Protein Alignment Myo10A and LOC100493121

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_012809641.1
• Gene: LOC100493121 / 100493121
• XenbaseID: XB-GENE-29081519
• Length: 1935
• Species: Xenopus tropicalis
• Alignment Length: 2556
• Identity: 543/2556 - (21%)
• Similarity: 931/2556 - (36%)
• Gaps: 806/2556 - (31%)

  Fly   127 SDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSI 191
            |.|..:..:.|.:.|.:          ...:|||.::..|:|.|:|:||:.||...:|||::|..
 Frog    67 STVTVKDDEIFPMNPPK----------YDKIEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLF 121

  Fly   192 LIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGESGSGKT 253
            ...|||||..| .|..||...|.|:.....|||:|:|...|:..:.:.   |.|:|:||||:|||
 Frog   122 CATVNPYKWLP-VYNPEVVNAYRGKKRQEAPPHIFSISDNAYQYMLTDRENQSVLITGESGAGKT 185

  Fly   254 ESTKLVMQYLAAVVPGG---------GSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYL 309
            .:||.|:||.|.:...|         |.....:.:||::|.|||||||||:|.||||||||||::
 Frog   186 VNTKRVIQYFATIAAIGDKKKEEAAPGKIQGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFI 250

  Fly   310 EVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYF--Y 371
            .::| .:|.:..|.|..|||||||:..|...||:||:||:::.. ...|.....|:..:.|.  |
 Frog   251 RIHFGTTGKLSSADIETYLLEKSRVTFQLSAERSYHIFYQIMSN-KRPELIDMLLITTNPYDFPY 314

  Fly   372 LNQGATDCASGRVDWESL---QGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQE-- 431
            ::||....|| ..|.|.|   ..|:.:||.:..|:.||.::..||:|.||:.|.::|.....|
 Frog   315 VSQGEITVAS-IDDQEELMATDSAIDILGFNNDEKNGIYKLTGAVMHYGNMKFKQKQREEQAEPD 378

  Fly   432 GVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLF 496
            |.||...     ||:|:.:::..|.:||.....:...|.:.....:.|..::..|..|::|..:|
 Frog   379 GTEVADK-----AAYLMGLNSADLLKALCYPRVKVGNEFVTKGQTVQQVYNSVGALGKSVYEKMF 438

  Fly   497 NWLVSRINSIVQKGGTHD--AHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQ 559
            .|:|.|||   |:..|..  .|.|.:|||.|||....||.||||||:.||.||.:||.|:|.|||
 Frog   439 LWMVIRIN---QQLDTKQPRQHFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQ 500

  Fly   560 AEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELY 623
            .||.:|.::|..:.:..:|.....|.:||:||..:|::|..||:|||.||..|.:..| ..|..:
 Frog   501 EEYKKEGIDWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNF 565

  Fly   624 ARPRIG----AQEFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL------TK 678
            .:|:.|    ...|.:.||||.|.|.:.|:||||:|.|...|:.|...|.:.|:..|      |.
 Frog   566 QKPKPGKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNETVIGLYQKSSVKLLSFLYSAYSGTD 630

  Fly   679 QLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHAL 743
            .....:..||  .|||:.:         ||:|.|.::|.:|:.::...||.||||:.||:.|...
 Frog   631 ADTGGKKGGK--KKGSSFQ---------TVSALFRENLNKLMANLRSTHPHFVRCLIPNETKTPG 684

  Fly   744 RMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSPLARGTPYRELCRALLEAM 808
            .||...|:.|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.:..| .:.:..:|..:.:
 Frog   685 AMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKILNASAIPEG-QFIDSKKASEKLL 748

  Fly   809 PRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAA 870
            ....|:...|:.|.|:||.:..|...||..|.|||.:.....|...||.|:|   ||:..|:.:.
 Frog   749 GSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDERLAQLITRTQAMCRGYLMRVEFRQMMERRESI 813

