DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myo15a

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_031749377.1 Gene:myo15a / 100488159 XenbaseID:XB-GENE-492608 Length:2303 Species:Xenopus tropicalis


Alignment Length:3061 Identity:845/3061 - (27%)
Similarity:1297/3061 - (42%) Gaps:882/3061 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   195 VNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTEST 256
            :|||||. :.||.:...:|.|:.||..|||||||...|:..|   .:.|.::|||||||||||:|
 Frog     1 MNPYKML-NIYGTDHVLKYEGKALGENPPHLFAIANVAYTKLMDAKNNQCIIISGESGSGKTEAT 64

  Fly   257 KLVMQYLAAVVPGGGSASAVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVGA 321
            |||::||.||....|     :|.:||||.||||:||||:|.||||||||||::|:|.:.|.|.||
 Frog    65 KLVLRYLVAVNQRRG-----VTSKILEATPLLESFGNAKTVRNDNSSRFGKFIEIYLEEGVICGA 124

  Fly   322 KITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDC----ASG 382
            ..:||||||||||.||..|||||:|||:|.||...::..:.|.:|:.|:|||||. :|    .|.
 Frog   125 ITSQYLLEKSRIVFQAKNERNYHIFYEMLAGLPSQQKQMFYLQDAETYYYLNQGG-NCDIPAKSD 188

  Fly   383 RVDWESLQGAMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHL 447
            ..|:..|..||:.|..:..:::.|.|:|:::||||||||.:.: ...||...|.|.:||:..|.|
 Frog   189 ADDFRRLLNAMESLSFTGEDQDSIFRILSSILHLGNVYFEKYE-TESQEIASVVSASEIRVVAEL 252

  Fly   448 LHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGT 512
            |.||.:||.:|:|.:.||...|::.|||.:|.|:|||||.||.||:.||:||..|||.:|..  .
 Frog   253 LQISPEGLQKAITYKVTETMREKILTPLTVDSAVDARDAIAKILYSLLFSWLTDRINKLVYP--K 315

  Fly   513 HDAHRISILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDN 577
            .||..|:||||:|||||:.|||||||||||||.||.:|||.:||.||.||.||:::|..:::.||
 Frog   316 QDALSIAILDIYGFEDLSFNSFEQLCINYANEYLQFFFNKIIFKEEQEEYIREQIDWREISFSDN 380

  Fly   578 LPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQV 642
            ...|.::::||.||..:|||:|.||:|||.:||:||||:|..::||.:|::...|||:.|:||:|
 Frog   381 QACIDIISQKPHGILRILDDQSCFPQATDHTFLQKCHYHHGTNDLYCKPKMPLPEFGIKHFAGKV 445

  Fly   643 WYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL---TKQLRAQRDAGKTLPKGSNGRFVTMKPR 704
            .|.|..|||||.|.:|.|||:|..:||:.:|..|   ..|:.||:   ||:...||  .||.|.:
 Frog   446 TYQVHKFLDKNYDQVRQDVLDLFVNSRIKVVANLFFSHAQVLAQQ---KTMMGKSN--TVTRKYK 505

  Fly   705 TPTVAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRG 769
            ..||||:|..||.:|::.|.||:|:||||||||..|.....:...|..||:|.|:|:||:||:.|
 Frog   506 ASTVAAKFQQSLLELVEKMERCNPFFVRCIKPNSRKEPSLFESDIVTSQLKYSGILETIRIRKEG 570

  Fly   770 YPVRLRFQHFVERYRHLL---PSPLARG----TPYRELCRALLEAMPRTGVEGPDYQLGATRVFL 827
            :|||:.|..|:.|||.::   |:....|    |..::||.:...:|         |.:|.:::|:
 Frog   571 FPVRIPFHFFLSRYRCVMDLGPNVRVDGQICVTVLKKLCPSASPSM---------YCIGVSKLFM 626

  Fly   828 REALHRALESGRTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKG 892
            :|.:::.|||.|...:.:|||::||:.||.|.||:....:....:|||..||..|::::...||.
 Frog   627 KENVYQQLESKRDLLMNKAAVTLQRYSRGYLTRRRYYILRYRIIQLQAVARGYLARKKFYNWRKI 691

