Protein Alignment Myo10A and myo1e

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001121497.2
• Gene: myo1e / 100158599
• XenbaseID: XB-GENE-1005591
• Length: 1108
• Species: Xenopus tropicalis
• Alignment Length: 828
• Identity: 274/828 - (33%)
• Similarity: 433/828 - (52%)
• Gaps: 111/828 - (13%)

  Fly   155 SGVEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLG 219
            |||:||.||..:.|.|::.||:.||....|:|:.|.:||:|||:|..| .:|.:..:.|.|....
 Frog    19 SGVDDMVLLSKITEDSIVDNLKKRYMDDFIFTYIGPVLISVNPFKQMP-YFGDKEIEMYQGAAQY 82

  Fly   220 SLPPHLFAIGAAAHAAL---PSPQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQI 281
            ..|||::|:....:..:   ...|.|:||||||:|||.:.|.:|.|::. |.|||.....:.:.|
 Frog    83 ENPPHIYALADNMYRNMIIDRENQCVIISGESGAGKTVAAKYIMSYISK-VSGGGPKVQHVKDII 146

  Fly   282 LEAAPLLEAFGNARTARNDNSSRFGKYLEVYFKSGAIV-GAKITQYLLEKSRIVTQAPGERNYHV 345
            |::.|||||||||:|.||:||||||||.|:.|..|... |.||:.:||||||:|.:.||||::|:
 Frog   147 LQSNPLLEAFGNAKTVRNNNSSRFGKYFEIQFSPGGEPDGGKISNFLLEKSRVVMRNPGERSFHI 211

  Fly   346 FYELLGGLSETERSKYGLLEADKYFYLNQGAT---DCASGRVDWESLQGAMQVLGVSEGEREGIV 407
            ||:|:.|.|:.:|...|:...|.|.||||..:   |..:.:.|::....||.|:|:|...:..::
 Frog   212 FYQLIEGASKDQRESLGITSLDYYNYLNQSGSYKVDDINDKRDFQETMHAMNVIGISAEGQAMVM 276

  Fly   408 RVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEA----RA 468
            :::|.||||||:.|..:......|..|.     :.:.|.||.|:...|...||||..::    ::
 Frog   277 QIVAGVLHLGNIGFKEKGNYAAVENEEF-----LAFPAFLLGINQSRLKDKLTSRQMDSKWGGKS 336

  Fly   469 ERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIFGFEDLAENS 533
            |.::..|.::||...|||.:|||::.:|::||..||..::|  .|:.:.|.:|||:|||...:|.
 Frog   337 ESINVTLNVEQACYTRDALSKALHSRVFDYLVDSINKAMKK--DHEEYNIGVLDIYGFEIFQKNG 399

  Fly   534 FEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKK--PVGICHLLD 596
            |||.|||:.||.||..|.:...|.||.||.:|.:.|||:.:.:|..|..|:..|  |.|:..:||
 Frog   400 FEQFCINFVNEKLQQIFIELTLKAEQEEYVQEGIRWTPIEYFNNKIVCDLIENKVNPPGVMSILD 464

  Fly   597 DESNFPRA----TDLSFLEKC--------HYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDGF 649
            |......|    .|.:.|:|.        |:|.           ..|.|.:.||||:|.|.||||
 Frog   465 DVCATMHAVGEGADQTLLQKLQMAVGTHEHFNS-----------WNQGFIIHHYAGKVSYDVDGF 518

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGEL-TKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFA 713
            .::|||.|..|::||:.||:.|.:..| .:.|:|::                 |.|..|..::..
 Frog   519 CERNRDVLFMDLIELMQSSQQPFMQALFPENLQAEK-----------------KGRPTTAGSKIK 566

  Fly   714 DSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQH 778
            .....|:.::.:|.|.::||||||:.|.....:...|..|:.|||:.:.|::|:.||..|..|:.
 Frog   567 KQANDLVNTLMKCTPHYIRCIKPNETKKPRDWEESRVKHQVEYLGLKENIRVRRAGYAYRRVFKK 631

  Fly   779 FVERYRHLLPS--PLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLR--EALHRALESGR 839
            |::||..|...  |..:|    :..:.:|..:....::...:|||.|::|::  |:|. .||..|
 Frog   632 FLQRYAILTKETWPSWKG----DEKKGVLHLLHSVNMDSDQFQLGKTKIFIKAPESLF-LLEEMR 691

  Fly   840 TERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQRYERLRKGALTAQRLWRGRQ 904
            ..:....|.|:|:                       .||...|:::|.::|:   .|..|:..::
 Frog   692 ERKYDGYARSIQK-----------------------AWRKYVARKKYVQMRE---QASDLFLNKK 730

  Fly   905 ARRRVQQLRS---DHRRRQEAREAAQRAREAREAKQAVLERSQLSYLD 949
            .|||....|:   |:....          |..|.:|.|.:|.::.:.|
 Frog   731 ERRRNSINRNFIGDYIGMD----------ERPELRQFVGKREKIDFAD 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	240/686 (35%)
		PTZ00121	<828..>943	CDD:173412	24/119 (20%)
		MyTH4	1014..1171	CDD:470587
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo1e	NP_001121497.2	MYSc_Myo1	33..679	CDD:276829	240/686 (35%)
		Myosin_TH1	719..921	CDD:461801	14/63 (22%)
		SH3_MyoIe_If_like	1055..1107	CDD:212761