  Fly   871 TRLQ---------ARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAA 926
            ..:|         ..|...:...:.:.|.|.|          ::.:.:|.::.:..:.:||...:
 Frog   814 FCIQYNVRSFMNVKHWPWMKLYFKIKPLLKSA----------ESEKEMQNMKEEFEKTKEALAKS 868

  Fly   927 QRAREAREAKQ-AVLERSQLSYLDIPAE---LAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSA 987
            :..|:..|.|. |:|:.....:|.:.:|   ||....:.:|         |:|          :.
 Frog   869 EAKRKELEEKMVAILQEKNDLHLQVTSESESLADAEERCEG---------LIK----------AK 914

  Fly   988 VQLPEDLGQFSFGKFSSVYCNGLRLQPRRE---PITA---PLLTRAASRDQDFQD-ALAVFKLIL 1045
            :||...:.:|:           .||:...|   .:||   .|....:...:|..| .|.:.|:
 Frog   915 IQLEAKIKEFN-----------ERLEDEEESNAELTAKKRKLEDECSELKKDIDDLELTLAKV-- 966

  Fly  1046 RWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCC 1110
                      .|||...:..|........:.||.:.:|..:...|
 Frog   967 ----------EKEKHATENKVKNLTEEMAILDETIAKLTKEKKAL-------------------- 1001

  Fly  1111 FQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRG 1175
                                         |...||
 Frog  1002 -----------------------------QEAHQQ------------------------------ 1007

  Fly  1176 CDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDL 1240
                   ||.|..::...|::.|..:....                    ||:.|..|     .|
 Frog  1008 -------TLDDLQAEEDKVNTLTKAKTKLE--------------------QQVDDLEG-----SL 1040

  Fly  1241 IAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSR 1305
            ..||:|       |.|:.|:..|.                        :.|:...:.|:.:|.:.
 Frog  1041 EQEKKL-------RMDMERAKRKL------------------------EGDLKLAQESTMDLEND 1074

  Fly  1306 SSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLN 1370
            ...|:|:..::|        ....|.:|:.:. :..||..:         |:.:..|......|.
 Frog  1075 RQQLDEKVKKKE--------FEISQLQSKIED-EQALAAQL---------QKKIKELQARIEELE 1121

  Fly  1371 DRYHSAERL--APVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEA-- 1431
            :.. .|||.  |...|......::.:....|...|...:.:....:|...|.......|..||
 Frog  1122 EEI-EAERAARAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATL 1185

  Fly  1432 --PSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEI 1494
              .:.||.:|:.:..|.| ::.:.:|:|                   ..::....::::|.:.||
 Frog  1186 QHEATASALRKKQADSVA-ELGEQIDNL-------------------QRVKQKLEKEKSELKMEI 1230

  Fly  1495 DDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPI 1559
            |||...:..:.:   ...||||:                           ...|:|..:|:
 Frog  1231 DDLASNMESVSK---AKSNLEKM---------------------------CRTLEDQFSEV---- 1261

  Fly  1560 PVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMA 1624
                   |...:|||.|      ..|.|.....||        ||:|.  :.:|::..  :|.::
 Frog  1262 -------KTKEEEHLRV------INDINAQRARLH--------TENGE--FSRQLEEK--ESMIS 1301

  Fly  1625 QNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSL 1689
            |..:.:|....|.:.|:..|.::                                     |::..
 Frog  1302 QLSRAKQAFTQQTEELKRQLEEE-------------------------------------TKAKN 1329

  Fly  1690 VVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFF 1754
            .:...||                    ..||..|..                  ..|::.|::
 Frog  1330 ALAHGLQ--------------------SARHDCDLL------------------REQYEEEQE-- 1354

  Fly  1755 AFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSI 1819
                                 :.|.:..|   ...|::...:|.
 Frog  1355 ---------------------AKGELQRS---LSKANSEVSQWR--------------------- 1374

  Fly  1820 RLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQ 1884
                 |...|.|:   .|..|.::             |||                 ||:..:::
 Frog  1375 -----TKYETDAI---QRTEELEE-------------AKK-----------------KLAQRLQE 1401

