DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and ECM16

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_013847.1	Gene:	ECM16 / 855158	SGDID:	S000004735	Length:	1267	Species:	Saccharomyces cerevisiae

Alignment Length:	1302	Identity:	307/1302 - (23%)
Similarity:	530/1302 - (40%)	Gaps:	276/1302 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SDIRTTNVPAAPKSQAADNKSRKTELHVLRLNDESRQMTMDTLRQIHGPEFQLDDISKYKDRGRG 82
            :|.|..|..:||...:....:...|: :..|.:|.::|....|:::..|  :...:|:.|.: |.
Yeast    37 NDERVENPDSAPAESSTTEPNANAEI-LEPLTEEEKKMKKRKLQELFTP--KESKVSRLKKK-RL 97

  Fly    83 GHGVKHSYWQDRGTLVVQSVQGVSSTRGNDSDGDRLRRYALAKLENYGFQAVHCLEAYEHCSGDT 147
            ...::|...::....::..:|.........:...||......|.|.  |:....||.....:..|
Yeast    98 DKFIEHQLKREERKTIIGKLQDYKIDTSLLTSSKRLGEGRQTKKEE--FKEALSLERQGRGNEQT 160

  Fly   148 EAALLLLYRRYMRIPDEEQLTLEPPSEQEILDMRADEKEALESIFDKAY---------EEREANR 203
            ..   :||..|           ||....|..:..:.|.:..|..|:.::         ||::::.
Yeast   161 NE---ILYEEY-----------EPKVWDEYGEGGSSEDDDGEDDFEASFGSMPKPTDNEEKKSSG 211

  Fly   204 VWNLKFRIDHL--------LAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRCRNFDRDGTC 260
            .      |||.        |:...|.::                .::|:.|.|.:
Yeast   212 F------IDHRPAKFGGSGLSFGFSNIK----------------VINKESKTPKK---------- 244

  Fly   261 KYGPKCRF------AHLPQQPTESDTTKKDSVDENDNELWFHVEVRFPPGSRYPYEAPFIYLKTT 319
            ||..:.|.      .|..:...:.|||.:|..:|.|.|         .....:|.|.|...:::.
Yeast   245 KYNWRQRVEMEELKKHGKEDEMDFDTTSEDDDEEEDQE---------EEDKMHPSENPLEEVESA 300

  Fly   320 CHDIPHELRLRYARH-LYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDE 383
            ..:...|   ::.:: :..|.|:...             |..::|.||  .....:|..::.|
Yeast   301 DSETGSE---KFDQNDVANEFKDWAN-------------QEIKKLEGR--DQELVTPTLNIDY-- 345

  Fly   384 PAGGGVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIID 448
                            ||   ...:...:||..:..|.......|:..  :||..:.:..||
Yeast   346 ----------------KP---IIRKEDLDDGLQEAYVPINENSTRKAF--YVEVSRSDEIQK--- 386

  Fly   449 GRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVE-- 511
            .|.|||.|.|..:|:..|..:.||:|.||||.||:||||||:.:..|       ..|:.|...
Yeast   387 ARIQLPVFGEEHKIMEAIHHNDVVIICGETGSGKTTQVPQFLYEAGF-------GAEDSPDYPGM 444

  Fly   512 IICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLG 576
            :..|||||::|:.:|||||.|..|. |..||||||.::...:.|::.|.|.|:|||.:..|..|.
Yeast   445 VGITQPRRVAAVSMAERVANELGDH-GHKVGYQIRFDSTAKEDTKVKFMTDGVLLREMMHDFKLT 508

  Fly   577 SVTHVIVDEVHERSEESDFLLLILKNLLR-----------ERKDLKVILMSATLNAALFSD---- 626
            ..:.:|:||.|||:..:|.|:.:|...:|           |.|.||:|:|||||..:.||:
Yeast   509 KYSSIIIDEAHERNINTDILIGMLSRCVRLRAKLHKENPIEHKKLKLIIMSATLRVSDFSENKTL 573

