Protein Alignment Myo10A and myh11

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_031748845.1
• Gene: myh11 / 100490639
• XenbaseID: XB-GENE-6459772
• Length: 1980
• Species: Xenopus tropicalis
• Alignment Length: 2016
• Identity: 514/2016 - (25%)
• Similarity: 830/2016 - (41%)
• Gaps: 431/2016 - (21%)

  Fly   120 KRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLI 184
            |:::....|:...:|..|                 |.||||..|..|:|||:|.|||.||..|||
 Frog    66 KKITISKDDIQKMNPPKF-----------------SKVEDMAELTCLNEASVLHNLRERYFSGLI 113

  Fly   185 YTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISG 246
            ||::|...:.|||||..| .|..::...|.|:....:|||::||...|:.::   ...|.::.:|
 Frog   114 YTYSGLFCVVVNPYKALP-IYSEKIIDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTG 177

  Fly   247 ESGSGKTESTKLVMQYLAAVVPG-GGSASAVITE-----------QILEAAPLLEAFGNARTARN 299
            |||:||||:||.|:||||.|... .|.....||:           |:|:|.|:|||||||:|.:|
 Frog   178 ESGAGKTENTKKVIQYLAVVASSHKGKKDTTITQGPSFAYGELEKQLLQANPILEAFGNAKTVKN 242

  Fly   300 DNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGL 363
            ||||||||::.:.|. :|.||||.|..|||||||.:.||..||.:|:||.|:.|.....|....|
 Frog   243 DNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTFHIFYYLIQGAKPAWREDLLL 307

  Fly   364 LEADKYFYLNQG-----ATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHR 423
            .....|.:|:.|     |.|  .|.:..|:|: ||:::|.||.|:..::||:::||.|||:.|.:
 Frog   308 EGFGNYTFLSYGYVPVPAAD--DGDMFQETLE-AMEIMGFSEDEQLSMMRVVSSVLQLGNIVFKK 369

  Fly   424 RQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRA-LTSRTTEAR--AERLHTPLGIDQALDARD 485
            .:   ..:...:..|...:...||..|:.....|. ||.|....|  .::..|.   :||..|.:
 Frog   370 ER---NTDQASMPDDTAAQKVCHLAGINVTDFARCILTPRIKVGRDFVQKAQTK---EQADFAIE 428

  Fly   486 AFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYF 550
            |.|||.|..||.|:::|:|..:.|.....|..:.||||.|||....||||||||||.||.||..|
 Frog   429 ALAKATYERLFLWILNRVNKALDKTKRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLF 493

  Fly   551 NKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAK--KPVGICHLLDDESNFPRATDLSFLEK 612
            |..:|.|||.||.||.:||..:.:. |..|.|.|:.:  .|.||..|||:|..||:|||:||:||
 Frog   494 NHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGILALLDEECWFPKATDVSFVEK 558

  Fly   613 C---HYNHALSELYARPRIGAQE---------FGVTHYAGQVWYCVDGFLDKNRDALRGDVLELL 665
            .   ..||          |..|:         |.:.||||:|.|....:|.||.|.|..:|..||
 Frog   559 VIQEQGNH----------IKFQKTKQLKDKTIFTLVHYAGKVDYDATSWLTKNMDPLNDNVTALL 613

  Fly   666 ASSRLPLVGELTKQLRAQRDAG---------KTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQ 721
            ..|....||:|.|.:  .|..|         .:||..|.    |.|....||...:.:.|.:|:.
 Frog   614 NQSSDKFVGDLWKDV--DRIVGLDQMAKMTESSLPSASK----TKKGMFRTVGQLYKEQLTKLMT 672

  Fly   722 SMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHL 786
            ::....|.|||||.||.||.:.::|...||:|||..|:|:.|:|.::|:|.|:.||.|.:||..|
 Frog   673 TLRNTSPNFVRCIIPNHEKRSGKLDAHLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEIL 737

  Fly   787 LPSPLARG-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSV 850
            ....:.:| ...::.|..:::|:.   ::...|::|.::||.|..:...||..|..::....::.
 Frog   738 TAGAIPKGFMDGKQSCMLMMKALE---LDTNLYRIGQSKVFFRTGVLAHLEEERDLKITDIIITF 799

  Fly   851 QRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSD 915
            |...||.|.|:..|:||...|.::..   ||....|.:||.        |:..:...:|:.|...
 Frog   800 QALARGFLARKAFAKRQQQLTAMKVI---QRNCAAYLKLRN--------WQWWRLFTKVKPLLQV 853

  Fly   916 HRRRQEAR---EAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKV- 976
            .|:.:|.:   |..||..|.....:..|:..|:.::.:..|...:..:||..:..:.:...:::
 Frog   854 TRQEEEMQLKDEELQRVNEKFFKTEIELKEIQMKHIQLVEEKTLLQEQLQAETELYAEAEELRIR 918

  Fly   977 -------LGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDF 1034
                   |..|.......::..||.||              :||..::        :...:.||.
 Frog   919 LQAKKQELEEVLHEMEVRLEEEEDRGQ--------------QLQAEKK--------KTLQQMQDL 961

  Fly  1035 QDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQ-------------LCNQ 1086
            ::.|            :..|.|::||..:.:..:| ..:.|.|::||.             |..:
 Frog   962 EEQL------------EEEEAARQKLQLEKVTAEA-KIKKLEDDVLVMDDHHNKLTKEKKILEER 1013

  Fly  1087 VHGLPPNSGE----ATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGG 1147
            |:.|..|..|    |..|.:|..      :..:..|:..:|...:|........:.|:|
 Frog  1014 VNDLTTNLAEEEEKAKNLTKLKN------KHESMISELEVRLKKEEKGRQELEKVKRKL------ 1066

