Protein Alignment Myo10A and myha

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_021332193.1
• Gene: myha / 100149148
• ZFINID: ZDB-GENE-060531-50
• Length: 1933
• Species: Danio rerio
• Alignment Length: 2197
• Identity: 493/2197 - (22%)
• Similarity: 828/2197 - (37%)
• Gaps: 600/2197 - (27%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.::..|:|.|:|:||:.||...:|||::|.....|||||..| .|..||...|.|:.....
Zfish    89 IEDMAMMTHLNEPSVLYNLKERYAAWMIYTYSGLFCATVNPYKWLP-VYDAEVVAAYRGKKRMEA 152

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLAAV-VPGG--------GSAS 274
            |||:|::...|:..:.:.   |.|:|:||||:|||.:||.|:||.|.| |.||        |...
Zfish   153 PPHIFSVSDNAYQFMLTDRENQSVLITGESGAGKTVNTKRVIQYFATVAVQGGDKKKEQTPGKMQ 217

  Fly   275 AVITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAP 338
            ..:.:||:.|.|||||:|||:|.||||||||||::.::| .:|.:..|.|..|||||||:..|.|
Zfish   218 GSLEDQIIAANPLLEAYGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLP 282

  Fly   339 GERNYHVFYELLGGLSETERSKYGLLEADKYFYLNQGATDCASGRV------DWESL---QGAMQ 394
            .||.||:||:::.. .:.|..:..|:..:.|.:     ..|:.|::      |.|.|   ..|:.
Zfish   283 DERGYHIFYQMMTN-HKPELIEMTLITTNPYDF-----PMCSQGQITVASIDDKEELVATDTAID 341

  Fly   395 VLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRAL 459
            :||.:..|:.||.:...||||.||:.|.::|   .:|..|.....|....::||.:::..:.:||
Zfish   342 ILGFTGEEKMGIYKFTGAVLHHGNMKFKQKQ---REEQAEPDGTEEADKISYLLGLNSAEMLKAL 403

  Fly   460 TSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHRISILDIF 524
            .....:...|.:.....:.|..::..|.:|::|..:|.|:|.|||.::......:.. |.:|||.
Zfish   404 CYPRVKVGNEFVTKGQTVPQVYNSVSALSKSIYERMFLWMVIRINQMLDTKQQRNFF-IGVLDIA 467

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....||.||||||:.||.||.:||.|:|.|||.||.:|.:.|..:.:..:|.....|.:||:
Zfish   468 GFEIFDFNSMEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIVWEFIDFGMDLAACIELIEKPM 532

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNHALSELYA----RPRIGAQE--FGVTHYAGQVWYCVDG 648
            ||..:|::|..||:|||.||..|.:..| |.:..|    ||:.|..|  |.:.||||.|.|.|.|
Zfish   533 GIFSILEEECMFPKATDTSFKNKLYDQH-LGKCNAFQKPRPQKGKAEAHFSLVHYAGTVDYNVSG 596

  Fly   649 FLDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDAGKTLPKGSNGRFVTMKPRTPTVAARFA 713
            :||||:|.|...|::|...|.:.|:..|...:  ..|..|   ||...:..:|:    ||:::|.
Zfish   597 WLDKNKDPLNESVVQLYQKSSVKLLATLYPPV--VEDTSK---KGGKKKGGSMQ----TVSSQFR 652

  Fly   714 DSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQH 778
            ::|.:|:.::...||.||||:.||:.|....|:...|:.|||..|:|:.|:|.::|:|.|:.:..
Zfish   653 ENLGKLMTNLRSTHPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYAD 717

  Fly   779 FVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERL 843
            |.:||:.|..|.:..| .:.:..:|..:.:....|...:|:.|.|:||.:..|...||..|.|:|
Zfish   718 FKQRYKVLNASVIPEG-QFIDNKKASEKLLGSIDVNHDEYRFGHTKVFFKAGLLGTLEEMRDEKL 781

