DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1582 and YLR419W

DIOPT Version :9

Sequence 1:	NP_001285098.1	Gene:	CG1582 / 32021	FlyBaseID:	FBgn0030246	Length:	1288	Species:	Drosophila melanogaster
Sequence 2:	NP_013523.3	Gene:	YLR419W / 851137	SGDID:	S000004411	Length:	1435	Species:	Saccharomyces cerevisiae

Alignment Length:	1337	Identity:	365/1337 - (27%)
Similarity:	600/1337 - (44%)	Gaps:	274/1337 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDESSRKHMEDCFLRSPSDIRTTNVPAAPKSQAADNKSRKTELHVLRLND---ESRQMTMDTLRQ 62
            :|||||:.:|.. |:...|.:...:....::.|.:.:..|.:|..|:...   |...:..|.|..
Yeast   271 LDESSRQLIETS-LKEKIDWQAKKISHKNETIAENREDLKAKLLTLQFRPKHVEEAMLYKDPLSF 334

  Fly    63 I--HGPEFQLDDISKYKDRGRGGHGVKHSYWQDRGTLVVQSVQGVSSTRGNDSDGDRLRRYALAK 125
            :  :.||   ||:..:..:.:|....|           |:......||           |..:.:
Yeast   335 LLFNLPE---DDLPPFFHKKKGDTKNK-----------VEITNLPLST-----------RMIVER 374

  Fly   126 LENYGFQAVHCLEAYEHCSGDTEAALLLLYRRYMRIPDEEQLTLEPPSEQEILDMRADEKEALES 190
            |...|..:...|.|.:....:...|...|.|..  :|.....|.||.||.|.::....|.|:|||
Yeast   375 LTEIGVSSDEALLALQQNDMNENEAAGFLTREI--LPTLNSNTNEPVSETESIECWNQELESLES 437

  Fly   191 IFDKAYEEREANRVWNLKFRIDHLLAHSPSEVRKAREAVLAAAAAAAQAALDKKKKPPLRCRNFD 255
            |::....:.:.:..:.|.. |:.|                            |.|....|.:|
Yeast   438 IYEGCVMDAKEDSHYTLNL-IEKL----------------------------KIKLKVYRTKN-- 471

  Fly   256 RDGTCKYGPKCRFAHLPQQPTESDTTKKDSVDENDNELWFHVEVRFPPGSRYPYEAPFIYLKT-- 318
                                                               ||...|.|.:.|
Yeast   472 ---------------------------------------------------YPASLPGIVVSTFD 485

  Fly   319 TCHDIPHELRLRYARHLYKEAKEICRDGIPCVYSICDLLQSNEQLAGRLDTSAFPSPKRSLFYDE 383
            ..:.:|..::.:....|....:|....|...||.|.:.|:.|                .|...|.
Yeast   486 KNYKLPDYIKKQILTRLLHYLQEGNLIGDMLVYHIYEWLKEN----------------ISKIIDN 534

  Fly   384 PAGGGVNPDAEHHQSPKPSHYARGQTSRNDGGHQRNVEAQTRENRR--LLQQFVERRKEERYQKI 446
            |  |.:.||::...:....:.:.|:.|.|:...::..:....|:..  |.:::.:|.|...|:.:
Yeast   535 P--GPLIPDSDSKGAINKRNISNGKRSINNSSSRKFTKTTISEDTLSVLREEYTKRIKSSEYKSM 597

  Fly   447 IDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKENLPHVE 511
            ...|:||||:.:.:.|:.:|..:.||:|:||||.||||||.|||||     .|| ..|.:....:
Yeast   598 QLVREQLPAWKKQKVIIDIINKNEVVLITGETGSGKSTQVVQFILD-----FLQ-KEKGDFGKTK 656

  Fly   512 IICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLG 576
            |:||||||:||||:||||:.||....|:.|||.||..||...|||:.|.|||:|:|.|.:...:.
Yeast   657 IVCTQPRRISAIGLAERVSDERCVTCGEEVGYVIRGVNKTKASTRIKFMTTGVLVRLLQNARTML 721

