DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment v and TDO2

DIOPT Version :9

Sequence 1:	NP_511113.1	Gene:	v / 32026	FlyBaseID:	FBgn0003965	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_005642.1	Gene:	TDO2 / 6999	HGNCID:	11708	Length:	406	Species:	Homo sapiens

Alignment Length:	391	Identity:	222/391 - (56%)
Similarity:	283/391 - (72%)	Gaps:	24/391 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CPYAGN------------GNDHDDS--AVPLTTEVGKIYGEYLMLDKLLDAQCMLSEEDKRPVHD 53
            ||:.||            |::.|.|  .|...::.|.|||.||.|:|:|:||.:.||.....:||
Human     4 CPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHD 68

  Fly    54 EHLFIITHQAYELWFKQIIFEFDSIRDML-DAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILE 117
            ||||||||||||||||||::|.||:|::. :..|.||...|::|.|::||.:||||||.|..|||
Human    69 EHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILE 133

  Fly   118 TMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYNQK-YSDVFSDEEARNSIRNSEK 181
            |||.|||.|||:||:||||||||||||:|||:|||...||.||:: |.|.|..|| ...:..||:
Human   134 TMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEE-NELLLKSEQ 197

  Fly   182 DPSLLELVQRWLERTPGLEESGFNFWAKFQESVDRFLEAQ---VQSAMEEPVEKAKNYRLMDIEK 243
            :.:|||||:.|||||||||..|||||.|.::::.|.||.:   :| |.||..||.:  ::.:.:|
Human   198 EKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQ-AKEESEEKEE--QVAEFQK 259

  Fly   244 RREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKW 308
            ::||..|:||...|:.|:.:|:||.|:||||||:||.|||:||||..|.||||.|||||||:|||
Human   260 QKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKW 324

  Fly   309 RYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIRKK 373
            |||||.||.||:|| :.||||||||.|||||:|||||||:|||||||:||||..||.::.||.|.
Human   325 RYNHVCMVHRMLGS-KAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKF 388

  Fly   374 L 374
            |
Human   389 L 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
v	NP_511113.1	Trp_dioxygenase	11..357	CDD:281317	207/352 (59%)
TDO2	NP_005642.1	Trp_dioxygenase	26..372	CDD:281317	207/350 (59%)
TDO2	NP_005642.1	Substrate binding. /evidence=ECO:0000255\|HAMAP-Rule:MF_03020, ECO:0000269\|PubMed:27762317, ECO:0007744\|PDB:5TI9	72..76		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157034
Domainoid	1	1.000	389	1.000	Domainoid score	I792
eggNOG	1	0.900	-	-		E1_COG3483
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4132
Inparanoid	1	1.050	410	1.000	Inparanoid score	I1868
Isobase	1	0.950	-	0	Normalized mean entropy	S2816
OMA	1	1.010	-	-		QHG55891
OrthoDB	1	1.010	-	-		D307028at33208
OrthoFinder	1	1.000	-	-		FOG0006066
OrthoInspector	1	1.000	-	-		oto91756
orthoMCL	1	0.900	-	-		OOG6_105300
Panther	1	1.100	-	-	LDO	PTHR10138
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3964
SonicParanoid	1	1.000	-	-		X4361
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750