Protein Alignment Myo10A and myo15b

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_031750066.1
• Gene: myo15b / 100485698
• XenbaseID: XB-GENE-6045939
• Length: 3748
• Species: Xenopus tropicalis
• Alignment Length: 3238
• Identity: 838/3238 - (25%)
• Similarity: 1306/3238 - (40%)
• Gaps: 850/3238 - (26%)

  Fly    54 QRGGGGSVTPSPAQSPSLALLSPHVLRRQRP-ASLEDFE-DLPNLSAKH----PALP----SSRL 108
            |:..|.::.|.|...    .:...::....| ...||.| |||..:..|    ..:|    |.|.
 Frog  1197 QQEMGDNLEPQPVDE----RVDDSLVESSTPETEEEDAELDLPYEATTHVHWAQGVPGRGDSIRW 1257

  Fly   109 RRLKCRYPQV-VKRLSTLCSDVIARHPQTF-ALQPG--------------EGSLRARQDLG---- 153
            ...:...||: |:.||..........|:|. ||||.              :.|:..:|..|
 Frog  1258 LSSETLLPQLTVENLSKWSMYHGMPRPKTVQALQPTRDRWEAEDSSEDMLQMSMNKKQVRGADCP 1322

  Fly   154 -SSGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRP 217
             :..|.|:..|.|:.|:::|..|:.|:.:...||..|.:|:::||.|.. :.:..::|:.|....
 Frog  1323 EAEEVSDLCFLKDVCESAVLLCLKRRFHRNETYTHVGHMLLSMNPGKAL-NIHSPDMAQVYWDGE 1386

  Fly   218 LGSLPPHLFAIGAAAHAALPSPQV---VVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITE 279
            ....|||:||:...|::...:..|   :::||.|||||:|:.||:..||..:       |....|
 Frog  1387 SVEKPPHIFAVAEDAYSLSQTSDVAPNILLSGHSGSGKSEAVKLMALYLVTL-------STRQEE 1444

  Fly   280 QILEA---APLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIVGAKITQYLLEKSRIVTQAPGER 341
            :||:.   ..:||:||||:|..||||:|||:.|::|..|||:||..::.:||||||:|.||.|||
 Frog  1445 KILQLEDFLKVLESFGNAKTVFNDNSTRFGQVLQLYLHSGAVVGGMVSPFLLEKSRVVFQAQGER 1509

  Fly   342 NYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRVDWES---LQGAMQVLGVSEGER 403
            .:|||||||.||...|:.:..|.|.:.|:|||||......|:.|.:.   |...::.:|:|..|.
 Frog  1510 GFHVFYELLRGLPAHEKQRLYLQEPETYYYLNQGRACDVRGKNDKQDFVLLGKCLRAIGLSFTEL 1574

  Fly   404 EGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVG-SDAEIKWAAHLLHISADGLHRALTSRTTEAR 467
            ..|..||:|:|.|||:.|  ........|:... |..|::..|.||.||.:||.||:|.|.|...
 Frog  1575 TAIWAVLSAILQLGNICF--SSCEKDSFGLAAAFSATEVRIVASLLQISPEGLQRAITQRVTVTS 1637

  Fly   468 AERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIV--QKGGTHDAHRISILDIFGFEDLA 530
            .:|:.:||.::.::|.|||.::.||:.|||||:.:.||.:  ||..    ..:.|:|:.|||:|.
 Frog  1638 YDRVLSPLSVEASIDVRDAISQTLYSLLFNWLLEKGNSWLHPQKMD----KTLGIVDVCGFENLG 1698

  Fly   531 ENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLL 595
            .||.||||.|||||::|.|..:.:...||||||||.|.|.||..:...|.:.||.:.|.||.|:|
 Frog  1699 VNSLEQLCRNYANEHIQHYSKQRLVIQEQAEYAREGLRWVPLNQESVGPCLGLLTEPPHGIFHML 1763

