Protein Alignment Myo10A and LOC100495212

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_031750436.1
• Gene: LOC100495212 / 100495212
• XenbaseID: XB-GENE-29082603
• Length: 1936
• Species: Xenopus tropicalis
• Alignment Length: 2521
• Identity: 530/2521 - (21%)
• Similarity: 915/2521 - (36%)
• Gaps: 786/2521 - (31%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|:|.|:|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
 Frog    88 IEDMAMLTHLNEPSVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNPEVVNAYRGKKRQEA 151

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG---------GSAS 274
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|.:...|         |...
 Frog   152 PPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAAIGDKKKEEAAPGKIQ 216

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||::|.|||||||||:|.||||||||||::.::| .:|.:..|.|..|||||||:..|..
 Frog   217 GTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLSSADIETYLLEKSRVTFQLS 281

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYF--YLNQGATDCASGRVDWESL---QGAMQVLGV 398
            .||:||:||:::.. ...|.....|:..:.:.  :::||....|| ..|.|.|   ..|:.:||.
 Frog   282 AERSYHIFYQIMSN-KRPELIDMLLITTNPFDFPFVSQGEISVAS-IDDQEELMATDSAIDILGF 344

  Fly   399 SEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLHRALTS 461
            :..|:.||.::..||:|.||:.|.::|.....|  |.||...     ||:|:.:::..|.:||..
 Frog   345 NADEKVGIYKMTGAVMHYGNMKFKQKQREEQAEPDGTEVADK-----AAYLMGLNSADLLKALCF 404

  Fly   462 RTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHD--AHRISILDIF 524
            ...:...|.:.....:.|..::..|..|::|..:|.|:|.|||   |:..|..  .|.|.:|||.
 Frog   405 PRVKVGNEFVTKGQTVQQVYNSVGALGKSVYEKMFLWMVIRIN---QQLDTKQPRQHFIGVLDIA 466

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....||.||||||:.||.||.:||.|:|.|||.||.:|.:||..:.:..:|.....|.:||:
 Frog   467 GFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPM 531

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRIG----AQEFGVTHYAGQVWYCVDGF 649
            ||..:|::|..||:|||.||..|.:..| ..|..:.:|:.|    ...|.:.||||.|.|.:.|:
 Frog   532 GIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPGKGKAEAHFSLVHYAGTVDYNISGW 596

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFAD 714
            ||||:|.|...|:.|...|.:.|:..|.... |..||.....||...:..:.:    ||:|.|.:
 Frog   597 LDKNKDPLNETVIGLYQKSSVKLLSFLYSAY-AGSDADTGGKKGGKKKGSSFQ----TVSALFRE 656

  Fly   715 SLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHF 779
            :|.:|:.::...||.||||:.||:.|....||...|:.|||..|:|:.|:|.::|:|.|:.:..|
 Frog   657 NLNKLMSNLRSTHPHFVRCLIPNETKTPGAMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYGDF 721

  Fly   780 VERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLR 844
            .:||:.|..|.:..| .:.:..:|..:.:....|:...|:.|.|:||.:..|...||..|.:||.
 Frog   722 KQRYKILNASAIPEG-QFIDSKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLA 785

  Fly   845 RAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALTAQ 897
            :.....|...||.|:|   |::..|:.:...:|         ..|...:...:.:.|.|.|
 Frog   786 QLITRTQAMCRGFLMRVEFRKMMERRESVFCIQYNIRSFMNVKHWPWMKLYFKIKPLLKSA---- 846

  Fly   898 RLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQ-AVLERSQLSYLDIPAE---LAFIY 958
                  ::.:.:|.::.:..:.:||...::..|:..|.|. |:|:......|.:.:|   ||...
 Frog   847 ------ESEKEMQNMKEEFEKTKEALAKSEAKRKELEEKMVAILQEKNDLQLQVTSESEGLADAE 905

  Fly   959 SKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRRE---PIT 1020
            .:.:|         |:|          :.:||...:.:.:           .||:...|   .:|
 Frog   906 ERCEG---------LIK----------AKIQLEAKIKEAN-----------ERLEDEEESNAELT 940

  Fly  1021 A---PLLTRAASRDQDFQD-ALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILV 1081
            |   .|....:...:|..| .|.:.|:            .|||...:..|........:.||.:.
 Frog   941 AKKRKLEDECSELKKDIDDLELTLAKV------------EKEKHATENKVKNLTEEMAVLDETIA 993

  Fly  1082 QLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQG 1146
            :|..:...|                                                 |...||
 Frog   994 KLTKEKKAL-------------------------------------------------QEAHQQ- 1008

  Fly  1147 GGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSL 1211
                                                ||.|..::...|::.|..:....
 Frog  1009 ------------------------------------TLDDLQAEEDKVNTLTKAKTKLE------ 1031

  Fly  1212 GVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRP 1276
                          ||:.|..|     .|..||:|       |.|:.|:..|.
 Frog  1032 --------------QQVDDLEG-----SLEQEKKL-------RMDMERAKRKL------------ 1058

  Fly  1277 AVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDL 1341
                        :.|:...:.|:.:|.:....|:|:..::|        ....|.:|:.:. :..
 Frog  1059 ------------EGDLKLAQESTMDLENDRQQLDEKVKKKE--------FEISQLQSKIED-EQA 1102

  Fly  1342 LAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERL--APVGKDTGPRYQKSQHAGRRSHAAS 1404
            ||..:         |:.:..|......|.:.. .|||.  |...|......::.:....|...|.
 Frog  1103 LAAQL---------QKKIKELQARIEELEEEI-EAERAARAKAEKQRSDLSRELEEISERLEEAG 1157

