Protein Alignment Myo10A and LOC100485637

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_002939061.1
• Gene: LOC100485637 / 100485637
• XenbaseID: XB-GENE-29077903
• Length: 1937
• Species: Xenopus tropicalis
• Alignment Length: 2194
• Identity: 490/2194 - (22%)
• Similarity: 851/2194 - (38%)
• Gaps: 588/2194 - (26%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:|..|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
 Frog    87 IEDMAMLTFLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNTEVVAAYRGKKRSEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAVVPGG-------GSASAV 276
            |||:|:|...|:..:.:.   |.::|:||||:|||.:||.|:||.|.:...|       .:....
 Frog   151 PPHIFSISDNAYQYMLTDRENQSILITGESGAGKTVNTKRVIQYFAYIASVGERKKDTSSAGKGT 215

  Fly   277 ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGE 340
            :.:||::|.|.|||||||:|.||||||||||::.::| .:|.:..|.|..|||||||::.|...|
 Frog   216 LEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKSE 280

  Fly   341 RNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCASGRVD----WESLQGAMQ 394
            |:||:||::|      ...|..|||       ...|.|::||.|..||  :|    ..:...|..
 Frog   281 RDYHIFYQIL------SNKKPELLEMLLITNNPYDYSYVSQGETTVAS--IDDADELMATDSAFD 337

  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRAL 459
            |||.::.|:..|.::..|::|.||:.|.::|   .:|..|.....|...||:|..:::..|.:.|
 Frog   338 VLGFTQEEKNSIYKLTGAIMHCGNMRFKQKQ---REEQAEPDGTEEADKAAYLKGLNSADLLKGL 399

  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIF 524
            .....:...|.:.....::|...|..|.||::|..:|.|:|.|||:.::...... :.|.:|||.
 Frog   400 CHPRVKVGNEYVTRGQTVEQVNYATGALAKSVYEKMFLWMVVRINATLETKQPRQ-YFIGVLDIA 463

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....|||||||||:.||.||.:||.|:|.|||.||.:|.:||..:.:..:|.....|.:||:
 Frog   464 GFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWVFIDFGMDLQACIDLIEKPM 528

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWYCVDGF 649
            ||..:|::|..||:|:|.:|..|.:.|| ..|..:.:||  .|..|  |.:.||||.|.|.:..:
 Frog   529 GIMSILEEECMFPKASDTTFKAKLYDNHLGKSANFQKPRNIKGKPEAHFALVHYAGTVDYNILNW 593

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFAD 714
            |.||:|.|...|:.|...|.|.|:..|...............||:..:..|.:    ||:|...:
 Frog   594 LTKNKDPLNETVVGLYQKSSLKLLAVLFANYAGADSVDPGTKKGTKKKGSTFQ----TVSALHRE 654

  Fly   715 SLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHF 779
            :|.:|:.::...||.|||||.||:.|....||...|:.|||..|:|:.|:|.::|:|.|:.:..|
 Frog   655 NLNKLMTNLRSTHPHFVRCIIPNETKAPGVMDNRLVMHQLRCNGVLEGIRICRKGFPNRILYGDF 719

  Fly   780 VERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTER 842
            .:|||.|.|:.:..|  ...|:....||.::.   ::...|:.|.|:||.:..|...||..|.||
 Frog   720 RQRYRILNPAAIPDGQFIDSRKGAEKLLASLE---IDHTQYKFGHTKVFFKAGLLGQLEEMRDER 781

  Fly   843 LRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALT 895
            |.|....:|...||:|.|   :::..|:.|...:|         ..|...:...:.:.|.|.|
 Frog   782 LARIITRIQAQSRGVLSRIEFKKMVERRDALLVIQWNVRAFMGVKNWPWMKLYFKIKPLLKSA-- 844

  Fly   896 AQRLWRGRQARRRVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAELAFIYSK 960
                    :..:.:|.::.:.:|.:||.|.:       ||::..||...:|.|....:|     :
 Frog   845 --------ETEKEMQNMKEEFQRLKEALEKS-------EARRKELEEKMVSLLQEKNDL-----Q 889

  Fly   961 LQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLT 1025
            ||                         ||..:|..:.:..:...:..|.:.|:.:        |.
 Frog   890 LQ-------------------------VQAEQDNLEDAEERCEQLIKNKINLEAK--------LK 921

  Fly  1026 RAASRDQDFQDALAVFKLILRWSNDKALEGAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGL 1090
            ....|.:|                       :|::.|:....|    |.|.||     |::
 Frog   922 EQTERLED-----------------------EEEMNAELTAKK----RKLEDE-----CSE---- 950

  Fly  1091 PPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVG 1155
                                          |.:.:||
 Frog   951 ------------------------------LKKDIDD---------------------------- 957

  Fly  1156 AGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTS--CEEAAAL--AVSSLGVASR 1216
                                    |.|||.....:..|.::...  .||.|||  .::.|....:
 Frog   958 ------------------------LELTLAKVEKEKHATENKVKNMTEEMAALDEIIAKLTKEKK 998

  Fly  1217 GWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPP 1281
            .   :.:..||..|        ||.||::..       :.|.:|.||..:..  |.::
 Frog   999 A---LQEAHQQALD--------DLQAEEDKV-------NSLTKSKAKLEQQV--DDLE------- 1036

  Fly  1282 APPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDI 1346
                  |..:..::.|...|.:.|                    ...|..|...:||.||
 Frog  1037 ------GSLEQEKKVRMDLERVKR--------------------KLEGDLKLTQESLMDL----- 1070

