DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo5a

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_031755040.1 Gene:myo5a / 100495365 XenbaseID:XB-GENE-1004102 Length:1888 Species:Xenopus tropicalis


Alignment Length:1714 Identity:455/1714 - (26%)
Similarity:715/1714 - (41%) Gaps:449/1714 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 QPGEGSLRARQDLGSS----------------------GVEDMTLLDDLHEASLLWNLRLRY-DK 181
            :||:..||.|.:.|:.                      |..|:|.|..|||.::|.||::|: |.
 Frog    32 KPGDTVLRLRLEEGTDLEYRLDAKTKELPPLRNPDILVGENDLTALSYLHEPAVLHNLKVRFIDS 96

  Fly   182 GLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVV 243
            .||||:.|.:|:|:|||:..| .||.::...|:|:.:|.:.||:||:...|:..:...   |.::
 Frog    97 KLIYTYCGIVLVAINPYEQLP-IYGSDIINAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSII 160

  Fly   244 ISGESGSGKTESTKLVMQYLAAVVPGGGSASAV-ITEQILEAAPLLEAFGNARTARNDNSSRFGK 307
            :|||||:|||.|.|..|:|.|.|   .||||.. :.|::|.:.|::|:.|||:|.||||||||||
 Frog   161 VSGESGAGKTVSAKYAMRYFATV---SGSASETNVEERVLASNPIMESIGNAKTTRNDNSSRFGK 222

  Fly   308 YLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFY 371
            |:|:.| |...|:||.:..|||||||:|.||..|||||:||:|....|..|.....|..|:.:.|
 Frog   223 YIEIGFDKRYRILGAHMRTYLLEKSRVVFQAEEERNYHIFYQLCASASLPEFKMLRLGTANDFHY 287

  Fly   372 LNQGATDCASGRVDWESLQGAMQ---VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGV 433
            ..||.:....|..|...::...|   :||:.:..:.||.|:|||:||||||.|..|.        
 Frog   288 TKQGGSPVIEGVDDQREMKNTRQACTLLGIGDSYQMGIFRILAAILHLGNVEFKSRD-------- 344

  Fly   434 EVGSD--------AEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKA 490
               ||        |.:.....|:.:..:.:...|..|.....||....|:...||.:||||.||.
 Frog   345 ---SDSCLVPPKHAPLNIFCDLMGVEYEEMSHWLCHRKLVTAAETYIKPISRLQATNARDALAKH 406

  Fly   491 LYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVF 555
            :||.||||:|..:|..:. ..|.....|.:|||:|||....|||||.|||||||.||..||.|||
 Frog   407 IYAFLFNWIVCHVNKALH-SSTKQNSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNLHVF 470

  Fly   556 KLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-AL 619
            ||||.||.:|::.||.:.:.||.|.|:|:..| :||..|||:|...|:.:|.::.:|.:..| ..
 Frog   471 KLEQEEYMKEQIPWTLIDFYDNQPCINLIEAK-MGILDLLDEECKMPKGSDSTWAQKLYNTHLKK 534

  Fly   620 SELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASS--RLPLVGELTKQ--- 679
            |.|:.:||:....|.:.|:|.:|.|..:|||:||:|.:..:.:::|.:|  :..|:.||.::   
 Frog   535 SALFEKPRLSNVAFIIKHFADKVEYQCEGFLEKNKDTVFEEQIKVLKASKKKFTLLTELFQEEEQ 599

  Fly   680 ----LRAQRDAGKTLPKGSNGRFVTMKP------RTPTVAARFADSLQQLLQSMGRCHPWFVRCI 734
                ..:...:|:||...:..|.:..||      ...||..:|.:||..|::::....|.:||||
 Frog   600 ILSPTSSAPPSGRTLLSRTGLRSLKPKPEQTSKEHKKTVGHQFRNSLHLLMETLNATTPHYVRCI 664

  Fly   735 KPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRE 799
            |||..|:....|....:||||..|:|:||:|...|:|.|..:|.|..|||.|:...... :..::
 Frog   665 KPNDFKYPFTFDSKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVL-SDRKQ 728

  Fly   800 LCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLA 864
            .|:.:||.:.   ::...||.|.|::|.|......||..|.::||.|.:.:|:.:||.|:|:   
 Frog   729 TCKNVLEKLI---LDKDKYQFGKTKIFFRAGQVAYLEKIRADKLRMACIRIQKTIRGWLLRK--- 787

  Fly   865 RRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQAR------RRVQQ------------ 911
                                :|.|:||.|:|.||..||.|||      ||.|.            
 Frog   788 --------------------KYLRMRKAAITIQRYVRGYQARCYAQFLRRTQAAIIIQKFQRMYV 832