  Fly  1405 HGSHSSKYADKAEYATRSSAMSDTSEA----PSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGS 1465
            ..:.:....:|...|.......|..||    .:.|:.:|:.:..|.| ::.:.:|:|
 Frog  1158 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKQADSVA-ELGEQIDNL-------- 1213

  Fly  1466 LDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGG 1530
                       ..::....::::|.:.|||||...:..:.:   ...||||:
 Frog  1214 -----------QRVKQKLEKEKSELKMEIDDLASNMESVSK---AKSNLEKM------------- 1251

  Fly  1531 GVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQ 1595
                          ...|:|..:|:           |...:|||.|      ..|.|.....||
 Frog  1252 --------------CRTLEDQFSEV-----------KTKEEEHLRV------INDINAQRARLH- 1284

  Fly  1596 LMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPP 1660
                   ||:|.  |.:|::..  :|.::|..:.:|....|.:.|:..|.::
 Frog  1285 -------TENGE--YARQLEEK--ESLISQLSRAKQAFTQQTEELKRQLEEE------------- 1325

  Fly  1661 PAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPY 1725
                                    |::...:...||                    ..||..|..
 Frog  1326 ------------------------TKAKNALAHGLQ--------------------SARHDCDLL 1346

  Fly  1726 GRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGA 1790
                              ..|::.|::                       :.|.:..|...|.|.
 Frog  1347 ------------------REQYEEEQE-----------------------AKGELQRSLSKANGE 1370

  Fly  1791 SATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTK 1855
            .|   :|.                          |...|.|:   .|..|.::
 Frog  1371 VA---QWR--------------------------TKYETDAI---QRTEELEE------------ 1391

  Fly  1856 LAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQ 1920
             |||                 ||:..:::..||:.|       |::|.     |.||.| |..||
 Frog  1392 -AKK-----------------KLAQRLQEAEEQIEA-------VNSKC-----ASLEKT-KQRLQ 1425

  Fly  1921 QQLGGLFASVSGGNSGPGGVVDSH-------ATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAP 1978
            .::..|...|...||....:....       |..:.:.|..:.:|.
 Frog  1426 NEVEDLMVDVERSNSACAALDKKQKNFDKVLADWKQKFEESQAELE------------------- 1471

  Fly  1979 SVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAV 2043
                                   .|...:||...|.....:|.:...:.:.. ::|:.::.
 Frog  1472 -----------------------ASQKESRSLSTEVFKMKNSYEEALDQLET-LKRENKNL---- 1508

  Fly  2044 RQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDRE---DYSESVWDRAEVE-GPA 2104
              ||.||.....:.:...|......|.:|.|.|:|..::...:.|   ::.|:...|.::| ...
 Frog  1509 --QQEISDLTEQVAEAGKSIHEIEKAKKQIESEKSDLQAALEEAEASLEHEEAKILRIQLELNQV 1571

  Fly  2105 SGSGSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATF 2169
            .|....|..||.|       ||.|::|..:          |.:: ||.:|.......|...|...
 Frog  1572 KGEIDRKIAEKDE-------EIEQIKRNSQ----------RALE-SMQSTLDAEIRSRNDALRLK 1618

  Fly  2170 R------THMAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGV 2228
            :      ..|..:..|..::.:.:...:| .:.|::..|
 Frog  1619 KKMEGDLNEMEIQLSHANRQAAESQKQLR-NVQSLYKDT-------------------------- 1656

  Fly  2229 LMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVAL-----DLLFAQVLGDVFGVTPCLR 2288
                                :|.: .:..:.::.:...:|:     :|:.|::
 Frog  1657 --------------------QLHL-DDALRGNDDLKEQLAIVERRNNLMTAEI------------ 1688

  Fly  2289 ITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQVRALVKRHLVDMARDWPLYFARLFAV 2353
               :|..|||....                        :.|.:.::.|:|:..
 Frog  1689 ---EEMRSALEQTE------------------------RGRKVAEQELIDVTE------------ 1714

  Fly  2354 QGAPLYPDVSIMGVSHSGLYLARR--DADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLA 2416
                   .|.::...::.|...::  :||   |.|..|  |::.||.         ..||....|
 Frog  1715 -------RVQLLHSQNTSLINTKKKLEAD---VSQLQS--EVEEAVQ---------EARNADEKA 1758

  Fly  2417 LHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGG 2481
            ..|...||:.:      :|.:|.|..::.|....:...||:.....||:..:..|.:      ||
 Frog  1759 KKAITDAAMMA------EELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLAMK------GG 1811

  Fly  2482 SRQNEQLQQ--SELHHHLQQQQ-------------QQQQQQQHHQQQQQQQ---QLEDAMEEQHM 2528
            .:|.::|:.  .||.:.|..:|             :::.::..:|.::.::   :|:|.:::..:
 Frog  1812 KKQLQKLEARVRELENELDAEQKRGSDAIKGVRKFERRVKELSYQSEEDKKNVFRLQDLVDKLQL 1876

  Fly  2529 ATDHQQQQQQQLGQQQG-QQQRFLKQQSYLHSARKSNAGQQPSSLTNGQVH 2578
            .....::|.:.:.:|.. ...||.|.|..|..|      ::.:.:...||:
 Frog  1877 KVKAYKRQSEDVEEQANVHLSRFRKAQHELEEA------EERADIAESQVN 1921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	247/685 (36%)
		PTZ00121	<828..>943	CDD:173412	26/127 (20%)
		MyTH4	1014..1171	CDD:470587	19/163 (12%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	11/66 (17%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
LOC100495212	XP_031750436.1	Myosin_N	33..77	CDD:460670
		Motor_domain	100..769	CDD:473979	247/685 (36%)
		Myosin_tail_1	849..1926	CDD:460256	259/1733 (15%)