DRSC/TRiP Functional Genomics Resources

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Protein Alignment Myo10A and myhb

DIOPT Version :9

Sequence 1:NP_001036269.2 Gene:Myo10A / 32028 FlyBaseID:FBgn0263705 Length:3145 Species:Drosophila melanogaster
Sequence 2:XP_001339206.5 Gene:myhb / 100002040 ZFINID:ZDB-GENE-081124-1 Length:1937 Species:Danio rerio


Alignment Length:2209 Identity:505/2209 - (22%)
Similarity:873/2209 - (39%) Gaps:552/2209 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 LSTLCSDVI-ARHPQTFALQPGEGSLRARQDLGSSGVEDMTLLDDLHEASLLWNLRLRYDKGLIY 185
            :.|||...: .:..:.|.:.|.:          ...:|||.::..|:|.::|:||:.||...:||
Zfish    62 VQTLCGKTLTVKEDEIFPMNPPK----------FDKIEDMAMMTHLNEPTVLYNLKERYAAWMIY 116

  Fly   186 TFAGSILIAVNPYKMFPDAYGLEVAKQYAGRPLGSLPPHLFAIGAAAHAALPSP---QVVVISGE 247
            |::|...:.|||||..| .|...|...|.|:.....|||:|:|...|:..:.:.   |.::|:||
Zfish   117 TYSGLFCVTVNPYKWLP-VYDAVVVSGYRGKKRIEAPPHIFSISDNAYQFMLTDRENQSILITGE 180

  Fly   248 SGSGKTESTKLVMQYLAAVVPGG--------GSASAVITEQILEAAPLLEAFGNARTARNDNSSR 304
            ||:|||.:||.|:||.|.:...|        |.....:.:||:.|.|||||:|||:|.|||||||
Zfish   181 SGAGKTVNTKRVIQYFATIAVAGKQKQEPIPGKMQGSLEDQIIAANPLLEAYGNAKTVRNDNSSR 245

  Fly   305 FGKYLEVYF-KSGAIVGAKITQYLLEKSRIVTQAPGERNYHVFYELLGGLSETERSKYGLLEA-- 366
            |||::.::| .:|.:..|.|..|||||||:..|...||:||:||:|..|      .|..||||  
Zfish   246 FGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLSAERSYHIFYQLCTG------HKPELLEALL 304

  Fly   367 ---DKYFY--LNQG--------------ATDCASGRVDWESLQGAMQVLGVSEGEREGIVRVLAA 412
               :.|.|  ::||              |||.            |:.:||.:..|:.||.::..|
Zfish   305 ITTNPYDYPMISQGEITVKSINDVEEFIATDT------------AIDILGFNAEEKVGIYKLTGA 357

  Fly   413 VLHLGNVYFHRRQLRHGQE--GVEVGSDAEIKWAAHLLHISADGLHRALTSRTTEARAERLHTPL 475
            |:|.||:.|.::|.....|  |.||...     .|:||.:::..:.:||.....:...|.:....
Zfish   358 VMHHGNMKFKQKQREEQAEPDGTEVADK-----IAYLLGLNSADMLKALCYPRVKVGNEFVTKGQ 417

  Fly   476 GIDQALDARDAFAKALYAGLFNWLVSRINSIVQKGGTHDAHR--ISILDIFGFEDLAENSFEQLC 538
            .:.|..:|..|..|::|..:|.|:|.|||.::.   |....:  |.:|||.|||....||.||||
Zfish   418 TVPQVNNATMALCKSVYEKMFLWMVVRINEMLD---TKQPRQFFIGVLDIAGFEIFDFNSLEQLC 479

  Fly   539 INYANENLQLYFNKHVFKLEQAEYARERLEWTPLAWDDNLPVIHLLAKKPVGICHLLDDESNFPR 603
            ||:.||.||.:||.|:|.|||.||.:|.:||..:.:..:|.....|.:||:||..:|::|..||:
Zfish   480 INFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPK 544

