Protein Alignment Myo10A and myo3a

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_031760347.1
• Gene: myo3a / 100495574
• XenbaseID: XB-GENE-6032645
• Length: 1607
• Species: Xenopus tropicalis
• Alignment Length: 1549
• Identity: 437/1549 - (28%)
• Similarity: 671/1549 - (43%)
• Gaps: 374/1549 - (24%)

  Fly    87 LEDFEDLPNLS--AKHPALPSSRLRRLKCRYPQVVKRLSTLCS-----DVIA--RHPQTFALQPG 142
            ::|||..|.:|  .:||.     :::||.....:.|:|..|..     .::|  ||.:   :...
 Frog   270 IKDFEKRPTVSDLLEHPF-----IKQLKDNENALQKQLMELIDIHQQMGIMAKKRHER---INTK 326

  Fly   143 EGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGL 207
            :|..:.........|:|:..|:.|.|.::...|:.||::..|||:.|.||:||||::.. |.|..
 Frog   327 KGHFKESMAPNQDDVDDLATLEALDENTVTDQLQKRYNRDQIYTYVGDILVAVNPFRPM-DLYSS 390

  Fly   208 EVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPG 269
            :.::.|.|......|||:||:...|:.::   .|.|.:|||||||:||||...|::|.|..:
 Frog   391 QYSQMYIGAKRTDNPPHIFAVADLAYQSMVTYNSDQCIVISGESGAGKTEGAHLLVQQLTVL--- 452

  Fly   270 GGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKS-GAIVGAKITQYLLEKSRI 333
            |.:.:..:.|:||:...|:||||||.|..|:||||||||||:.|.| |.:|.|:|::|||||||:
 Frog   453 GKANNRTLQEKILQVNNLVEAFGNACTIINENSSRFGKYLEMKFTSNGTVVAAQISEYLLEKSRV 517

  Fly   334 VTQAPGERNYHVFYELLGGLSETER-SKYGLLE------------------ADKYFYLNQGATDC 379
            |.||.||:|:|:||.:..||||.:: :.|.|.:                  .:|.||.:|
 Frog   518 VHQALGEKNFHIFYYIYAGLSEKKKLAHYKLPDIKPPRYLQNEHIKMVQDFMNKPFYKSQ----- 577

  Fly   380 ASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWA 444
                  :|.::...:|:|.|..|...:..:|||:|::||:.|......|..:...:.:...::.|
 Frog   578 ------FELIEQCFKVIGFSMEELGSVYSILAAILNVGNIDFTSVASEHQIDKSHINNPTVLENA 636

  Fly   445 AHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIV-- 507
            |.||.|..|.|..||||.....|.|.:.....:::|.|.|||.:||||..||:|:|:|||:::
 Frog   637 ASLLCIQPDELKDALTSHCVVTRGETIIQQNTVEKAADVRDAMSKALYGRLFSWIVNRINALLKP 701

  Fly   508 QKGGTHDA-HRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTP 571
            :|....|| ..|.||||||||:..:|||||||||.|||.:|.|||:|:|..||.||..|.::...
 Frog   702 EKLSEDDAGFNIGILDIFGFENFKKNSFEQLCINIANEQIQFYFNQHIFAWEQNEYLNEDVDVRL 766

  Fly   572 LAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVT 636
            :.::||.|::.:..:||:|:..|||:||.||||||.:.:||...| ..|:.:.||:.....||:.
 Frog   767 IEYEDNRPILDMFLQKPMGLLSLLDEESRFPRATDQTLVEKFEDN-LKSKNFWRPKRVDLTFGIH 830

  Fly   637 HYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLV-----GELTKQ---LRAQRDAGKTLP-- 691
            ||||::.|...|||:||||.|..|::.||.||...|:     ..|||.   ...:...|.:|.
 Frog   831 HYAGKLLYNASGFLEKNRDTLPADIVLLLRSSENSLIRILASNPLTKTGNLAHTKTKGGTSLQSW 895

  Fly   692 ---KGSNGR----FVTMKPR------TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHAL 743
               |.||..    ..|..||      |.||::.|..||..||..|....|.||||||||.::.|.
 Frog   896 TSHKSSNHSKSDFSETYHPRETTNMKTQTVSSYFRYSLMDLLSKMVAGQPHFVRCIKPNNDRLAN 960

  Fly   744 RMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLL--------PSPLARGTPYREL 800
            :.|...||.||||.|:|:|.:||:.||..|:.|.:|::|||.|.        .||        |.
 Frog   961 KFDREKVLVQLRYTGILETARIRRLGYSHRILFANFIKRYRLLCFKSNEDPPVSP--------ES 1017

