DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myo9aa

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_021333664.1 Gene:myo9aa / 100006612 ZFINID:ZDB-GENE-080424-5 Length:2590 Species:Danio rerio


Alignment Length:2973 Identity:664/2973 - (22%)
Similarity:1070/2973 - (35%) Gaps:1040/2973 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            :|:..|.||:|.:||.|||.|:.:..|||:.|||||.:||:|..| .|..:..|.|....||.|.
Zfish   150 DDLCNLPDLNEKTLLDNLRSRFKQEKIYTYVGSILIVINPFKFLP-IYNPKYVKMYDNHQLGKLE 213

  Fly   223 PHLFAIG-AAAHAALPS--PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEA 284
            ||::|:. .|.||.|.|  .|.:|||||||||||:||..::.:|.|:...|.::.  :.:.||.|
Zfish   214 PHIYAVADVAYHAMLQSRQNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASG--VEQIILGA 276

  Fly   285 APLLEAFGNARTARNDNSSRFGKYLEV-YFKSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYE 348
            .|:|||||||:||.|:|||||||:::| |.:||.:.||.:.:|||||||:|.|...||||||||.
Zfish   277 GPVLEAFGNAKTAHNNNSSRFGKFIQVNYQESGTVRGAYVEKYLLEKSRLVYQEHNERNYHVFYY 341

  Fly   349 LLGGLSETERSKYGLLEADKYFYLNQ----------------GATDC--ASG---RVDWESLQGA 392
            ||.|.||.||:.:.|.:.::|.||||                ...||  ..|   :.|:|.||.|
Zfish   342 LLAGTSEEERTAFHLKKPEEYHYLNQMTKKPHRPHWGNYYENEPQDCFTVEGEDLKHDFERLQLA 406

  Fly   393 MQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHR 457
            |:::|.....|:.|..:|:|:|||||:.:.::..|  .:.:::.:...:...:.||.:..:.|..
Zfish   407 MEMVGFLPTTRKQIFSLLSAILHLGNIRYKKKIYR--DDSIDICNPEVLPVVSELLEVKEEMLFE 469

  Fly   458 ALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRIN-SIVQKGGTHDAHR---I 518
            |||:|.|....|:|..|..:.:|...||:.||:||:.||:|:|.||| :::.:....::.:   |
Zfish   470 ALTTRKTVTVGEKLIVPYKLAEAGTVRDSMAKSLYSALFDWIVFRINHALLNQRDLEESAKILSI 534

  Fly   519 SILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHL 583
            .:||||||||...|||||.|||:|||.||.|||:|:|||||.||..|.:.|..:.:.||...|.|
Zfish   535 GVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRAEGITWHNIDYIDNTSCITL 599

  Fly   584 LAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDG 648
            ::|||..:.||||:|.|||:||:.:.|:|....|..:.....|.:....|.:.||||:|.|.|..
Zfish   600 ISKKPTALLHLLDEECNFPQATNQTLLDKFKRQHEGNSYIEFPAVMEPAFIIKHYAGKVKYGVKD 664

  Fly   649 FLDKNRDALRGDVLELLASSR----LPLVG----------ELTKQLRAQ---RDAGK-------- 688
            |.:||.|.:|.|::.||.||:    ..|:|          .|....||.   |||||        
Zfish   665 FREKNTDHMRPDIVALLKSSKNAFICGLIGIDPVATFRWAVLRAYFRAMVAFRDAGKRHVEKRSG 729

  Fly   689 ---------------------------------------------------------TLP----- 691
                                                                     |.|     
Zfish   730 HDAAAPAVKSVDSFSFLHHPVHQRSLEILQRCKEEKYIQHACFSGSPPLSPHWSPSSTPPAHCTH 794

  Fly   692 --------------------------------------KGSNGR-------------------FV 699
                                                  :|.|||                   |:
Zfish   795 SFFDDSGLTIGLLDGGVNRRNPRTPLSDLQGSNAINQREGWNGRPGRQNRLSSFGSFSEEEGIFI 859

