DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and myh15

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_002932332.2 Gene:myh15 / 100487082 XenbaseID:XB-GENE-999078 Length:1937 Species:Xenopus tropicalis


Alignment Length:2222 Identity:513/2222 - (23%)
Similarity:848/2222 - (38%) Gaps:582/2222 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|:|||:|:|||.||...:|||::|...:.|||||..| .|..||...|.|:.....
 Frog    85 MEDMAMLTHLNEASVLFNLRKRYANWMIYTYSGLFCVTVNPYKWLP-VYKTEVVAAYKGKRRSEA 148

  Fly   222 PPHLFAIG-AAAHAALPS--PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSAS--------- 274
            |||:|:|. .|.|..|.:  .|.::|:||||:|||.:||.|:||.|.|...|...|         
 Frog   149 PPHIFSIADNAYHDMLRNRENQSMLITGESGAGKTVNTKRVIQYFATVAAIGDPMSKKNQPATKT 213

  Fly   275 -AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQA 337
             ..:.:||::|.|.|||||||:|.||||||||||::.::| .:|.:..|.|..|||||||::.|.
 Frog   214 GGTLEDQIIQANPALEAFGNAKTLRNDNSSRFGKFIRIHFGTTGKLSSADIEIYLLEKSRVIFQQ 278

  Fly   338 PGERNYHVFYELLGG-LSETERSKYGLLEADKY-FYLNQGATDCASGRVDWESL---QGAMQVLG 397
            ||||:||:||::|.| :||.:...  |:..:.| |:.:...........|.|.|   ..|..:||
 Frog   279 PGERSYHIFYQILSGKMSELQDML--LVSTNPYDFHFSSQGVVTVDNLDDSEELIATDQAFDILG 341

  Fly   398 VSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSR 462
            ....|:.|..::..|::|.||:.|.::|   .:|..|.........||:|:.||:..|.:.|...
 Frog   342 FIPDEKYGSYKLTGAIMHFGNMKFKQKQ---REEQAEADGTENTDKAAYLMGISSSDLVKGLLHP 403

  Fly   463 TTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR-----ISILD 522
            ..:...|.:.....:.|.:.|..|.||.:|..:|.|||.|||.      |.|...     |.:||
 Frog   404 RVKVGNEYVTKGQTVAQVVYAVGALAKGIYDRMFKWLVVRINK------TLDTKLPRQFFIGVLD 462

  Fly   523 IFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKK 587
            |.|||....|||||||||:.||.||.:||.|:|.|||.||.:|.::|..:.:..:|.....|.:|
 Frog   463 IAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGLDLQACIDLIEK 527

  Fly   588 PVGICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRIGAQ-----EFGVTHYAGQVWYCV 646
            |:||..:|::|..||:|||::|..|.:.|| ..|..:.:||:..:     .|.:.||||.|.|.:
 Frog   528 PLGIMSILEEECMFPKATDMTFKSKLYDNHLGKSPNFQKPRLDKKRKYEAHFELMHYAGVVPYNI 592

  Fly   647 DGFLDKNRDALRGDVLELLASSRLPLVGELTKQL----RAQRDAGKTLPKGSNGRFVTMKPRTPT 707
            .|:|:||:|.|...|:.|...|...|:|.|.:..    .|.:...|...||::.:         |
 Frog   593 MGWLEKNKDPLNETVVGLFQKSSNKLLGCLFENYVSSDSADQGGEKKRKKGASFQ---------T 648

  Fly   708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPV 772
            |::...::|.:|:.::....|.|||||.||:.|....||...||.|||..|:|:.|:|.::|:|.
 Frog   649 VSSLHKENLNKLMTNLRSTSPHFVRCIIPNETKTPGAMDPFLVLHQLRCNGVLEGIRICRKGFPN 713

  Fly   773 RLRFQHFVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRAL 835
            |:.:..|.:|||.|.||  |..:....|:....||..:.   ::...|:.|.|:||.:..|...|
 Frog   714 RVLYADFKQRYRILNPSAIPEDKFVDSRKASEKLLGTLE---IDHTQYRFGHTKVFFKAGLLGNL 775