  Fly   893 ALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERS--QLSYLDIPAELA 955
            .:..:.:......||:..:::::.||..|        .|.::|:|.:.:|.  .:::|::|||||
 Frog   692 MMRFRAVVNIYVNRRKYLRMKAEARRIAE--------EERKKAEQELTKREVVNVTHLELPAELA 748

  Fly   956 FIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREP-- 1018
            .:............|  .|..:........|.:.||.|:..:...|:..|:.        :||  
 Frog   749 GLLRSTAATKNLTLD--FVLPIQCPQVEADSQLTLPLDINNYLMFKYVRVFF--------KEPLF 803

  Fly  1019 --ITAPLLTRAASRDQDF-QDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEIL 1080
              :|.||.:.....:.|. |.|::.||||||:..|..|.|.:|.|..:|||.|.||:.|||||||
 Frog   804 GMLTVPLGSSLLPVEDDLRQHAISSFKLILRFMGDPYLGGTQEMLFGNYIVQKGLSNTGLRDEIL 868

  Fly  1081 VQLCNQV-HGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLR- 1143
            .|:.||| ....||:.|  |.|.||..||..|.||....|||:::|.|.|....:|:...:|:: 
 Frog   869 AQIGNQVWRNTNPNNEE--RGWYLLACCLSTFAPSPNLDKYLLKYVSDYAYNGYKPVCQHKLIQA 931

  Fly  1144 ----QQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAA 1204
                |||..|:         |:|.|:.|||.|.....:||:.:...|.|..:..:.|||..||.|
 Frog   932 IQKSQQGSETA---------RNFPPSLLEWTASRERANMAIDIHCFDGAKISCPIHSWTDGEEIA 987

  Fly  1205 ALAVSSLGVAS--RGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFART 1267
            ...:...||..  |||::.|.:|.|.|:..|.|||:|||...||...||..:|..:         
 Frog   988 GDVLRHRGVIEGFRGWSVSLKEGGQWTELAGQDYVLDLICNMELPREFPKQKSYFI--------- 1043

  Fly  1268 TLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAK 1332
            |..:|.:..:..|.|...:.|:                                           
 Frog  1044 TASEATQENSSQPIAVFENRGE------------------------------------------- 1065

  Fly  1333 SRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAG 1397
                      |||.||.|                              |..|           |.
 Frog  1066 ----------AGDAVPPP------------------------------PTTK-----------AP 1079

  Fly  1398 RRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVL 1462
            ...|..|.|.|::.              ||:            |..|.....:|.:||.||.|||
 Frog  1080 SLPHHDSEGYHNND--------------SDS------------VSEPQSQKGMDHYLDSLFDPVL 1118

  Fly  1463 DGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAII 1527
                                                .|.|.         :|||||:..|.   :
 Frog  1119 ------------------------------------SYGNG---------DLEKLTAMSQK---M 1135

  Fly  1528 KGGGVASKPEERDEESEIEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPL 1592
            ||||.....:.|:                  :|                       .|||.:...
 Frog  1136 KGGGGVGGRDGRE------------------VP-----------------------RDSNFSGDE 1159

  Fly  1593 LHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNST 1657
            .|:       .:...::|.|  |:|::..        |..||||...:|.:..||   ...||| 
 Frog  1160 AHR-------ADLDQSMYAQ--QQAYINQ--------QAMLLAQQMTMQAMALQQ---QMVNNS- 1203

  Fly  1658 SPPPAPPILSSLSISPPP--PQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRH 1720
                  |...|::.||.|  ...||...:.|.:         |...|.|....|.:       |.
 Frog  1204 ------PAEISMTNSPGPSIAAQPMPSNSQRVT---------PTVAPMPRTGVPFQ-------RR 1246

  Fly  1721 FLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGP 1785
            .::  |....::|...|                     ...||:..|...||             
 Frog  1247 VVN--GTPSRIQISSAR---------------------ESSQRRPGPSNPHH------------- 1275

  Fly  1786 GARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQS 1850
                                                                         |...
 Frog  1276 -------------------------------------------------------------PEDL 1279