  Fly   700 T---------------------MKP-----------------------------------RTPTV 708
            .                     |||                                   :.|::
Zfish   860 NSTSSKLLERAHGILMRNKNYKMKPSLPKHLLDVKSLKYLSNLTLQDRITKSLLHLHKKKKPPSI 924

  Fly   709 AARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVR 773
            :|:|..||.:|::::|:..|:||:||:.|.||..||.:...||:||||.|||:|::|||.||.::
Zfish   925 SAQFQASLNKLMETLGQSQPYFVKCIRSNSEKLPLRFNDSLVLRQLRYTGMLETVRIRQSGYSIK 989

  Fly   774 LRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESG 838
            ..||.|...:..|||....:.:  :|..|..|:.:..| .||  :|:|.|.|||||...:.|:..
Zfish   990 YTFQDFARHFHVLLPEGSNQAS--QEAIRQYLQQVDLT-PEG--FQVGRTMVFLREIERQRLQDL 1049

  Fly   839 RTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR-----YE-RLRKGALTA- 896
            ..:.:....|.:||..|.:|.|:...|.:.||.::|..||..::.||     |: |:::||:.. 
Zfish  1050 LHKEVLSRIVYLQRRFRALLERKNFLRVRQAACQIQNWWRSCQSLQRDSQLEYDMRVQEGAVVCI 1114

  Fly   897 QRLWRGRQARRRV-----------------QQLRSDHR-----RRQEAREAAQRAREAREAKQAV 939
            |..|||.:.|||:                 :|.|:..:     ||..|||...|.|:|....|||
Zfish  1115 QSAWRGFRERRRLLLWREASVLIQRTWRLYRQRRAALQIQTAWRRHRARELFLRQRDATIRLQAV 1179

  Fly   940 ------------LERSQLSYLDIP---AELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQ 989
                        |::.:|....:|   |.|.....||                            
Zfish  1180 GRGYLARQRFRELQKQRLKITHLPNGKASLLTEEDKL---------------------------- 1216

  Fly   990 LPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALE 1054
              ||:|                       :.|.:| ..:..:||              .:.:||.
Zfish  1217 --EDMG-----------------------LDASML-EDSFEEQD--------------RSKQALS 1241

  Fly  1055 GAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSK 1119
            .|.|           .|..|:.:|:.|::   :.|:.|                  .|||     
Zfish  1242 SAVE-----------ASGAGVLEEMEVEM---MEGMAP------------------AQPS----- 1269

  Fly  1120 YLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTL 1184
                      ||    :.:|:                                       .|.||
Zfish  1270 ----------PE----VTIRE---------------------------------------RPRTL 1281

  Fly  1185 PDEASQTVAV-DSWTSCE-EAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELC 1247
            .|...:|.|. :|....| |.|..::..|.|.|.|.|...|:.:         :.|:|::|    
Zfish  1282 EDPNQRTRAKRESRRMRELEQAKFSLELLKVRSTGGTSPSDERR---------WSMELVSE---- 1333

  Fly  1248 PAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNER 1312
                            .|.|           |...|.:.|.|        .|.|||:    :::.
Zfish  1334 ----------------IAHT-----------PQGTPDSQSSK--------GSFELLN----IDDY 1359

  Fly  1313 YFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVP-----VPTDCDSQEPLHTLGLSESRLNDR 1372
            :.::.|...|                :||.:...||     :|:|..:.:.|.            
Zfish  1360 FKDKAPCAEP----------------EDLGSPSSVPDQHNVLPSDTSTPDILS------------ 1396

  Fly  1373 YHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASH 1437
                   .|..:...||.|                    |:....|       :..||:.||.  
Zfish  1397 -------KPDDQSKPPRMQ--------------------YSLPTFY-------TPPSESSSLV-- 1425

  Fly  1438 VRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYIN 1502
                 :.|..:.|....|.|..|    |.|:....|                             
Zfish  1426 -----IKSTTNSVTPCPDGLSKP----SKDKKESTR----------------------------- 1452

