Protein Alignment Myo10A and myo9aa

DIOPT Version :10

• Sequence 1: NP_001036269.2
• Gene: Myo10A / 32028
• FlyBaseID: FBgn0263705
• Length: 3145
• Species: Drosophila melanogaster
• Sequence 2: XP_068078215.1
• Gene: myo9aa / 100006612
• ZFINID: ZDB-GENE-080424-5
• Length: 2584
• Species: Danio rerio
• Alignment Length: 2951
• Identity: 674/2951 - (22%)
• Similarity: 1073/2951 - (36%)
• Gaps: 1002/2951 - (33%)

  Fly   158 EDMTLLDDLHEASLLWNLRLRYDKGLIYTFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLP 222
            :|:..|.||:|.:||.|||.|:.:..|||:.|||||.:||:|..| .|..:..|.|....||.|.
Zfish   150 DDLCNLPDLNEKTLLDNLRSRFKQEKIYTYVGSILIVINPFKFLP-IYNPKYVKMYDNHQLGKLE 213

  Fly   223 PHLFAIG-AAAHAALPS--PQVVVISGESGSGKTESTKLVMQYLAAVVPGGGSASAVITEQILEA 284
            ||::|:. .|.||.|.|  .|.:|||||||||||:||..::.:|.|:...|.::.  :.:.||.|
Zfish   214 PHIYAVADVAYHAMLQSRQNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASG--VEQIILGA 276

  Fly   285 APLLEAFGNARTARNDNSSRFGKYLEV-YFKSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYE 348
            .|:|||||||:||.|:|||||||:::| |.:||.:.||.:.:|||||||:|.|...||||||||.
Zfish   277 GPVLEAFGNAKTAHNNNSSRFGKFIQVNYQESGTVRGAYVEKYLLEKSRLVYQEHNERNYHVFYY 341

  Fly   349 LLGGLSETERSKYGLLEADKYFYLNQ----------------GATDC--ASG---RVDWESLQGA 392
            ||.|.||.||:.:.|.:.::|.||||                ...||  ..|   :.|:|.||.|
Zfish   342 LLAGTSEEERTAFHLKKPEEYHYLNQMTKKPHRPHWGNYYENEPQDCFTVEGEDLKHDFERLQLA 406

  Fly   393 MQVLGVSEGEREGIVRVLAAVLHLGNVYFHRRQLRHGQEGVEVGSDAEIKWAAHLLHISADGLHR 457
            |:::|.....|:.|..:|:|:|||||:.:.::..|  .:.:::.:...:...:.||.:..:.|..
Zfish   407 MEMVGFLPTTRKQIFSLLSAILHLGNIRYKKKIYR--DDSIDICNPEVLPVVSELLEVKEEMLFE 469

  Fly   458 ALTSRTTEARAERLHTPLGIDQALDARDAFAKALYAGLFNWLVSRIN-SIVQKGGTHDAHR---I 518
            |||:|.|....|:|..|..:.:|...||:.||:||:.||:|:|.||| :::.:....::.:   |
Zfish   470 ALTTRKTVTVGEKLIVPYKLAEAGTVRDSMAKSLYSALFDWIVFRINHALLNQRDLEESAKILSI 534

  Fly   519 SILDIFGFEDLAENSFEQLCINYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHL 583
            .:||||||||...|||||.|||:|||.||.|||:|:|||||.||..|.:.|..:.:.||...|.|
Zfish   535 GVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRAEGITWHNIDYIDNTSCITL 599

  Fly   584 LAKKPVGICHLLDDESNFPRATDLSFLEKCHYNHALSELYARPRIGAQEFGVTHYAGQVWYCVDG 648
            ::|||..:.||||:|.|||:||:.:.|:|....|..:.....|.:....|.:.||||:|.|.|..
Zfish   600 ISKKPTALLHLLDEECNFPQATNQTLLDKFKRQHEGNSYIEFPAVMEPAFIIKHYAGKVKYGVKD 664

  Fly   649 FLDKNRDALRGDVLELLASSR----LPLVG----------ELTKQLRAQ---RDAGK-------- 688
            |.:||.|.:|.|::.||.||:    ..|:|          .|....||.   |||||
Zfish   665 FREKNTDHMRPDIVALLKSSKNAFICGLIGIDPVATFRWAVLRAYFRAMVAFRDAGKRHVEKRSG 729

  Fly   689 ---------------------------------------------------------TLP----- 691
                                                                     |.|
Zfish   730 HDAAAPAVKSVDSFSFLHHPVHQRSLEILQRCKEEKYIQHACFSGSPPLSPHWSPSSTPPAHCTH 794

  Fly   692 --------------------------------------KGSNGR-------------------FV 699
                                                  :|.|||                   |:
Zfish   795 SFFDDSGLTIGLLDGGVNRRNPRTPLSDLQGSNAINQREGWNGRPGRQNRLSSFGSFSEEEGIFI 859