  Fly   604 ATDLSFLEKCHYNH-ALSELYARPR--IGAQE--FGVTHYAGQVWYCVDGFLDKNRDALRGDVLE 663
            |||.:|..|.|..| ..:..:.:|:  .|..|  |.:.||||.|.|.:.|:||||:|.|...|::
Zfish   545 ATDTTFKNKLHDQHLGKTNCFQKPKPAKGKAEAHFSLVHYAGTVDYNISGWLDKNKDPLNDSVVQ 609

  Fly   664 LLASSRLPLVGELTKQLRAQRDA---GKTLPKGSNGRFVTMKPRTPTVAARFADSLQQLLQSMGR 725
            |...|.:.|:..| ....|..:|   ||...|...|.|       .||:|.|.::|.:|:.::..
Zfish   610 LYQKSSVKLLCHL-YAAHASTEAESGGKKGGKKKGGSF-------QTVSALFRENLGKLMTNLRS 666

  Fly   726 CHPWFVRCIKPNQEKHALRMDMPCVLQQLRYLGMLDTIQIRQRGYPVRLRFQHFVERYRHLLPSP 790
            .||.||||:.||:.|....|:...|:.|||..|:|:.|:|.::|:|.|:.:..|.:||:.|..|.
Zfish   667 THPHFVRCLIPNESKTPGLMENFLVIHQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASV 731

  Fly   791 LARGTPYRELCRALLEAMPRTGVEGPDYQLGATRVFLREALHRALESGRTERLRRAAVSVQRHVR 855
            :..| .:.:..:|..:.:....|:...|:.|.|:||.:..|...||..|.|:|.......|...|
Zfish   732 IPEG-QFIDNKKASEKLLGSIDVDHTQYKFGHTKVFFKAGLLGTLEEMRDEKLVILVTMTQAVCR 795

  Fly   856 GMLVRRQ----LARRQAAATRLQ---------ARWRGQRAQQRYERLRKGALTAQRLWRGRQARR 907
            |.::|::    :|||::..: :|         ..|...:...:.:.|.|.|.|.:.:        
Zfish   796 GYVMRKEFVKMMARRESIYS-IQYNIRSFMNVKHWPWMKLYFKIKPLLKSAETEKEM-------- 851

  Fly   908 RVQQLRSDHRRRQEAREAAQRAREAREAKQAVLERSQLSYLDIPAE---LAFIYSKLQGWSPPHG 969
             .....:..:.:::..:|..:.:|..|....:|:......|.:.:|   |:....:.:|      
Zfish   852 -AAMKENFEKMKEDLAKALAKKKELEEKMVTLLQEKNDLQLQVASETENLSDAEERCEG------ 909

  Fly   970 DRHLVKVLGTVPGPPSSAVQLPEDLGQFSFGKFSSVYCNGLRLQPRREPITAPLLTRAASRDQDF 1034
               |:|          |.:||...|.:.:           .||:...| |.|.|    .::.:..
Zfish   910 ---LIK----------SKIQLEAKLKEAT-----------ERLEDEEE-INAEL----TAKKRKL 945

  Fly  1035 QDALAVFKLILRWSNDKALEGA---KEKLLADYIVHKALSSRGLRDEILVQLCNQVHGLPPNSGE 1096
            :|..:..|..:   :|..|..|   |||...:..|.........:||::|:|..:...|.    |
Zfish   946 EDECSELKKDI---DDLELTLAKVEKEKHATENKVKNLTEEMTSQDEVIVKLTKEKKALQ----E 1003

  Fly  1097 ATRLWQLLGQCLCCFQP--------SAAFSKYLMRFVDD-----EAPESLRPLLLRQLLRQQGGG 1148
            |.:      |.|...|.        :.|.:| |.:.|||     |..:.||..|.|...:.:|  
Zfish  1004 AHQ------QTLDDLQAEEDKVNTLTKAKAK-LEQQVDDLEGSLEQEKKLRMDLERAKRKLEG-- 1059