  Fly  1503 DIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLD--DYINELFEPIPVAEGL 1565
               :|:.:|.:::|.|..:                    |::::.|:  |...:..||...|:  
Zfish  1453 ---RPMVVVISMQKETLLN--------------------EADVKPLEVKDSAAQTSEPPSPAQ-- 1492

  Fly  1566 DKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQN--LQ 1628
                            .||||:   .:|.:|.:|..|.|......:||.::..::....|.  |:
Zfish  1493 ----------------PSTDSS---YVLEKLEKLNEEKEERQKHQRQQNEKEMMEQIRQQTHILE 1538

  Fly  1629 IQQQLLAQN-------QALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPP----QSPMRM 1682
            .|::.|.||       |..:||...:.:...::...:..|||       |:.|.|    |.|.|.
Zfish  1539 EQRRNLVQNEREKLEKQRAETLRRIEQSRQESSGGRTDRPAP-------IAQPEPDLTSQRPARE 1596

  Fly  1683 KATRSSLVVMESLQPPPPPPPPPMPPPLECKD-PSETRHF---------LDPYGRAKTVRIGKWR 1737
            |.                      ..||..:| |.:.::.         |:..|.....||.|  
Zfish  1597 KD----------------------GAPLILRDRPKDAQNLAEGWAPKLTLESRGDEARSRINK-- 1637

  Fly  1738 WPPPQDEPQFQTEED----FFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWE 1798
             .|..........|.    ||:.|.:....|......:.:.|         |||:. ..:.:.::
Zfish  1638 -KPSNQNVNISMSERPGNIFFSPKTKIAYSKLNKDLANQEKT---------PGAQN-EVSLLGYK 1691

  Fly  1799 EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEI 1863
            ..:.|...|.....::.|:  |.:..|.::::.......:.|..:.  |:.:  .|.|.|:..|.
Zfish  1692 STKTEVGRPGHKKARMART--RSDFLTRSSSTQGEGESEEEEYDET--PLYA--GTPLPKQDSEE 1750

  Fly  1864 GADRPPPGSVGKLKLSS-EMRQRLEQVTAG----HSVRSTV----STKSEQRAPAKLEDTRKLML 1919
            .|..........|..:: |.:.|.:.:.:|    |..|...    ..:.:.|...|.::..|...
Zfish  1751 SAVEACHSDSEMLTTAAEEQKNRCKTLPSGELGKHDTRKNSHGDGRVRGKMRFWGKAKNAEKKSS 1815

  Fly  1920 QQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPP 1984
            :::|      :.|.::..|...::...:...:||    ||||.:|..     .|.........|.
Zfish  1816 RERL------LCGSDTLEGDYTEATLLMEEGVER----LSPPHSPDL-----TLQREFKENKEPS 1865

  Fly  1985 PPI---RPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQ 2046
            |.:   |...::..|..|........:......||::.:..::|:......:..::||...|..:
Zfish  1866 PKVKRRRSVKISSVALEPVQWQNDALQILTCTSDYKSMNDFLMKKITDLDTEDGKKDTMVDVVFK 1930

  Fly  2047 QMISSHHLHLEDHSASSSPAV------------AAWEQAERERSRSRSRSRDREDYSES---VW- 2095
            :.:....::: .:|.|::.|:            |.:||...:..|...|     |:|||   || 
Zfish  1931 KALKEFRVNI-FNSYSTALAMDDGKSIRYKDLYALFEQILEKNMRQEQR-----DWSESPVKVWV 1989

  Fly  2096 -------DRAEVE----GPASGSGSEKEREKRERERERLYEIRQVERERESH--KVYQPAPPRVI 2147
                   |....|    ..:.|...:.:|:||.::...:.|      |...|  |..|.:.|...
Zfish  1990 NTFKVFLDEFMTEHKPLDSSLGKAPKPDRKKRRKKDTDVVE------EHNGHIFKSTQYSIPTYC 2048

  Fly  2148 QA------SMD--------------------TTGGHRREDRTGGLATFRTHMAQKYEHERK---- 2182
            :.      .||                    ||...::.|.......|...:::....||.    
Zfish  2049 EYCSSLIWMMDKACVCKLCRYACHRKCCQKMTTKCSKKYDPELSSRQFGVELSRLTNDERTVPLV 2113