  Fly   700 T---------------------MKP-----------------------------------RTPTV 708
            .                     |||                                   :.|::
Zfish   860 NSTSSKLLERAHGILMRNKNYKMKPSLPKHLLDVKSLKYLSNLTLQDRITKSLLHLHKKKKPPSI 924

  Fly   709 AARFADSLQQLLQSMGRCHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVR 773
            :|:|..||.:|::::|:..|:||:||:.|.||..||.:...||:||||.|||:|::|||.||.::
Zfish   925 SAQFQASLNKLMETLGQSQPYFVKCIRSNSEKLPLRFNDSLVLRQLRYTGMLETVRIRQSGYSIK 989

  Fly   774 LRFQHFVERYRHLLPSPLARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESG 838
            ..||.|...:..|||....:.:  :|..|..|:.:..| .||  :|:|.|.|||||...:.|:..
Zfish   990 YTFQDFARHFHVLLPEGSNQAS--QEAIRQYLQQVDLT-PEG--FQVGRTMVFLREIERQRLQDL 1049

  Fly   839 RTERLRRAAVSVQRHVRGMLVRRQLARRQAAATRLQARWRGQRAQQR-----YE-RLRKGALTA- 896
            ..:.:....|.:||..|.:|.|:...|.:.||.::|..||..::.||     |: |:::||:..
Zfish  1050 LHKEVLSRIVYLQRRFRALLERKNFLRVRQAACQIQNWWRSCQSLQRDSQLEYDMRVQEGAVVCI 1114

  Fly   897 QRLWRGRQARRRV-----------------QQLRSDHR-----RRQEAREAAQRAREAREAKQAV 939
            |..|||.:.|||:                 :|.|:..:     ||..|||...|.|:|....|||
Zfish  1115 QSAWRGFRERRRLLLWREASVLIQRTWRLYRQRRAALQIQTAWRRHRARELFLRQRDATIRLQAV 1179

  Fly   940 ------------LERSQLSYLDIP---AELAFIYSKLQGWSPPHGDRHLVKVLGTVPGPPSSAVQ 989
                        |::.:|....:|   |.|.....||
Zfish  1180 GRGYLARQRFRELQKQRLKITHLPNGKASLLTEEDKL---------------------------- 1216

  Fly   990 LPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDFQDALAVFKLILRWSNDKALE 1054
              ||:|                       :.|.:| ..:..:||              .:.:||.
Zfish  1217 --EDMG-----------------------LDASML-EDSFEEQD--------------RSKQALS 1241

  Fly  1055 GAKEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGEATRLWQLLGQCLCCFQPSAAFSK 1119
            .|.|           .|..|:.:|:.|::   :.|:.|                  .|||
Zfish  1242 SAVE-----------ASGAGVLEEMEVEM---MEGMAP------------------AQPS----- 1269

  Fly  1120 YLMRFVDDEAPESLRPLLLRQLLRQQGGGTSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTL 1184
                      ||    :.:|:                                       .|.||
Zfish  1270 ----------PE----VTIRE---------------------------------------RPRTL 1281

  Fly  1185 PDEASQTVAV-DSWTSCE-EAAALAVSSLGVASRGWTLVLDDGQQLTDSCGLDYVMDLIAEKELC 1247
            .|...:|.|. :|....| |.|..::..|.|.|.|.|...|:.:         :.|:|::|
Zfish  1282 EDPNQRTRAKRESRRMRELEQAKFSLELLKVRSTGGTSPSDERR---------WSMELVSE---- 1333

  Fly  1248 PAFPAPRSDLLRSGAKFARTTLPDAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNER 1312
                            .|.|           |...|.:.|.|        .|.|||:    :::.
Zfish  1334 ----------------IAHT-----------PQGTPDSQSSK--------GSFELLN----IDDY 1359

  Fly  1313 YFEREPSPGPGQGSSTGQAKSRSKSLDDLLAGDIVP-----VPTDCDSQEPLHTLGLSESRLNDR 1372
            :.::.|...|                :||.:...||     :|:|..:.:.|.
Zfish  1360 FKDKAPCAEP----------------EDLGSPSSVPDQHNVLPSDTSTPDILS------------ 1396

  Fly  1373 YHSAERLAPVGKDTGPRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMSDTSEAPSLASH 1437
                   .|..:...||.|                    |:....|       :..||:.||.
Zfish  1397 -------KPDDQSKPPRMQ--------------------YSLPTFY-------TPPSESSSLV-- 1425

  Fly  1438 VRRVRVPSQASDVDQFLDDLFSPVLDGSLDELSDARSLAASIRGGSYEQENEAESEIDDLDDYIN 1502
                 :.|..:.|....|.|..|    |.|:....|
Zfish  1426 -----IKSTTNSVTPCPDGLSKP----SKDKKESTR----------------------------- 1452