  Fly   801 CRALLEAMPRTGVEGPDYQLGATRVFLR----EALHRALESGRTERLRRAAVSVQRHVRGMLVRR 861
            |.|:||   :..|:  ::.||.|:|||:    |.|.|.:     :.:....|.||..|||.|..:
 Frog  1018 CAAILE---KANVD--NWVLGKTKVFLKYYHAEHLDRMI-----KHIVGGIVLVQACVRGWLAAK 1072

  Fly   862 Q----LARRQAAATRLQARWRG-----QRAQQRYERLRKGALTA-QRLWRGRQARRRVQQLRSD- 915
            :    ||||:.:|.::|:.:||     :....:.|::.:..:|. |...||...|:|:::...:
 Frog  1073 RFQKVLARREESAVKIQSAYRGYVVRKEMGHIQSEKMMEHIITQFQAYARGYLVRKRIKEQHEND 1137

  Fly   916 -------HRRRQEAREAAQRAREAREAKQAV----LERSQLSYLDIPA------ELAFIYSKLQG 963
                   |.|..:.|::.:|.||:.::||..    :|..|.|..:|.|      |.|.:...
 Frog  1138 AAITIQSHYRGFKERKSFKRKRESMKSKQCKTPENVEPEQNSEEEIIAEGKSEEEAAVVIQS--- 1199

  Fly   964 WSPPHGDRHLVKVLGTVPGPPSSAVQLPE-----DLGQFSFGKFSSVYCNGLRLQPRREPITAPL 1023
                |.:|..:    ..|...:.||..||     ||.                        |.|.
 Frog  1200 ----HKERKEM----NEPHQSNGAVTAPEAEDTVDLD------------------------TGPN 1232

  Fly  1024 LTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK----ALSSRGLRDEILVQLC 1084
            ......:|.....|..|.:...|...|:       |.|.:...|:    ...|....:|::
 Frog  1233 NNDDTEKDSREDQAATVIQSNYRGHRDR-------KKLKERSGHEINPTKTDSNNPTEELI---- 1286

  Fly  1085 NQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGT 1149
             |.:|:..::.....|.|..|                                     .|:|...
 Frog  1287 -QANGIQGSNNPTEELIQANG-------------------------------------IQEGQQA 1313

  Fly  1150 SSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVA 1214
            ::|       :|..|            :..||....|...|...|||.....|..|:..:|..
 Frog  1314 TNG-------KSPEP------------ETTLPSNQEDVVKQNEKVDSPAEDNEEEAVPSTSEN-- 1357

  Fly  1215 SRGWTLVLDDGQQLTDSCGLDYVMDLI-----AEKELCPAFPAPRSDLLRSGAKFARTTLPDAVK 1274
                    |..::|.:....|....:|     ..||         .|.||...|.
 Frog  1358 --------DQHEELLEDTDRDKAAVVIQSNYRGHKE---------RDKLRKEGKI---------- 1395

  Fly  1275 RPAVPPPAPPTSSGKEDVP--RERRSSRELLS-------------RSSALNERYFEREPSPGPGQ 1324
                     |...||::..  :|:.|..|.||             ..|.|:|:|...:
 Frog  1396 ---------PAKKGKDEKTNIKEKNSENETLSVLKEIEDLAAFTEEISKLSEKYLILQ------- 1444

  Fly  1325 GSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPR 1389
                       ::|::::..:::         :|.:|....:.:.|:. .|.|....:.|....
 Frog  1445 -----------QTLNEMILLNLL---------KPENTATYIKKKTNES-QSCENEIVITKQVDD- 1487

  Fly  1390 YQKSQHAGRRSHAASHGSHSSKYADKAE-YATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQF 1453
             .|.|...||....:..|     :|:|. |:.....:.|....|       |...|.:..:.:.:
 Frog  1488 -VKPQRVPRRQKPKTLNS-----SDEATYYSLLHLPVKDEKRKP-------RKDSPGKVLESEDY 1539

  Fly  1454 LDDLFSP------VLDG-SLDELSD----ARSLAASIRGGSYEQENEAESEIDD 1496
            ..:::|.      ..|| |..|..|    .|||.|          .|...|.||
 Frog  1540 YKEIYSSNSLSINKCDGVSATEFPDLNPSERSLGA----------EEPPPETDD 1583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	279/715 (39%)
		PTZ00121	<828..>943	CDD:173412	34/140 (24%)
		MyTH4	1014..1171	CDD:470587	22/160 (14%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	14/71 (20%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo3a	XP_031760347.1	Protein Kinases, catalytic domain	7..288	CDD:473864	7/22 (32%)
		MYSc_Myo3	353..1040	CDD:276830	279/715 (39%)
		MBD_Myo3a	1410..1458	CDD:439318	9/74 (12%)