  Fly   836 ESGRTERLRRAAVSVQRHVRGMLVR----RQLARRQA--------AATRLQARWRGQRAQQRYER 888
            |..|.|||.:....:|...||.|:|    :.|.||.|        .|......|...:...:.:.
 Frog   776 EEMRDERLSKILTLIQARARGKLMRIEFQKILERRDALLVIQWNIRAFMTVKNWPWMKLFFKIKP 840

  Fly   889 LRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVL--ERSQLSYLDIP 951
            |.|.|          :..:.:..::.:..:.:||.|.::..|:..|.||..|  |::.|: |.:.
 Frog   841 LLKSA----------ETEKEMANMKEEFLKLKEALEKSEARRKELEEKQVTLVQEKNDLT-LQLQ 894

  Fly   952 AEL-----------AFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSV 1005
            ||.           ..|.||:|..|         |:               :||.:         
 Frog   895 AEQDMFADAEERCDLLIKSKIQMES---------KI---------------KDLTE--------- 926

  Fly  1006 YCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKAL 1070
                 |::...|     :.:...|:.:..:|..:..|..:........:..|||...:       
 Frog   927 -----RIEDEEE-----MNSELTSKKRKLEDECSELKKDIDDLEITLAKAEKEKHATE------- 974

  Fly  1071 SSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRP 1135
                          |:|..|...                            |..:||...:..:.
 Frog   975 --------------NKVKNLTEE----------------------------MASLDDTINKLTKE 997

  Fly  1136 LLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSC 1200
            ....|...||                                     ||.|..::...|:|.|..
 Frog   998 KKALQEAHQQ-------------------------------------TLDDLQAEEDKVNSLTKI 1025

  Fly  1201 EEAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDL------LR 1259
            :....                    ||:.|..|     .|..||::       |.||      |.
 Frog  1026 KTKLE--------------------QQVDDLEG-----SLEQEKKV-------RMDLERAKRKLE 1058

  Fly  1260 SGAKFARTTLPDA----------VKRPAVPPPAPPTSSGKED----VPRERRSSRELLSRSSALN 1310
            ...|..:.:|.||          :|:...  .....||..||    |.:.::..:||.:|...|.
 Frog  1059 GDLKLTQESLMDAENDKQQMEEKLKKKEF--EISQMSSKIEDEQAIVMQLQKKIKELQARIEELE 1121

  Fly  1311 ERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHS 1375
            |..          :.....:||...:..|  ||.::         :|      ||| ||.:...:
 Frog  1122 EEL----------EAERAARAKVEKQRSD--LAREL---------EE------LSE-RLEEAGGA 1158

  Fly  1376 AERLAPVGKDTGPRYQKSQHAGRRS-------HAASHGSHSSKYADKAEYATRSSAMSDTSEAPS 1433
            :.....:.|.....|.|.    ||.       |.|:..|...|:||            ..:|...
 Frog  1159 SAAQIEMNKKRETEYLKM----RRDLEEATLHHEATAASLRKKHAD------------TVAELGE 1207

  Fly  1434 LASHVRRV--RVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDD 1496
            ...:::||  ::..:.|::....|||.|     |:::|..|:.::..:.....:|.||.::::|:
 Frog  1208 QIDNLQRVKQKLEKEKSELKLEADDLSS-----SMEQLVKAKGISEKLCRTYEDQLNETKAKLDE 1267

  Fly  1497 LDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLDDYINELFEPIPV 1561
            :...:|::            .|.|.:|               :.|..|...|             
 Frog  1268 MTRQVNEL------------TTQKGRL---------------QTENGEFGRL------------- 1292

  Fly  1562 AEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQN 1626
                  |..||.|...:..|.|:.:...:.|..||.:   ||::..||...      ||||....
 Frog  1293 ------LEEKESLISQLSRGKSSFTQQIEDLRKQLEE---ETKAKNALAHA------LQSARHDC 1342

