Protein Alignment Myo10A and myh9

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_017949131.2
• Gene: myh9 / 100487997
• XenbaseID: XB-GENE-1002222
• Length: 1960
• Species: Xenopus tropicalis
• Alignment Length: 2541
• Identity: 558/2541 - (21%)
• Similarity: 951/2541 - (37%)
• Gaps: 766/2541 - (30%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |.||||:.|..|:|||:|.||:.||..|||||::|...:.:||||..| .|..|:.:.|.|:...
 Frog    81 SKVEDMSELACLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKYLP-IYSEEIVEMYKGKKRH 144

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGS--ASAVITE 279
            .:|||::||...|:.::   ...|.::.:||||:||||:||.|:||||.|.....|  ....:..
 Frog   145 EMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVATSHKSKKEQGELER 209

  Fly   280 QILEAAPLLEAFGNARTARNDNSSRFGKYLEVYFK-SGAIVGAKITQYLLEKSRIVTQAPGERNY 343
            |:|:|.|:|||||||:|.:|||||||||::.:.|. :|.||||.|..|||||||.:.||..||.:
 Frog   210 QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTF 274

  Fly   344 HVFYELLGGLSETERSKYGLLEA-DKYFYLNQGATDCASGRVD---WESLQGAMQVLGVSEGERE 404
            |:||.||.|..|..:|.. |||| :||.:|:.|.. ...|:.|   ::....||:::|.:|.|:.
 Frog   275 HIFYYLLSGAGEHLKSDL-LLEAYNKYRFLSNGHV-TIPGQQDKDLFQETMEAMKIMGFTEEEQI 337

  Fly   405 GIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAE 469
            |::||:::||.|||:.|.:.:   ..:...:..:...:...||:.|:.:...|.:.....:...:
 Frog   338 GLLRVVSSVLQLGNIAFKKER---NTDQASMPDNTAAQKLCHLMGINVNDFTRGILLPRIKVGRD 399

  Fly   470 RLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENSF 534
            .:......:||..|.:|.|||.|..:|.|||.|:|..:.|.....|..|.||||.|||....|||
 Frog   400 FVQKAQTKEQADFAIEALAKATYERMFRWLVMRVNKALDKTKRQGASFIGILDIAGFEIFELNSF 464

  Fly   535 EQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAKK--PVGICHLLD 596
            |||||||.||.||..||..:|.|||.||.||.:||..:.:. |..|.|.|:.|.  |.||..|||
 Frog   465 EQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIEKPAGPPGILALLD 529

  Fly   597 DESNFPRATDLSFLEKCHYNHALSELYARPR--IGAQEFGVTHYAGQVWYCVDGFLDKNRDALRG 659
            :|..||:|||.||:||..........:.:|:  ....:|.:.||||:|.|..|.:|.||.|.|..
 Frog   530 EECWFPKATDKSFVEKVVQEQGSHSKFQKPKQLKDKADFCIIHYAGKVDYKADEWLLKNMDPLND 594

  Fly   660 DVLELLASSRLPLVGELTK---------QLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFADS 715
            :|..||..|....|.||.:         |:....|.  .||    |.|.|.|....||...:.:.
 Frog   595 NVATLLNQSSDKFVSELWRDVDRIVGLDQVAGMADT--ALP----GAFKTRKGMFRTVGQLYKEQ 653

  Fly   716 LQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFV 780
            |.:|:.::...:|.|||||.||.||.:.::|...||.|||..|:|:.|:|.::|:|.|:.||.|.
 Frog   654 LSKLMATLRNTNPNFVRCIIPNHEKKSGKLDAHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFR 718

  Fly   781 ERYRHLLPSPLARG-TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLR 844
            :||..|.|:.:.:| ...::.|..:::|:.   ::...|::|.::||.|..:...||..|..::.
 Frog   719 QRYEILTPNSIPKGFMDGKQACVLMIKALE---LDSNLYRIGQSKVFFRAGVLAHLEEERDLKIT 780

  Fly   845 RAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRV 909
            ...:|.|...||.|.|:..|:||...|.::..   ||....|.:||.        |:..:...:|
 Frog   781 DVIISFQAFCRGYLARKAFAKRQQQLTAMKVI---QRNCAAYLKLRN--------WQWWRLFTKV 834

