DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and DHX34

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_055496.2	Gene:	DHX34 / 9704	HGNCID:	16719	Length:	1143	Species:	Homo sapiens

Alignment Length:	963	Identity:	306/963 - (31%)
Similarity:	432/963 - (44%)	Gaps:	237/963 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 GQTSRNDGGHQRNVEAQ-TRENRRLLQQFVERRKEE---RYQKIIDGRKQLPAFAEIERILALIE 467
            |..:|...|..|::.|: ..|.||.|..:::..:::   |..|:...|..||......|||..::
Human   112 GPATRGSQGLGRHLPAERVAEFRRALLHYLDFGQKQAFGRLAKLQRERAALPIAQYGNRILQTLK 176

  Fly   468 SSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAE 532
            ...|||::|:|||||||||||::|...|            .||  .||||||::.|.:|:||..|
Human   177 EHQVVVVAGDTGCGKSTQVPQYLLAAGF------------SHV--ACTQPRRIACISLAKRVGFE 227

  Fly   533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLL 597
            .|.:.|..||||||.|:..|.:|::.|.|.|:|||::..:|.|.....:||||||||...:||||
Human   228 SLSQYGSQVGYQIRFESTRSAATKIVFLTVGLLLRQIQREPSLPQYEVLIVDEVHERHLHNDFLL 292

  Fly   598 LILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYD 662
            .:|:.||..|.||||||||||:|.:|||.||..|||:.:|||.||:..::
Human   293 GVLQRLLPTRPDLKVILMSATINISLFSSYFSNAPVVQVPGRLFPITVVY--------------- 342

  Fly   663 TKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEP 727
                     |.||        |:...|        |.|||
Human   343 ---------QPQE--------AEPTTS--------KSEKL------------------------- 357

  Fly   728 MTINPELIESVLKYIVEGSHDWPRE--GTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPL 790
               :|.....||:.|   .|.:|.|  |.:|:||.|..||.:|.::.   ..::....:::::||
Human   358 ---DPRPFLRVLESI---DHKYPPEERGDLLVFLSGMAEISAVLEAA---QTYASHTQRWVVLPL 413

  Fly   791 HSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLV 855
            |||||..||..||..||||.||.:|||||||||||||...||||.|.:||..:|....::.|...
Human   414 HSALSVADQDKVFDVAPPGVRKCILSTNIAETSVTIDGIRFVVDSGKVKEMSYDPQAKLQRLQEF 478

  Fly   856 WVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRN 920
            |:|:|:|:||||||||..||||..||....|. .....|||||:||.|:.:||::|::.....|.
Human   479 WISQASAEQRKGRAGRTGPGVCFRLYAESDYD-AFAPYPVPEIRRVALDSLVLQMKSMSVGDPRT 542

  Fly   921 TLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCL 985
                 ...:|.|...|:..|:..|||.||||:.:.|||:|..||.|||||.|||:::.|::|..:
Human   543 -----FPFIEPPPPASLETAILYLRDQGALDSSEALTPIGSLLAQLPVDVVIGKMLILGSMFSLV 602

  Fly   986 DSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDV--ARRGNYAASR 1048
            :.||||||.||.:|||........|....:|.......|..|:.|.:..|:.|  .|..|   ||
Human   603 EPVLTIAAALSVQSPFTRSAQSSPECAAARRPLESDQGDPFTLFNVFNAWVQVKSERSRN---SR 664

  Fly  1049 NYASEHFLSLNTLETIADLKYQYLELLVSIGFV-------------------------------P 1082
            .:.....:..:.|..:|:|:.|:.|||...|.:                               .
Human   665 KWCRRRGIEEHRLYEMANLRRQFKELLEDHGLLAGAQAAQVGDSYSRLQQRRERRALHQLKRQHE 729

  Fly  1083 IDVPRRRKNACDNILTLTGVEQNHNGDNNR----------------------------------- 1112
            ....||||     :|.|...:...:.|.:|
Human   730 EGAGRRRK-----VLRLQEEQDGGSSDEDRAGPAPPGASDGVDIQDVKFKLRHDLAQLQAAASSA 789

  Fly  1113 ---------LLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPS 1168
                     ||..:|...|||   ::..||         |........|..|.|:......:||:
Human   790 QDLSREQLALLKLVLGRGLYP---QLAVPD---------AFNSSRKDSDQIFHTQAKQGAVLHPT 842

  Fly  1169 SV-NSQVSVFQA----------------------PFLVFQEKVRTSAIYIRDCSMLP-LIAMVLF 1209
            .| .....|..|                      ..|.|...:.|:..|:.:|..:| |.:::||
Human   843 CVFAGSPEVLHAQELEASNCDGSRDDKDKMSSKHQLLSFVSLLETNKPYLVNCVRIPALQSLLLF 907

  Fly  1210 AGS-DFKVELHDGDFLFLLESGWIILKAHDLETAEMVQCLRAEMIKLLEEKIR 1261
            :.| |     .:||...|:..||:.|:..|.|:|          |:||...:|
Human   908 SRSLD-----TNGDCSRLVADGWLELQLADSESA----------IRLLAASLR 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	285/893 (32%)
		DEXDc	471..619	CDD:238005	74/147 (50%)
		HELICc	781..871	CDD:197757	49/89 (55%)
		HA2	948..1029	CDD:214852	35/80 (44%)
		OB_NTP_bind	1070..1212	CDD:285018	39/240 (16%)
DHX34	NP_055496.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..94
		HrpA	154..>686	CDD:224557	242/628 (39%)
		DEXDc	179..314	CDD:238005	74/148 (50%)
		DEAH box	279..282		2/2 (100%)
		HELICc	410..496	CDD:197757	51/85 (60%)
		HA2	565..645	CDD:214852	34/79 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	724..766		8/46 (17%)
		OB_NTP_bind	<791..911	CDD:285018	26/131 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820