  Fly   912 LRSDHRRRQE---AREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSK-LQGWSPPHGDRH 972
            :|..:|..|.   |.::..|...||:..|.:|.          |..|.|..| ::||        
 Frog   833 VRQKYRHMQSITLALQSYMRGYAARKRFQGMLR----------AHKATIIQKHVRGW-------- 879

  Fly   973 LVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDA 1037
            |.:|  |.....|:.|.|               .|...|:..:||.....:..|:....:...:.
 Frog   880 LARV--TYKRNLSAIVYL---------------QCCYRRMMAKRELKKLKIEARSVEHYKKLNNG 927

  Fly  1038 LAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQ 1102
            :....:.|:...|:  :....|.|.:.:.|..::....:|::...:....|              
 Frog   928 MENKIMQLQRKVDE--QNKDNKSLLERLTHLEVTYNTEKDKLRSDVDRLRH-------------- 976

  Fly  1103 LLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWL 1167
                    |:..|..:...|..:.||...      ||:.|:|.....:.               :
 Frog   977 --------FEEEAKNAANRMVSLQDELAR------LRKELQQTQTEKNK---------------I 1012

  Fly  1168 EWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSC 1232
            |.||               |..||..........|..||                          
 Frog  1013 EERA---------------EKYQTETEKLVAELREQNAL-------------------------- 1036

  Fly  1233 GLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERR 1297
                   |.||||       ..:.|::..||    .:.:.:::..:    ..|...:.::..||.
 Frog  1037 -------LKAEKE-------ELNLLIQEQAK----KMTEDMEKKII----EETKQLELELNDERL 1079

  Fly  1298 SSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTL 1362
            ..:.||:..|.|.|||                         |||              ::.::|:
 Frog  1080 RYQNLLNEYSRLEERY-------------------------DDL--------------KDEINTM 1105

  Fly  1363 GLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKY------ADKAEYATR 1421
                                   :.|:      .|.:...::|.|:.|:|      .:..:|..|
 Frog  1106 -----------------------SPPK------PGHKRTDSTHSSNESEYTFSSEITESEDYPYR 1141

  Fly  1422 SSAMSDTSEAPSLASHV---RRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAAS---IR 1480
            :...:|......::..:   :||:...|...|.|  ||     ||...:::..|:.:..:   .|
 Frog  1142 NEEPADRKTPLDMSLFLKLQKRVKELEQEKQVMQ--DD-----LDKKEEQIIRAKIMEEAKTPTR 1199

  Fly  1481 GGSYEQEN----EAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGG----------- 1530
            |...|.|:    |.|||...|.:.:|::.:.|         |.|....|...||           
 Frog  1200 GTELEYESLKRQELESENKKLKNELNELRRAI---------TEKASPDATGPGGTVYKVLLEQMT 1255

  Fly  1531 GVASKPEERDEE---------SEIEDL---DDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGS 1583
            .|:.:.|.|.||         |::|.:   ||. :.:.:.:.::|.:.|:..|..:|.:..|...
 Frog  1256 SVSEELEVRKEEVLILRSQLVSQMEAIPHKDDK-DTMTDSMVLSEDVQKMKDKREIAQAYTGMKE 1319

  Fly  1584 TDS-----------------NGA-----DPLLHQLMQLPGETESGPALYQQQVQ--RAFLQSAMA 1624
            |:|                 :|.     |.|......|..:.:|....::.:|:  |..:|:...
 Frog  1320 TNSLETIERNLPPDYQALNEDGELWLVYDGLKQANRVLESQLQSQKKAFENEVEALRGEIQALKE 1384

  Fly  1625 QNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLS------------ISPPPPQ 1677
            :|.: ||||||||..|                   ||...|.:||.            .......
 Frog  1385 ENNR-QQQLLAQNLQL-------------------PPEARIEASLQHEITRLTNENLFFEELYAD 1429

  Fly  1678 SPMRMKATRSSLV-----VMESLQ 1696
            .||:.::.|.||.     :||.|:
 Frog  1430 EPMKYQSYRISLYRRIIDLMEQLE 1453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 267/712 (38%)
MYSc_Myo15 169..828 CDD:276838 259/691 (37%)
MyTH4 1014..1171 CDD:295320 20/156 (13%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myo5aXP_031755040.1 MYSc_Myo5 83..754 CDD:276831 259/691 (37%)
IQ 768..789 CDD:197470 8/43 (19%)
IQ 791..813 CDD:197470 12/21 (57%)
IQ 816..838 CDD:197470 4/21 (19%)
IQ 865..886 CDD:197470 9/40 (23%)
SMC_prok_B 905..>1477 CDD:274008 132/762 (17%)
Myo5a_CBD 1514..1888 CDD:271262
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.910

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