Protein Alignment CG1582 and DHX38

DIOPT Version :10

• Sequence 1: NP_572663.1
• Gene: CG1582 / 32021
• FlyBaseID: FBgn0030246
• Length: 1288
• Species: Drosophila melanogaster
• Sequence 2: NP_054722.2
• Gene: DHX38 / 9785
• HGNCID: 17211
• Length: 1227
• Species: Homo sapiens
• Alignment Length: 1311
• Identity: 321/1311 - (24%)
• Similarity: 531/1311 - (40%)
• Gaps: 366/1311 - (27%)

  Fly     2 DESSRKHMEDCFLRSPSDIRTTNVPAAPKSQAADNKSRKTELH------VLRLNDESRQM-TMDT 59
            :.|||::..:.....|.|..|.:.....:..:....||:::..      ..|.::.|.:: |.|.
Human   189 ERSSRRNEPESPRHRPKDAATPSRSTWEEEDSGYGSSRRSQWESPSPTPSYRDSERSHRLSTRDR 253

  Fly    60 LRQIHGPEFQLDDISKYK-DRGRGGHGVKHSYW-QDRGTLVVQSVQGVSSTRGNDSDGDRLRRYA 122
            .|.:.|         ||. |........|::.| .||..|  .|...:|..||...:|:
Human   254 DRSVRG---------KYSDDTPLPTPSYKYNEWADDRRHL--GSTPRLSRGRGRREEGE------ 301

  Fly   123 LAKLENYGFQAVHCLEAYEHCSGDTEAALLLLYRRYMRIPDEEQLTLEPPSEQEILDMRADEKEA 187
                              |..|.|||                                  :|::.
Human   302 ------------------EGISFDTE----------------------------------EERQQ 314

  Fly   188 LESIFDKAYEEREANRVWNLKFRID-------HLLAHSPSEVRKAREAVLAAAAAAAQAALDKKK 245
            .|.      ::|:|:|.|   :.:|       :.||:|..:..:.||..|..         .|:|
Human   315 WED------DQRQADRDW---YMMDEGYDEFHNPLAYSSEDYVRRREQHLHK---------QKQK 361

  Fly   246 KPPLRCRNFDRDGTCKYGPKCRFAHLPQQPTESDTTKKDSVDEN---DNELWFHVEVR--FPP-- 303
            :...:.|..:.|..       |:.  ..:...|....:..|||:   ||....|:.|.  .||
Human   362 RISAQRRQINEDNE-------RWE--TNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVPPFL 417

  Fly   304 -----GSRYPYEAPFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQL 363
                 .::.|  .|.|.:|....|:                ..|.|.|...|      .:..||.
Human   418 DGRIVFTKQP--EPVIPVKDATSDL----------------AIIARKGSQTV------RKHREQK 458

  Fly   364 AGRLDTSAFPSPKRSLFYDEPAGGGVNPDAEHHQSPKPSHYARGQTSRND-GGHQRNVE---AQT 424
            ..:                         .|:|      .|:....|...| .|.::..|   |.|
Human   459 ERK-------------------------KAQH------KHWELAGTKLGDIMGVKKEEEPDKAVT 492

  Fly   425 RENR---RLLQQFVE--RRKEE------RYQKIIDGRKQLPAFAEIERILALIESSPVVVISGET 478
            .:.:   |..|:|.:  :||.|      :.:.|::.|:.||.||..:.:|.:|..:.:|::.|||
Human   493 EDGKVDYRTEQKFADHMKRKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGET 557

  Fly   479 GCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGY 543
            |.||:||:.|::.::.:           ..:..|.||||||::|:.||:||:.|....:|:.|||
Human   558 GSGKTTQLTQYLHEDGY-----------TDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGY 611

  Fly   544 QIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERK 608
            .||.|:..|::|.:.:.|.|||||....:..|...:.:|:||.||||..:|.|..:|:.::..|.
Human   612 AIRFEDCTSENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRS 676

  Fly   609 DLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQE 673
            |||:|:.|||::|..|:.:||..|:..||||||||..||                     .|..:
Human   677 DLKLIVTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILF---------------------SKTPQ 720

  Fly   674 QEILERELEYA-DVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIES 737
            ::.:|..::.: .|..|| ||
Human   721 EDYVEAAVKQSLQVHLSG-AP-------------------------------------------- 740

  Fly   738 VLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQALV 802
                           |.||||:||..:|:...|.::::......|....::|::|.|..:.||.:
Human   741 ---------------GDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKI 790

  Fly   803 FKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKG 867
            |:|||.|.||.:::|||||||:|:|..:||:|.|..|.|.|:....|::|.:..:|:|||.||.|
Human   791 FQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSG 855

  Fly   868 RAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLE--TLE 930
            ||||..||.|..|||...|:..:|...||||||..|..:||.:|:|       .:..||:  .::
Human   856 RAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSL-------GVQDLLQFHFMD 913

  Fly   931 APTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACL 995
            .|.||::|.::.:|..:||||....||..|..:...|:|..:.|:::......|...:|.|.:.|
Human   914 PPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSML 978

  Fly   996 SNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNT 1060
            |..:.|..|..:..|:|:.:..||:..|||||.||.|.:|    :..||  |..:.::||:....
Human   979 SVPAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQW----KNNNY--STIWCNDHFIHAKA 1037

  Fly  1061 LETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPN 1125
            :..:.:::.|..:::|.        .|....:|              |.:..::...:|||.:..
Human  1038 MRKVREVRAQLKDIMVQ--------QRMSLASC--------------GTDWDIVRKCICAAYFHQ 1080

  Fly  1126 IVKIM-TPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVF----QAPFLVFQ 1185
            ..|:. ..:.|.|:|.      .|.|              :||:|     |:|    ...::|:.
Human  1081 AAKLKGIGEYVNIRTG------MPCH--------------LHPTS-----SLFGMGYTPDYIVYH 1120

  Fly  1186 EKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFLLESGWIILKAHDLETAEMVQCLRA 1250
            |.|.|:..|:: |        |.....::..||  |...:.::......:.:.....|....:..
Human  1121 ELVMTTKEYMQ-C--------VTAVDGEWLAEL--GPMFYSVKQAGKSRQENRRRAKEEASAMEE 1174

  Fly  1251 EMIKLLEEKIR 1261
            || .|.||::|
Human  1175 EM-ALAEEQLR 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_572663.1	UBA_like_SF	123..154	CDD:473871	5/30 (17%)
		RWD_DHX57	175..367	CDD:467661	39/210 (19%)
		zf-CCCH	245..272	CDD:459885	4/26 (15%)
		HrpA	452..>1075	CDD:441249	198/625 (32%)
		OB_NTP_bind	1114..1212	CDD:400182	21/102 (21%)
DHX38	NP_054722.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..320		34/205 (17%)
		HrpA	532..>1146	CDD:441249	225/776 (29%)
		DEAH box	652..655		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1155..1227		7/31 (23%)