DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo10.2

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_031749628.1 Gene:myo10.2 / 100495096 XenbaseID:XB-GENE-5995373 Length:1997 Species:Xenopus tropicalis


Alignment Length:3148 Identity:674/3148 - (21%)
Similarity:1057/3148 - (33%) Gaps:1319/3148 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   156 GVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGS 220
            |||||:||.||||||::.||||||.:..|||..||||.:|||||.....|..:....|:....|.
 Frog     8 GVEDMSLLSDLHEASIMLNLRLRYQQDKIYTNIGSILASVNPYKSIAGLYDEKCVDLYSSHHFGE 72

  Fly   221 LPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAV---VPGGGSASAVITE 279
            ||||:|||....:..|   ...|.|:||||||:||||||||::::|:::   ..|||.....:.|
 Frog    73 LPPHIFAIANECYRCLWKRHDSQCVLISGESGAGKTESTKLLLKFLSSMSQNSAGGGGTQTHVEE 137

  Fly   280 QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNY 343
            .|:|::|:|||||||:|..|:|||||||:::::| :.|.|.|.::..|||||:|:..|:||||||
 Frog   138 AIMESSPILEAFGNAKTVYNNNSSRFGKFIQLHFSEQGHIQGGRVVDYLLEKTRVTRQSPGERNY 202

  Fly   344 HVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGEREG 405
            |:||.||.|.:..|:...||.:...|.||.......|.|..|   :|.:..|:||:..|:.|...
 Frog   203 HIFYALLTGANREEKEALGLSDPHTYQYLRASGCATAEGLNDKDMYEKVLAALQVMDFSDEEIRE 267

  Fly   406 IVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAER 470
            :.::|:.:|.|||:.|    :..|  |.::.:.|.:..||.||.:.:..|...||.|:...|.|.
 Frog   268 VWKLLSGILQLGNLEF----MTAG--GAQITTKAVLSDAADLLGLDSFQLSEVLTQRSMILRGEE 326

  Fly   471 LHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFE 535
            :.:||.::||.|:||:.|.||||..|:||:.|||:.::  |..:...:.||||||||:...|.||
 Frog   327 ISSPLTVEQATDSRDSLAMALYAQCFSWLLGRINARIR--GKENFKSVGILDIFGFENFQVNRFE 389

  Fly   536 QLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESN 600
            |..||||||.||.|||||:|.|||.||.||.:.|..:.|.||...:.|:.|| :||..|:::||.
 Frog   390 QFNINYANEKLQEYFNKHIFSLEQLEYNREGIHWDAIGWMDNAECLDLIEKK-LGILALINEESR 453

  Fly   601 FPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELL 665
            ||:.||.:.|||.|..|:.:..|.:||:...:||:.||||:|.|.|.|||:||||..|.|:|.:|
 Frog   454 FPKGTDFTLLEKLHNQHSNNPHYVKPRVTEHQFGIKHYAGEVTYDVQGFLEKNRDTFRDDILNML 518

  Fly   666 ASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWF 730
            ..|||..|.:|.::: ..|::.:||..|:       :.:.|||:::|.:||..|:..:...:|:|
 Frog   519 RDSRLDFVYDLFEKV-CSRNSEETLKMGT-------QRKKPTVSSQFRESLHSLMAMLSTSNPFF 575

  Fly   731 VRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGT 795
            :||||||.||.:...:...||.||||.|||:|::||:.|:|||..:|.|..||:.|:.: |....
 Frog   576 IRCIKPNTEKLSNTFNPDVVLNQLRYSGMLETVKIRRAGFPVRRLYQDFASRYKMLIKN-LKATD 639

  Fly   796 PYRELCRALLEAMPRTGVEG--PDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGML 858
            ..|..|.|.|:.     .||  .::|||.|:|||:|||.:.||..|...|||||..:..|::|.:
 Frog   640 DVRGKCAAFLQF-----YEGSKKEWQLGRTKVFLKEALEQKLEKSREGELRRAASVICAHIQGYI 699

