Protein Alignment Myo10A and LOC100493774

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_004916275.2
• Gene: LOC100493774 / 100493774
• XenbaseID: XB-GENE-29081879
• Length: 1989
• Species: Xenopus tropicalis
• Alignment Length: 2242
• Identity: 524/2242 - (23%)
• Similarity: 863/2242 - (38%)
• Gaps: 541/2242 - (24%)

  Fly   120 KRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLI 184
            ||:.....|:...:|..|                 :.||||..|..|:|||:|.||:.||..|||
 Frog    67 KRVPVAKDDIQKMNPPKF-----------------TKVEDMAELTCLNEASVLHNLKDRYYSGLI 114

  Fly   185 YTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISG 246
            ||::|...:.:||||..| .|..::.:.|.|:....:|||::||...|:.::   ...|.::.:|
 Frog   115 YTYSGLFCVVINPYKNLP-IYTEQIVEMYRGKKRHEIPPHIYAISETAYRSMLQDREDQSILCTG 178

  Fly   247 ESGSGKTESTKLVMQYLAAV-----------VPGGGSA-SAVITEQILEAAPLLEAFGNARTARN 299
            |||:||||:||.|:||||.|           .|...:. ...:..|:|:|.|:|||||||:|.:|
 Frog   179 ESGAGKTENTKKVIQYLAHVASSHKGRKEHTAPSSSNTFYGELEHQLLQANPILEAFGNAKTVKN 243

  Fly   300 DNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGL 363
            ||||||||::.:.|. :|.||||.|..|||||||.:.||..||.:||||:||.|..|..::...|
 Frog   244 DNSSRFGKFIRINFDVAGYIVGANIETYLLEKSRAIRQAKDERTFHVFYQLLAGAGEHMKTDLLL 308

  Fly   364 LEADKYFYLNQGATDCASGRVDWESLQ---GAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQ 425
            ...::|.:|:.|... ..|:.|.|..|   .:|:::|.:..|...::::::|||..||:.|.:.:
 Frog   309 EGFNQYRFLSNGNLP-IPGQQDREIFQETMESMKIMGFNHEEIMSMLKMVSAVLQFGNIVFRKER 372

  Fly   426 LRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKA 490
               ..:...:..:...:...|||.::.....||:.....:...:.:......:||..|.:|.|||
 Frog   373 ---NTDQASMPDNTAAQKLCHLLGLNVTEFSRAILMPRIKVGRDYVQKAQTKEQADFAVEALAKA 434

  Fly   491 LYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVF 555
            ||..||.|||.|||..:.:.....|..|.||||.|||....||||||||||.||.||..||..:|
 Frog   435 LYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 499

  Fly   556 KLEQAEYARERLEWTPLAWD-DNLPVIHLLAK--KPVGICHLLDDESNFPRATDLSFLEKCHYNH 617
            .|||.||.||.:||..:.:. |..|.|.|:.:  .|.|:..|||:|..||:|||.||:||
 Frog   500 VLEQEEYQREGIEWNFIDFGLDLQPCIDLIERPANPPGVLSLLDEECWFPKATDKSFVEK----- 559

  Fly   618 ALSELYARPRI-------GAQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGE 675
            .:.||...|:.       ...:..:.||||:|.|..|.:|.||.|.|..:|..||..|......|
 Frog   560 VIQELGNHPKFQKPRQLRDKADLCIIHYAGKVDYKADEWLMKNMDPLNDNVATLLHQSTDKYTAE 624

  Fly   676 LTKQLRAQRDAGKTLPKGS-----NGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIK 735
            |.|.:  .|..|.....|.     ...:.|.|....||...:.:||.:|:.::...:|.|||||.
 Frog   625 LWKDV--DRIVGLDQVSGMGEMSFGSSYKTKKGMFRTVGQLYKESLSKLMSTLRNTNPNFVRCII 687

  Fly   736 PNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARG-TPYRE 799
            ||.||.|.:::...||.|||..|:|:.|:|.::|:|.|:.||.|.:||..|.|:.:.:| ...::
 Frog   688 PNHEKKAGKLEPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQ 752

