DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myh7b

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_031750297.1 Gene:myh7b / 100486122 XenbaseID:XB-GENE-6048377 Length:1942 Species:Xenopus tropicalis


Alignment Length:2030 Identity:499/2030 - (24%)
Similarity:817/2030 - (40%) Gaps:391/2030 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 KRLSTLCSDVIARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLI 184
            |.|:....|:...:|..|.:                 :|||.:|..|:|||:|.||:.||...:|
 Frog    68 KTLTVKEDDIQQMNPPKFDM-----------------IEDMAMLTHLNEASVLSNLKRRYANWMI 115

  Fly   185 YTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAAL---PSPQVVVISG 246
            ||::|...:.|||||..| .|...|...|.|:.....|||:::|...|:..:   ...|.::|:|
 Frog   116 YTYSGLFCVTVNPYKWLP-VYTATVVAAYKGKRRSEAPPHIYSIADNAYNDMVRNRENQSMLITG 179

  Fly   247 ESGSGKTESTKLVMQY---LAAVVPGGGSASAVIT-------EQILEAAPLLEAFGNARTARNDN 301
            |||:|||.:||.|:||   :||:..|.|..||..|       :||:||.|.:||||||:|.||||
 Frog   180 ESGAGKTVNTKRVIQYFAIVAALGEGLGKKSAPATKTGGTLEDQIIEANPAMEAFGNAKTLRNDN 244

  Fly   302 SSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLE 365
            ||||||::.::| .:|.:..|.|..|||||||::.|.||||:||::|::|.| .:.|.....|:.
 Frog   245 SSRFGKFIRIHFGPTGKLASADIDIYLLEKSRVIFQQPGERSYHIYYQILSG-KKPELQDMLLVS 308

  Fly   366 ADKYFY--LNQGATDCASGRVDWESLQG---AMQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQ 425
            .:.|.|  .:||.| ......|.|.|..   ||.:||.|:.|:.|..:::.||:|.||:.|.::|
 Frog   309 TNPYDYHFCSQGVT-TVDNLDDGEELMATDHAMDILGFSQEEKTGSYKIVGAVMHFGNMKFKQKQ 372

  Fly   426 LRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPLGIDQALDARDAFAKA 490
               .:|..|.........||:|:.||:..|.:.|.....:...|.:.....::|.:.|..|.|||
 Frog   373 ---REEQAETDGTESADKAAYLMGISSADLIKGLLHPRVKIGNEYVTKGQNVEQVVYAVGALAKA 434

  Fly   491 LYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLCINYANENLQLYFNKH 553
            .|..:|.|||||||..:.   |..|.:  |.:|||.|||....|||||||||:.||.||.:||.|
 Frog   435 TYDRMFKWLVSRINRTLD---TKLARQFFIGVLDIAGFEIFEYNSFEQLCINFTNEKLQQFFNHH 496

  Fly   554 VFKLEQAEYARERLEWTPLAWD-DNLPVIHLLAKKPVGICHLLDDESNFPRATDLSFLEKCHYNH 617
            :|.|||.||.:|.:||..:.:. |..|.|.|: :||:||..:|::|..||:|:|::|..|.:.||
 Frog   497 MFVLEQEEYKKEGIEWVFIDFGLDLQPCIDLI-EKPLGILSILEEECMFPKASDMTFKAKLYDNH 560

  Fly   618 -ALSELYARPRIGAQ-----EFGVTHYAGQVWYCVDGFLDKNRDALRGDVLELLASSRLPLVGEL 676
             ..|..:.:|::..:     .|.:.||||.|.|.:.|:||||:|.|...|:.:...|...|:..|
 Frog   561 LGKSPNFQKPKLDKKRRYEPHFELMHYAGVVPYNIVGWLDKNKDPLNETVVTVFQKSSNKLLASL 625

  Fly   677 -TKQLRAQRDAGKTLPKGSNGRFVTMKPRT----------PTVAARFADSLQQLLQSMGRCHPWF 730
             .|.:.:..|..:             ||..          .||:....::|.:|:.::....|.|
 Frog   626 YEKYISSYSDEHQ-------------KPGVKEKRKKAASFQTVSQLHKENLNKLMTNLRSTQPHF 677