  Fly   859 VRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAR 923
            .|:|..|.:.:...:|..:|....:..|.|||:.|:..|:.|||..|||..||:..:.|:|:|..
 Frog   700 ARKQFTRVRLSIVTIQKNYRAHFWRATYLRLRQSAVQFQKHWRGTVARRLYQQMLEEERKRREEE 764

  Fly   924 EAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAV 988
            |..::..|.|..::...:|                                              
 Frog   765 ERKRKEEEERRRRELEEQR---------------------------------------------- 783

  Fly   989 QLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKAL 1053
            ::.|:                   :.|||        ....|:|:..:|              .|
 Frog   784 RIEEE-------------------RKRRE--------EEEKREQERLEA--------------EL 807

  Fly  1054 EGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFS 1118
            ..|:|                                                            
 Frog   808 RAAQE------------------------------------------------------------ 812

  Fly  1119 KYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLT 1183
                   :.|..::|..:||::..|:|                                      
 Frog   813 -------EQEKAKNLENILLQEEERRQ-------------------------------------- 832

  Fly  1184 LPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCP 1248
                            .||...|                                    |||:  
 Frog   833 ----------------MEEILRL------------------------------------EKEI-- 843

  Fly  1249 AFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERY 1313
                   :.|....|.      |.|....       |.:.||.:.:......:|...:|.:.:.:
 Frog   844 -------EKLHHQQKL------DGVSTSC-------TETRKELIRQREEQIHKLEKEASRVAQEF 888

  Fly  1314 FEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAER 1378
            .|.         ...|..:..:.||::...|.:        |.|......|:|..:::.:|:.:.
 Frog   889 LEL---------LDFGNLEESAHSLENGFDGTV--------SAEGSMVAPLAEEEVDEGFHADDE 936

  Fly  1379 LAP-----VGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEY--------ATRSSAMSDTSE 1430
            :.|     :.:|.|||..:|                  ::::..|        ..:||:.::|..
 Frog   937 MLPPPPPMLLEDDGPRTSES------------------FSEEETYTNIPMDVPGAQSSSCTETPL 983

  Fly  1431 APSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEID 1495
            :||         .|..|.|.       :|.:.|.|                              
 Frog   984 SPS---------EPPSAQDP-------YSAISDKS------------------------------ 1002

  Fly  1496 DLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEE------RDEESEIEDLDDYINE 1554
                  ..|:|.:           .|.|:       .:.:|:|      .|.||      ||.:|
 Frog  1003 ------ESIYQCV-----------SDTLS-------TSEEPQEPIYSYPPDVES------DYDHE 1037

  Fly  1555 LFEPIPVAEGLD----KLTSKEHLAVSIRGG-----GSTDSNGADPLLHQLMQLPGETESGPALY 1610
            .|:..|....::    .||.:|.:.:|..|.     ||.||                        
 Frog  1038 EFDEAPPGSSMNLSDGHLTDEEIMRISQPGSFGSRCGSVDS------------------------ 1078

  Fly  1611 QQQVQRAFLQS--AMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISP 1673
                   ||.|  .:..::...::|:.....|            .|..               .|
 Frog  1079 -------FLDSDEEVDSHIDTDEELMTGRVTL------------FNGG---------------GP 1109

  Fly  1674 PPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRW 1738
            |...|.:.|||                                           ...:.|.:.||
 Frog  1110 PYFHSYLYMKA-------------------------------------------GGLMNIWRRRW 1131

  Fly  1739 PPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEE---- 1799
            ...:|       :.|..|:.:|...|            :|.:.:.|.|.  ::.:...|:.    
 Frog  1132 CVLKD-------DTFMWFRTKQEALK------------SGWLYKKGGGM--STLSRRNWKRRWFV 1175

  Fly  1800 --------FEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKL 1856
                    ||.:|.       :.:|.:|.:.    |..:.::..:::...        .:||   
 Frog  1176 LRESKLMYFENDSE-------ERLRGTIDIR----TAKAVIDIHEKENAL--------DIVT--- 1218

