Protein Alignment Myo10A and smyhc2

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: NP_001096096.2
• Gene: smyhc2 / 100124599
• ZFINID: ZDB-GENE-070822-12
• Length: 1939
• Species: Danio rerio
• Alignment Length: 2236
• Identity: 500/2236 - (22%)
• Similarity: 859/2236 - (38%)
• Gaps: 581/2236 - (25%)

  Fly   157 VEDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSL 221
            :|||.:...|||.::|:||:.||...:|||::|...:.|||||..| .|..||...|.|:.....
Zfish    87 IEDMAMFTFLHEPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLP-VYNQEVVVAYRGKKRTEA 150

  Fly   222 PPHLFAIGAAAHAALPSP---QVVVISGESGSGKTESTKLVMQYLA--AVVPGG-----GSASAV 276
            |||:|:|...|:..:.|.   |.|:|:||||:|||.:||.|:||.|  |..|||     ......
Zfish   151 PPHIFSISDNAYQYMLSDRENQSVLITGESGAGKTVNTKRVIQYFASIAAAPGGKKDPSQEKKGT 215

  Fly   277 ITEQILEAAPLLEAFGNARTARNDNSSRFGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGE 340
            :.:||::..|.|||||||:|.||||||||||::.::| .||.:..|.|..|||||||:..|...|
Zfish   216 LEDQIIQCNPALEAFGNAKTIRNDNSSRFGKFIRIHFGVSGKLSSADIETYLLEKSRVTYQLKAE 280

  Fly   341 RNYHVFYELLGGLSETERSKYGLLE-------ADKYFYLNQGATDCAS--GRVDWESLQGAMQVL 396
            |:||:||::|      .:.|..|||       ...|.|::||.|..||  .|.:..:...|..||
Zfish   281 RDYHIFYQIL------SQRKPELLEMLLITNNPYDYSYISQGETQVASIDDRDELIATDEAFDVL 339

  Fly   397 GVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHRALTS 461
            |.::.|:..|.::..|::|.||:.|.::|   .:|..|.....:....|:|:.:::..|.:.|..
Zfish   340 GFTQEEKNSIYKLTGAIMHYGNMKFKQKQ---REEQAEADGTEDADKVAYLMGLNSADLIKGLCH 401

  Fly   462 RTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIF 524
            ...:...|.:.....:.|...:..|.||::|..:|.|:|.|||   |...|....:  |.:|||.
Zfish   402 PRVKVGNEWVTKGQNVQQVYYSIGALAKSVYEKMFLWMVVRIN---QSLDTKQPRQYFIGVLDIA 463

  Fly   525 GFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPV 589
            |||....|:|||||||:.||.||.:||.|:|.|||.||.:|.:||..:.:..:|.....|.:||:
Zfish   464 GFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLQACIELIEKPM 528

  Fly   590 GICHLLDDESNFPRATDLSFLEKCHYNH-ALSELYARPRI--GAQE--FGVTHYAGQVWYCVDGF 649
            ||..:|::|..||:|:|.:|..|.:.|| ..:..:.:|||  |..|  |.:.||||.|.|.:..:
Zfish   529 GIMSILEEECMFPKASDATFKAKLYDNHLGKNPNFQKPRIVKGRPEAHFALVHYAGTVDYNISNW 593

  Fly   650 LDKNRDALRGDVLELLASSRLPLVGELTKQLRAQRDA-------GKTLPKGSNGRFVTMKPRTPT 707
            |.||:|.|...|:.|...|.|.|:|.|.........|       |....|||:.:         |
Zfish   594 LVKNKDPLNETVVGLFQKSTLKLLGTLFANYAGAESADSGGKGKGGAKKKGSSFQ---------T 649

  Fly   708 VAARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPV 772
            |:|...::|.:|:.::...||.||||:.||:.|....|:.|.|:.|||..|:|:.|:|.::|:|.
Zfish   650 VSALHRENLNKLMTNLRSTHPHFVRCLIPNETKTPGAMENPLVMHQLRCNGVLEGIRICRKGFPN 714

  Fly   773 RLRFQHFVERYRHLLPSPLARG--TPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRAL 835
            |:.:..|.:|||.|.||.:..|  ...::....||.::   .::...|:||.|:||.:..|...|
Zfish   715 RILYGDFKQRYRILNPSAIPEGQFIDNKKGAEKLLGSL---DIDHNQYKLGHTKVFFKAGLLGTL 776