  Fly  1149 TSSGAVGAGACRSFVPAWLEWRAWTRGCDMALPLTLPDEASQTVAVDSWTSCEEAAALAVSSLGV 1213
                                            .|.|..|:...:..|.....|:.......:...
Zfish  1060 --------------------------------DLKLAQESLMDLENDKQQLEEKLKKKDFETSQF 1092

  Fly  1214 ASRGWTLVLDDGQQLTDSCGLDY---VMDLIA-----EKELCPAFPAPRSDLLRSGAKFARTTLP 1270
            .||     ::|.|.|    |:.:   :.:|.|     |:|: .|..|.|:.:.:..:..|| .|.
Zfish  1093 LSR-----IEDEQSL----GIQFQKKIKELQARIEELEEEI-EAERAARAKVEKQRSDLAR-ELE 1146

  Fly  1271 DAVKRPAVPPPAPPTSSGKEDVPRERRSSRELLSRSSALNERYFEREPSPGPGQGSSTGQAKSRS 1335
            :..:|   ...|...:|.:.::.::|.:..:.|.|.  |.|...:.|.:....:...........
Zfish  1147 EISER---LEEAGGATSAQIEMNKKREAEFQKLRRD--LEESTLQHEATAAALRKKQADSVAELG 1206

  Fly  1336 KSLDDL-------------LAGDIVPVPTDCDSQEPLHTLGLSESRLNDRYHSAERLAPVGKDTG 1387
            :.:|:|             |..::..|.:..::        :::|:.|     .|::....:|  
Zfish  1207 EQIDNLQRVKQKLEKEKSELKMEVDDVSSSMEA--------VAKSKTN-----LEKMCRTLED-- 1256

  Fly  1388 PRYQKSQHAGRRSHAASHGSHSSKYADKAEYATRSSAMS-DTSEAPSLASHVRRVRVPSQASDVD 1451
               |.|:...:......|.:..|  |.||...|.:..|. ...|..||.|.:.|.:   ||  ..
Zfish  1257 ---QLSEFKSKHDEHVRHINDLS--AQKARLQTENGEMGRQLEEKESLVSQLTRSK---QA--YT 1311

  Fly  1452 QFLDDLFSPVLDGSLDELSDARSLAASIRGG---------SYEQENEAESEID-DLDDYINDIFQ 1506
            |.:::|...:    .:|:....|||.:::..         .||:|.||::|:. .:....:::.|
Zfish  1312 QQIEELKRQI----EEEVKAKNSLAHAVQSSRHDCDLLREQYEEEQEAKAELQRSMSKANSEVAQ 1372

  Fly  1507 --------PIPLVQNLEKLTSK---------DQLAAIIKGGGVASKPEERDEESEIEDLDDYINE 1554
                    .|...:.||:...|         :.:.|:........|.::| .::|:|||   :.:
Zfish  1373 WRTKYETDAIQRTEELEEAKKKLAQRLQDAEESIEAVNAKCASLEKTKQR-LQNEVEDL---MID 1433

  Fly  1555 LFEPIPVAEGLDKLTSK------------EHLAVSIRGGGSTDSNGADPLLHQLMQLPGETESGP 1607
            :.....:|..|||....            |.....:.|.    ...|..|..:|.::...     
Zfish  1434 VERANALAANLDKKQRNFDKVLAEWKQKYEETQAELEGA----QKEARSLSTELFKMKNS----- 1489

  Fly  1608 ALYQQQVQRAFLQSAMAQNLQIQQQLLAQNQAL----QTL--LSQ------------QAAAAAAN 1654
              |::.:..  |::...:|..:||::....:.|    :|:  |.:            |||...|.
Zfish  1490 --YEETLDH--LETLKRENKNLQQEITDLTEQLGETGKTIHELEKGKKTAEIEKSEIQAALEEAE 1550

  Fly  1655 NSTSPPPAPPILSSLSISPPPPQSPMRM--------KATRSSLVVMESLQPPPPPPPPPMPPPLE 1711
            .:.....:..:...|.::....:...::        :..|:|..:::|:|..             
Zfish  1551 ATLEHEESKILRVQLELNQVKGEIDRKLAEKDEEIEQIKRNSQRIIDSMQST------------- 1602