  Fly  1885 RLEQVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSH----- 1944
            ..||:.|       |::|.     |.||.| |..||.::..|...|...||....:....
 Frog  1402 AEEQIEA-------VNSKC-----ASLEKT-KQRLQNEVEDLMVDVERSNSACAALDKKQKNFDK 1453

  Fly  1945 --ATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTA 2007
              |..:.:.|..:.:|.                                          .|...:
 Frog  1454 VLADWKQKFEESQAELE------------------------------------------ASQKES 1476

  Fly  2008 RSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAV----A 2068
            ||...|.....:|.:...:.:.. ::|:.::.      ||.||.    |.:..|.|...:    .
 Frog  1477 RSLSTEVFKMKNSYEEALDQLET-LKRENKNL------QQEISD----LTEQIAESGKTIHEIEK 1530

  Fly  2069 AWEQAERERSRSRSRSRDRE---DYSESVWDRAEVE-GPASGSGSEKEREKRERERERLYEIRQV 2129
            |.:|.|:|:|..:|...:.|   ::.|:...|.::| ....|....|..||.|       ||.|:
 Frog  1531 AKKQIEQEKSDLQSALEEAEGSLEHEEAKVLRIQLELNQVKGEVDRKIAEKDE-------EIEQL 1588

  Fly  2130 ERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHE-RKRKSSASSGMRE 2193
            :|..:          |.:: ||.:|.......|...|     .:.:|.|.: .:.:...|...|:
 Frog  1589 KRNSQ----------RALE-SMQSTLDAEIRSRNDAL-----RLKKKMEGDLNEMEIQLSHANRQ 1637

  Fly  2194 ELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQ 2258
            ..:|...                     |..|.|:|..:                :|.: .:..:
 Frog  1638 AAESQKQ---------------------LRNVQGLLKDT----------------QLHL-DDAQR 1664

  Fly  2259 PHEPIGPPVAL-----DLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSG 2318
            .::.:...:|:     :|:.|::               :|..|||....
 Frog  1665 GNDDLKEQLAIVERRNNLMTAEI---------------EEMRSALEQTE---------------- 1698

  Fly  2319 AGGGGNGGQVRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLARR--DADY 2381
                    :.|.:.::.|:|:..                   .|.::...::.|...::  ::|
 Frog  1699 --------RGRKVAEQELIDVTE-------------------RVQLLHSQNTSLINTKKKIESD- 1735

  Fly  2382 LIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTL 2446
              |.|..|  |::.||.         ..||....|..|...||:.:      :|.:|.|..::.|
 Frog  1736 --VSQLQS--EVEEAVQ---------EARNADEKAKKAITDAAMMA------EELKKEQDTSAHL 1781

  Fly  2447 SSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQ--SELHHHLQQQQ-------- 2501
            ....:...||:.....||:..:..|.:      ||.:|.::|:.  .||.:.|..:|
 Frog  1782 ERMKKNLEQTVKDLQHRLDEAEQLAMK------GGKKQLQKLEARVRELENELDAEQKRGSDAIK 1840

  Fly  2502 -----QQQQQQQHHQQQQQQQ---QLEDAMEEQHMATDHQQQQQQQLGQQQG-QQQRFLKQQSYL 2557
                 :::.::..:|.::.::   :|:|.:::..:.....::|.:.:.:|.. ...||.|.|..|
 Frog  1841 GVRKFERRVKELSYQSEEDKKNVFRLQDLVDKLQLKVKTYKRQTEDIEEQANVHLSRFRKAQHEL 1905

  Fly  2558 HSARKSNAGQQPSSLTNGQVH 2578
            ..|      ::.:.:...||:
 Frog  1906 EEA------EERADIAESQVN 1920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	250/691 (36%)
		PTZ00121	<828..>943	CDD:173412	28/127 (22%)
		MyTH4	1014..1171	CDD:470587	19/163 (12%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	11/66 (17%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
LOC100493121	XP_012809641.1	Myosin_N	32..76	CDD:460670	2/8 (25%)
		Motor_domain	99..768	CDD:473979	250/691 (36%)
		Myosin_tail_1	848..1925	CDD:460256	264/1732 (15%)