  Fly  1857 AKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQ 1921
            .::::.|.|:.|                  |..:...:|.|.|.:.:.|    :|.|.|      
 Frog  1219 EERTYHIVAETP------------------EDASGWFNVLSRVHSATSQ----QLRDMR------ 1255

  Fly  1922 QLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPP 1986
                                |..|..:..:..::..|                  ..||.|...|
 Frog  1256 --------------------DEQANPKNAVGTLDVGL------------------IDSVCASDCP 1282

  Fly  1987 IRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISS 2051
            .||.|..                       ..::::|:  |....|..:               .
 Frog  1283 DRPNSFV-----------------------IITANRVI--HCNTDIAEE---------------M 1307

  Fly  2052 HHLHLEDHSASSSPAVAAW-EQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREK 2115
            ||                | ...::.|..::.   |.:::....|...||:     |.::....|
 Frog  1308 HH----------------WISLLQKPRGEAKV---DGQEFLVRGWLHKEVQ-----SSNKTASLK 1348

  Fly  2116 RERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHE 2180
            .:|        |.....|.|...|                                         
 Frog  1349 LKR--------RWFVLNRNSLDYY----------------------------------------- 1364

  Fly  2181 RKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNR 2245
               |||...|.:                             ||.:                    
 Frog  1365 ---KSSERGGSK-----------------------------LGTL-------------------- 1377

  Fly  2246 VPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDT 2310
                                          ||..:     |..:.|.||                
 Frog  1378 ------------------------------VLNSL-----CSVVQPDEK---------------- 1391

  Fly  2311 LSNRNGSGAGGGGNGGQVRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLA 2375
                                                      |.....|.::.:.|..||     
 Frog  1392 ------------------------------------------VHSETGYWNLVVYGRKHS----- 1409

  Fly  2376 RRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAAR-AAAIQSMVTTFVQEFRKS 2439
                 |.:..:.::                            .|.| |.|||.::          
 Frog  1410 -----YRLYTKLLN----------------------------EAMRWANAIQGVI---------- 1431

  Fly  2440 QSKASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQ 2504
            .|||                |:|                                          
 Frog  1432 DSKA----------------PIE------------------------------------------ 1438

  Fly  2505 QQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQQP 2569
                    ...||.:.|..|                                  ::..|.|.:  
 Frog  1439 --------TPTQQLIRDIKE----------------------------------NSLNSEAVE-- 1459

  Fly  2570 SSLTNGQVHHQEQMLQQQQQQSQS----LPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFR 2630
                  |.:.:..:|:..|....|    ||:.|::.| ||.|                       
 Frog  1460 ------QTYKRNPILRYTQHPLHSPLLPLPYGDVNLN-LQKE----------------------- 1494

  Fly  2631 NDQLRDADRHHERHQSAANRSYAELVKWQGHAIRLPLLRLPNDLAPLALECFDCILRYCGDIPLD 2695
                               :.|..|   |..|:|                    |.....:|...
 Frog  1495 -------------------KGYTTL---QDEAVR--------------------IFNSLQEIETV 1517

  Fly  2696 PDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPDS--SQRAWRLLSILAAYF--GC 2756
            ||  .|..:..:|..|....:|||||||||:|||  |..|.|:|  :.|.|:|||.::..|  | 
 Frog  1518 PD--PVPIIQGILQTCQDLKSLRDEVYCQLIKQT--NHVPEPNSPGNLRHWQLLSCMSCTFLPG- 1577

  Fly  2757 SDALRPYLMEHLTSAASDRRRSCHGT-----AAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRS 2816
            .|.|| ||..||...    |.|..||     |...:..|:|| :|  |:.|||.||::|:.....
 Frog  1578 RDILR-YLKFHLKRV----RDSFPGTEVEQFAHFIVDALKKT-KC--REMVPSQEEISALLTRSH 1634

