DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and DHX57

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_945314.1	Gene:	DHX57 / 90957	HGNCID:	20086	Length:	1386	Species:	Homo sapiens

Alignment Length:	1359	Identity:	534/1359 - (39%)
Similarity:	781/1359 - (57%)	Gaps:	133/1359 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RSPSDIRTTNVPAAPKSQAADNKSRKTELHVLRLNDESRQMTMDTLRQIHGPEFQLDDISKYKDR 79
            |.||....:|: :..:|:.......|..|..|.:..|:::.....||     :.|..|.....:|
Human    71 RRPSRPSNSNI-SKGESRPKWKPKAKVPLQTLHMTSENQEKVKALLR-----DLQEQDADAGSER 129

  Fly    80 GRGGHGV--------KHSYWQ--DRGTLVVQ----SVQGVSSTRGNDSDGDRLRRYALAKLENYG 130
            |..|...        ...||.  ...:||..    ...|::|......: ..:..:|:.||..||
Human   130 GLSGEEEDDEPDCCNDERYWPAGQEPSLVPDLDPLEYAGLASVEPYVPE-FTVSPFAVQKLSRYG 193

  Fly   131 FQAVHCLEAYEHCSGDTEAALLLL--------YRRYMRIPDE-EQLTLEPPSEQEILDMRADEKE 186
            |....|......|.||..|:|..|        :...|:|.:. .|::|:     |.::.|.:|..
Human   194 FNTERCQAVLRMCDGDVGASLEHLLTQCFSETFGERMKISEAVNQISLD-----ECMEQRQEEAF 253

  Fly   187 ALESIFDKAYEEREANRVWNLKFRIDHLLAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRC 251
            ||:||..:.:.||..||||.:...:::|    .|..||::          .:.:....::..|..
Human   254 ALKSICGEKFIERIQNRVWTIGLELEYL----TSRFRKSK----------PKESTKNVQENSLEI 304

  Fly   252 RNFDRDGTCKYGPKCRFAH-LPQQPTESDTTKKDSVDEN------DNELWFHVEVRFPPGSRYPY 309
            ..|...|.||:|.||||.| :|  |.:.....:.|||::      |....:.:|:||....:|||
Human   305 CKFYLKGNCKFGSKCRFKHEVP--PNQIVGRIERSVDDSHLNAIEDASFLYELEIRFSKDHKYPY 367

  Fly   310 EAPFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTS--AF 372
            :||.:...:|..::|...||..:..||.:|........|.|||:..||:...::...|..:  .:
Human   368 QAPLVAFYSTNENLPLACRLHISEFLYDKALTFAETSEPVVYSLITLLEEESEIVKLLTNTHHKY 432

  Fly   373 PSPKRSLFYDEPAGGGVNPDAEH-----------HQSPKPSHYARGQTSRNDGG----------- 415
            ..|..: |...|:...:|..|.|           :|.|:....:..:.|..|.|
Human   433 SDPPVN-FLPVPSRTRINNPACHKTVIPNNSFVSNQIPEVEKASESEESDEDDGPAPVIVENESY 496

  Fly   416 -------------HQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIE 467
                         ..::|.|   ||.::.:||..::...::|.|:..|:.|||:.|.|.||.|:.
Human   497 VNLKKKISKRYDWQAKSVHA---ENGKICKQFRMKQASRQFQSILQERQSLPAWEERETILNLLR 558

  Fly   468 SSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAE 532
            ...||||||.|||||:||:||||||:    :|..|.::   ...||||||||:|||.||||||.|
Human   559 KHQVVVISGMTGCGKTTQIPQFILDD----SLNGPPEK---VANIICTQPRRISAISVAERVAKE 616

  Fly   533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLL 597
            |.:|:|..||||||||:..|.:|||.:||||:|||||..|..|..|:|:||||||||:|||||||
Human   617 RAERVGLTVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVSHIIVDEVHERTEESDFLL 681

  Fly   598 LILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYD 662
            |:||:::.:|..|:||||||||||.||||||...||:.||||||||.|.||||.:.::.:|::..
Human   682 LVLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITIPGRTFPVDQFFLEDAIAVTRYVLQDG 746

  Fly   663 TKYCRKLK----------------KQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRY 711
            :.|.|.:|                ::.:|.|...|...|..:..:|    :.|::|...:...||
Human   747 SPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQDQDSVKDA----VPDQQLDFKQLLARY 807

