Protein Alignment Myo10A and myo5c

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_012815050.1
• Gene: myo5c / 100495210
• XenbaseID: XB-GENE-1004095
• Length: 1721
• Species: Xenopus tropicalis
• Alignment Length: 1046
• Identity: 332/1046 - (31%)
• Similarity: 530/1046 - (50%)
• Gaps: 151/1046 - (14%)

  Fly   156 GVEDMTLLDDLHEASLLWNLRLRY-DKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |..|:|.|..|||.::|.||::|: :..:|||::|.||:|:||||..| .||..:...|:|:.:|
 Frog    73 GENDLTALSYLHEPAVLHNLKVRFVESNVIYTYSGIILVAINPYKELP-IYGDAIIHAYSGQNMG 136

  Fly   220 SLPPHLFAIGAAAHAALP---SPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            .:.||:||:...|:..:.   ..|.:::|||||:|||.|.:..|:|.|.|  ...|:.|.:.:::
 Frog   137 DIDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYTMRYFATV--SKTSSKAHVEDKV 199

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHV 345
            |.:.|:.||.|||:|.|||||||||||.|:.| :...|:||.:..|||||||:|.|:..|||||:
 Frog   200 LASNPITEAIGNAKTTRNDNSSRFGKYTEISFDRRYKIIGANLRTYLLEKSRVVFQSENERNYHI 264

  Fly   346 FYELLGGLSETERSKYGLLEADKYFYLNQGATDCASG---RVDWESLQGAMQVLGVSEGEREGIV 407
            ||:|....::.|.....|..|:::.|.:.|.....:|   :.|....|....:||:....:..:.
 Frog   265 FYQLCASANKPEFEHLHLTRAEEFNYTSMGGCTVITGVDDKKDMLDTQKTFALLGLGTDFQMDVF 329

  Fly   408 RVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLH 472
            :|:||:||||||...|  :...:..|:| :|..:|....||::.|..:.:.|.:|.....::.:.
 Frog   330 KVVAAILHLGNVEIKR--VSDDRSSVDV-NDKHLKIFCDLLNLEASKVAQWLCNRRIVTVSDTVI 391

  Fly   473 TPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQL 537
            .|:...||.:||||.||.:|:.||::::.:||:.:|..|..... |.:|||:|||....|||||.
 Frog   392 KPMTKQQADNARDALAKKIYSHLFDYVIDKINNALQYPGKQHTF-IGVLDIYGFETFEINSFEQF 455

  Fly   538 CINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFP 602
            |||||||.||..||.|||||||.||.:|.:.||.:.:.||..||.|:..| :||..|||:|...|
 Frog   456 CINYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDFYDNQIVIDLIEAK-MGILDLLDEECLLP 519

  Fly   603 RATDLSFLEKCHYNHALSE--LYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELL 665
            :.||.::|:|. ||:.|::  |:.:||:..:.|.:.|:|.:|.|..||||:||||.:...:::||
 Frog   520 QGTDENWLQKL-YNNYLNKNPLFEKPRMSNRSFIIQHFADKVEYKCDGFLEKNRDTVYDVLIDLL 583

  Fly   666 ASSRLPLVGELTK-------------QLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQ 717
            .:|:..|.....:             |:::.|.|    .|.||..|      ..||.::|.:||.
 Frog   584 RTSKFQLCSSFFQDNTSKSAQFSSGIQVKSARPA----IKSSNKEF------RMTVGSKFRNSLC 638

  Fly   718 QLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVER 782
            .|::::....|.:|||||||..|.....|...|:||||..|:|:||:|..:.||.|..:..|..|
 Frog   639 LLMETLNATTPHYVRCIKPNDLKLPFEFDAKRVVQQLRACGVLETIRISAQSYPSRWTYIEFFGR 703

  Fly   783 YRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAA 847
            |..|:..........:.:|:.:|:.:.:   :...||.|.|::|.|......||..|:::||.|.
 Frog   704 YSILMTQQELSLNDKKYICKIVLQRLIQ---DSNQYQFGRTKIFFRAGQVAYLEKLRSDKLRNAC 765

  Fly   848 VSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR--------------------------- 885
            |.:|:.|||.:.:::.:|.:.:|..:|..:|||||.::
 Frog   766 VIIQKSVRGWVQKKKFSRARRSAIVIQQYFRGQRAVRQAISGKALKHAWAAIIIQKYVRGFLVRR 830

  Fly   886 -YERLRKGALTAQRLWRGRQARRRVQQLRSDHRR--RQEAREAAQRAREAREAKQAVLERSQLSY 947
             |:.:....:|.|...||..||:|..::|.:|:.  .|:...|....|..:..::.|| ..||||
 Frog   831 IYQLILVATVTIQSFTRGYLARKRYHKMREEHKALILQKYARAWLARRRFQNVRRFVL-NIQLSY 894

  Fly   948 LDIPAELAFIYSKLQGWSPP-HGDRHLVKVLGTVPGPPSSAV----QLPEDLGQFSF-------- 999
                 .:..:..||:..:.. ||   |::.|.::....:..|    :|..:|.:.|.
 Frog   895 -----RVQRLQKKLEDQNKENHG---LLERLTSLASSHTHDVDKVHKLESELEKISSQKKHLDEK 951

  Fly  1000 ---------GKFSSVYCNGLRLQPRREPITAPLLTRAAS-RDQ---------------------- 1032
                     .|.:.:......|..::..:...|.|:... :||
 Frog   952 GKKYKEEAEEKMTKLQAQNAELLEQKHQMEVKLETKTQEMKDQMDQLTNQLFTDVEKEEKQRMKL 1016

  Fly  1033 --DFQDALAVF-----KL-----ILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCN 1085
              .|:..:..|     ||     :|:..|...|:.|:|:.|.         :.|||:|| .||..
 Frog  1017 EKHFEAQVTEFDTMIEKLKDEIQVLKERNKHLLKQAEEEQLV---------NDGLREEI-DQLSI 1071

  Fly  1086 QVHGLP 1091
            ||..:|
 Frog  1072 QVKKIP 1077

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	250/681 (37%)
		PTZ00121	<828..>943	CDD:173412	35/144 (24%)
		MyTH4	1014..1171	CDD:470587	24/113 (21%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo5c	XP_012815050.1	COG5022	15..1330	CDD:227355	332/1046 (32%)
		MYSc_Myo5	86..746	CDD:276831	250/681 (37%)
		Myo5c_CBD	1348..1715	CDD:271260