Protein Alignment Myo10A and LOC100495065

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_031750435.1
• Gene: LOC100495065 / 100495065
• XenbaseID: XB-GENE-29082551
• Length: 1941
• Species: Xenopus tropicalis
• Alignment Length: 2232
• Identity: 518/2232 - (23%)
• Similarity: 846/2232 - (37%)
• Gaps: 630/2232 - (28%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
 Frog    87 IEDMAMLTHLHEPAVLYNLKERYKAWMIYTYSGLFCVTVNPYKWLP-VYNPEVVNAYRGKKRSEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQY---LAAVV-------PGGGSA 273
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||   :||||       ....|.
 Frog   151 PPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAAVVDPKKKEKESTASM 215

  Fly   274 SAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQA 337
            ...:.:||::|.|||||||||:|.||||||||||::.::| .:|.:..|.|..|||||||:..|.
 Frog   216 KGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQL 280

  Fly   338 PGERNYHVFYELLGGLSETERSKYGLLEADKYF--YLNQGATDCASGRVDWESL---QGAMQVLG 397
            ..||:||:||::|.. .:.|.....|:..:.|.  |::||....|| ..|.|.|   ..|:.:||
 Frog   281 LAERSYHIFYQILSN-KKPELIDMLLITTNPYDFPYISQGEISVAS-IDDTEELLATDSAIDILG 343

  Fly   398 VSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLHRALT 460
            .:..|:.||.::..||:|.|.:.|.:|......|  |.||...     .|:|..:::..|.:||.
 Frog   344 FTPEEKNGIYKLTGAVMHYGTMKFKQRPREEQAEPDGTEVADK-----TAYLTGLNSADLLKALC 403

  Fly   461 SRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTH--DAHRISILDI 523
            ....:...|.:.....::|.....:|.:|::|..||.|:|:|||   |:..|.  ..|.|.:|||
 Frog   404 YPRVKVGNEYVTKGQTVEQVHYNVNALSKSVYEKLFLWMVTRIN---QQLDTKLPRQHFIGVLDI 465

  Fly   524 FGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKP 588
            .|||....||.||||||:.||.||.:||.|:|.|||.||.:|.:|||.:.:..:|.....|.:||
 Frog   466 AGFEIFEFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKP 530

  Fly   589 VGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWYCVDG 648
            :||..:|::|..||:|||.||..|.:..| ..|..:.:|:  .|..|  |.:.||||.|.|.:.|
 Frog   531 MGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAHFSLIHYAGTVDYNIKG 595

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGEL---TKQLRAQRDAGK-TLPKGSNGRFVTMKPRTPTVA 709
            :|:||:|.|...|:.|...|.:.|:..|   .:...|:....| |..|||:.:         ||:
 Frog   596 WLEKNKDPLNETVVGLYQKSSMKLLANLYATYESTNAEATTKKATKKKGSSFQ---------TVS 651

  Fly   710 ARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRL 774
            |.|.::|.:|:.::...||.|||||.||:.|....||...||.|||..|:|:.|:|.::|:|.|:
 Frog   652 ALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGDMDHHLVLHQLRCNGVLEGIRICRKGFPNRI 716

  Fly   775 RFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALES 837
            .:..|.:|||.|..|.:..|  ...::.|..||.::   .::...|:.|.|:||.:..|...||.
 Frog   717 LYGDFKQRYRILNASAIPEGQFIDSKKACEKLLGSI---DIDHTQYKFGHTKVFFKAGLLGTLEE 778

  Fly   838 GRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRL 899
            .|.:||.......|...||.|:|   .::..|:.|...:|...|              |....:.
 Frog   779 MRDDRLVLVITRTQARCRGFLMRLEFMKMMERRDAIFSIQYNIR--------------AFMNVKH 829

  Fly   900 WRGRQARRRVQQ-LRSDHRRRQEA--REAAQRARE---AREAKQAVLERSQLSYLDIPAELAFIY 958
            |...:...:::. |||....::.|  :|..:|.:|   ..|||:..:|...:..|....:|..
 Frog   830 WPWMKLYFKIKPLLRSAETEKEMAAMKEEFERTKENLAKSEAKRKEMEEKMVKLLQEKNDLQL-- 892

  Fly   959 SKLQGWSPPHGDR-----HLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRRE- 1017
             ::|..|....|.     .|:|          |.:||...:.:.:           .||:...|
 Frog   893 -QVQSESENLSDAEERCDQLIK----------SKIQLEAKIKELN-----------ERLEDEEES 935

  Fly  1018 --PITA---PLLTRAASRDQDFQD-ALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLR 1076
              .:||   .|....:...:|..| .|.:.|:            .||:...:..|........:.
 Frog   936 NAELTAKKRKLEDECSELKKDIDDLELTLAKV------------EKERHATENKVKNLTEEMAVL 988

  Fly  1077 DEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQL 1141
            ||.:|:|..:...|                                                 |.
 Frog   989 DETIVKLTKEKKAL-------------------------------------------------QE 1004

  Fly  1142 LRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAAL 1206
            ..||                                     ||.|..::...|:|.|..:  |.|
 Frog  1005 AHQQ-------------------------------------TLDDLQAEEDKVNSLTKLK--AKL 1030

  Fly  1207 AVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSD------LLRSGAKFA 1265
            .                  ||:.|..|     .|..||:|       |.|      .|....|.|
 Frog  1031 E------------------QQIDDLQG-----SLEQEKKL-------RMDNERAKRKLEGDLKLA 1065

