DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and PRP2

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_014408.1	Gene:	PRP2 / 855745	SGDID:	S000005294	Length:	876	Species:	Saccharomyces cerevisiae

Alignment Length:	1065	Identity:	261/1065 - (24%)
Similarity:	437/1065 - (41%)	Gaps:	270/1065 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 EREANRVWNLKFRIDHLLAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRCRNFDRDGTCKY 262
            :|...|.:.:..:.|:.:...||.:.:..:          :.|.||.....|:        ..:|
Yeast    10 KRRVKRTYEVTRQNDNAVRIEPSSLGEEED----------KEAKDKNSALQLK--------RSRY 56

  Fly   263 GPKCRFAHLPQQPTESD-------------------------TTKKDSVDENDNEL-------WF 295
            .|...|::..|.|.:::                         ||||..:.:::||.       .|
Yeast    57 DPNKVFSNTNQGPEKNNLKGEQLGSQKKSSKYDEKITSNNELTTKKGLLGDSENETKYASSNSKF 121

  Fly   296 HVEVRFPPGSRYPYEAPFIYLKTTCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSN 360
            :|||                                 .|..|.||||  |.|
Yeast   122 NVEV---------------------------------THKIKNAKEI--DKI------------- 138

  Fly   361 EQLAGRLDTSAFPSPKRSLFYDEP------AGGGVNPDAEHHQSPKPSHYARGQTSRNDGGHQRN 419
                           .|...::|.      ||...:||....:......|.....:..|..::.:
Yeast   139 ---------------NRQRMWEEQQLRNAMAGQSDHPDDITLEGSDKYDYVFDTDAMIDYTNEED 188

  Fly   420 ---VEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCG 481
               .|.:.:...||.|..  ..:|:|...|.:.||.||.....:.:|..|:.:.|::|.||||.|
Yeast   189 DLLPEEKLQYEARLAQAL--ETEEKRILTIQEARKLLPVHQYKDELLQEIKKNQVLIIMGETGSG 251

  Fly   482 KSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIR 546
            |:||:||:::::.|         .:...::|..|||||::|..||.|||.|....:|:.||||||
Yeast   252 KTTQLPQYLVEDGF---------TDQGKLQIAITQPRRVAATSVAARVADEMNVVLGKEVGYQIR 307

  Fly   547 LENKVS-QSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDL 610
            .|:|.: ..|.|.:.|.|:|||...:|..|...:.:::||.|||:..:|.|:.:||::|.:|..|
Yeast   308 FEDKTTPNKTVLKYMTDGMLLREFLTDSKLSKYSCIMIDEAHERTLATDILIGLLKDILPQRPTL 372

  Fly   611 KVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQE 675
            |:::.|||:||..||::|...|:.::|||.:||                  |..|
Yeast   373 KLLISSATMNAKKFSEFFDNCPIFNVPGRRYPV------------------DIHY---------- 409

  Fly   676 ILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLK 740
            .|:.|..|  :.|:              :...:|.:...|.|
Yeast   410 TLQPEANY--IHAA--------------ITTIFQIHTTQSLP----------------------- 435

  Fly   741 YIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLD-NALFSPRAGKFILVPLHSALSGEDQALVFK 804
                        |.||:||.|..||:.....|.: .:....|..:.|:.|:::.|..|.|..:|:
Yeast   436 ------------GDILVFLTGQEEIERTKTKLEEIMSKLGSRTKQMIITPIYANLPQEQQLKIFQ 488

  Fly   805 KAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRA 869
            ..|...||:||:|||||||:|||...:|:|.|.:||..:..:..|..|..|..|||:..||.|||
Yeast   489 PTPENCRKVVLATNIAETSLTIDGIRYVIDPGFVKENSYVPSTGMTQLLTVPCSRASVDQRAGRA 553

  Fly   870 GRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTE 934
            |||.||.|..::|.:.|.:.:...|.|||.|..|...||.:.:|..     |..:....::.|:.
Yeast   554 GRVGPGKCFRIFTKWSYLHELELMPKPEITRTNLSNTVLLLLSLGV-----TDLIKFPLMDKPSI 613

  Fly   935 DSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIF-QC---LDSVLTIAACL 995
            .::..:|..|..:|||:::..:|.||..:...|.:....|::...|.. ||   |:..|||.:.|
Yeast   614 PTLRKSLENLYILGALNSKGTITRLGKMMCEFPCEPEFAKVLYTAATHEQCQGVLEECLTIVSML 678

  Fly   996 SNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNT 1060
             :::|.:....||   |....:.:...|||:..|..:.:|      .|...||::..:|.:...|
Yeast   679 -HETPSLFIGQKR---DAAASVLSEVESDHILYLEIFNQW------RNSKFSRSWCQDHKIQFKT 733

  Fly  1061 LETIADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPN 1125
            :..:.:::.|.......:|.|..:...|.|..            |..|..|..:|....:....|
Yeast   734 MLRVRNIRNQLFRCSEKVGLVEKNDQARMKIG------------NIAGYINARITRCFISGFPMN 786

  Fly  1126 IVKIMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSV----NSQVSVFQAPFLVFQE 1186
            ||::                 .|:.:....::.|...|.:||:|:    :.:.:...:.::::|:
Yeast   787 IVQL-----------------GPTGYQTMGRSSGGLNVSVHPTSILFVNHKEKAQRPSKYVLYQQ 834

  Fly  1187 KVRTSAIYIRDCSMLP----LIAMV 1207
            .:.||..:||||.::|    ||.||
Yeast   835 LMLTSKEFIRDCLVIPKEEWLIDMV 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036	3/21 (14%)
		RWD	<284..360	CDD:283440	14/82 (17%)
		HrpA	419..1206	CDD:224557	219/803 (27%)
		DEXDc	471..619	CDD:238005	59/148 (40%)
		HELICc	781..871	CDD:197757	38/89 (43%)
		HA2	948..1029	CDD:214852	23/84 (27%)
		OB_NTP_bind	1070..1212	CDD:285018	30/146 (21%)
PRP2	NP_014408.1	PTZ00121	<7..174	CDD:173412	38/244 (16%)
PRP2	NP_014408.1	HrpA	185..876	CDD:224557	221/809 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810