DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment v and tdo2a

DIOPT Version :9

Sequence 1:	NP_511113.1	Gene:	v / 32026	FlyBaseID:	FBgn0003965	Length:	379	Species:	Drosophila melanogaster
Sequence 2:	NP_001096086.1	Gene:	tdo2a / 100008541	ZFINID:	ZDB-GENE-030131-1187	Length:	406	Species:	Danio rerio

Alignment Length:	380	Identity:	205/380 - (53%)
Similarity:	275/380 - (72%)	Gaps:	17/380 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CPY-------------AGNGNDHDDSAVPLTTEVGKIYGEYLMLDKLLDAQCMLSEEDKRPVHDE 54
            |||             ....||...:.:...::.|.|||:||.|||::.:|.:.||.....:|||
Zfish     4 CPYFQRKFLSTSKQHLKEEENDEAQTGINKASKGGLIYGDYLQLDKIVTSQVLQSELKGNKIHDE 68

  Fly    55 HLFIITHQAYELWFKQIIFEFDSIRDM-LDAEVIDETKTLEIVKRLNRVVLILKLLVDQVPILET 118
            ||||:|||||||||||:::|.||:|:: :...|.||...|::..|::|:|:|.:||:||..:|||
Zfish    69 HLFIVTHQAYELWFKQVLWELDSVREIFISGHVRDERNMLKVNTRIHRIVMIFRLLLDQFAVLET 133

  Fly   119 MTPLDFMDFRKYLAPASGFQSLQFRLIENKLGVLTEQRVRYNQK-YSDVFSDEEARNSIRNSEKD 182
            ||.|||.|||.||:||||||||||||:|||:||...|||.||:: |.|.|.|:|: ..:.:||::
Zfish   134 MTALDFYDFRGYLSPASGFQSLQFRLLENKIGVPHNQRVPYNRRHYRDNFRDQES-ELLLHSEQE 197

  Fly   183 PSLLELVQRWLERTPGLEESGFNFWAKFQESVDRFLEAQVQSAMEEPVEKAKNYRLMDIEKRREV 247
            |:||:||::||||||||||.|||||.|.::::...|..:.:...::|..:.|...|.::.|:|::
Zfish   198 PTLLQLVEQWLERTPGLEEDGFNFWGKLEKNIFEGLRREKEHIEQKPASERKEEMLAELIKQRDI 262

  Fly   248 YRSIFDPAVHDALVRRGDRRFSHRALQGAIMITFYRDEPRFSQPHQLLTLLMDIDSLITKWRYNH 312
            :.|:||...||.||..|.||.|::|||||:||.|||:||||..|.||||.|||||:|:|||||||
Zfish   263 FLSLFDEKRHDHLVSTGQRRLSYKALQGALMIYFYREEPRFQVPFQLLTSLMDIDTLMTKWRYNH 327

  Fly   313 VIMVQRMIGSQQLGTGGSSGYQYLRSTLSDRYKVFLDLFNLSTFLIPREAIPPLD 367
            |.||.||||.:. ||||||||||||||:|||||||:|||||:||||||:.:|.||
Zfish   328 VCMVHRMIGRKD-GTGGSSGYQYLRSTVSDRYKVFVDLFNLATFLIPRDWVPKLD 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
v	NP_511113.1	Trp_dioxygenase	11..357	CDD:281317	193/347 (56%)
tdo2a	NP_001096086.1	Trp_dioxygenase	25..371	CDD:281317	193/347 (56%)
tdo2a	NP_001096086.1	Substrate binding. /evidence=ECO:0000255\|HAMAP-Rule:MF_03020	71..75		2/3 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592704
Domainoid	1	1.000	398	1.000	Domainoid score	I710
eggNOG	1	0.900	-	-		E1_COG3483
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4132
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1812
OMA	1	1.010	-	-		QHG55891
OrthoDB	1	1.010	-	-		D307028at33208
OrthoFinder	1	1.000	-	-		FOG0006066
OrthoInspector	1	1.000	-	-		otm25805
orthoMCL	1	0.900	-	-		OOG6_105300
Panther	1	1.100	-	-	LDO	PTHR10138
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3964
SonicParanoid	1	1.000	-	-		X4361
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800