DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2145 and POU3F3

DIOPT Version :9

Sequence 1:	NP_001285102.1	Gene:	CG2145 / 32027	FlyBaseID:	FBgn0030251	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_006227.1	Gene:	POU3F3 / 5455	HGNCID:	9216	Length:	500	Species:	Homo sapiens

Alignment Length:	482	Identity:	95/482 - (19%)
Similarity:	145/482 - (30%)	Gaps:	149/482 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 PKSVVVTPTAANKPPPLV--------------------ISHAPLMPLGPRPDTPGSSPFGASQNP 120
            |.|..||..|....|..|                    :|||... :...|....::...|:...
Human    53 PGSAAVTSGAYRGDPSSVKMVQSDFMQGAMAASNGGHMLSHAHQW-VTALPHAAAAAAAAAAAAV 116

  Fly   121 QTPPQWPSSTRATPSHPSQPSQPSQQPPLPGFASYRPQKPQ----PNSYDLSYGG---------- 171
            :....|..|.......|.||.||   ||.|      ||.|.    ....||..|.
Human   117 EASSPWSGSAVGMAGSPQQPPQP---PPPP------PQGPDVKGGAGRDDLHAGTALHHRGPPHL 172

  Fly   172 GPQPAPAGTGRPGFGLGISSTTSTTTTAKPITSTTGKTPQQKEDFPALPGPRRP-------SQKE 229
            ||.|.|...|.|| |.|.::..:....|....:          ..|::.|.::|       ||..
Human   173 GPPPPPPHQGHPG-GWGAAAAAAAAAAAAAAAA----------HLPSMAGGQQPPPQSLLYSQPG 226

  Fly   230 DFPALPAPKTPPGSPTPTPGSPSAWQSPL-------PTPQ---------HPVHPPTKATSAATPT 278
            .|........|||......|:....||.:       .||:         |..||.
Human   227 GFTVNGMLSAPPGPGGGGGGAGGGAQSLVHPGLVRGDTPELAEHHHHHHHHAHPH---------- 281

  Fly   279 PTPTPSFSSSVTPTPAHGSSVGPHKDGGGGGGGGTTTVRPGFQS----SGNSVATDDEIRQLTEL 339
                       .|.|.|..  ||...||||||.|     ||..|    |.....|.|::.|..:.
Human   282 -----------PPHPHHAQ--GPPHHGGGGGGAG-----PGLNSHDPHSDEDTPTSDDLEQFAKQ 328

  Fly   340 LYTKESNSQIGNIQVNLQGRTRSIDSADEAPNPLLTVDSKALESPTIVKMRLLFNNY--EHDTHV 402
            .  |:...::|..|.::.....::.....:...:...::..|....:.|::.|.|.:  |.|:..
Human   329 F--KQRRIKLGFTQADVGLALGTLYGNVFSQTTICRFEALQLSFKNMCKLKPLLNKWLEEADSST 391

  Fly   403 N-----EHVTPNERKEENDFLDAVMATPVMRQAMLFLQQKGVVS------PDPKTHR-------- 448
            .     :.:....||.:             ::..:.:..||.:.      |.|....
Human   392 GSPTSIDKIAAQGRKRK-------------KRTSIEVSVKGALESHFLKCPKPSAQEITNLADSL 443

  Fly   449 DLVKE---LWFTQYSRGQGKIGSSGFE 472
            .|.||   :||....:.:.::...|.:
Human   444 QLEKEVVRVWFCNRRQKEKRMTPPGIQ 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2145	NP_001285102.1	XendoU	330..590	CDD:286496	23/167 (14%)
POU3F3	NP_006227.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..63		4/9 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..190		25/77 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..319		27/115 (23%)
		POU	314..388	CDD:197673	11/75 (15%)
		Homeobox	409..463	CDD:395001	9/53 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..500		1/10 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000