  Fly   731 VRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPS--PLAR 793
            ||||.||:.|....||...||.|||..|:|:.|:|.::|||.||.:..|.:|||.|.|:  |..:
 Frog   678 VRCIIPNESKTPGVMDPFMVLHQLRCNGVLEGIRICRKGYPNRLLYADFKQRYRILNPNAIPDDK 742

  Fly   794 GTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVRGML 858
            ....|:....||.::   .::...|:.|.|:||.:..|...||..|.|||.:....:|...||.|
 Frog   743 FVDSRKATEKLLGSL---DIDHTQYKFGHTKVFFKAGLLGQLEEMRDERLAKIITMLQARSRGRL 804

  Fly   859 VR---RQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHRRRQ 920
            :|   .::..|:.|...:|...|...|.:.:..: |.....:.|.:..|..:.:..::.:..:.:
 Frog   805 MRIEYHKIIARKDALMVIQWNIRAFNAVKNWSWM-KLFFKIKPLLKSAQTEKEMANMKEEFLKLK 868

  Fly   921 EAREAAQRAREAREAKQAVL----------------------ERSQL---SYLDIPAELAFIYSK 960
            ||.|.::..|:..|.:|..|                      ||..|   :.:.:.|::..:..:
 Frog   869 EALEKSEAKRKELEERQVTLTQEKNDLGLQLQAEQDNLADAEERCDLLIKTKIQLEAKVKELTER 933

  Fly   961 LQGWSPPHGD--------------------------------RHLV--KVLGTVPGPPSSAVQLP 991
            |:.....:.|                                :|..  ||...:    .....|.
 Frog   934 LEDEEEMNSDLTSKKRKLEDECAELKKDIDDLEITLAKVEKEKHATENKVKNLI----EEMAALD 994

  Fly   992 EDLGQFSFGK--FSSVYCNGL-RLQPRREPITAPLLTRA-ASRDQDFQDALAVFKLILRWSNDKA 1052
            |.:.:.:..|  ....:...| .||...:.:..  ||:| |..:|...|.....:...:...|  
 Frog   995 EIIARLTKEKKALQEAHQQALDDLQAEEDKVNT--LTKAKAKLEQQVDDLEGSLEQEKKLRMD-- 1055

  Fly  1053 LEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQ----VHGLPPNSGEATRL-WQLLGQCLCCFQ 1112
            ||.||.||..|.         .|..|.::.|.|.    ...|.....|.::| .::..:.:.|.|
 Frog  1056 LERAKRKLEGDL---------KLTQESVMDLDNDKQQLEEKLKKKDFEISQLNSRIEDEQVMCAQ 1111

  Fly  1113 PSAAFSKYLMRF----------------VDDEAPESLRPL-LLRQLLRQQGGGTS--------SG 1152
            ......:...|.                |:.:..|..:.| .|.:.|.:.||.||        ..
 Frog  1112 LQKKIKELQARIEELEEELEAERATRAKVEKQRAEVAKELEELSERLEEAGGATSVQIEMNKKRE 1176

  Fly  1153 AVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVA-----VDSWTSCEEAAALAVSSLG 1212
            |......|....|.|...|...|        |..:.:.|||     :||....::......|.: 
 Frog  1177 AEFLKLRRDLEEATLHHEATAAG--------LRKKHADTVAELGEQIDSLQRVKQKLEKEKSEM- 1232

  Fly  1213 VASRGWTLVLDDG----QQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAV 1273
                  .:.:||.    :|||.:.|       .||| ||..:....|:......:..|.....::
 Frog  1233 ------KMEIDDFTSNIEQLTKNKG-------NAEK-LCRTYEDQLSEAKSKVDELQRQLADISL 1283

  Fly  1274 KRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSL 1338
            .|..:     .|.:|:        .||.|..:.|.:|:.        ..|:.|.|...:...:.|
 Frog  1284 HRARL-----QTENGE--------LSRLLEEKESLVNQL--------SRGKASFTQTIEELKRQL 1327