  Fly  1347 VPVPTDCDSQ---EPLHTLGLSESRLN----DRYHSAERLAPVGKDTGPRYQKSQ---HAGRRSH 1401
                 :.|.|   |.|.......|::|    |..:.|.:|....|:...|.::.:   .|.|.:.
 Frog  1071 -----ENDKQQLEEKLKKKDFEISQMNTKIEDEQNVASQLLKKLKELQARIEELEEELEAERAAR 1130

  Fly  1402 AASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSL 1466
            |......|....:..|.:.|   :.:...|.|:...:.:.|      :: :||.      |...|
 Frog  1131 AKVEKLRSDLSRELEEISER---LEEAGGATSVQLELNKKR------EI-EFLK------LRRDL 1179

  Fly  1467 DELS-DARSLAASIRGGSYEQENEAESEID------------------DLDDYINDIFQPIPLVQ 1512
            :|.: .:.:.||::|....:...|...:||                  :|||..:::.|.|....
 Frog  1180 EESTLQSEATAAALRKKHADSVAELSEQIDNLQRVKQKLEKEKSELKLELDDVASNMEQVIKGKA 1244

  Fly  1513 NLEKL--TSKDQLAAIIKGGGVASKPEERDEESE--IEDLDDYINELFEPIPVAEGLDKLTSKEH 1573
            |||||  |.:||          |::...:.||::  ..||.....:|  .....|...:|..||.
 Frog  1245 NLEKLCRTLEDQ----------ANEYRTKSEETQRTANDLSTQRAKL--QTENGELTRRLDEKEA 1297

  Fly  1574 LAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQ 1638
            |...:..|..|.:...:.|..||.:   |:::..||...      ||||......:::|...:.:
 Frog  1298 LVSQLTRGKQTYTQQLEDLKRQLEE---ESKAKNALAHA------LQSARHDCDLLREQYEEEQE 1353

  Fly  1639 A---LQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSPMRMKATRSSLVVMESLQPPPP 1700
            |   ||.:||:..:..|...:.....|  |..:..:.....:...|::....::..:.:
 Frog  1354 AKAELQRILSKANSEVAQWRTKYETDA--IQRTEELEEAKKKLAQRLQEAEEAVEAVNA------ 1410

  Fly  1701 PPPPPMPPPLECKDPSETRH---------------------FLDPYGRAKTVRIGKWRWPPPQDE 1744
                      :|....:|:|                     .||...|.....:.:|:....:.:
 Frog  1411 ----------KCSSLEKTKHRLQNEIEDLMVDLERSNAAAAALDKKQRNFDKILSEWKQKFEESQ 1465

  Fly  1745 PQFQTEE------DFFAFKMRQHQRKTTP------------QAQHHQMTSNGGMMESGPGARGAS 1791
            .:.::.:      ....||::....::..            |.:...:|...|  |||.......
 Frog  1466 AELESSQKEARSLSTELFKLKNSYEESLEHLETFKRENKNLQEEISDLTEQLG--ESGKSIHELE 1528

  Fly  1792 AT--AIEWEEFEIESPTPPP------MSGQLMRSSIRLETTTTTTTSAVNNRDRD-----RETQD 1843
            ..  .:|.|:.|::|.....      ..|:::|..:.|:.........::.:|.:     |..|.
 Frog  1529 KVRKQLEQEKMELQSALEEAEGSLEHEEGKILRVQLELQQIKAEFERKLSEKDEEFDQAKRNNQR 1593

  Fly  1844 VGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKL--------KLSSEMRQRLE---------QVTA 1891
            ....:|:.:..:...::..:...:...|.:.::        :::||.:::|:         |:..
 Frog  1594 AVDTLQASLEAETRSRNEALRVKKKMEGDLNEMEIHLSQANRIASEAQKQLKNLQGVLKDTQLQL 1658

  Fly  1892 GHSVRSTVSTKS-----EQR---APAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVVDSHATVR 1948
            ..::|.....|.     |:|   ..|:||:.|.::.|.:.....|...        :::::..|:
 Frog  1659 DDTLRINEDLKENTAIVERRNTLLQAELEELRSILEQTERSRKLAEQE--------LIETNERVQ 1715

  Fly  1949 ----------TQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPAPPPAPQS 2003
                      .|.::||..||                                   .......::
 Frog  1716 LLHSQNTSLINQKKKMENDLS-----------------------------------QLQGEVEEA 1745

  Fly  2004 PPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLEDHSASSSPAVA 2068
            ....|:.|.:.....:.:.::.|.:     ::|:||           |.||
 Frog  1746 VQECRNAEEKAKKAITDAAMMAEEL-----KKEQDT-----------SAHL-------------- 1780

  Fly  2069 AWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERER 2133
              |:.::...::....:.|.|.:|.:          :..|.:|:.:|.|.      .:|:::.|.
 Frog  1781 --ERMKKNMEQTIKDLQQRLDEAEQI----------AMKGGKKQLQKLEA------RVRELDNEL 1827

  Fly  2134 ESHKVYQPAPPRVIQASMDTTGGHRREDRTGGLATFRTHMAQKYEHERK 2182
            |:.:          :.:.::..|.|:.:|.....|::|      |.:||
 Frog  1828 EAEQ----------KRNAESVKGMRKYERRIKELTYQT------EEDRK 1860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	245/687 (36%)
		PTZ00121	<828..>943	CDD:173412	29/126 (23%)
		MyTH4	1014..1171	CDD:470587	14/156 (9%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	18/70 (26%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
LOC100485637	XP_002939061.1	COG5022	37..1432	CDD:227355	418/1655 (25%)
		MYSc_class_II	99..767	CDD:276951	245/687 (36%)
		SMC_prok_B	1215..>1928	CDD:274008	121/794 (15%)