  Fly  1266 RTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSR-----SSALNERYFEREPSPGPGQG 1325
            :.::                    .|:..:|:...|.|.:     |..|::  .|.|...|....
 Frog  1066 QDSI--------------------MDLENDRQQLDEKLKKKDFEISQLLSK--IEDEQVLGNQYQ 1108

  Fly  1326 SSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHS----AERLAPVGKDT 1386
            ....:.::|.:.|::           :.||:..  |...:|.:..|....    :|||...|..|
 Frog  1109 KKIKELQARIEELEE-----------EIDSERA--TRAKAEKQRADLTRELEEISERLEEAGGAT 1160

  Fly  1387 GPR----------YQKSQHAGRR-------SHAASHGSHSSKYADK-AEYATRSSAMSDTSEAPS 1433
            ..:          :||.    ||       .|.|:..|...|:||. |||..:
 Frog  1161 ASQLELNKKREVEFQKV----RRDLEEMSLQHEATVASLRKKHADSAAEYGEQ------------ 1209

  Fly  1434 LASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLD 1498
             ..:::||:         |.|:                             ::::|...|||||.
 Frog  1210 -IDNLQRVK---------QKLE-----------------------------KEKSEMRMEIDDLS 1235

  Fly  1499 DYINDIFQPIPLVQNLEKL--TSKDQLAAI----------------------IKGGGVASKPEER 1539
            ..:..:.:.   ..|||||  |.:|||:..                      .:.|.:|.:.|||
 Frog  1236 SNLESVTKS---KANLEKLCRTLEDQLSEFKAKSEETHRLVADLTMHKSRLQTETGELARQLEER 1297

  Fly  1540 DE------------ESEIEDLDDYINELFEPIPVAEGL-DKLTSKEHLAVSIRGGGSTDSNGADP 1591
            |.            ..:||:|...:.   |.:.....| ..|.|..|....:|.....:......
 Frog  1298 DSLVSQLSRSKQAFTQQIEELKRLME---EEVKAKNALAHSLQSSRHDCDLLREQYEEEQEAKSE 1359

  Fly  1592 LLHQLMQLPGETESGPALYQ-QQVQRA-FLQSA---MAQNLQ-IQQQLLAQNQALQTLLS----- 1645
            |...|.:..||.......|: ..:||. .|:.|   :||.|| .::|:.|.|....:|..
 Frog  1360 LQRSLSKANGEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEQIEAVNSKCSSLEKTKQRL 1424

  Fly  1646 -----------QQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMR--MKATRSSLVVMESLQP 1697
                       ::|.:|||...........||:.........||.:.  ||.:||
 Frog  1425 QGEVEDLMIDVERANSAAAALDKKQKNFDKILAEWKQKYEESQSELESAMKESRS---------- 1479

  Fly  1698 PPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQ 1762
                                                             ..||    .|||:...
 Frog  1480 -------------------------------------------------LSTE----LFKMKNAY 1491

  Fly  1763 RKTTPQ----------AQH------HQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMS 1811
            .::..|          .||      .|::|:|.::.....|:    ..:|.|:.|::|......:
 Frog  1492 EESLDQLETIKRENKNLQHEIGDLTEQISSSGKIIHELEKAK----KQVELEKSEMQSSLEEAEA 1552

  Fly  1812 ------GQLMRSSIRLETTTTTTTSAVNNRDRD-----RETQDVGQPMQSVVTTKLAKKSFEIGA 1865
                  .:::|..:.|..........|..:|.:     |..|.:.:.||:.:.:::..::..:..
 Frog  1553 ALEHEEAKILRIQLELTQVKADIERKVAEKDEEIDQLKRNHQRIMESMQTALDSEIRSRNEAVRI 1617

  Fly  1866 DRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTR-----KLMLQQQLGG 1925
            .:...|.:.::::......|:          :|.:.|..:....:|:||:     .|..|:.|..
 Frog  1618 KKKMEGDLNEMEIQLSHANRI----------ATETQKYLRNVQGQLKDTQIHLDDALRGQEDLKE 1672

  Fly  1926 LFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPP 1990
            ..|.|...|:          .:.|:||.:...|.
 Frog  1673 QLAIVERRNN----------LMLTEIEELRAALE------------------------------- 1696

  Fly  1991 SMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLH 2055
                       |:..:.:..|.|....|...|::.....:.|..:::.....|:.|..|......
 Frog  1697 -----------QTERSRKVAEQELVDATERVQLLHSQNTSLITTKKKLESDVVQLQGEIEDTTKE 1750

  Fly  2056 LEDHSASSSPAV--AAW--EQAERERSRSRSRSRDREDYSESVWD---RAEVEGPASGSGSEKER 2113
            ..:....:..|:  ||.  |:.::|:..|....|.:::..::|.|   |.|.....:..|.:|:.
 Frog  1751 ARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQVRLEEAEQLALKGGKKQL 1815

  Fly  2114 EKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYE 2178
            :|.|.      .:|::|.|.:...          :.:::...|.|:.:|.....||::      |
 Frog  1816 QKLEA------RVRELENELDLEN----------KKNVEVVKGIRKYERRVKELTFQS------E 1858

  Fly  2179 HERKRKSSASSGMREELDSMHM 2200
            .:||.    |..:::.:|.:.:
 Frog  1859 EDRKN----SLRLQDLVDKLQL 1876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	256/692 (37%)
		PTZ00121	<828..>943	CDD:173412	28/123 (23%)
		MyTH4	1014..1171	CDD:470587	19/163 (12%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	14/66 (21%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
LOC100495065	XP_031750435.1	Myosin_N	32..76	CDD:460670
		MYSc_Myh3	99..769	CDD:276878	256/692 (37%)
		Myosin_tail_1	849..1926	CDD:460256	235/1433 (16%)