  Fly  1627 LQIQQQLLAQNQA---LQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSS 1688
            ..:::|...:.:|   ||..||:..|..|...:.....|  |..:..:.....:...|::....:
 Frog  1343 DLLREQFDEEQEAKAELQRSLSKGNAEVATWRNKYETDA--IQRTEELEEAKKKLAARLQEAEEA 1405

  Fly  1689 LVVMESLQPPPPPPPPPMPPPLECKDPSETRHFL---------------------DPYGRAKTVR 1732
            :....:                :|....:|:|.|                     |...|.....
 Frog  1406 VEAANA----------------KCASLEKTKHRLQNELEDMMIDLERSNAAAAAMDKKQRNFDKL 1454

  Fly  1733 IGKWRWPPPQDEPQFQTEE--------DFFAFK-------------------MRQHQRKTTPQAQ 1770
            |..|:....:.:.:.:|.:        :.|..|                   :::.....|.|..
 Frog  1455 IADWKQKYEETQAELETSQKDARGLSTELFKLKNAYEEVLDNLETVKRENKNLQEEISDLTDQIS 1519

  Fly  1771 H-----HQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTS 1830
            .     |::......:|.   .:.....|:|..|..:|......:..||..|.|:.|.....:  
 Frog  1520 EGNKSLHEIEKVKKQVEQ---EKSEVQVALEEAEGALEHEESKTLRFQLELSQIKAEFERKLS-- 1579

  Fly  1831 AVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLE--QVTAGH 1893
                 ::|.||:::.:.:|.::      :|.:...:.........::|..:|...|.  ::...|
 Frog  1580 -----EKDEETENIRRNLQRII------ESLQSNLESEAKSRNEAVRLKKKMEGDLNEMEIQLSH 1633

  Fly  1894 SVR-STVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHAT-VRTQIERMEG 1956
            |:| :|.:||:.:...|:.:|     ||.|... :..:|........|::...| ::::::.:..
 Frog  1634 SIRQATEATKAMRNLQAQYKD-----LQVQYDD-YIHLSEDLKEQAAVIERRNTLLQSELDELRA 1692

  Fly  1957 KLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSS 2021
            .|.                                             .|.|:       |..|.
 Frog  1693 ALD---------------------------------------------QTERA-------RKLSE 1705

  Fly  2022 QVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASS---------------SPAVAAWE 2071
            |.:.|..........::| ..:.|::.:.:...|:::....|               :.|....|
 Frog  1706 QELLESTERVNLLHSQNT-SLINQKKKLETDISHMQNEVEESIQECRNAEDKAKKAITDAAMMAE 1769

  Fly  2072 QAERERSRSRSRSRDREDYSESV------WDRAEVEGPASGSGSEKEREKRERERERLYEIRQVE 2130
            :.::|:..|....|.:::..:::      .|.||......|....::.|.|.||.|...|..| .
 Frog  1770 ELKKEQDTSAHLERMKKNMEQTIKDLQKRLDEAEQIAMKGGKKQIQKLESRVRELENELESEQ-R 1833

  Fly  2131 RERESHKVYQPAPPRV----IQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASS-- 2189
            |..||.|.::....|:    .|...|.....|.:|....|..    ..:.|:|:.:..|..|:  
 Frog  1834 RNSESLKGFRKFERRIKELTYQGEEDKKNLIRMQDLIDKLQL----KVKSYKHQAEEASEQSNQY 1894

  Fly  2190 -----GMREELD 2196
                 .::.|||
 Frog  1895 LSKYKKLQHELD 1906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 261/714 (37%)
MYSc_Myo15 169..828 CDD:276838 254/694 (37%)
MyTH4 1014..1171 CDD:295320 16/156 (10%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myh15XP_002932332.2 Myosin_N 32..70 CDD:367160
Motor_domain 97..768 CDD:354959 254/694 (37%)
Myosin_tail_1 848..1925 CDD:366712 232/1425 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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