  Fly   844 RRAAVSVQRHVRGMLVRRQ----LARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALT 895
            .......|...|..|:||:    :.||::..| :|         ..|...:...:.:.|.|.|.|
Zfish   782 ASLVTMTQALCRAYLMRREFVKMMERRESIYT-IQYNIRSFMNVKHWPWMKVYYKIKPLLKSAET 845

  Fly   896 AQRLWRGRQARRRVQQLRSDH-RRRQEAREAAQRAREAREAKQAVLERS---QLSYLDIPAELAF 956
            .:.|          ..::.|. :.:::..:|..:.:|..|...|:|:..   ||:.......|:.
Zfish   846 EKEL----------ANMKEDFVKCKEDLVKAEAKKKELEEKMVALLQEKNDLQLAVASEAENLSD 900

  Fly   957 IYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITA 1021
            ...:.:|         |:|          |.:||...|.:.:           .||:...| |.|
Zfish   901 AEERCEG---------LIK----------SKIQLEAKLKETT-----------ERLEDEEE-INA 934

  Fly  1022 PLLTRAASRDQDFQDALAVFKLILRWSNDKALEGA---KEKLLADYIVHKALSSRGLRDEILVQL 1083
            .|    .::.:..:|..:..|..:   :|..|..|   |||...:..|.........:||.:.:|
Zfish   935 EL----TAKKRKLEDECSELKKDI---DDLELTLAKVEKEKHATENKVKNLTEEMASQDESIAKL 992

  Fly  1084 CNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQLLRQQGGG 1148
            ..:...|                                                 |...||
Zfish   993 TKEKKAL-------------------------------------------------QEAHQQ--- 1005

  Fly  1149 TSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGV 1213
                                              ||.|..::...|::.|..:....
Zfish  1006 ----------------------------------TLDDLQAEEDKVNTLTKSKTKLE-------- 1028

  Fly  1214 ASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPDAVKRPAV 1278
                        ||:.|..|     .|..||:|       |.||
Zfish  1029 ------------QQVDDLEG-----SLEQEKKL-------RMDL--------------------- 1048

  Fly  1279 PPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRSKSLDDLLA 1343
                             .|:.|:|                         .|..|...:|:.||
Zfish  1049 -----------------ERAKRKL-------------------------EGDLKLAQESIMDL-- 1069

  Fly  1344 GDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSH 1408
                                     .||:..|.|::..  ||    ::.||...:.....|.|:.
Zfish  1070 -------------------------ENDKQQSEEKIKK--KD----FETSQLLSKIEDEQSLGAQ 1103

  Fly  1409 SSKYADKAEYATRSSAMSDTSEAPSLASHVRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDAR 1473
            ..|..  .|...|...:.:..||...|    |.:|..|.:|            |...|:|:|:..
Zfish  1104 LQKKI--KELQARIEELEEEIEAERAA----RAKVEKQRAD------------LSRELEEISERL 1150

  Fly  1474 SLAASIRGGSYEQENEAESEIDDLDDYINDIFQPIPLVQNLEKLTSKDQLAAII----KGGGVAS 1534
            ..|........|...:.|:|           ||  .|.::||:.|.:.:..|..    :...||.
Zfish  1151 EEAGGATAAQIEMNKKREAE-----------FQ--KLRRDLEESTLQHEATAAALRKKQADSVAE 1202

  Fly  1535 KPEERD-----------EESEIE-DLDDYINELFEPIPVAEGLDKL--TSKEHLAVSIRGGGSTD 1585
            ..|:.|           |:||.: ::||..:.:.........|:|:  |.::.|        |..
Zfish  1203 LGEQIDNLQRVKQKLEKEKSEYKMEIDDLSSNMEAVAKAKANLEKMCRTLEDQL--------SEI 1259

  Fly  1586 SNGADPLLHQLMQLPG-----ETESG---------PALYQQ--QVQRAFLQSAMAQNLQIQQQLL 1634
            .:.:|..|.|:..|..     :||:|         .||..|  :.::||.|.......||::::.
Zfish  1260 KSKSDENLRQINDLSAQRARLQTENGEFGRQLEEKEALVSQLTRGKQAFTQQIEELKRQIEEEVK 1324