  Fly   712 AEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNA 776
            ...||...|::.:|:...:|.||||::|::||:|.|.:| .|.||:||||..||:.:::.|..|:
Human   808 KGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYP-PGAILVFLPGLAEIKMLYEQLQSNS 871

  Fly   777 LF-SPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKE 840
            || :.|:.:.::.||||:||.|:|..||.|.|.|..||::||||||||:||||.|:|:|.|.|||
Human   872 LFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTNIAETSITIDDVVYVIDSGKMKE 936

  Fly   841 KCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQ 905
            |.:|:::.||||:..:||:|||.|||||||||..|||.||:||:.|.:.:|.|.:||||||||||
Human   937 KRYDASKGMESLEDTFVSQANALQRKGRAGRVASGVCFHLFTSHHYNHQLLKQQLPEIQRVPLEQ 1001

  Fly   906 IVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDV 970
            :.||||.|:.|::.|..||....:|.|..||:..:..||||:|||..:::|||||:|||:|||||
Human  1002 LCLRIKILEMFSAHNLQSVFSRLIEPPHTDSLRASKIRLRDLGALTPDERLTPLGYHLASLPVDV 1066

  Fly   971 RIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKW 1035
            |||||||:|:||:|||..|||||.|:.|||||||.:|:.||::.|..||..|||:|.:|.||:.|
Human  1067 RIGKLMLFGSIFRCLDPALTIAASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLQAYKGW 1131

  Fly  1036 LDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRR----RKNACDNI 1096
             .::.:....||.||..::|||...|:.:|.||.|:.|||..|||....:..|    |....|.:
Human  1132 -QLSTKEGVRASYNYCRQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGGDGV 1195

  Fly  1097 LTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDG 1161
            |..||.|.|.|.:|.:|::::||||||||:|::.:|:..:.:|:.|||..:|...:|:|.|:.||
Human  1196 LDATGEEANSNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTKNDG 1260

  Fly  1162 YVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGSDFKVELHDGDFLFL 1226
            ||.|||||||.||..|.:|:|::.||::||.::||||||:.:..:|||.|....|:|..|:|:..
Human  1261 YVHIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRGEFVVS 1325

  Fly  1227 LESGWIILKAHDLETAEMVQCLRAEMIKLLEEKIRDPCLNLLHHKNGCRMIANIVHLIS 1285
            |:.|||...|...:.||:|:.||.|:.:||::||::|.::|.....|.|:|:.||.|::
Human  1326 LDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPSIDLCTCPRGSRIISTIVKLVT 1384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	11/30 (37%)
		zf-CCCH	250..272	CDD:279036	10/22 (45%)
		RWD	<284..360	CDD:283440	25/81 (31%)
		HrpA	419..1206	CDD:224557	397/807 (49%)
		DEXDc	471..619	CDD:238005	93/147 (63%)
		HELICc	781..871	CDD:197757	52/89 (58%)
		HA2	948..1029	CDD:214852	52/80 (65%)
		OB_NTP_bind	1070..1212	CDD:285018	65/145 (45%)
DHX57	NP_945314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106		8/35 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..147		4/26 (15%)
		UBA_DHX57	181..218	CDD:270502	12/36 (33%)
		RWD	243..418	CDD:283440	55/190 (29%)
		ZnF_C3H1	303..323	CDD:214632	9/19 (47%)
		DEXDc	550..730	CDD:214692	117/186 (63%)
		DEXDc	561..703	CDD:238005	93/148 (63%)
		DEVH box	668..671		2/2 (100%)
		Helicase_C	832..968	CDD:278689	73/136 (54%)
		HA2	1043..1125	CDD:214852	52/81 (64%)
		OB_NTP_bind	1164..1310	CDD:285018	65/145 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155233
Domainoid	1	1.000	183	1.000	Domainoid score	I3448
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56267
Inparanoid	1	1.050	880	1.000	Inparanoid score	I408
Isobase	1	0.950	-	0	Normalized mean entropy	S3191
OMA	1	1.010	-	-		QHG47570
OrthoDB	1	1.010	-	-		D222681at33208
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	1	1.000	-	-		oto89458
orthoMCL	1	0.900	-	-		OOG6_100595
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X384
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.760