  Fly  1851 VVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQ---RAPAKLE 1912
            |..|.:..:.|      |.|                     .|:::..::...:.   |.||.  
 Frog  1280 VQHTAMNSEHF------PEP---------------------SHNIKDIINRYKQPGAIRQPAP-- 1315

  Fly  1913 DTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPA 1977
                 ::::|...||          |..:|.|   ...:..::|::  |..|.:|          
 Frog  1316 -----VIRKQPAKLF----------GRKIDPH---EEALSILKGQM--PTHPLTG---------- 1350

  Fly  1978 PSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSS--SQVVKEHVPAFIQRQERDTF 2040
                  |.|:...|..|.||      ..|....:|.|..:|.:  :|....||        |.| 
 Frog  1351 ------PTPVSNMSYVPKAP------RDTVALVKPVPSIKTKTPVAQPPVSHV--------RPT- 1394

  Fly  2041 GAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPAS 2105
                                  .:|.||.                                    
 Frog  1395 ----------------------PAPTVAV------------------------------------ 1401

  Fly  2106 GSGSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFR 2170
                                .|::..|:|:                                 .:
 Frog  1402 --------------------NRELSEEQEN---------------------------------IQ 1413

  Fly  2171 THMAQKYEHERKRKSSASSGMREELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSG 2235
            |.:.::|..|                                                       
 Frog  1414 TQLHRQYSEE------------------------------------------------------- 1423

  Fly  2236 GSTACLTYNRVPWKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNM 2300
                ..||..|||::.:|||||.|.:....|:.|||:|.|::.|.. ...|:|::.:|:....::
 Frog  1424 ----YYTYTNVPWRIYIRKEVFYPRDSFNNPLILDLIFKQIINDTL-TENCIRLSKEERQKMRSL 1483

  Fly  2301 LHGHGVSVDTLSNRNGSGAGGGGNGGQVRAL----VKRHLVDMAR-DWPLYFARLFAVQGAPLYP 2360
            |....:                   |.:.|:    ||:.:|.:|| :..:||:|||...|: :..
 Frog  1484 LADFRL-------------------GSINAIADDSVKKKIVTVAREELEVYFSRLFPAAGS-VGT 1528

  Fly  2361 DVSIMGVSHSGLYLAR------RDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHA 2419
            .|..:||||.|:.|.:      ...:.|.|:::.|:.:|. .||:.....|:.||.|.| |.|.:
 Frog  1529 GVQFLGVSHVGIKLLKLLRSGGSTPEQLRVLRSYSYTDIM-FVTVLSKNMLEFNLTNEK-LILFS 1591

  Fly  2420 ARAAAIQSMVTTFVQEFRKSQ----------SKASTLSSGARAAAQTLNVPLERLESRQAHAQRN 2474
            :|::.:::|:..|:.|.:|..          ::..||.|..:.....|. ||:.|:..|      
 Frog  1592 SRSSQVKTMIDCFLMELKKDSNYVVAVQNYVTEDKTLLSFHKGDIIRLQ-PLDGLKKGQ------ 1649

  Fly  2475 EHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQ 2539
            .:|.                                           .:.::.|..:..::..|.
 Frog  1650 NYGC-------------------------------------------VVRKKVMYLEELKRGTQD 1671

  Fly  2540 LGQQQGQQQRFLKQQSYLHSARKSNAGQQPS---------SLTNGQVHHQEQMLQQQQQQSQSLP 2595
            .|.:.|              |..|.||..|:         ...|.....:|:...:|.:.:.|..
 Frog  1672 FGWKFG--------------AIHSRAGVFPAECVQPVAAPDFVNLPADRKEEPRNRQSRAAASAA 1722

  Fly  2596 ----------HHDLD---------ANYLQ--DESNGGTPPSVTK-------YSLLQFAMQHFRND 2632
                      .|:.|         :.|.:  ||.   |.|:.::       |::.:||.::||..
 Frog  1723 VAVAVASTAVAHEFDRKMDGSPTPSEYAESLDEY---TDPNTSEIMLQGSPYNMEEFAKKYFREG 1784

