DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment v and Tdo2

DIOPT Version :9

Sequence 1:	NP_511113.1	Gene:	v / 32026	FlyBaseID:	FBgn0003965	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_071798.1	Gene:	Tdo2 / 64206	RGDID:	68370	Length:	406	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	212/393 - (53%)
Similarity:	279/393 - (70%)	Gaps:	28/393 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CPYAGNG------------NDHD--DSAVPLTTEVGKIYGEYLMLDKLLDAQCMLSEEDKRPVHD 53
            ||::||.            |:.|  .:.|...::.|.|||:||.|:|:|:||.:.||.....:||
  Rat     4 CPFSGNSVGYTLKNLSMEDNEEDGAQTGVNRASKGGLIYGDYLQLEKILNAQELQSEIKGNKIHD 68

  Fly    54 EHLFIITHQAYELWFKQIIFEFDSIRDML-DAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILE 117
            ||||||||||||||||||::|.||:|::. :..|.||...|:::.|::|||:|.||||.|..:||
  Rat    69 EHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVMTRMHRVVVIFKLLVQQFSVLE 133

  Fly   118 TMTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYNQK-YSDVFSDEEARNSIRNSEK 181
            |||.|||.|||:||:||||||||||||:|||:|||...||.||:| |.|.| :.:....:..||:
  Rat   134 TMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQSLRVPYNRKHYRDNF-EGDYNELLLKSEQ 197

  Fly   182 DPSLLELVQRWLERTPGLEESGFNFWAKFQESV-----DRFLEAQVQSAMEEPVEKAKNYRLMDI 241
            :.:||:||:.|||||||||..|||||.||::::     :.||:.|.:...||..|:...:|
  Rat   198 EQTLLQLVEAWLERTPGLEPHGFNFWGKFEKNILKGLEEEFLKIQAKKDSEEKEEQMAEFR---- 258

  Fly   242 EKRREVYRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLIT 306
             |::||...:||...||.|:.:|:||.|:||||||:||.|||:||||..|.||||.|||||:|:|
  Rat   259 -KQKEVLLCLFDEKRHDYLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMT 322

  Fly   307 KWRYNHVIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLDETIR 371
            |||||||.||.||:|| :.||||||||.|||||:|||||||:||||||::|:||..||.::..|.
  Rat   323 KWRYNHVCMVHRMLGS-KAGTGGSSGYYYLRSTVSDRYKVFVDLFNLSSYLVPRHWIPKMNPIIH 386

  Fly   372 KKL 374
            |.|
  Rat   387 KFL 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
v	NP_511113.1	Trp_dioxygenase	11..357	CDD:281317	199/354 (56%)
Tdo2	NP_071798.1	Trp_dioxygenase	26..372	CDD:281317	199/352 (57%)
Tdo2	NP_071798.1	Substrate binding. /evidence=ECO:0000255\|HAMAP-Rule:MF_03020	72..76		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350993
Domainoid	1	1.000	383	1.000	Domainoid score	I793
eggNOG	1	0.900	-	-		E1_COG3483
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4132
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1877
OMA	1	1.010	-	-		QHG55891
OrthoDB	1	1.010	-	-		D307028at33208
OrthoFinder	1	1.000	-	-		FOG0006066
OrthoInspector	1	1.000	-	-		oto98822
orthoMCL	1	0.900	-	-		OOG6_105300
Panther	1	1.100	-	-	LDO	PTHR10138
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4361
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770