DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myo10A and smyhc2

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:NP_001096096.2 Gene:smyhc2 / 100124599 ZFINID:ZDB-GENE-070822-12 Length:1939 Species:Danio rerio


Alignment Length:2240 Identity:505/2240 - (22%)
Similarity:861/2240 - (38%) Gaps:589/2240 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:...|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Zfish    87 IEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNQEVVVAYRGKKRTEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLA--AVVPGG-----GSASAV 276
            |||:|:|...|:..:.|.   |.|:|:||||:|||.:||.|:||.|  |..|||     ......
Zfish   151 PPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAAPGGKKDPSQEKKGT 215

  Fly   277 ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGE 340
            :.:||::..|.|||||||:|.||||||||||::.::| .||.:..|.|..|||||||:..|...|
Zfish   216 LEDQIIQCNPALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLSSADIETYLLEKSRVTYQLKAE 280

  Fly   341 RNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCAS--GRVDWESLQGAMQVL 396
            |:||:||::|      .:.|..|||       ...|.|::||.|..||  .|.:..:...|..||
Zfish   281 RDYHIFYQIL------SQRKPELLEMLLITNNPYDYSYISQGETQVASIDDRDELIATDEAFDVL 339

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTS 461
            |.::.|:..|.::..|::|.||:.|.::|   .:|..|.....:....|:|:.:::..|.:.|..
Zfish   340 GFTQEEKNSIYKLTGAIMHYGNMKFKQKQ---REEQAEADGTEDADKVAYLMGLNSADLIKGLCH 401

  Fly   462 RTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIF 524
            ...:...|.:.....:.|...:..|.||::|..:|.|:|.|||   |...|....:  |.:|||.
Zfish   402 PRVKVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVRIN---QSLDTKQPRQYFIGVLDIA 463

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....|:|||||||:.||.||.:||.|:|.|||.||.:|.:||..:.:..:|.....|.:||:
Zfish   464 GFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIELIEKPM 528

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRI--GAQE--FGVTHYAGQVWYCVDGF 649
            ||..:|::|..||:|:|.:|..|.:.|| ..:..:.:|||  |..|  |.:.||||.|.|.:..:
Zfish   529 GIMSILEEECMFPKASDATFKAKLYDNHLGKNPNFQKPRIVKGRPEAHFALVHYAGTVDYNISNW 593

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDA-------GKTLPKGSNGRFVTMKPRTPT 707
            |.||:|.|...|:.|...|.|.|:|.|.........|       |....|||:.:         |
Zfish   594 LVKNKDPLNETVVGLFQKSTLKLLGTLFANYAGAESADSGGKGKGGAKKKGSSFQ---------T 649

  Fly   708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPV 772
            |:|...::|.:|:.::...||.||||:.||:.|....|:.|.|:.|||..|:|:.|:|.::|:|.
Zfish   650 VSALHRENLNKLMTNLRSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPN 714

  Fly   773 RLRFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRAL 835
            |:.:..|.:|||.|.||.:..|  ...::....||.::   .::...|:||.|:||.:..|...|
Zfish   715 RILYGDFKQRYRILNPSAIPEGQFIDNKKGAEKLLGSL---DIDHNQYKLGHTKVFFKAGLLGTL 776

  Fly   836 ESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYER 888
            |..|.:||......:|...||:|.|   :::..|:.:...:|         ..|...:...:.:.
Zfish   777 EEMRDDRLALIITGIQARARGILSRIEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKP 841

  Fly   889 LRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEA-REAAQRAREAREAKQAVLERSQLSYLDIPA 952
            |.|.|          :..:.:..::.:..:.:|| .::..|.:|..|...::|:......|.:.:
Zfish   842 LLKTA----------ETEKEMANMKEEFTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQS 896

  Fly   953 E---LAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQP 1014
            |   ||....:.:|         |:|          |.:|....:.:.:           .||:.
Zfish   897 EQDNLADAEERCEG---------LIK----------SKIQFEAKVKELT-----------ERLED 931

  Fly  1015 RREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGA---KEKLLADYIVHKALSSRGLR 1076
            ..| :.|.|:    ::.:..:|..:..|..:   :|..|..|   |||...:..|..........
Zfish   932 EEE-MNAELV----AKKRKLEDECSELKKDI---DDLELTLAKVEKEKHATENKVKNLTEEMAAL 988

  Fly  1077 DEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQL 1141
            |||:.:|..:...|                                                 |.
Zfish   989 DEIIAKLTKEKKAL-------------------------------------------------QE 1004

  Fly  1142 LRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAAL 1206
            ..||                                     ||.|..|:...|::.|..:  |.|
Zfish  1005 AHQQ-------------------------------------TLDDLQSEEDKVNTLTKAK--AKL 1030

  Fly  1207 AVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPD 1271
            .                  ||:.|..|     .|..||::       |.||.|     |:..|..
Zfish  1031 E------------------QQVDDLEG-----SLEQEKKI-------RMDLER-----AKRKLEG 1060

  Fly  1272 AVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRS----SALNERYFEREPSPGPGQGSSTGQAK 1332
            .:|.         |.....|:..:::...|.|.:.    |.||.:..:.:        :...|.:
Zfish  1061 DLKL---------TQENLMDLENDKQQMEERLKKKDFEISQLNSKIEDEQ--------ALEAQLQ 1108

  Fly  1333 SRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERL--APVGKDTGPRYQKSQH 1395
            .:.|.|...:.          :.:|.|               .|||.  |.|.|......::.:.
Zfish  1109 KKLKELQARIE----------ELEEEL---------------EAERAARAKVEKQRADLSRELEE 1148