  Fly   596 DDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGFLDKNRDALRGD 660
            :::|:..:|||.:||:||||:|..|..|.:|::....|.:.||||.|.|.|..||:||||.|...
 Frog  1764 EEQSSLAQATDHTFLQKCHYHHGNSGCYIKPKLPLPVFTLQHYAGPVTYQVHNFLNKNRDRLPAA 1828

  Fly   661 VLELLASSRLPLVGELTKQLRA--QRDAGKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSM 723
            ..|:|:.|||.|:.||..|.|:  |:..|..|.|            ..|:..||..|||:|...:
 Frog  1829 ATEVLSQSRLRLLSELFTQSRSSNQQKEGGALAK------------ELTLTGRFQASLQELTSCL 1881

  Fly   724 GRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLP 788
            .|....|||||.||.::.....|:..|..|||..|:|:|:|:.:.|||:|:..:.||.||.:|:.
 Frog  1882 ERGRTLFVRCIAPNPKQLRGIFDVDFVSSQLRNSGILETVQLMKEGYPIRIPLKDFVARYGYLVR 1946

  Fly   789 SPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRR-AAVSVQR 852
            |..:.... :|.|.|:|  ....|.....||:|.::|||:|.....|: |..:.:|| ||:::||
 Frog  1947 SSASFAND-QECCTAVL--TKAVGDASKLYQIGLSKVFLKEEGKEMLQ-GYLDVIRRHAAITLQR 2007

  Fly   853 HVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQARRRVQQLRSDHR 917
            ::||.|.|:.....:...|.:||..||.:|::||.:|:.     .|:..|  |...:.::.|.|.
 Frog  2008 NLRGFLNRKNFQVYRNKITVIQAHVRGHQARRRYRQLKH-----TRVQLG--AVLLISKVHSKHL 2065

  Fly   918 RRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSKLQGWSPPHGDRHLVKVLGTVPG 982
            :             .:|..|..|....|:.|.||||||.:...      |....|......|...
 Frog  2066 K-------------LKEPGQDSLLSMDLTRLAIPAELASLLKS------PEVRSHAQSARITEVS 2111

  Fly   983 PP----SSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKL 1043
            ||    .||:.||.|:..|.|..|...|.....|.|..:|::.| |||.:..|..  .||.::||
 Frog  2112 PPQVVAQSALSLPSDINNFPFSNFIQSYFKDPTLPPIGQPLSDP-LTRVSRNDNG--AALELYKL 2173

  Fly  1044 ILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCN-QVHGLPPNSGEATRLWQLLGQC 1107
            .||:..|.::...:::::.:||..:.|....|:||:|.|:.: .:..  .|..:..|.|.||...
 Frog  2174 ALRFVGDTSMPSWQQRIVGNYIAERCLRQPSLKDEVLCQVASLTIQN--TNEEQCQRAWLLLSIL 2236

  Fly  1108 LCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAW 1172
            |.|..||....|.|:::|.|:.||..:.:...::||    |.|.|.......||..|..:||.|.
 Frog  2237 LSCLTPSPTLEKPLLKYVSDQGPEGYKAMCQHKILR----GGSQGQKTLENLRSHAPTLMEWTAS 2297

  Fly  1173 TRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGVAS--RGWTLVLDDGQQLTDSCGLD 1235
            .|...|.|.|...::...|..|||||:.|:.|...:.|.||..  |||.:.:.||.|..|..|.|
 Frog  2298 ERRGKMVLDLNTYNDDRYTTEVDSWTTGEQIAGWLLQSRGVGEMPRGWAVSILDGDQYLDLSGGD 2362

  Fly  1236 YVMDLIAE-KELCPAFPAPRSDLLRSGAKFARTTLPD---------AVKRPAVP----PPAPPTS 1286
            :::|:||| ::..|  |.|.:    :|..|..:.:|:         ..:.|..|    |||||
 Frog  2363 FILDVIAEVEDGVP--PNPEA----TGFPFGDSGIPEPPPDFAPQFPFENPGFPPPGLPPAPP-- 2419

