DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG15208 and MEX67

DIOPT Version :9

Sequence 1:	NP_001285099.1	Gene:	CG15208 / 32022	FlyBaseID:	FBgn0030247	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_015156.1	Gene:	MEX67 / 855934	SGDID:	S000006090	Length:	599	Species:	Saccharomyces cerevisiae

Alignment Length:	401	Identity:	81/401 - (20%)
Similarity:	137/401 - (34%)	Gaps:	103/401 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 LEVLSLSMNKITSLKSLVRCTR----LKELYLRQNEIADFDELKYLVNA-KSLTSLWLLDNPCSI 103
            :|.::|:.|::..:.::....:    ||.|.|..|:|..|..|:...|. |.|..|.:.:||  |
Yeast   164 VESVNLADNQLKDISAISTLAQTFPNLKNLCLANNQIFRFRSLEVWKNKFKDLRELLMTNNP--I 226

  Fly   104 AAGSNYRASVLRMLPNLKKLDNVDVAEEE-------LESALRYDYY---------PDVGSAILN- 151
            .....||..:||:.|.|..||||.|.:|:       |...::..::         .|..:..||
Yeast   227 TTDKLYRTEMLRLFPKLVVLDNVIVRDEQKLQTVYSLPMKIQQFFFENDALGQSSTDFATNFLNL 291

  Fly   152 ------PVLDL------------SNCSPDDMAYRDMIE------QCDRTIRQVQQQQ--RKRFAS 190
                  .:|:|            |...|..:...|...      ...|.|.:|..::  ::|.:.
Yeast   292 WDNNREQLLNLYSPQSQFSVSVDSTIPPSTVTDSDQTPAFGYYMSSSRNISKVSSEKSIQQRLSI 356

  Fly   191 GDAK-------------NIDELARIRSRSVL----VNGERLPL--FFPSDLRQVRQAQKAQDALR 236
            |...             ::.|.....|...:    :||..:.|  ||....:...::.|......
Yeast   357 GQESINSIFKTLPKTKHHLQEQPNEYSMETISYPQINGFVITLHGFFEETGKPELESNKKTGKNN 421

  Fly   237 KQKNQPIWHNEQVQQAHK---------FTMTPQ-----------AVHEQVQGIQSISSDRNADSP 281
            .|||:...|.......:|         :.:.|.           .|.....|....:|...|..|
Yeast   422 YQKNRRYNHGYNSTSNNKLSKKSFDRTWVIVPMNNSVIIASDLLTVRAYSTGAWKTASIAIAQPP 486

  Fly   282 AASTSTLAENLIELINSRRQDVVTPPGHLLPNVSSGLALNGANSTTLERHNNSLSAALLLIQD-- 344
            ....|.|.:     :.|...::.|||......|..|:::.||....:     .::..|.|..|
Yeast   487 QQQASVLPQ-----VASMNPNITTPPQPQPSVVPGGMSIPGAPQGAM-----VMAPTLQLPPDVQ 541

  Fly   345 --MNASQLETL 353
              :|..|||.|
Yeast   542 SRLNPVQLELL 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15208	NP_001285099.1	LRR_4	42..83	CDD:289563	10/42 (24%)
		leucine-rich repeat	44..65	CDD:275382	3/20 (15%)
		leucine-rich repeat	66..89	CDD:275382	9/23 (39%)
		leucine-rich repeat	91..119	CDD:275382	9/27 (33%)
MEX67	NP_015156.1	RRM_9	23..92	CDD:408240
		leucine-rich repeat	119..163	CDD:275382
		PPP1R42	<155..256	CDD:411060	30/93 (32%)
		leucine-rich repeat	164..189	CDD:275382	3/24 (13%)
		leucine-rich repeat	190..217	CDD:275382	10/26 (38%)
		leucine-rich repeat	218..242	CDD:275382	8/25 (32%)
		TAP_C	537..597	CDD:197882	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910