  Fly  1712 CKDPSETRHFLDPYGRAK--TVRIGKWRWPPPQDEPQFQTEEDFFAFKMR-QHQRKTTPQAQ--- 1770
                      ||...|::  .:||.|            :.|.|....::: .|..:...:||   
Zfish  1603 ----------LDAEVRSRNDALRIKK------------KMEGDLNEMEIQLSHANRQAAEAQKQL 1645

  Fly  1771 --------------------HHQMTSNGGMMESGPGARGASATAIEWEEFEI---ESPTPPPMSG 1812
                                ...|.....|:|     |..:....|.||..:   ::.....::.
Zfish  1646 RNVQGQLKDAQLHLDEALRAQEDMKEQVAMVE-----RRNNLMQAEIEELRVALEQTERGRKVAE 1705

  Fly  1813 Q-LMRSSIRLETTTTTTTSAVNNRDR--------DRETQDVGQPMQSVVTTKLAKKSFEIGADRP 1868
            | |:.:|.|:....:..||.:|.:.:        ..|.:||.|..::  ..:.|||:....|   
Zfish  1706 QELVDASERVTLLHSQNTSLINTKKKLEADLVQIQGEMEDVVQEARN--AEEKAKKAITDAA--- 1765

  Fly  1869 PPGSVGKLKLSSEMRQRLEQVTAGHSVRS----TVSTKSEQRAPAKLEDTRKLMLQQQLGGLFAS 1929
                    .::.|:::  ||.|:.|..|.    .|:.|..|.   :|::...|.::         
Zfish  1766 --------MMAEELKK--EQDTSAHLERMKKNLEVTVKDLQH---RLDEAESLAMK--------- 1808

  Fly  1930 VSGGNSGPGGVVDSHATVRTQIERMEGKLSPPPAPPSGGWPGVLLPPAPSVPAPPPPIRPPSMAP 1994
                    ||        :.|::::|.::                                    
Zfish  1809 --------GG--------KKQLQKLEARV------------------------------------ 1821

  Fly  1995 PAPPPAPQSPPTARSPEPEPDYRTSSSQV-----VKEHVPAFIQRQERDTFGAVRQQQMISSHHL 2054
                       .....|.|.:.|..:..|     .:..|.....:.|.|....:|.|.::....|
Zfish  1822 -----------RELESEVEAEQRRGADAVKGVRKYERRVKELTYQTEEDKKNIIRLQDLVDKLQL 1875

  Fly  2055 HLEDHSASSSPAVAAWEQAERERSRSR------SRSRDREDYSESVWDRAEVEGPASGSGSEKE 2112
            .::.:...|..|.   |||....:|.|      ..:::|.|.:||..::...:....|.|.|.|
Zfish  1876 KVKAYKRQSEDAE---EQANTHLTRFRKVQHELEEAQERADIAESQVNKLRAKSREFGKGKEAE 1936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Myo10ANP_001036269.2 MYSc 156..836 CDD:214580 254/724 (35%)
MYSc_Myo15 169..828 CDD:276838 248/703 (35%)
MyTH4 1014..1171 CDD:295320 35/172 (20%)
MyTH4 2704..2810 CDD:279165
B41 2823..3033 CDD:214604
FERM_B-lobe 2920..3025 CDD:271216
FERM_C_MyoXV 3029..3138 CDD:270022
myhbXP_001339206.5 Myosin_N 36..73 CDD:280832 3/10 (30%)
Myosin_head 88..768 CDD:278492 253/715 (35%)
MYSc_class_II 100..768 CDD:276951 248/703 (35%)
Myosin_tail_1 848..1925 CDD:279860 224/1363 (16%)
Uso1_p115_C 898..1011 CDD:282695 32/160 (20%)
COG6 1374..>1509 CDD:303003 23/151 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.000

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