  Fly  2183 -------------------RKSSASSGMRE------------ELDSMHMTTPPPVIVP--APVPP 2214
                               |||.:::.::|            .||..::.....|...  ..:|.
Zfish  2114 VEKLVNYIEMHGLYTEGIYRKSGSTNKIKELKQGLDTDVNGVNLDDYNINVIASVFKQWLRDLPN 2178

  Fly  2215 PSST---------SPGL----GVVSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPHEPIGPP 2266
            |..|         :.||    .|:.||.........|...|..|:.:.| ||             
Zfish  2179 PLMTFELYEEFLRAMGLQDKKEVIRGVYSVIDQLSRTHLNTLERLIFHL-VR------------- 2229

  Fly  2267 VAL----DLLFAQVLGDVFGVTPCLRITPQEKSSALNMLHGHGVSVDTLSNRNGSGAGGGGNGGQ 2327
            :||    :.:.|..|..||  .||:...|.              ::|.|.:..        :.|:
Zfish  2230 IALQEETNRMSANALAIVF--APCILRCPD--------------TIDPLRSVQ--------DIGK 2270

  Fly  2328 VRALVKRHLVDMARDWPLYFARLFAVQGAPLYPDVSIM----GVSHSGLYLARRDADYLIVVQAI 2388
            ..|.|:..:.:....   |.|||         .|::.:    ..:.|.|...||....:|:  |:
Zfish  2271 TTACVELIICEQMNK---YRARL---------KDINTLEFAENKAKSRLTFIRRSMKPVII--AV 2321

  Fly  2389 SFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMVTTFVQEFRKSQSKASTLSSGARAA 2453
            .|      :::.|.||...::|.||. .:|..|              :|......|..|..|...
Zfish  2322 RF------MSITRSAAASGSMRKGKG-PVHRLR--------------YRTPSPPTSPRSPTAPEV 2365

  Fly  2454 AQTLNVPLERLESRQAHAQRNEHGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQ 2518
            .|                   :.|.:...|..|..:|.::   ..||:::...:|....|:::::
Zfish  2366 MQ-------------------DSGEEEPGRDPEVSEQQQV---AMQQEEKVLTEQIESLQKEKEE 2408

  Fly  2519 L--EDAMEEQHMATDHQQQQQQQLG--------------------------------QQQGQQQR 2549
            |  |....|...:.|...:.:..:|                                :.:|:.:|
Zfish  2409 LTFEMLALEPRASDDETLESEASIGTADSSENLNVDSEGATSDYSERGPALAATRPKKSEGKSRR 2473

  Fly  2550 FL-KQQSYLHS-------ARKSNAGQQPSSLTNGQVHHQEQMLQQQQQQSQSL----PHHDLDAN 2602
            .| ||...|.|       :..|::..||:|.|:       ::..:.:..|:.|    |...||  
Zfish  2474 VLRKQPESLDSIDSCSTVSSVSSSYMQPTSRTH-------KLSLRSKSPSKRLYLSSPSESLD-- 2529

  Fly  2603 YLQDESNGGTPPSVTKYSLLQFAMQHFRN-----DQLRDADRHHERHQ 2645
              |.|.:|...|        ||..:...|     .:|:.|....:||:
Zfish  2530 --QPEQDGEERP--------QFTSRGTFNPEKGKQRLQGAKSSPQRHR 2567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 302/906 (33%)
MYSc_Myo15 169..828 CDD:276838 294/887 (33%)
MyTH4 1014..1171 CDD:295320 20/156 (13%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myo9aaXP_021333664.1 UBQ 7..111 CDD:320785
MYSc_Myo9 161..1039 CDD:276836 294/887 (33%)
IQ 1145..1166 CDD:197470 7/20 (35%)
Activator_LAG-3 <1464..1574 CDD:331748 27/150 (18%)
C1_1 2035..2083 CDD:278556 8/47 (17%)
RhoGAP 2096..2281 CDD:295372 38/222 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4229
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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