  Fly   910 QQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLV 974
            :.|...:|..:|.        .|:|.:...::..|:|.....:|:..:...||
 Frog   835 KPLLQANRFDEEL--------HAKEVELQKVKELQVSSEQKVSEMENVQMMLQ------------ 879

  Fly   975 KVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALA 1039
                      ...:||.|.|..            .:.|....|.:.|    |.|::.|:.::.|.
 Frog   880 ----------QEKMQLQEQLQA------------EIELCAEAEEMRA----RLATKKQELEEILH 918

  Fly  1040 VFKLILRWSNDKA--LEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQ 1102
            ..:..:....::.  |:..|:|:                ...:|:|..|:.
 Frog   919 DLESRVEEEEERCQILQADKKKM----------------QHNIVELEEQLE-------------- 953

  Fly  1103 LLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWL 1167
                     :..||..|..:..|..||.       :::|...
 Frog   954 ---------EEEAARQKLQLEKVTVEAK-------MKKLEED----------------------- 979

  Fly  1168 EWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVASRGWTLVLDDGQQLTDSC 1232
                         .|.|.|:.|:                               |...::|.:..
 Frog   980 -------------VLVLEDQNSK-------------------------------LGKEKKLYEER 1000

  Fly  1233 GLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERR 1297
            ..::..:|..|:|        :|..|........|.:.|.                :|.:.||.:
 Frog  1001 IAEFTTNLAEEEE--------KSKSLAKLKNKHETMISDL----------------EERLRREEK 1041

  Fly  1298 SSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTL 1362
            ..:||                            .|:|.|     |.||    .||
 Frog  1042 QRQEL----------------------------EKTRRK-----LEGD----STD---------- 1059

  Fly  1363 GLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSD 1427
                  |:|:.  ||..|.:.:      .|.|.|.:                :.|.....:.:.:
 Frog  1060 ------LHDQI--AELQAQIAE------LKMQLAKK----------------EEELQAALARVEE 1094

  Fly  1428 TSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAES 1492
            .|...::|  ::::|                  .|:..:.||.:......:.|..:.:|:.:...
 Frog  1095 ESAQKNIA--LKKIR------------------ELESQISELQEDLETERAARNKAEKQKRDLGE 1139

  Fly  1493 EIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDL----DDYIN 1553
            |::.|...:.|........|.|.  |.::|....:|   ...:.|.|..|.:|:::    ...:.
 Frog  1140 ELEALKTELEDTLDSTAAQQELR--TKREQEVTQLK---KTLEDEARTHEVQIQEIRQKHSQAVE 1199

  Fly  1554 ELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAF 1618
            ||.|.:...:.|.  .:.|....|:.|..:..:|....||    |..|::|......:.|:|.
 Frog  1200 ELSEQLEQTKRLK--GNLEKAKQSLEGERNELANEVKALL----QGKGDSEHKRKKVEGQLQE-- 1256

  Fly  1619 LQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMK 1683
            ||..:.:..:::.:|..:...||..|         :|..|      :||...
 Frog  1257 LQVKVTEGDRVRAELSEKANRLQVEL---------DNVNS------LLSQAD------------- 1293

  Fly  1684 ATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQD----E 1744
                                                        .|::::||       |    |
 Frog  1294 --------------------------------------------GKSIKLGK-------DFSTLE 1307

  Fly  1745 PQFQTEEDFFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPP 1809
            .|.|..::....:.||....:|...|...  ...|::|.           ||.||
 Frog  1308 SQLQDTQELLQEETRQKLSFSTKLKQMED--EKNGLLEQ-----------IEEEE---------- 1349

  Fly  1810 MSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVG 1874
                                .|..|..:...|      :||.: ..:.||..|         :||
 Frog  1350 --------------------EAKKNLSKQIST------LQSQM-ADMKKKMDE---------NVG 1378

  Fly  1875 KLKLSSEMRQRLEQVTAGHSVRSTVSTKSEQRAPA--KLEDTRKLMLQQQLGGLFASVSGGNSGP 1937
            .|:...|::::|::..      .:|:.:.|::|.|  |||.| |..|||:|..:...
 Frog  1379 SLETVEELKKKLQKDL------ESVNQRFEEKAAAYDKLEKT-KTRLQQELDDIAVD-------- 1428

