLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRA 1171
                                             |...||
 Frog  1003 ---------------------------------QEAHQQ-------------------------- 1008

  Fly  1172 WTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDY 1236
                       ||.|..::...|.|.|..:....                    ||:.|..|
 Frog  1009 -----------TLDDLQAEEDKVSSLTKAKTKLE--------------------QQVDDLEG--- 1039

  Fly  1237 VMDLIAEKELCPAFPAPRSDL------LRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRE 1295
              .|..||:|       |.||      |....|.::.|:                    .|:..:
 Frog  1040 --SLEQEKKL-------RLDLERAKRKLEGDLKLSQETV--------------------MDLEND 1075

  Fly  1296 RRSSRELLSRS----SALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQ 1356
            ::.:.|.|.:.    |.|..: .|.|.|.|........:.::|.:.|::.:..:.. .....:.|
 Frog  1076 KQQTEEKLKKKDFEISQLQAK-IEDEQSLGSQLQKKIKELQARIEELEEEIEAERA-ARAKIEKQ 1138

  Fly  1357 EPLHTLGLSE--SRLNDRYHSAERLAPVGKDTGPRYQKSQ---HAGRRSHAASHGSHSSKYADKA 1416
            ....:..|.|  .||.:...:......:.|.....:||.:   ......|.|:.|:...|:||
 Frog  1139 RADLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKVRRDLEEATLQHEATAGALRKKHAD-- 1201

  Fly  1417 EYATRSSAMSDTSEAPSLASHVRRV--RVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASI 1479
                      ..:|......:::||  ::..:.|::...:|||.|     :|:.:|.:::....:
 Frog  1202 ----------SVAELGEQIDNLQRVKQKLEKEKSELKMEIDDLAS-----NLENVSKSKANLEKV 1251

  Fly  1480 RGGSYEQENEAESEIDDLDDYINDI------FQPIPLVQNLE---KLTSKDQLAAIIKGG--GVA 1533
            .....:|.:|.:|:.|:....:||:      ||    .:|.|   ::..|:.|.:.:..|  |..
 Frog  1252 NRVIEDQLSEVKSKSDEQQRLLNDLSAQRARFQ----TENGELSRQVEEKESLISQLSRGKQGFT 1312

  Fly  1534 SKPEE----RDEESEIEDL-----------DDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGS 1583
            .:.||    .:|||:.::.           .|.:.|.:|        ::..:|..|..|:
 Frog  1313 QQIEELKRQLEEESKAKNALAHALQSARHDSDLLREQYE--------EEQEAKAELQRSL----- 1364

  Fly  1584 TDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQ-IQQQLLAQN---------- 1637
            :.:||      ::.|...:.|:......::::.|  :..:||.|| .::|:.|.|
 Frog  1365 SKANG------EVSQWRTKYETDAIQRTEELEEA--KKKLAQRLQDAEEQVEAVNSKCASLEKTK 1421

  Fly  1638 QALQTLLS------QQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMR--MKATRS------- 1687
            |.||:.:.      ::|.:|||...........:||.........|:.:.  :|..||
 Frog  1422 QRLQSEVEDLMVDVERANSAAAALDKKQRNFDKVLSEWKQKYEEGQAELEAALKEARSQSTEIFK 1486

  Fly  1688 -------SLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEP 1745
                   ||..:|:|:                   .|.::.                    |.|.
 Frog  1487 MKNAYEESLEHVETLK-------------------RENKNL--------------------QQEI 1512

  Fly  1746 QFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPM 1810
            ...||:...:.|......|...|.:..:......:.|    |.|    ::|.||
 Frog  1513 SDLTEQIGESGKSINELEKAKKQVEQEKSDLQAALEE----AEG----SLEHEE----------- 1558

  Fly  1811 SGQLMRSSIRLETTTTTTTSAVNNRDRD-----RETQDVGQPMQSVVTTKLAKKSFEIGADRPPP 1870
             .:::|..:.|....:.....:..:|.:     |.:|.....:||.:.:::..::..:...:...
 Frog  1559 -AKILRIQLELNQIKSEVDRKIAEKDEEIEQLKRNSQRAIDTLQSTLDSEIRSRNDALRLKKKME 1622

  Fly  1871 GSVGKLKL--------SSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLF 1927
            |.:.:|::        ::|.:::|..|.|.:           :.|..:|:|.  |..|..|....
 Frog  1623 GDLNELEIQLSHANRQAAEAQKQLRNVQAQY-----------KDAQLQLDDA--LRGQDDLKEQV 1674

  Fly  1928 ASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSM 1992
            |.:...|:.....::.:.....|.||.. |::...          ||..:..|..
 Frog  1675 AVIERRNNLQQAEIEENRAALEQTERSR-KIAEQE----------LLDASERVQL---------- 1718

  Fly  1993 APPAPPPAPQSPPTARSPEPEPDYRTSSSQVV--KEHVPAFIQRQERDTFGAVRQQQMISSHHLH 2055
                                   ..:.::.::  |:.:.|.|.:.:.:...||::     :.:..
 Frog  1719 -----------------------LHSQNTSLIGSKKKLEADISQLQSEAEEAVQE-----ARNAE 1755

  Fly  2056 LEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWD---RAEVEGPASGSGSEKEREKRE 2117
            .:...|.:..|:.| |:.::|:..|....|.:::..::|.|   |.:.....:..|.:|:.:|.|
 Frog  1756 EKAKKAITDAALMA-EELKKEQDTSAHLERMKKNLEQTVKDLQNRLDEAEQLAMKGGKKQLQKLE 1819

  Fly  2118 RERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERK 2182
            .      .:|::|.|.::.:          :..:|...|.|:.:|.....|::|      |.:||
 Frog  1820 T------RVRELENELDNEQ----------KRGVDAVKGVRKYERRVKELTYQT------EEDRK 1862

  Fly  2183  2182
             Frog  1863  1862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	245/693 (35%)
		PTZ00121	<828..>943	CDD:173412	28/128 (22%)
		MyTH4	1014..1171	CDD:470587	19/163 (12%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	12/66 (18%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myh4l	XP_031747897.1	Myosin_N	32..76	CDD:460670	3/19 (16%)
		Motor_domain	100..769	CDD:473979	244/692 (35%)
		Myosin_tail_1	849..1926	CDD:460256	223/1383 (16%)