DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and PRP43

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_011395.1	Gene:	PRP43 / 852757	SGDID:	S000003088	Length:	767	Species:	Saccharomyces cerevisiae

Alignment Length:	885	Identity:	266/885 - (30%)
Similarity:	403/885 - (45%)	Gaps:	176/885 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 TSAFPSPKRSLFYDEPAGGGVNPDAEHHQSPKPS-----HYARGQTSRNDGGHQRNVEAQTRENR 428
            :|..|.|..:...::.|........:|   |.||     |:..|:.......|....|||..|:.
Yeast     8 SSEHPDPVETSIPEQAAEIAEELSKQH---PLPSEEPLVHHDAGEFKGLQRHHTSAEEAQKLEDG 69

  Fly   429 RLLQQFVERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDN 493
            : :..|..|....:|..|:..|::||..|:.:..|.|.:::.::|..||||.||:||:|||:|
Yeast    70 K-INPFTGREFTPKYVDILKIRRELPVHAQRDEFLKLYQNNQIMVFVGETGSGKTTQIPQFVL-- 131

  Fly   494 WFFRALQLPAKENLPHVE---IICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQST 555
                      .:.:||:|   :.||||||::|:.||:|||.|...::|:.|||.||.|||.|..|
Yeast   132 ----------FDEMPHLENTQVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFENKTSNKT 186

  Fly   556 RLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLN 620
            .|.:.|.|:|||....|..|...:.:|:||.|||:..:|.|:.:||.:::.|.|||:|:|||||:
Yeast   187 ILKYMTDGMLLREAMEDHDLSRYSCIILDEAHERTLATDILMGLLKQVVKRRPDLKIIIMSATLD 251

  Fly   621 AALFSDYFGGAPVLDIPGRTFPVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYAD 685
            |..|..||..||:|.:||||:||                                    ||.|
Yeast   252 AEKFQRYFNDAPLLAVPGRTYPV------------------------------------ELYY-- 278

  Fly   686 VQASGEAPGKKIKDEKLTLAETYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYIVEGSHDWP 750
                               ...:||                      :.::|.::.::: .|...
Yeast   279 -------------------TPEFQR----------------------DYLDSAIRTVLQ-IHATE 301

  Fly   751 REGTILIFLPGFGEIQSVHDSLL---DNALFSPRAGKFILVPLHSALSGEDQALVFKKAP----- 807
            ..|.||:||.|..||:.....:.   |..:.....|...:.||:.:|....|..:|:.||
Yeast   302 EAGDILLFLTGEDEIEDAVRKISLEGDQLVREEGCGPLSVYPLYGSLPPHQQQRIFEPAPESHNG 366

  Fly   808 -PGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGR 871
             || ||:|:||||||||:|||..|:|||.|..|:|.::....:|||.:..:|:|:|:||.|||||
Yeast   367 RPG-RKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGR 430

  Fly   872 VMPGVCIHLYTSYRYQYHILAQPVPEIQRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDS 936
            ..||.|..|||...:|..::.|..|||.|..|...||.:|.|    ..:.| |..:.::.|..::
Yeast   431 TRPGKCFRLYTEEAFQKELIEQSYPEILRSNLSSTVLELKKL----GIDDL-VHFDFMDPPAPET 490

  Fly   937 VLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPF 1001
            ::.||..|..:..||.|..|||||...:..|:|..:..:::....|||...:|||.|.||..:.|
Yeast   491 MMRALEELNYLACLDDEGNLTPLGRLASQFPLDPMLAVMLIGSFEFQCSQEILTIVAMLSVPNVF 555

  Fly  1002 VSPLNKRTEADKCKRMFALGNSDHLTVLNAYRKWLDVARRGNYA---ASRNYASEHFLSLNTLET 1063
            :.|...:..||..|.:||..:.||:|:||.|.     |.:.:.|   ....:..:|:|:..:|..
Yeast   556 IRPTKDKKRADDAKNIFAHPDGDHITLLNVYH-----AFKSDEAYEYGIHKWCRDHYLNYRSLSA 615

  Fly  1064 IADLKYQYLELLVSIGFVPIDVPRRRKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVK 1128
            ..:::.| ||.|:              |..:..|..|..|.....||.|   ..|.:..:..:.|
Yeast   616 ADNIRSQ-LERLM--------------NRYNLELNTTDYESPKYFDNIR---KALASGFFMQVAK 662

  Fly  1129 IMTPDRVYIQTAGGAVPREPSHHDLRFKTRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAI 1193
            ..:..:.||..                |...|  |.||||:|...    .|.::::.|.|.||..
Yeast   663 KRSGAKGYITV----------------KDNQD--VLIHPSTVLGH----DAEWVIYNEFVLTSKN 705

  Fly  1194 YIRDCS-----MLPLIAMVLFAGSDFKVELHDGDFLFLLE 1228
            |||..:     .|..||...:..|:|:    .||....||
Yeast   706 YIRTVTSVRPEWLIEIAPAYYDLSNFQ----KGDVKLSLE 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366
		zf-CCCH	250..272	CDD:279036
		RWD	<284..360	CDD:283440
		HrpA	419..1206	CDD:224557	248/806 (31%)
		DEXDc	471..619	CDD:238005	66/150 (44%)
		HELICc	781..871	CDD:197757	42/95 (44%)
		HA2	948..1029	CDD:214852	29/80 (36%)
		OB_NTP_bind	1070..1212	CDD:285018	34/146 (23%)
PRP43	NP_011395.1	HrpA	55..753	CDD:224557	256/835 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810