  Fly  1287 SGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVPVPT 1351
                                           |:|.|                        .|.|
 Frog  2420 -------------------------------PAPPP------------------------PPAP- 2428

  Fly  1352 DCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKA 1416
                 .||:.:..|             :.|     .|:.|
 Frog  2429 -----PPLNMMNSS-------------IPP-----APQLQ------------------------- 2445

  Fly  1417 EYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRG 1481
                          |||:...:.|      ....:.::|:||||::..|.| ......|:..::|
 Frog  2446 --------------APSMPQGLGR------QQRFENYVDELFSPLVSPSAD-WDGPEYLSRRMKG 2489

  Fly  1482 GSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAIIKG--GGVASKPEERDEESE 1544
            |.....|                                 :..|...|  ||:|..|.
 Frog  2490 GGGIGPN---------------------------------RQGAFSAGGYGGMAPMPS------- 2514

  Fly  1545 IEDLDDYINELFEPIPVAEGLDKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPAL 1609
                        ..:|:..|:.:......:..|:.|      ....|::.|:|  |.:....|.:
 Frog  2515 ------------YSMPMMNGMMQPMGNAPMMPSMAG------MAPQPMMPQMM--PQQMMPQPMM 2559

  Fly  1610 YQQQVQRAF------------LQSAMAQNLQIQQQ--LLAQNQALQ-TLLSQQ------------ 1647
            .||.:.:..            .|.|..|...|.||  ||||...|| |:||||
 Frog  2560 PQQMMPQMMPASQPVMPSVDPSQVAAQQQAFINQQALLLAQQMTLQATMLSQQQQKNLQKQSRPT 2624

  Fly  1648 ---------AAAAAAN------NSTSPPPAPPILSS--LSISPPPPQSPMRMKATRSSLVVMESL 1695
                     :.|.||.      .:|:||||||..::  .|.:||.|.:|.
 Frog  2625 DSTPSPRDPSPARAAKPVPKPAAATAPPPAPPTSTAPPTSTAPPAPPAPS--------------- 2674

  Fly  1696 QPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDEPQ---FQTEEDFFAFK 1757
            ..|||.|..|.|.|                 .||         |.|:::..   ::||:|   .:
 Frog  2675 ADPPPAPAAPTPAP-----------------AAK---------PKPENKQTKVLWETEDD---DE 2710

  Fly  1758 MRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLE 1822
            :...::|.|.|.:.|.....|.                  :|.:|:|..||        |.|.|
 Frog  2711 LEYAEQKQTFQQKMHFFQRMGS------------------QEIKIKSLKPP--------SKILL- 2748

  Fly  1823 TTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKLSSEMRQRLE 1887
                                                           |.|.|:
 Frog  2749 -----------------------------------------------PNSGGQ------------ 2754

  Fly  1888 QVTAGHSVRSTVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVRTQIE 1952
                      .:.|.|:.      :|
 Frog  2755 ----------NIGTDSDS------DD--------------------------------------- 2764

  Fly  1953 RMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQSPPTARSPEPEPDYR 2017
                  .||.||.               |.|.|  :|.:..|..|||||:.|..     .:.|.:
 Frog  2765 ------EPPKAPE---------------PEPKP--KPKTPTPKVPPPAPKKPNL-----KDKDPK 2801

  Fly  2018 TSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVAAWEQAERERSRSRS 2082
            .|..:..|:.||    :::....|||.:.             :....|:....|..:..:||.:.
 Frog  2802 DSKDEESKDKVP----KKKDSKKGAVLKP-------------APKPEPSQQIREIIKMYQSRPQP 2849

  Fly  2083 RSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERESHKVYQPAPPRVI 2147
            ..:..|          .|..||.....:|:.::...||.:|
 Frog  2850 ELKPYE----------PVRRPAQSFLKKKDPKQEALERLQL------------------------ 2880

