Protein Alignment Myo10A and myo1f

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_002938604.1
• Gene: myo1f / 100493342
• XenbaseID: XB-GENE-5909751
• Length: 1095
• Species: Xenopus tropicalis
• Alignment Length: 1310
• Identity: 365/1310 - (27%)
• Similarity: 575/1310 - (43%)
• Gaps: 311/1310 - (23%)

  Fly   150 QDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYA 214
            |::..|||:||.||..:.|.:::.||:.||....|:|:.||:||:|||:|..|.....|: :.|.
 Frog    12 QNVKQSGVDDMVLLSKITEDAIVENLKKRYLDDYIFTYIGSVLISVNPFKQMPYFTEREI-ELYQ 75

  Fly   215 GRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAV 276
            |......|||::|:....:..:   ...|.|:||||||:|||.:.|.:|.|::. |.||||....
 Frog    76 GAAQYENPPHIYALTDNMYRNMLIDGENQCVIISGESGAGKTVAAKYIMGYISK-VSGGGSKVQH 139

  Fly   277 ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGE 340
            :.:.||::.|||||||||:|.||:||||||||.|:.| :.|...|.||:.:||||||:|:|...|
 Frog   140 VKDIILQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSRGGEPDGGKISNFLLEKSRVVSQNENE 204

  Fly   341 RNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVD----WESLQGAMQVLGVSEG 401
            ||:||||:|:.|.|:.:|...|::..|.:|||||..|....|..|    :|.|: ||.|:|||..
 Frog   205 RNFHVFYQLIEGASDEQRQNLGIMTPDYFFYLNQSETYKVEGTNDKKDFYEMLE-AMMVIGVSAE 268

  Fly   402 EREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIK------WAAHLLHISADGLHRALT 460
            |::.::::.|.:|||||:.|.           |.|:.|:::      :.|:||.:....|:..||
 Frog   269 EQQMVLQISAGILHLGNISFQ-----------EQGNYAKVECPDLLDFPAYLLGVQKGRLNDKLT 322

  Fly   461 SRTTEA----RAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISIL 521
            ||..::    |:|.:...|.::||...|||.:|||||.:|::||..||..:||  .::.:.|.:|
 Frog   323 SRKMDSKWGGRSESITVTLNVEQASYTRDALSKALYARVFDFLVESINKAMQK--PYEEYSIGVL 385

  Fly   522 DIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAK 586
            ||:|||...:|.|||.|||:.||.||..|.:...|.||.||..|.:.|||:.:.:|..|..|:..
 Frog   386 DIYGFEIFQKNGFEQFCINFVNEKLQQIFIELTLKAEQEEYVAEGIRWTPIEYFNNKIVCDLIEN 450

  Fly   587 K--PVGICHLLDDESNFPRAT----DLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYC 645
            |  |.||..:|||......||    |.:.|:|........|.::...:|   |.:.||||:|.|.
 Frog   451 KLNPPGIMSVLDDVCATMHATGGGADQTLLQKLQAAVGTHEHFSNWNLG---FVIHHYAGKVSYY 512

  Fly   646 VDGFLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAA 710
            |:||.::|||.|..|::||:.||....:..|..:   :.|:.|             |.|..|..:
 Frog   513 VEGFCERNRDVLFIDLIELMQSSEYQFIQSLFPE---RLDSDK-------------KSRPTTAGS 561

  Fly   711 RFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLR 775
            :.......|:.::.:|.|.::||||||:.|.....:...|..|:.|||:.:.|::|:.|:..|..
 Frog   562 KIKKQANDLVNTLMKCTPHYIRCIKPNETKKPKDWEESRVKHQVEYLGLKENIRVRRAGFAYRRV 626

  Fly   776 FQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR--EALHRALE 836
            |..|::||..|...  |..||.. |:..:.||.::   .::...||:|.::||::  |:|. .||
 Frog   627 FNKFLQRYAILTQETWPRWRGDE-RQGVQHLLRSV---NMDSDQYQMGKSKVFVKNPESLF-LLE 686

  Fly   837 SGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWR 901
            ..|..:....|.::|:                       .||...|:::||::|:   .|..:..
 Frog   687 EMRERKFDTFARTIQK-----------------------AWRRYIARRKYEQMRE---EASNILY 725

  Fly   902 GRQARRRVQQLRS---DHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQG 963
            |.:.|||....|:   |:...:          :..|.:|.:.:|.::.:.|
 Frog   726 GYKERRRNSINRNFVGDYLGME----------DRPELRQFMTKRERIDFAD-------------- 766

  Fly   964 WSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAA 1028
             |....||                             :|.|:         :|:.|.:|
 Frog   767 -SVSKYDR-----------------------------RFKSI---------KRDLILSP------ 786

  Fly  1029 SRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHK---------ALSSRGLRDEILVQLC 1084
                         |.:.....:|..:|.::..:.:.:..|         :||:|  :|:..: |.
 Frog   787 -------------KYLYLIGREKVKKGPEKGQIKEILKKKVEIMNIQSISLSTR--QDDFFI-LQ 835

  Fly  1085 NQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGT 1149
            ...|.....|...|....|    :|.........|..:.|.|        .|.||  ::::|.
 Frog   836 EVDHDTLMESVFKTEFISL----MCKRYEEITSRKLRLNFTD--------TLQLR--VKKEGW-- 884

  Fly  1150 SSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVA 1214
                 |.|..|:.        .:.||                           ...:||...|
 Frog   885 -----GGGGTRNL--------QFIRG---------------------------QGEIAVQKAG-- 907

  Fly  1215 SRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCP------------AFPAPRSDLLRSGA-KFAR 1266
              |.|||:..|..|..:..        ..::..|            |.|.|.|...|:|| :|.:
 Frog   908 --GKTLVISIGDGLPKNSK--------PTRKGAPQSRGHRAPPSRAAPPPPSSGSFRNGAPQFPK 962

  Fly  1267 TTL--PDAVKRPAVPPPAPPTSSGKEDVPRERR----SSRELLS----------RSSALNERYFE 1315
            .|.  |...:.|..|...|..:..|:..||..|    .:.:.|:          |..::..|
 Frog   963 GTSRNPSYAQVPRQPRAPPSAALPKQTAPRRSRVPSDHNMDFLNVPDQGVAGAQRRKSVTHR--- 1024

  Fly  1316 REPSPGPGQGSSTGQAK---SRSKSLDDLLAGDI------VPVPTDCDSQEPLHTLGLSESRLND 1371
                |.|..|....|:|   .|.|::...:..|:      |....|...::|   .|..:.||
 Frog  1025 ----PPPAVGRPKPQSKPAGPRCKAIYQYIGQDVDELSFNVNEVIDIILEDP---SGWWKGRL-- 1080

  Fly  1372 RYHSAERLAP 1381
              |..|.|.|
 Frog  1081 --HGKEGLFP 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	250/684 (37%)
		PTZ00121	<828..>943	CDD:173412	22/119 (18%)
		MyTH4	1014..1171	CDD:470587	27/165 (16%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	9/66 (14%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo1f	XP_002938604.1	MYSc_Myo1	31..677	CDD:276829	250/684 (37%)
		Myosin_TH1	717..915	CDD:461801	53/345 (15%)
		PHA03378	<958..>1041	CDD:223065	18/89 (20%)
		SH3_MyoIe_If_like	1042..1094	CDD:212761	13/54 (24%)