  Fly   800 LCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLA 864
            .|..::.|:.   ::...|::|.:::|.|..:...||..|..::....|..|...||.|.||...
 Frog   753 ACAIMIRALE---LDPNLYRIGQSKIFFRAGVLAHLEEERDLKITDIIVFFQAAARGYLARRAFY 814

  Fly   865 RRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRA 929
            ::|...:.|:.   .||....|.:||.        |:..:...:|:.|..           ..|.
 Frog   815 KKQQQMSALKV---VQRNCAAYLKLRH--------WQWWRLFTKVKPLLQ-----------VTRQ 857

  Fly   930 REAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDL 994
            .|..:||...|::.:.:.:...:||..:.:|.|                          ||.|:
 Frog   858 DEVMQAKVVELQKVKDTQVKTESELKEMANKYQ--------------------------QLFEE- 895

  Fly   995 GQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKAL------ 1053
                    .|:....|:.:.........:..|.||:.|:.::.|...:..:....::.|
 Frog   896 --------KSILAEQLQAETELFAEAEEMRARLASKKQELEEILHDLEARVEEEEERTLQLQNEK 952

  Fly  1054 -----------------EGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLW 1101
                             |||::||..:.:..::...: :.::||:        |...:.:..:..
 Frog   953 KKMHQHIQDLEEQLEEEEGARQKLQLEKVTTESRLKK-MEEDILL--------LEDQNAKLAKER 1008

  Fly  1102 QLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLL---------LRQLLRQQGGGTSSGAVGAG 1157
            :||...:..|..:.|        .::|..:||..|.         |...|:::..|..
 Frog  1009 KLLDDRIGEFTSTMA--------EEEEKVKSLNKLRNKYEAVIADLEDRLKKEEKGRQ------- 1058

  Fly  1158 ACRSFVPAWLEWRAWTRGCD----------MALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLG 1212
                      |.....|..|          :.|...:.:...|....:.    |..||||.....
 Frog  1059 ----------EMEKMKRKLDGETTDLQDQLLELQQQIEELKQQLARKEE----ELQAALARVDDE 1109

  Fly  1213 VASRGWTLVLDDGQQLTD--SCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKF--ARTTLPDAV 1273
            |..:...|     :||.|  |...:...||.:||.........|.||   |.:.  .:|.|.|.:
 Frog  1110 VGQKNNLL-----KQLRDLQSQLAELHEDLESEKAARAKAEKQRRDL---GEELEALKTELEDTL 1166

  Fly  1274 KRPAVPPPAPPTSSGKEDVPRERRSSR--ELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSK 1336
            ...|              ..:|.|:.|  |:......:.|....|:......:.......:..|:
 Frog  1167 DSTA--------------AQQELRAKREQEVTDLKKTIEEDVKVRDAQVTEMRQRHNQVVEEISE 1217

  Fly  1337 SLDDL--LAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRR 1399
            .|:..  ..|::..|.         .||   ||...|.....:.|....:|:..|.:|.:.....
 Frog  1218 QLEQARRFKGNLEKVK---------QTL---ESENTDLIKEVKNLQAAKQDSEQRRKKLEQQVSE 1270

  Fly  1400 SHAASHGSHSSKY--ADK-----AEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDL 1457
            ....::.|...|:  |:|     ||....|.|:..| |..|:........|.||..|..:.|.
 Frog  1271 FQIRTNESEKVKFELAEKLQKLQAELDGVSGALGST-EGKSIKLTKDLSTVQSQLQDTQELLQ-- 1332

  Fly  1458 FSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEK--LTSK 1520
                     :|.....:.::.:|    :.|.|..:.:::|::..:...|....:|.|::  |.||
 Frog  1333 ---------EETRQKLNFSSRVR----QLEEEKNNLMENLEEEESAKAQLSRQLQALQQQLLESK 1384