  Fly  2633 QLRDADRHHERHQSAAN-------------RSYAELVKWQGHAIRLPLLRLPN-DLAPLALECFD 2683
            ....|....::.|..:.             |...|::|:....|:..|:...: .:..:|.|.|.
 Frog  1785 LRLAAQAQDDKSQKMSGDSIKQGSKKSKDARDPQEMLKFTKTPIQESLIEFSDGSMNRIAAEVFT 1849

  Fly  2684 CILRYCGDIPLDPDLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLS 2748
            .|:::.||:||... :|:..|.::|..|.::..::||.|||:|||.|.|.|...||.||.||||.
 Frog  1850 GIMKFMGDLPLKGQ-SELDAVCSILKLCGEHEVMKDEGYCQIMKQITDNTSGSTDSCQRGWRLLF 1913

  Fly  2749 ILAAYFGCSDALRPYLMEHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSA 2813
            ||.||:.||:.|:|||.:.|............|.|..|..|||||.:.|||...||..|:.|:.|
 Frog  1914 ILTAYYKCSEVLKPYLFKFLQETCRSPGLHYQGIAKACEQNLRKTIQYGGRIEYPSAIELKAMVA 1978

  Fly  2814 GRSARRQIYRLPGGAERVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLA 2878
            |||::||::.||||.||.:..:..:|..|||.|:|..:||..|....|::::.:........||.
 Frog  1979 GRSSKRQLFLLPGGVERHLKIKTCSVAFDVIEEICMEMGVHKEEAFHEYAIFAVTNRGQNVRPLN 2043

  Fly  2879 ADEYILDVTTELLKSGQPFYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAPDYLEGLLLELPGN 2943
            ..||||||:.|:.::...:...|.|.:|...:|.|   ..|||.:.:|||.||||:| |..:..:
 Frog  2044 RKEYILDVSAEMEQTDSNYMFWFRRIIWAQQMKFE---NELYVTMHYNQVLPDYLKG-LFNVVSH 2104

  Fly  2944 GVPVPEMVRDMARIAALLHRAADLSHVPAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWPQVAN 3008
            .....:..:.::|:|||.|||.|..::|..:|::..:|...  .:.::|..|:.:|.....|:..
 Frog  2105 MKTTEQQFQQISRLAALQHRAKDSVYLPTAREVQDYIPSQF--YKALKPQSWLNMVMQHMQQIQP 2167

  Fly  3009 LSPGQVKAQFLNVLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNT 3073
            |||.|.:||||.:::.:|:||||||.::..          :::.:....|||:|:.|:.||:..|
 Frog  2168 LSPHQGRAQFLGLVSAFPMFGSSFFYIQSC----------SNNTVIAPCILAVNQNGLNFLNKET 2222

  Fly  3074 HETLQHWSFMEVISTRKVRSEDGAL--FLDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITMAQI 3136
            ||.:..:...::.|||..|...|..  ::|:.:|::..||:.::|.||..|:.|:|..::... :
 Frog  2223 HELVVIFPLNDIQSTRTQRPASGFSYPYVDVMLGDVTSQRITQLQLEQGLELCRVVATHMENL-L 2286

  Fly  3137 SQRDKR 3142
            ..||||
 Frog  2287 QSRDKR 2292

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 309/657 (47%)
MYSc_Myo15 169..828 CDD:276838 308/649 (47%)
MyTH4 1014..1171 CDD:295320 66/167 (40%)
MyTH4 2704..2810 CDD:279165 47/105 (45%)
B41 2823..3033 CDD:214604 70/209 (33%)
FERM_B-lobe 2920..3025 CDD:271216 34/104 (33%)
FERM_C_MyoXV 3029..3138 CDD:270022 30/110 (27%)
myo15aXP_031749377.1 Motor_domain 2..627 CDD:419868 308/648 (48%)
MyTH4 805..956 CDD:214535 65/161 (40%)
PHA03247 <1203..1406 CDD:223021 61/480 (13%)
SH3_MYO15A 1614..1693 CDD:213000 18/142 (13%)
MyTH4 1823..1976 CDD:214535 58/153 (38%)
FERM_B-lobe 2082..2182 CDD:271216 34/102 (33%)
FERM_C_MyoXV 2188..2289 CDD:270022 30/111 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D10566at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

Return to query results.
Submit another query.