  Fly  1148 GTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQT--VAVDSWTSCEEAAALAVSS 1210
                    .|..........:.:|  :..::.:.|...:|..|.  ..::..|:.:..|...:..
 Frog  1067 --------EGEANDLNEQIADLQA--QIAELKMQLAKKEEELQAALARLEDETAQKNNALKKIRE 1121

  Fly  1211 LGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKF--ARTTLPDAV 1273
            |                  :|...|...||.:||.........:.||   |.:.  .:|.|.|.:
 Frog  1122 L------------------ESHISDLQEDLESEKSARNKAEKSKRDL---GEELEALKTELEDTL 1165

  Fly  1274 KRPAVPPPAPPTSSGKEDVPRERRSSRE----LLSRSSALNERYFEREPSPGPGQGSSTGQAKSR 1334
            ...|              ..:|.|:.||    :|.|  ||.|.....|......:...|...:..
 Frog  1166 DSTA--------------TQQELRAKREQEVTVLKR--ALEEETRSHESQVQEMRQKHTQAVEEL 1214

  Fly  1335 SKSLDDL------LAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKS 1393
            ::.|:.:      |......:..| :|:..:....|:::: .|..|..::|....::...:|...
 Frog  1215 TEQLEQVKRVRVTLEKSKQALEKD-NSELTIEIRSLNQAK-QDVEHKKKKLESQLQELQSKYTDG 1277

  Fly  1394 QHAGRRSHAASH----------------GSHSSKYA----------------------DKAEYAT 1420
            :.........||                .:.|.|::                      .|...:|
 Frog  1278 ERVRNELTEKSHRVQVELENVTVLLSEAETKSIKFSKDVAGLTAQLQDTQELLQEETRQKLNVST 1342

  Fly  1421 RSSAMSD------------TSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDAR 1473
            :...:.|            |....:|..|:..:.:  |.||..:.|.: |:..:: |::|  ..:
 Frog  1343 KLRQVEDERNSLQEQLDEETEAKQTLERHISTLNI--QLSDSKKKLQE-FTATIE-SMEE--GKK 1401

  Fly  1474 SLAASIRGGS--YEQENEAESEID--------DLDDYINDIFQPIPLVQNLEKLTSK-DQLAAII 1527
            .|...|...:  :|::..|..:::        :|||.|.|:.....||.||||...| ||:.|..
 Frog  1402 KLQRDIESATQQFEEKASAYDKLEKTKNRLQQELDDLIVDLDNQRQLVSNLEKKQKKFDQMLAEE 1466

  Fly  1528 KGGGVASK-PEERDE-ESEIEDLDDYINELFEPIPVAEGLDK-LTSKEHL-------------AV 1576
            |  .::|| .:|||. |:|..:.:.      :.:.:|..||: |.|||.|             .|
 Frog  1467 K--TISSKYADERDRAEAEAREKET------KALSLARALDEALQSKEELERTNKLLKAEMEDLV 1523

  Fly  1577 SIRGGGSTDSNG----------------ADPLLHQLMQLPGE---TESGP---ALYQQQVQRAFL 1619
            |     |.|..|                .:.:..||.:|..|   ||...   .:..|.::..|.
 Frog  1524 S-----SKDDVGKNVHDLEKAKRGLEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFE 1583

  Fly  1620 QSAMA---QNLQIQQQLLAQNQALQTLL----SQQAAAAAANNSTSPPPAPPILSSLSISPPPPQ 1677
            :..:|   ||.:.::||:.|....:|.|    .|:..||||....          .:.:.....|
 Frog  1584 RDLLARDEQNEEKRRQLVKQVHEYETELEDERKQRTVAAAAKKKL----------EVDLKDLEGQ 1638

  Fly  1678 SPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAK-----TVRIGKWR 1737
            .....:|...::..:..||.             :.||   .:..||....|:     |.|..:.:
 Frog  1639 VDFASRARDEAIKQLRKLQG-------------QMKD---FQRDLDEARNAREEIFATARENEKK 1687

  Fly  1738 WPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQM---TSNGGMMESGPGARGASATAIEWEE 1799
            ....:.| ..|.:||..|.:..:.|.:...:....::   .|....::.......|..:.:| ||
 Frog  1688 AKSLEAE-LIQLQEDLAAAERARKQAELEKEELAEELAGSASGKSSLQDEKRRLEARISQLE-EE 1750

  Fly  1800 FEIESPTPPPMSGQLMRS-----SIRLETTTTTTTSAVNNRDR---DRETQDVGQPMQSVVTTKL 1856
            .|.|......||.::.::     .:..|.....:||..|...|   :|:.:::...:|.:..|..
 Frog  1751 LEEEQGNMEGMSDRMRKAVQQAEQLNNELAAERSTSQKNESARQQLERQNKELKAKLQEMEGTVK 1815

  Fly  1857 AKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQV-TAGHSVRSTVST-----KSEQRAPAKLEDTR 1915
            :|....|.|            |.:::.|..||| ......:|||.|     |..:.|..::||.|
 Frog  1816 SKFKSTIAA------------LEAKISQLEEQVEQESRDKQSTVKTLRQKEKKLKEALLQVEDER 1868

  Fly  1916 K 1916
            |
 Frog  1869 K 1869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	266/707 (38%)
		PTZ00121	<828..>943	CDD:173412	28/117 (24%)
		MyTH4	1014..1171	CDD:470587	26/173 (15%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	11/68 (16%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myh11	XP_031748845.1	Myosin_N	30..75	CDD:460670	1/8 (13%)
		Motor_domain	98..777	CDD:473979	266/707 (38%)
		Myosin_tail_1	854..1934	CDD:460256	215/1171 (18%)