DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and DHR2

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_012845.1	Gene:	DHR2 / 853784	SGDID:	S000001561	Length:	735	Species:	Saccharomyces cerevisiae

Alignment Length:	807	Identity:	231/807 - (28%)
Similarity:	375/807 - (46%)	Gaps:	151/807 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   412 NDGGHQRNVEAQTRENRRLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISG 476
            ||.|...:|..| |.|:..:..:  :..:.|...::..|:.||.:.....|::.|||:||.|:.|
Yeast    43 NDSGEGDHVSDQ-RSNKENVLTY--KSLKSRASDLLKMRETLPVYQHKREIMSYIESNPVTVLIG 104

  Fly   477 ETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLV 541
            |||.|||||:|||:|:..:         :...|..|..|||||::||.:|.|||.|...::|:.|
Yeast   105 ETGSGKSTQIPQFVLEKLY---------DTKKHGSIAVTQPRRVAAINLATRVAQEHGCKLGEQV 160

  Fly   542 GYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLR- 605
            ||.:|.:|..:..|||.:.|.|:|||.|..:..|...:.:::||.|||:..:|.:|..||:|::
Yeast   161 GYSVRFDNTTTTRTRLKYLTDGMLLRELMMNSDLREYSVIVIDEAHERTVLTDLILGFLKSLIQG 225

  Fly   606 ERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLK 670
            .|.||::|:|||||.|..||::|..||:|.:.||.|.|:|.:|:   ..:|.:::...:.|.::.
Yeast   226 PRPDLRIIVMSATLQAEKFSEFFNNAPILFVEGRKFDVKQYYLK---APTDDIVDAVIRCCIQIN 287

  Fly   671 KQEQEILERELEYADVQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELI 735
            :.|        |..|:...  .||::..|:.:|                              ::
Yeast   288 QGE--------ELGDILCF--LPGQEEIDKAVT------------------------------IM 312

  Fly   736 ESVLKYIVEGSHDWPREGTILIFLPGFGEIQSVHDSLLDNALFSPRAGKFILVPLHSALSGEDQA 800
            |.:.||:.:       |..:.:.:|                           .||::||....|:
Yeast   313 EKIAKYVSD-------EAPVPLIVP---------------------------YPLYAALPAVQQS 343

  Fly   801 LVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQR 865
            |||......|||:|.|||||||||||....||||.||.|.|.:.....:.:|..|.:|:|:|.||
Yeast   344 LVFAPIKGFKRKVVFSTNIAETSVTISGVKFVVDSGLRKVKVWRHQLGLATLLTVPISQASAMQR 408

  Fly   866 KGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLE--T 928
            .|||||...|....||....| ..:..|..|||.|..:...||.:|       |..:..||.  .
Yeast   409 SGRAGRESEGKSFRLYCESDY-VKLPKQSEPEIARSDVTSPVLMLK-------RYGVDDLLNWTW 465

  Fly   929 LEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAA 993
            .|.|.:::::..|..|.::||||...::|..|..:|.||:...:..:::..:...||..|:.|.:
Yeast   466 FENPGKEAIVMGLQELYELGALDTRGKITKRGQQMALLPLQPHLSSVLIKASEVGCLSQVIDIVS 530

  Fly   994 CLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSL 1058
            |||.::..::|  ...|.|:.       |...|::.||.:::      |:....:.....:|..|
Yeast   531 CLSVENLLLNP--SPEERDEV-------NERRLSLCNAGKRY------GDLIMLKELFDIYFYEL 580

  Fly  1059 NTLETIADLKYQYLE-LLVSI-GFV-PIDVPRRRKNACDNILTLTGVEQNHN---GDNNRLLTSL 1117
            ...:..:..:..:.: |.:|| ||. .|.|..:.:..|..:.:....|...:   |::..|::.:
Yeast   581 GKSQDASSERNDWCKGLCISIRGFKNVIRVRDQLRVYCKRLFSSISEEDEESKKIGEDGELISKI 645

  Fly  1118 LCAALYPNIVK---IMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVF-- 1177
            |...| ...:|   |..|||.|...:.|    ||              :.|||||:     :|
Yeast   646 LKCFL-TGFIKNTAIGMPDRSYRTVSTG----EP--------------ISIHPSSM-----LFMN 686

  Fly  1178 -QAPFLVFQEKVRTSAIYIRDCSMLPL 1203
             ..|.:::.|.|.|:..|.|:.|.:.|
Yeast   687 KSCPGIMYTEYVFTTKGYARNVSRIEL 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	228/800 (29%)
		DEXDc	471..619	CDD:238005	62/148 (42%)
		HELICc	781..871	CDD:197757	41/89 (46%)
		HA2	948..1029	CDD:214852	21/80 (26%)
		OB_NTP_bind	1070..1212	CDD:285018	36/146 (25%)
DHR2	NP_012845.1	HrpA	30..730	CDD:224557	231/807 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810