  Fly  1339 DD------LLAGDIVPVPTDCD--------SQEPLHTLGLSESRLN------------DRYHSAE 1377
            ::      .||..:.....|||        .||....|..|.|:.|            |.....|
 Frog  1328 EEETKAKNALAHALQASRHDCDLMREQYEEEQEAKGELQRSLSKANAEVAQWRNKYETDAIQRTE 1392

  Fly  1378 RLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVR 1442
            .|....|....|.|.::.|...::|.......:|:..:.|.   ...:.|...|.|.|:     .
 Frog  1393 ELEEAKKKLAARLQDAEEAVEVANAKCSSLEKTKHRLQTEI---EDLVIDLERANSAAA-----A 1449

  Fly  1443 VPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLD--------- 1498
            :..:..:.|:.|.: :....:.:..||..::..:.|:....::.:|..|..:|:|:         
 Frog  1450 LDKKQRNFDRILGE-WKQKYEETQAELEASQKESRSLSTELFKLKNAYEESLDNLETMKRENKNL 1513

  Fly  1499 -DYINDIFQPI----PLVQNLEKL------TSKDQLAAIIKGGGVASKPEERDEESEIE------ 1546
             :.|.|:...|    .::..|||:      ...|..||:.:..|.....|.:....::|      
 Frog  1514 QEEIADLTDQISASGKMIHELEKVKKALESEKSDIQAALEEAEGALEHEESKTLRIQLELSQIKA 1578

  Fly  1547 DLDDYINELFEPI------------PVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQL 1599
            |:|..:.|..|.|            .:...||......:.|:.::.....|.|..:..|:...:.
 Frog  1579 DVDRKVAEKDEEIENLRRNHQRAMESMQASLDAEAKARNEAIRLKKKMEGDLNEMEIQLNHANRQ 1643

  Fly  1600 PGETESGPALYQQQVQ--RAFLQSAMAQNLQIQQQ----------LLAQNQALQTLLSQ--QAAA 1650
            ..|::......|..::  :..|...:..|..:::|          |||:.:.|:..|.|  :...
 Frog  1644 AAESQKMVRNLQSHIKDLQIELDDTLRHNDDLKEQAAALERRNNLLLAEVEELRAALEQAERGRK 1708

  Fly  1651 AAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDP 1715
            .|............:|.|.:......:..:....::.:..|.||:|              ||::.
 Frog  1709 LAEQELLEATERVNLLHSQNTGLINQKKKLDADISQLTTEVEESVQ--------------ECRNA 1759

  Fly  1716 SETRHFLDPYGRAKTVRIGKWRWPPPQDEPQFQTEEDFFAF--KMRQHQRKTTPQAQ-----HHQ 1773
            .|         :||     |..........:.:.|:|..|.  :|:::..:|....|     ..|
 Frog  1760 EE---------KAK-----KAITDAAMMAEELKKEQDTTAHLERMKKNMEQTIKDLQMRLDEAEQ 1810

  Fly  1774 MTSNGGMMESGPGARGASATAIEWE-EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDR 1837
            :...||..:    .:...|...|.| |.|||..........:.:...|::..|..|       :.
 Frog  1811 IALKGGKKQ----IQKLEAKVRELEGELEIEQKKNAETQKGVRKYERRIKELTYQT-------EE 1864

  Fly  1838 DRET----QDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLEQVTAGHSVRST 1898
            ||:.    ||:...:|..|  |..|:..|....:.....|...|:..|:....|:........:.
 Frog  1865 DRKNLARMQDLIDKLQMKV--KSYKRQSEEAETQANSNLVKYRKIQHELDDAEERADVAEGQVNK 1927

  Fly  1899 VSTKSEQRAPAKLED 1913
            :..::.:.|.:|.|:
 Frog  1928 LRARTREAASSKHEE 1942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 266/720 (37%)
MYSc_Myo15 169..828 CDD:276838 259/699 (37%)
MyTH4 1014..1171 CDD:295320 37/187 (20%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myh7bXP_031750297.1 Myosin_N 35..73 CDD:397036 2/4 (50%)
MYSc_Myh7b 100..774 CDD:276953 259/699 (37%)
Myosin_tail_1 854..1931 CDD:396244 206/1187 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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