  Fly  1503 DIFQPIPLVQNLEKLTSKDQLAAIIKGGGVASKPEERDEESEIEDLD--DYINELFEPIPVAEGL 1565
               :|:.:|.:::|.|..:                    |::::.|:  |...:..||...|:
Zfish  1453 ---RPMVVVISMQKETLLN--------------------EADVKPLEVKDSAAQTSEPPSPAQ-- 1492

  Fly  1566 DKLTSKEHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGPALYQQQVQRAFLQSAMAQN--LQ 1628
                            .||||:   .:|.:|.:|..|.|......:||.::..::....|.  |:
Zfish  1493 ----------------PSTDSS---YVLEKLEKLNEEKEERQKHQRQQNEKEMMEQIRQQTHILE 1538

  Fly  1629 IQQQLLAQN-------QALQTLLSQQAAAAAANNSTSPPPAPPILSSLSISPPPP----QSPMRM 1682
            .|::.|.||       |..:||...:.:...::...:..|||       |:.|.|    |.|.|.
Zfish  1539 EQRRNLVQNEREKLEKQRAETLRRIEQSRQESSGGRTDRPAP-------IAQPEPDLTSQRPARE 1596

  Fly  1683 KATRSSLVVMESLQPPPPPPPPPMPPPLECKD-PSETRHF---------LDPYGRAKTVRIGKWR 1737
            |.                      ..||..:| |.:.::.         |:..|.....||.|
Zfish  1597 KD----------------------GAPLILRDRPKDAQNLAEGWAPKLTLESRGDEARSRINK-- 1637

  Fly  1738 WPPPQDEPQFQTEED----FFAFKMRQHQRKTTPQAQHHQMTSNGGMMESGPGARGASATAIEWE 1798
             .|..........|.    ||:.|.:....|......:.:.|         |||:. ..:.:.::
Zfish  1638 -KPSNQNVNISMSERPGNIFFSPKTKIAYSKLNKDLANQEKT---------PGAQN-EVSLLGYK 1691

  Fly  1799 EFEIESPTPPPMSGQLMRSSIRLETTTTTTTSAVNNRDRDRETQDVGQPMQSVVTTKLAKKSFEI 1863
            ..:.|...|.....::.|:  |.:..|.::::.......:.|..:.  |:.:  .|.|.|:..|.
Zfish  1692 STKTEVGRPGHKKARMART--RSDFLTRSSSTQGEGESEEEEYDET--PLYA--GTPLPKQDSEE 1750

  Fly  1864 GADRPPPGSVGKLKLSS-EMRQRLEQVTAG----HSVRSTV----STKSEQRAPAKLEDTRKLML 1919
            .|..........|..:: |.:.|.:.:.:|    |..|...    ..:.:.|...|.::..|...
Zfish  1751 SAVEACHSDSEMLTTAAEEQKNRCKTLPSGELGKHDTRKNSHGDGRVRGKMRFWGKAKNAEKKSS 1815

  Fly  1920 QQQLGGLFASVSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPP 1984
            :::|      :.|.::..|...::...:...:||    ||||.:|..     .|.........|.
Zfish  1816 RERL------LCGSDTLEGDYTEATLLMEEGVER----LSPPHSPDL-----TLQREFKENKEPS 1865

  Fly  1985 PPI---RPPSMAPPAPPPAPQSPPTARSPEPEPDYRTSSSQVVKEHVPAFIQRQERDTFGAVRQQ 2046
            |.:   |...::..|..|........:......||::.:..::|:......:..::||...|..:
Zfish  1866 PKVKRRRSVKISSVALEPVQWQNDALQILTCTSDYKSMNDFLMKKITDLDTEDGKKDTMVDVVFK 1930

  Fly  2047 QMISSHHLHLEDHSASSSPAV------------AAWEQAERERSRSRSRSRDREDYSES---VW- 2095
            :.:....::: .:|.|::.|:            |.:||...:..|...|     |:|||   ||
Zfish  1931 KALKEFRVNI-FNSYSTALAMDDGKSIRYKDLYALFEQILEKNMRQEQR-----DWSESPVKVWV 1989

  Fly  2096 -------DRAEVE----GPASGSGSEKEREKRERERERLYEIRQVERERESH--KVYQPAPPRVI 2147
                   |....|    ..:.|...:.:|:||.::...:.|      |...|  |..|.:.|...
Zfish  1990 NTFKVFLDEFMTEHKPLDSSLGKAPKPDRKKRRKKDTDVVE------EHNGHIFKSTQYSIPTYC 2048