  Fly  1521 DQLAAIIKGGGVASKPEER--------------DEESEIED------------LDDYINELFEPI 1559
            .::..  :||.|.:..|.:              ||:.:|.|            |||.:.:|....
 Frog  1385 KRMED--QGGMVEAMEEAKKKSYKELEFLQQRFDEKHQINDKLEKTRNRLQQELDDLMVDLDHQR 1447

  Fly  1560 PVAEGLDKLTSK------EHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAF 1618
            .:...|:|...|      |...:|.|.|...|.              .|.|:    .:::.:...
 Frog  1448 QIVSNLEKKQKKFDQMLAEEKNISARYGEERDR--------------AEAEA----REKETKALS 1494

  Fly  1619 LQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMK 1683
            |..|:.:.:.::.:|..||:                                          :::
 Frog  1495 LSRALEEAIDLKDELDRQNK------------------------------------------QLR 1517

  Fly  1684 ATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQ 1748
            |....||..:.                   |..:..|.|:...||...::.:.:....:.|.:.|
 Frog  1518 AEMDDLVSSKD-------------------DVGKNVHELERSKRALEQQVQEMKTQIEELEDELQ 1563

  Fly  1749 TEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQ 1813
            ..||   .|:|........:||..:...|..  :|....:......:  .|.|:|.........|
 Frog  1564 AIED---GKLRLEVNMQAMKAQFERDLQNRD--DSNDEKKKLLFKQV--REMEVELEEERKQKSQ 1621

  Fly  1814 LMRSSIRLETTTTTTTSAVN--NRDRDRETQDV-------GQPMQSVVTTKLAK-KSFEIGADRP 1868
            ::.:..:||.......|.::  |:.||...:.:       .:..:.|..|:.|: :.|....|..
 Frog  1622 ILAAKKKLEMDLQDMESQMDSANKGRDEAVKQLKKLQLQFKEVWREVEETRAARDEIFVQSRDNE 1686

  Fly  1869 PPGSVGKLK-LSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSG 1932
            .     ||| |.:|:.|..|.:.|.            :||        |...||:...|...:|.
 Frog  1687 K-----KLKSLEAELLQLQEDLAAA------------ERA--------KRQAQQERDDLADELSN 1726

  Fly  1933 GNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAP 1997
            |.||...::|....:..:|.::|.:|
 Frog  1727 GVSGKSALLDEKRALEMRISQLEEEL--------------------------------------- 1752

  Fly  1998 PPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSAS 2062
                             |...|:::::.:       |..:.|.    |.:.|::   .|....:.
 Frog  1753 -----------------DEEQSNTELIND-------RYRKLTL----QVETITT---ELSAERSF 1786

  Fly  2063 SSPAVAAWEQAERERSRSRSR-----SRDREDYSESVWDRAEVEGPASGSGSEKEREKRE----- 2117
            |..|..|.:|.||:....:.:     |..|..|..::   |.:|...|....:.|:|.:|
 Frog  1787 SQKAENARQQMERQNKELKVKLNEMDSTMRSKYKITI---ASLEAKISQLEEQMEQESKERIIAN 1848

  Fly  2118 ----RERERLYEI-RQVERER----------ESHKVYQPAPPRVIQASMD----TTGGHRR---- 2159
                |..:||.|: .|||.||          |...:......|.::.:.:    .....||
 Frog  1849 KLVRRAEKRLKEVLLQVEEERRNADQFKEQLEKANIRMKQLKRQLEEAEEEASRANSNRRRLQRE 1913

  Fly  2160 -EDRTGG-------LATFRTHMAQKYEHERKR 2183
             ||.|..       :.|.|:.:::....:|||
 Frog  1914 LEDVTESAESMNREVTTLRSRLSKLERQQRKR 1945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	253/693 (37%)
		PTZ00121	<828..>943	CDD:173412	26/114 (23%)
		MyTH4	1014..1171	CDD:470587	26/188 (14%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	16/68 (24%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
LOC100493774	XP_004916275.2	Myosin_N	31..76	CDD:460670	2/8 (25%)
		MYSc_Myh10	99..778	CDD:276952	253/693 (37%)
		Myosin_tail_1	855..1935	CDD:460256	235/1388 (17%)