  Fly  1635 AQN---QALQT------LL------SQQAAA------AAANNST----SPPPAPPILSSLSISPP 1674
            |:|   .|:|:      ||      .|:|.|      :.||:..    :......|..:..:...
Zfish  1325 AKNALAHAVQSARHDCDLLREQFEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEES 1389

  Fly  1675 PPQSPMRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWR-- 1737
            ..:...|::.....:..:.|                :|....:|:..|.  |..:.:.|...|
Zfish  1390 KKKLAQRLQEAEEQIEAVNS----------------KCASLEKTKQRLQ--GEVEDLMIDVERAN 1436

  Fly  1738 -------------------WPPPQDEPQFQTEE--------DFFAFKMRQHQRKTTPQAQHHQMT 1775
                               |....:|.|.:.|.        ....|||:....:|..|.:..:..
Zfish  1437 SLAANLDKKQRNFDKVLAEWKQKYEEGQAELEGAQKEARSLSTELFKMKNSYEETLDQLETLKRE 1501

  Fly  1776 SNGGMMESGP-----GARGAS-------ATAIEWEEFEIESP------TPPPMSGQLMRSSIRLE 1822
            :.....|...     |..|.|       ...:|.|:.||::.      |......:::|..:.|.
Zfish  1502 NKNLQQEISDLTEQIGETGKSIHELEKAKKTVETEKAEIQTALEEAEGTLEHEESKILRVQLELN 1566

  Fly  1823 TTTTTTTSAVNNRDRD-----RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVG--KLKLSS 1880
            .........:..:|.:     |.:|.|.:.|||.:.:::..::..:...:...|.:.  :::||.
Zfish  1567 QVKGEIDRKLAEKDEEIEQIKRNSQRVTEAMQSTLDSEVRSRNDALRIKKKMEGDLNEMEIQLSH 1631

  Fly  1881 EMRQRLEQVTAGHSVRS-----------TVSTKSEQRAPAKLEDTRKLMLQQQLGGLFASVS--- 1931
            ..||..|......:|:|           .|..:.:.:....:.:.|..::|.::..|.|::.
Zfish  1632 ANRQAAEAQKQLRNVQSQLKDAQLHLDDAVRAQEDMKEQVAMVERRNTLMQSEIEELRAALEQTE 1696

  Fly  1932 -GGNSGPGGVVDSHATV------RTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRP 1989
             |.......:||:...|      .|.:...:.||.
Zfish  1697 RGRKVAEQELVDASERVGLLHSQNTSLLNTKKKLE------------------------------ 1731

  Fly  1990 PSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTF-------------- 2040
             |...........:...||:.|.:.....:.:.::.|.:     ::|:||.
Zfish  1732 -SDLVQIQSEVEDTVQEARNAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLERMKKNLEITV 1790

  Fly  2041 ----------------GAVRQQQMISSHHLHLED-------HSASSSPAVAAWEQAERERSRSRS 2082
                            |..:|.|.:.|....||.       ..|.:...|..:|:..:|.:....
Zfish  1791 KDLQHRLDEAENLAMKGGKKQLQKLESRVRELESEIDAEQRRGADAVKGVRKYERRVKELTYQTE 1855

  Fly  2083 RSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLYEIRQVERERE 2134
            ..:...:..:.:.|:.:::..|....||   |..|:....|.::|:|:.|.|
Zfish  1856 EDKKNINRLQDLVDKLQLKVKAYKRQSE---EAEEQANSHLSKLRKVQHELE 1904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	245/686 (36%)
		PTZ00121	<828..>943	CDD:173412	27/128 (21%)
		MyTH4	1014..1171	CDD:470587	20/159 (13%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	11/66 (17%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myha	XP_021332193.1	Myosin_N	33..78	CDD:460670
		MYSc_class_II	101..766	CDD:276951	245/686 (36%)
		Myosin_tail_1	846..1923	CDD:460256	223/1417 (16%)