  Fly  1396 AGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEA----PSLASHVRRVRVPSQASDVDQFLDD 1456
            ...|...|...:.:....:|...|.......|..||    .:.||.:|:....| .||:.:.:|:
Zfish  1149 ISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEATLQHEATASTLRKKHADS-VSDLGEQIDN 1212

  Fly  1457 LFSPVLDGSLDELSDARSLAASIRGGSYEQENEAE-SEID-DLDDYINDIFQPIPLVQNLEKL-- 1517
            |                        ...:|:.|.| ||:. :|||.::::.|.:....||||:  
Zfish  1213 L------------------------QRVKQKLEKEKSELRLELDDVVSNMEQIVKAKANLEKMCR 1253

  Fly  1518 TSKDQLAAI----------------------IKGGGVASKPEERD---------EESEIEDLDDY 1551
            |.:||::..                      .:.|.::.:.||:|         ::|..:.::|.
Zfish  1254 TLEDQMSEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQSYTQQIEDL 1318

  Fly  1552 INELFEPIPVAEGL-DKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQ-QQV 1614
            ..:|.|.:.....| ..:.|..|.|..:|.....:......|...|.:...|.......|: ..:
Zfish  1319 KRQLEEEVKAKNALAHAVQSARHDAELLREQYEEEQEAKAELQRSLSKANSEVAQWRTKYETDAI 1383

  Fly  1615 QRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSP 1679
            ||       .:.|:..::.|||.     |...:.|..|.|..         .|||.      ::.
Zfish  1384 QR-------TEELEEAKKKLAQR-----LQDAEEAVEAVNAK---------CSSLE------KTK 1421

  Fly  1680 MRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDE 1744
            .|::.....|:|                   :.:..:.....||...|.....:.:|:....:.:
Zfish  1422 HRLQNEIEDLMV-------------------DVERSNAAAAALDKKQRNFDKVLAEWKQKYEESQ 1467

  Fly  1745 PQFQTEE--------DFFAFK------------MRQHQRKTTPQAQHHQMTSNGGMMESGPG--- 1786
            .:.::.:        :.|..|            |::..:..  |.:...:|...|  |||..   
Zfish  1468 TELESAQKESRSLSTELFKLKNSYEESLDHLESMKRENKNL--QEEISDLTEQLG--ESGKNIHE 1528

  Fly  1787 ----------ARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRD--- 1838
                      .:....||:|..|..:|..     .|:::|:.:............::.:|.:   
Zfish  1529 LEKVRKQLEQEKQEIQTALEEAEGSLEHE-----EGKILRAQLEFNQVKADIERKLSEKDEEMEQ 1588

  Fly  1839 --RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKL--------SSEMRQRLE------ 1887
              |..|.|...:||.:.::...::..:...:...|.:.::::        :||.:::|:      
Zfish  1589 AKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGLHGHL 1653

  Fly  1888 ---QVTAGHSVRSTVSTKS-----EQR---APAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVV 1941
               |:....::|.....|.     |:|   ..|:|::.|.|:.|.:.|...|...        ::
Zfish  1654 KDAQLQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQE--------LM 1710

  Fly  1942 D----------SHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPA 1996
            |          .:.::..|.:::||..:                                   ..
Zfish  1711 DVSERVQLLHSQNTSLLNQKKKLEGDNT-----------------------------------QL 1740

  Fly  1997 PPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLED--H 2059
            .....::....|:.|.:.....:.:.::.|.:     ::|:||  :...::|..:....::|  |
Zfish  1741 QTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-----KKEQDT--SAHLERMKKNMEQTIKDLQH 1798

  Fly  2060 SASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVE-GPASGSGSEKEREKRERERERL 2123
            ....:..: |.:..:::..:..||.|:.|         :||| .....|.|.|...|.||   |:
Zfish  1799 RLDEAEQI-AMKGGKKQVQKLESRVRELE---------SEVEMEQRKASDSVKGVRKYER---RI 1850

  Fly  2124 YEIR-QVERERESHKVYQPAPPRVIQ---ASMDTTGGHRREDRTGGLATFRTHMAQKYEHE---- 2180
            .|:. |.|.:|::....|....: :|   .|...|.....|.....|..||     |.:||    
Zfish  1851 KELTYQTEEDRKNLARLQDLVDK-LQLKVKSYKRTAEEAEEQANSNLGKFR-----KLQHELDEA 1909

  Fly  2181 ----------------RKRKSSASSGMREE 2194
                            :.|.|.:..|..||
Zfish  1910 EERADIAESQVNKLRAKSRDSGSKKGADEE 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 258/714 (36%)
MYSc_Myo15 169..828 CDD:276838 251/694 (36%)
MyTH4 1014..1171 CDD:295320 20/159 (13%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
smyhc2NP_001096096.2 Myosin_N 35..72 CDD:280832
Myosin_head 87..769 CDD:278492 257/706 (36%)
MYSc_class_II 99..769 CDD:276951 251/694 (36%)
Myosin_tail_1 849..1926 CDD:279860 226/1428 (16%)
RILP-like 964..1097 CDD:304877 42/264 (16%)
mycoplas_twoTM 1184..>1321 CDD:275320 31/161 (19%)
MIT_CorA-like <1298..>1410 CDD:294313 22/123 (18%)
COG6 1375..>1508 CDD:303003 24/178 (13%)
TMPIT 1458..>1563 CDD:285135 16/113 (14%)
TMPIT 1743..>1828 CDD:285135 14/101 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.000

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