  Fly   836 ESGRTERLRRAAVSVQRHVRGMLVR---RQLARRQAAATRLQ---------ARWRGQRAQQRYER 888
            |..|.:||......:|...||:|.|   :::..|:.:...:|         ..|...:...:.:.
Zfish   777 EEMRDDRLALIITGIQARARGILSRIEFQKIVERRDSLLVIQWNVRAFMGVKNWPWMKLYFKIKP 841

  Fly   889 LRKGALTAQRLWRGRQARRRVQQLRSDHRRRQEA-REAAQRAREAREAKQAVLERSQLSYLDIPA 952
            |.|.|          :..:.:..::.:..:.:|| .::..|.:|..|...::|:......|.:.:
Zfish   842 LLKTA----------ETEKEMANMKEEFTKLKEAYAKSEARKKELEEKMVSLLQEKNDLQLAVQS 896

  Fly   953 E---LAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQP 1014
            |   ||....:.:|         |:|          |.:|....:.:.:           .||:.
Zfish   897 EQDNLADAEERCEG---------LIK----------SKIQFEAKVKELT-----------ERLED 931

  Fly  1015 RREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALEGA---KEKLLADYIVHKALSSRGLR 1076
            ..| :.|.|:    ::.:..:|..:..|..:   :|..|..|   |||...:..|..........
Zfish   932 EEE-MNAELV----AKKRKLEDECSELKKDI---DDLELTLAKVEKEKHATENKVKNLTEEMAAL 988

  Fly  1077 DEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSKYLMRFVDDEAPESLRPLLLRQL 1141
            |||:.:|..:...|                                                 |.
Zfish   989 DEIIAKLTKEKKAL-------------------------------------------------QE 1004

  Fly  1142 LRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAAL 1206
            ..||                                     ||.|..|:...|::.|..:  |.|
Zfish  1005 AHQQ-------------------------------------TLDDLQSEEDKVNTLTKAK--AKL 1030

  Fly  1207 AVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELCPAFPAPRSDLLRSGAKFARTTLPD 1271
            .                  ||:.|..|     .|..||::       |.||.|     |:..|..
Zfish  1031 E------------------QQVDDLEG-----SLEQEKKI-------RMDLER-----AKRKLEG 1060

  Fly  1272 AVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRS----SALNERYFEREPSPGPGQGSSTGQAK 1332
            .:|.         |.....|:..:::...|.|.:.    |.||.:..:.:        :...|.:
Zfish  1061 DLKL---------TQENLMDLENDKQQMEERLKKKDFEISQLNSKIEDEQ--------ALEAQLQ 1108

  Fly  1333 SRSKSLDDLLAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERL--APVGKDTGPRYQKSQH 1395
            .:.|.|...:.          :.:|.|               .|||.  |.|.|......::.:.
Zfish  1109 KKLKELQARIE----------ELEEEL---------------EAERAARAKVEKQRADLSRELEE 1148

  Fly  1396 AGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEA----PSLASHVRRVRVPSQASDVDQFLDD 1456
            ...|...|...:.:....:|...|.......|..||    .:.||.:|:....| .||:.:.:|:
Zfish  1149 ISERLEEAGGATAAQIEMNKKREAEFQKLRRDLEEATLQHEATASTLRKKHADS-VSDLGEQIDN 1212

  Fly  1457 LFSPVLDGSLDELSDARSLAASIRGGSYEQENEAE-SEID-DLDDYINDIFQPIPLVQNLEKL-- 1517
            |                        ...:|:.|.| ||:. :|||.::::.|.:....||||:
Zfish  1213 L------------------------QRVKQKLEKEKSELRLELDDVVSNMEQIVKAKANLEKMCR 1253

  Fly  1518 TSKDQLAAI----------------------IKGGGVASKPEERD---------EESEIEDLDDY 1551
            |.:||::..                      .:.|.::.:.||:|         ::|..:.::|.
Zfish  1254 TLEDQMSEYRTKAEEGQRTINDFTMQKAKLQTENGELSRQLEEKDSLVSQLTRGKQSYTQQIEDL 1318

  Fly  1552 INELFEPIPVAEGL-DKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQ-QQV 1614
            ..:|.|.:.....| ..:.|..|.|..:|.....:......|...|.:...|.......|: ..:
Zfish  1319 KRQLEEEVKAKNALAHAVQSARHDAELLREQYEEEQEAKAELQRSLSKANSEVAQWRTKYETDAI 1383