  Fly  2817 ARRQIYRLPGGA----------------------------------------ERVVNTRCSTVVA 2841
            ....:|...||:                                        :|.|.:|  .:||
 Frog  1635 MTTSVYCHGGGSCQISINSHTTAGEVVEKLIRGLSMDNSRNMFALFEHNKHTDRAVESR--VIVA 1697

  Fly  2842 DVIAELCALLGVESEAEQQ-----EFSLYCIVQGDAFTMPLAADE--YILDVTTELLKSGQPFYL 2899
            ||:|:...:.|...|.:..     .|.|||.:  |..::|....|  ::.:...|.|.||     
 Frog  1698 DVLAKFERMAGTADEEDDPGPWNLYFKLYCFL--DVQSVPKEGIEFAFMFEQAHESLTSG----- 1755

  Fly  2900 IFCRSVWHFALKREPAPMPLYVEVLFNQVAPDYLEGLLLELP-GNGVPVP---EMVRDMARIAAL 2960
                   ||     |||    .|.|      .:|..|.|:.. |:...|.   :.|..:.|:.|.
 Frog  1756 -------HF-----PAP----EETL------QHLAALRLQYQHGDFSKVNWSLDTVYPVQRLKAK 1798

  Fly  2961 LHRAADLS---HVPAMKEIKFLLPKPALGIR-----------EIRPAQWVGLVQSA--------W 3003
            :.:|...|   |....:...||......|.:           |.....||....||        |
 Frog  1799 ILQATKSSTSGHTLERRRTSFLEGTLKRGFKVGSMRKQKVEEEQMMEMWVKEELSAARTSIAEKW 1863

  Fly  3004 PQVANLSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEG-PHVEDNHSPMWRDLILALNRRGVL 3067
            .::..:|..|...:::.:::.||.:||:.|.|:  :.|.| |:          ||.|.::...|.
 Frog  1864 SRLQGMSQHQAMVKYMTIVSEWPGYGSTLFDVE--YKEGGFPN----------DLWLGVSAENVS 1916

  Fly  3068 FLDPNTHETLQHWSFMEVI-------STRKVRSEDGALFLDMKVGNLMQQRVIRVQTEQAHEISR 3125
            .......:.|:.:.:..:|       :|.|:..:|..:|.               :|.|..||::
 Frog  1917 VYKRGDAKPLETFQYEHIIFFGAPQPNTFKITVDDREMFF---------------ETTQVGEITK 1966

  Fly  3126 LVRQYITM--------AQISQRDKRELN 3145
            ::|.||.|        ..::.:|.:..|
 Frog  1967 IMRAYINMIVKKRCSVRSVTSQDSQSSN 1994

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 299/691 (43%)
MYSc_Myo15 169..828 CDD:276838 284/670 (42%)
MyTH4 1014..1171 CDD:295320 15/156 (10%)
MyTH4 2704..2810 CDD:279165 47/114 (41%)
B41 2823..3033 CDD:214604 56/282 (20%)
FERM_B-lobe 2920..3025 CDD:271216 24/130 (18%)
FERM_C_MyoXV 3029..3138 CDD:270022 25/124 (20%)
myo10.2XP_031749628.1 MYSc_Myo10 21..669 CDD:276840 284/670 (42%)
IQ 729..751 CDD:197470 11/21 (52%)
MYO10_CC 836..880 CDD:407004 12/101 (12%)
MSCRAMM_ClfB <949..1095 CDD:411414 42/270 (16%)
PH-like 1115..>1147 CDD:418428 9/81 (11%)
PH2_MyoX 1150..1251 CDD:270108 21/158 (13%)
PH-like <1278..1322 CDD:418428 12/99 (12%)
PH3_MyoX-like 1316..1441 CDD:270109 41/440 (9%)
MyTH4 1524..1628 CDD:395633 47/114 (41%)
FERM_F1_Myosin-X 1632..1729 CDD:340726 17/98 (17%)
B41 1638..1893 CDD:214604 57/285 (20%)
FERM_C_MyoX 1889..1977 CDD:270023 25/114 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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