  Fly  2148 QASMDTTGGHRREDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELDSMH------MTTPPPV 2206
                   ||...||                        .:.|.:.||::|..      |....|.
 Frog  2881 -------GGKLYED------------------------PSKSPVYEEVNSFQDKQRSLMDLFQPS 2914

  Fly  2207 IVPAPVPPPSSTSPGLGVVSGV---LMGSGSGGSTAC-------LTYNRVPWKLRVRKEVFQPHE 2261
            ::|   |||...:|||......   |.|.....|:.|       .:|:.|.|:|.||||:|.|.|
 Frog  2915 LIP---PPPEMQAPGLEPPKSAGRYLEGDNLANSSLCKHTASVFFSYSDVGWRLYVRKEIFYPKE 2976

  Fly  2262 PIGPPVALDLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGG 2326
            ....|..|:||..|::.|.|..:. .|:|..|:....:.|....|..|..|....|
 Frog  2977 KFTHPYCLNLLCEQIIRDTFSDSG-FRLTKDERRKMRDFLTEFHVGADANSISEES--------- 3031

  Fly  2327 QVRALVKRHLVDMARD-WPLYFARLFAVQGAPLYPDVS--IMGVSHSGLYLARRDAD-------Y 2381
                 :|:.:|..||| |..||:|||.|:   |..|:.  ::||||.|:.|. :|..       :
 Frog  3032 -----IKKRIVIAARDNWENYFSRLFPVR---LEDDIDPLLLGVSHRGIRLV-KDVQAAGVQHRH 3087

  Fly  2382 LIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTL 2446
            |..:.:.||.:|.| :.:|..::|:..||: :.|.||:.||.::::::..||.|..|..:....|
 Frog  3088 LKTLCSYSFADILS-MEMPSSSSLRFCLRH-EELLLHSDRAQSLKALIEIFVHELVKDSNHVVAL 3150

  Fly  2447 SSGARAAAQTLN---------VPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQ 2502
            .|........|.         :|:|.|   |...|....|...|...:..:|.:....:....::
 Frog  3151 RSYVTDDKSLLQFKKGDIIKVLPMEGL---QPGWQFGSIGGRSGLFPSRMVQPAAAPDYFSVLER 3212

  Fly  2503 QQQQQQHHQQQQQQQQLEDAMEEQHMATDHQQQQQQQLGQQQGQQQRFLKQQSYLHSARKSNAGQ 2567
            :.:.::....:..|:.|....|.                                 ::|.|...:
 Frog  3213 KGETRKSPPPKVLQRSLSKESEA---------------------------------TSRASMISK 3244

  Fly  2568 QPSSLTNGQVHHQEQMLQQQQQQSQSLPHHDLDANYLQDESNGGTPPSVTKYSLLQFAMQHFRND 2632
            .||                      |.|...:||               ::|::::||:::||..
 Frog  3245 APS----------------------SAPPMPIDA---------------SQYTMVEFALKYFREA 3272

  Fly  2633 QLRDADRHHERHQSAANRSYAELVKWQGHAIRLPLLRLPN-DLAPLALECFDCILRYCGDIPLDP 2696
            |....    .:..:|..:...:||:.....|:..|:...: :|...|...|..::|:.||.....
 Frog  3273 QTMLG----WKGMAAEGKKAVQLVQHTKVPIQESLIYFEDKELNEPAANNFMSLMRFMGDQQFRQ 3333

  Fly  2697 DLTEVKCVYTVLMHCHKYLALRDEVYCQLMKQTTANRSPCPDSSQRAWRLLSILAAYFGCSDALR 2761
            . .::.|.:.:|..|.:...||||:|||::||.|||  |..||..|.||:||:|..::..|..|.
 Frog  3334 Q-DDMGCAFEILQLCREKQVLRDEIYCQVIKQITAN--PKQDSCNRGWRILSLLTGFYLPSPNLL 3395