  Fly  1615 QRAFLQSAMAQNLQIQQQLLAQNQALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPPQSP 1679
            ||       .:.|:..::.|||.     |...:.|..|.|..         .|||.      ::.
Zfish  1384 QR-------TEELEEAKKKLAQR-----LQDAEEAVEAVNAK---------CSSLE------KTK 1421

  Fly  1680 MRMKATRSSLVVMESLQPPPPPPPPPMPPPLECKDPSETRHFLDPYGRAKTVRIGKWRWPPPQDE 1744
            .|::.....|:|                   :.:..:.....||...|.....:.:|:....:.:
Zfish  1422 HRLQNEIEDLMV-------------------DVERSNAAAAALDKKQRNFDKVLAEWKQKYEESQ 1467

  Fly  1745 PQFQTEE--------DFFAFK------------MRQHQRKTTPQAQHHQMTSNGGMMESGPG--- 1786
            .:.::.:        :.|..|            |::..:..  |.:...:|...|  |||..
Zfish  1468 TELESAQKESRSLSTELFKLKNSYEESLDHLESMKRENKNL--QEEISDLTEQLG--ESGKNIHE 1528

  Fly  1787 ----------ARGASATAIEWEEFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRD--- 1838
                      .:....||:|..|..:|..     .|:::|:.:............::.:|.:
Zfish  1529 LEKVRKQLEQEKQEIQTALEEAEGSLEHE-----EGKILRAQLEFNQVKADIERKLSEKDEEMEQ 1588

  Fly  1839 --RETQDVGQPMQSVVTTKLAKKSFEIGADRPPPGSVGKLKL--------SSEMRQRLE------ 1887
              |..|.|...:||.:.::...::..:...:...|.:.::::        :||.:::|:
Zfish  1589 AKRNQQRVVDTLQSSLESETRSRNEALRLKKKMEGDLNEMEIQLSQANRQASEAQKQLKGLHGHL 1653

  Fly  1888 ---QVTAGHSVRSTVSTKS-----EQR---APAKLEDTRKLMLQQQLGGLFASVSGGNSGPGGVV 1941
               |:....::|.....|.     |:|   ..|:|::.|.|:.|.:.|...|...        ::
Zfish  1654 KDAQLQLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQE--------LM 1710

  Fly  1942 D----------SHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAPPA 1996
            |          .:.::..|.:::||..:                                   ..
Zfish  1711 DVSERVQLLHSQNTSLLNQKKKLEGDNT-----------------------------------QL 1740

  Fly  1997 PPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQQMISSHHLHLED--H 2059
            .....::....|:.|.:.....:.:.::.|.:     ::|:||  :...::|..:....::|  |
Zfish  1741 QTEVEEAVQECRNAEEKAKKAITDAAMMAEEL-----KKEQDT--SAHLERMKKNMEQTIKDLQH 1798

  Fly  2060 SASSSPAVAAWEQAERERSRSRSRSRDREDYSESVWDRAEVEGPASGSGSEKEREKRERERERLY 2124
            ....:..: |.:..:::..:..||.|:.|       ...|:|...:....:..|:...|.:|..|
Zfish  1799 RLDEAEQI-AMKGGKKQVQKLESRVRELE-------SEVEMEQRKASDSVKGVRKYERRIKELTY 1855

  Fly  2125 EIRQVERERESHKVYQPAPPRVIQ---ASMDTTGGHRREDRTGGLATFRTHMAQKYEHE------ 2180
               |.|.:|::....|....: :|   .|...|.....|.....|..||     |.:||
Zfish  1856 ---QTEEDRKNLARLQDLVDK-LQLKVKSYKRTAEEAEEQANSNLGKFR-----KLQHELDEAEE 1911

  Fly  2181 ----------RKRKSSASSGMREELD 2196
                      :.|..|..||.::..|
Zfish  1912 RADIAESQVNKLRAKSRDSGSKKGAD 1937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	251/694 (36%)
		PTZ00121	<828..>943	CDD:173412	23/127 (18%)
		MyTH4	1014..1171	CDD:470587	20/159 (13%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	14/66 (21%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
smyhc2	NP_001096096.2	Myosin_N	32..76	CDD:460670
		MYSc_class_II	99..769	CDD:276951	251/694 (36%)
		Myosin_tail_1	849..1926	CDD:460256	222/1426 (16%)