  Fly   627 YFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEIL----------EREL 681
            :....|||.:..|.|||...|....      ...|..:..||..|..|::.          ::|:
Yeast   574 FPIAPPVLQVDARQFPVSIHFNRRT------AFNYTDEAFRKTCKIHQKLPPGAILVFLTGQQEI 632

  Fly   682 EYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPT---CKSIYLMEPMTINPELIESVLKYIV 743
            .:...:...|.|.||.......|.....:....||.|   .:.|. .....|:.:..:|.::|..
Yeast   633 THMVKRLRKEFPFKKNSKYNKDLETPVSKMGINSKTTDLEAEDID-FSVQVIDQDKFKSAIRYEE 696

  Fly   744 --------EGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQA 800
                    |...|...||...:...|    |:.:|.|             .::||:|.|..::|.
Yeast   697 DEGNSGNGEDEEDEEEEGFEEVLTEG----QTANDPL-------------YVLPLYSLLPTKEQM 744

  Fly   801 LVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQR 865
            .||:|.|.|.|..:::||:||||:||....:|||.|..||:.::.:..::|.::.|||:|:|.||
Yeast   745 RVFQKPPQGSRLCIVATNVAETSLTIPGVRYVVDSGRSKERKYNESNGVQSFEVGWVSKASANQR 809

  Fly   866 KGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLE 930
            .|||||..||.|..||:|..:::.......|||.|:|:|.|||::|::   |..|.::....|
Yeast   810 SGRAGRTGPGHCYRLYSSAVFEHDFEQFSKPEILRMPVESIVLQMKSM---AIHNIINFPFPT-- 869

  Fly   931 APTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACL 995
            .|...::..|:..|:.:||||.::.:|..|..::..|:..|..|::|......||..::.|.:.|
Yeast   870 PPDRVALSKAIQLLQYLGALDNKEMITEDGKKMSLFPLSPRFSKMLLVSDEKACLPYIVAIVSAL 934

  Fly   996 SNKSPFVSPL------------------NKRTEAD------------KCKRMFALGNSDHLTVLN 1030
            |...||::..                  :|..|.|            :.:..|....|.    .:
Yeast   935 SVGDPFINEFELGINEISRKPNPDENLDDKIREHDESTPGMDPELKKELRSKFYKSRSQ----FS 995

  Fly  1031 AYRKWLDVARRGNYAASRNYA---------SEHFLSLNTLETIADLKYQYLELLVS-IGFVPIDV 1085
            ...|:.||.|..:..::.:|.         .::||....:|.|..|:.|.:.::.| .....|.|
Yeast   996 KLDKFSDVFRLLSVVSAMDYVPKEQKEIFMKKNFLRGKLMEEIVKLRKQLMYIIKSNTSKENIAV 1060

  Fly  1086 PRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNI---VKIMTPD--RVYIQTAGGAVP 1145
            ..|.::...:|.::..:         :||..::||....::   ..::.||  ::..:|:...:|
Yeast  1061 VIRNEDLKSDIPSVIQI---------KLLKQMICAGFVDHVAVRADVLFPDDAKITNRTSIINIP 1116

  Fly  1146 REPSHHDLRFKTRG--DGYVKIHPSSVNSQVSVFQAPFLVF-------QEKVRTSAIYIRDCSML 1201
            ..|.   |..:|..  |.:|.|||:|:.:.:......::::       ..|.|.:.:.  |.:..
Yeast  1117 YIPV---LATRTPNIEDCFVYIHPTSILNNLGEMPPKYMLYYSLHLGGNNKTRMNTLC--DIAST 1176

  Fly  1202 PL 1203
            ||
Yeast  1177 PL 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	6/30 (20%)
		zf-CCCH	250..272	CDD:279036	4/27 (15%)
		RWD	<284..360	CDD:283440	11/76 (14%)
		HrpA	419..1206	CDD:224557	237/877 (27%)
		DEXDc	471..619	CDD:238005	65/160 (41%)
		HELICc	781..871	CDD:197757	36/89 (40%)
		HA2	948..1029	CDD:214852	22/110 (20%)
		OB_NTP_bind	1070..1212	CDD:285018	28/149 (19%)
ECM16	NP_013847.1	HrpA	360..1267	CDD:224557	237/879 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810