  Fly  2762 PYLMEHLTSAASDRRRSCHGTAAVCLTNLRKTARCGGRKNVPSVEEVTAVSAGRSARRQIYRLPG 2826
            |.:.::|.....|.:.    .:.:|..:||:|....||:::||..|:.|:...|.:||.|.:|||
 Frog  3396 PCVTKYLQDCVGDYQE----VSRLCQEHLRRTVLYHGRRHLPSKAEMDALLNDRVSRRLIIKLPG 3456

  Fly  2827 GAERVVNTRCSTVVADVIAELCALLGVESEAEQQEFSLYCIVQGDAFTMPLAADEYILDVTTELL 2891
            |||.....:..||.|||:.|:|..:.|....|..||:|:..........||...|||.|.   ||
 Frog  3457 GAEFTTKIKTFTVAADVVPEICEQINVSEPEETDEFALFANKNKGEVVRPLRGGEYIHDF---LL 3518

  Fly  2892 KSGQPFYLIFCRSVWHFALKREPAPMPLYVEVLFNQVAPDYLEG-LLLELPGNGVPVPEMVRDMA 2955
            :... ..|.|.|..|...|:   ....||:::.|:|:..||::| .||..|.:.:.|     ...
 Frog  3519 RDNS-VDLEFRRVTWKATLR---GRSELYIQLHFSQMLSDYMQGKALLLSPSDLLGV-----QTG 3574

  Fly  2956 RIAALLHRAADLSHVPAMKEIKFLLPKPALGIREIRPAQWVGLVQSAWPQVANLSPGQVKAQFLN 3020
            |:||:|||...||..|:.:|:...:|........::.|| ..|:|.. .:..|:|..|.|.:||.
 Frog  3575 RVAAILHRIKGLSSPPSKQELLDYIPNSVHNRLNLQAAQ-QSLLQEL-RETQNISAHQAKIRFLE 3637

  Fly  3021 VLATWPLFGSSFFAVKRIWAEEGPHVEDNHSPMWRDLILALNRRGVLFLDPNTHETLQHWSFMEV 3085
            .::..|||..:.:.|.|| :|.|         |.....:|:|.:.:|.|:.|:.|.....:..::
 Frog  3638 TVSILPLFEYNVYHVTRI-SEPG---------MTSPCFVAINHQHLLVLEKNSQEPSMCINLQDI 3692

  Fly  3086 ISTRKVRSEDGALF--LDMKVGNLMQQRVIRVQTEQAHEISRLVRQYITMAQI 3136
            .|.|.:|..|....  :::..|:....|.:.|:.::|.|:      |.|:|.:
 Frog  3693 QSMRTMRPFDSNTLPGVEINYGSAANPRTMWVELQEAKEL------YHTLALV 3739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	260/672 (39%)
		PTZ00121	<828..>943	CDD:173412	30/115 (26%)
		MyTH4	1014..1171	CDD:470587	47/157 (30%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	27/69 (39%)
		MyTH4	2704..2810	CDD:459939	37/105 (35%)
		FERM_B-lobe	2920..3025	CDD:271216	31/105 (30%)
		FERM_C_MyoXV	3029..3138	CDD:270022	24/110 (22%)
myo15b	XP_031750066.1	PTZ00108	<45..273	CDD:240271
		MSCRAMM_ClfA	<372..701	CDD:468110
		UBAN	<800..861	CDD:197361
		Motor_domain	1339..1983	CDD:473979	260/672 (39%)
		IQ	2022..2042	CDD:197470	7/19 (37%)
		MyTH4	2147..2296	CDD:470587	47/157 (30%)
		SH3_MYO15B	3146..3200	CDD:213001	10/56 (18%)
		MyTH4	3342..3440	CDD:459939	37/103 (36%)
		FERM_M	3541..3650	CDD:459788	35/115 (30%)
		PH-like	3647..3743	CDD:473070	24/109 (22%)