  Fly  1938 GGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQ 2002
               :|....:.:.:|:.:.|...            ||
 Frog  1429 ---LDHQRQIVSNLEKKQKKFDQ------------LL---------------------------- 1450

  Fly  2003 SPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAV 2067
                       .:.:|.|::...|...|..:.:|::|......:.        ||:       |:
 Frog  1451 -----------GEEKTISAKYADERDRAEAEAREKETKALALARS--------LEE-------AL 1489

  Fly  2068 AAWEQAERERSRSRSRSRD----REDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIR- 2127
            .|..:.||...:.|:...|    ::|..:||              .|.|:.||..| :::.|::
 Frog  1490 EAKAELERLNKQLRTEMEDLVSSKDDVGKSV--------------HELEKSKRALE-QQVEEMKT 1539

  Fly  2128 QVERERESHKVYQPAPPRV--------IQASMDTTG-GHRREDRTGGLATFRTHMAQKYEHERKR 2183
            |:|...:..:..:.|..|:        .|...|..| ..:.||:...|......|..:.|.|||:
 Frog  1540 QLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEDKKKQLVRQVKEMEAELEDERKQ 1604

  Fly  2184 KSSASSGMRE-ELDSMHMTTPPPVIVPAPVPPPSSTSPGLGVVSGVLMGSGSGGSTACLTYNRVP 2247
            :|.|.:..:: |:|...:.                                  |.......||..
 Frog  1605 RSVAVAARKKLEMDLKDLE----------------------------------GQIDSANKNREE 1635

  Fly  2248 WKLRVRKEVFQPHEPIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLS 2312
            ...::||                 |.||:               ::....|:         ||.:
 Frog  1636 AIKQLRK-----------------LQAQI---------------KDYQRELD---------DTRA 1659

  Fly  2313 NRNGSGAGGGGNGGQVRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIMGVSHSGLYLARR 2377
            :|:...:....:..::::: :..::.|..:                      :..:..|...|::
 Frog  1660 SRDDILSQSKESEKKLKSM-EAEMIHMQEE----------------------LAAAERGKRQAQQ 1701

  Fly  2378 DADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGK-HLALHAARAAAIQSMVTTFVQEFRKSQS 2441
            :.|.|                     |.::...:|| .|||...|  .::|.:....:|..:.|.
 Frog  1702 ERDEL---------------------ADEIANNSGKGALALEEKR--RLESRIAQLEEELEEEQG 1743

  Fly  2442 KASTLSSGARAAAQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQ----LQQSE---------- 2492
            ....::...:.|...::.....|.:.:::||:||:......|||::    ||:.|
 Frog  1744 NTELVNDRLKKATLQVDQLNADLNAERSNAQKNENARQQMDRQNKELKTKLQELEGTVKSKFKAN 1808

  Fly  2493 ---LHHHLQQQQQQ------QQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQ 2548
               |...:.|.::|      ::|....|.::.:::|:|.|    |..|.:::..:|...|..:..
 Frog  1809 ITALEAKIAQLEEQLDTETKERQNASKQVRRTEKKLKDVM----MQVDDERRNAEQYKDQAEKNN 1869

  Fly  2549 RFLKQQSYLHSARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDANYLQDE-SNGGT 2612
            ..:||..     |:....::.:...|......::.|:...:.::::   :.:.|.|:.: ..||.
 Frog  1870 VRMKQLK-----RQVEEAEEEAQRANAMRRKLQRELEDATETAEAM---NREVNTLKSKLRRGGD 1926

  Fly  2613 PPSVTK 2618
            .|.||:
 Frog  1927 VPFVTR 1932

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	262/683 (38%)
		PTZ00121	<828..>943	CDD:173412	26/114 (23%)
		MyTH4	1014..1171	CDD:470587	19/158 (12%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	8/66 (12%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myh9	XP_017949131.2	Myosin_N	27..72	CDD:460670
		Motor_domain	95..764	CDD:473979	262/683 (38%)
		Myosin_tail_1	842..1921	CDD:460256	261/1741 (15%)