  Fly  2148 QA------SMDTT--------GGHRR--EDRTGGLATFRTHMAQKYEHERKRKSSASSGMREELD 2196
            :.      .||..        ..||:  :..|       |..::||:.|   .||...|:  ||.
Zfish  2049 EYCSSLIWMMDKACVCKLCRYACHRKCCQKMT-------TKCSKKYDPE---LSSRQFGV--ELS 2101

  Fly  2197 SMHMTTPPPVIVPAPVPPPSSTSPGLGV-VSGVLMGSGSGGSTACLTYNRVPWKLRVRKEVFQPH 2260
            .:   |.....||..|....:.....|: ..|:...|||        .|::       ||:.|..
Zfish  2102 RL---TNDERTVPLVVEKLVNYIEMHGLYTEGIYRKSGS--------TNKI-------KELKQGL 2148

  Fly  2261 EPIGPPVALDLLFAQVLGDVFGVTPCLRITP------------------QEKSSALNMLHGHGVS 2307
            :.....|.||.....|:..||  ...||..|                  |:|...:..::.   .
Zfish  2149 DTDVNGVNLDDYNINVIASVF--KQWLRDLPNPLMTFELYEEFLRAMGLQDKKEVIRGVYS---V 2208

  Fly  2308 VDTLSNRNGSGAGGGGNGGQVRALVKR--HLVDMA--RDWPLYFARLFAVQGAPLY---PDVSIM 2365
            :|.||..:            :..|.:.  |||.:|  .:.....|...|:..||..   ||.
Zfish  2209 IDQLSRTH------------LNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILRCPDT--- 2258

  Fly  2366 GVSHSGLYLARRDADYLIVVQAISFGEIQSAVTLPRPAALQLNLRNGKHLALHAARAAAIQSMV- 2429
                         .|.|..||.|  |:..:.|.|  ....|:|        .:.||...|.::.
Zfish  2259 -------------IDPLRSVQDI--GKTTACVEL--IICEQMN--------KYRARLKDINTLEF 2298

  Fly  2430 --------TTFVQEFRKSQSKASTLSSGARAAAQTLNVPLERLESR-----------QAHAQRNE 2475
                    .||::...|....|....|..|:||.... |:.||..|           .|.....:
Zfish  2299 AENKAKSRLTFIRRSMKPVIIAVRFMSITRSAAAGKG-PVHRLRYRTPSPPTSPRSPTAPEVMQD 2362

  Fly  2476 HGVDGGSRQNEQLQQSELHHHLQQQQQQQQQQQHHQQQQQQQQL--EDAMEEQHMATDHQQQQQQ 2538
            .|.:...|..|..:|.::   ..||:::...:|....|:::::|  |....|...:.|...:.:.
Zfish  2363 SGEEEPGRDPEVSEQQQV---AMQQEEKVLTEQIESLQKEKEELTFEMLALEPRASDDETLESEA 2424

  Fly  2539 QLG--------------------------------QQQGQQQRFL-KQQSYLHS-------ARKS 2563
            .:|                                :.:|:.:|.| ||...|.|       :..|
Zfish  2425 SIGTADSSENLNVDSEGATSDYSERGPALAATRPKKSEGKSRRVLRKQPESLDSIDSCSTVSSVS 2489

  Fly  2564 NAGQQPSSLTNGQVHHQEQMLQQQQQQSQSL----PHHDLDANYLQDESNGGTPPSVTKYSLLQF 2624
            ::..||:|.|:       ::..:.:..|:.|    |...||    |.|.:|...|        ||
Zfish  2490 SSYMQPTSRTH-------KLSLRSKSPSKRLYLSSPSESLD----QPEQDGEERP--------QF 2535

  Fly  2625 AMQHFRN-----DQLRDADRHHERHQ 2645
            ..:...|     .:|:.|....:||:
Zfish  2536 TSRGTFNPEKGKQRLQGAKSSPQRHR 2561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo10A	NP_001036269.2	MYSc_Myo15	169..828	CDD:276838	294/887 (33%)
		PTZ00121	<828..>943	CDD:173412	42/155 (27%)
		MyTH4	1014..1171	CDD:470587	20/156 (13%)
		Ubl1_cv_Nsp3_N-like	1178..>1245	CDD:475130	19/68 (28%)
		MyTH4	2704..2810	CDD:459939
		FERM_B-lobe	2920..3025	CDD:271216
		FERM_C_MyoXV	3029..3138	CDD:270022
myo9aa	XP_068078215.1	RA_Myosin-IXa	16..111	CDD:340736
		MYSc_Myo9	161..1039	CDD:276836	294/887 (33%)
		IQ	1145..1166	CDD:197470	7/20 (35%)
		Activator_LAG-3	<1464..1574	CDD:151935	27/150 (18%)
		C1_Myosin-IXa	2030..2087	CDD:410433	12/69 (17%)
		RhoGAP	2096..2281	CDD:470621	49/241 (20%)