  Fly   577 SVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTF 641
            ..|.|::|||||||.::|.::.::||||...:.:|::|||||:|..||..:|.|.....|.||||
Yeast   722 ENTIVVIDEVHERSIDTDLIVTLMKNLLHRVRGMKIVLMSATVNVDLFKKFFPGLATCHIEGRTF 786

  Fly   642 PVQQLFLEDILEMSDFVMEYDTKYCRKLKKQEQEILERELEYADVQASGEAPGKKIKDEKLTLAE 706
            |:...||||||...||          |:|:      |:.|.|.|     ::..::..|:
Yeast   787 PITDYFLEDILSDLDF----------KIKR------EKALSYDD-----DSVDERNNDD------ 824

  Fly   707 TYQRYAEYSKPTCKSIYLMEPMTINPELIESVLKYI---VEGSHDWPREGTILIFLPGFGEIQSV 768
                  :|.||...|.:..... ||.:|:..|::|:   ::.::|   .|:|::||||.|||...
Yeast   825 ------QYLKPRADSKFFTSGQ-INYDLLCQVVEYVHKRLKAAND---NGSIIVFLPGVGEINKC 879

  Fly   769 HDSLLDNALFSPRAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVV 833
            .:.|.:.:    ....|:::||||||:.|||..||||. .||||:|:||||||||:||||||..:
Yeast   880 CNLLANKS----NEADFMVLPLHSALTPEDQKRVFKKY-HGKRKVVVSTNIAETSITIDDCVATI 939

  Fly   834 DCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQYHILAQPVPEI 898
            |.|..|...::...|...|...::|:|..|||:||||||..|:...|::...|:..:::.|:|||
Yeast   940 DTGRAKSMFYNPKDNTTKLIESFISKAEVKQRRGRAGRVREGLSYKLFSKNLYENDMISMPIPEI 1004

  Fly   899 QRVPLEQIVLRIKTLQTFASRNTLSVLLETLEAPTEDSVLGALTRLRDVGALDAEDQ-LTPLGHH 962
            :|:|||.:.|.:|.:   ..::..:.|...|:||...::..|...|..:|.:|..|: ||.||..
Yeast  1005 KRIPLESLYLSVKAM---GIKDVKAFLSTALDAPPLPALQKAERILTTIGLVDESDKSLTQLGQF 1066

  Fly   963 LAALPV-DVRIGKLMLYGAIFQCLD-SVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNS-- 1023
            ::.:|| |.:.|||::||.:|.|.| |||.::.......||:.....|   :|.|::.....|
Yeast  1067 ISLMPVMDSKHGKLLIYGILFGCTDISVLLVSILGIGVLPFIGGFENR---EKIKKLLCKYESRG 1128

  Fly  1024 DHLTVLNAYRKWLDVARRGNYAASRNYASEHFLSLNTLETIADLKYQYLELLVSIGFVPIDVPRR 1088
            |...||...|.:..:.   :.:..|.|..::.||.|.:..|.....||..:|..:||:|:|.
Yeast  1129 DLFAVLEIVRDYFKIK---DSSIKRKYLRDNLLSYNKINEIKSSTAQYYSILKDVGFLPMDY--- 1187

  Fly  1089 RKNACDNILTLTGVEQNHNGDNNRLLTSLLCAALYPNIVKIMTPDRVYIQTAGGAVPREPSHHDL 1153
                  .:.:::  :.|.|..|..:|.::|..|.||:|.::..||..|:.|:.|||.::|....:
Yeast  1188 ------KVGSIS--DLNRNERNFDILRAILTGAFYPHIARVQLPDVKYLSTSSGAVEKDPEAKMI 1244

  Fly  1154 RFKTRGDGY-----------------------------VKIHPSSV------------------- 1170
            ::..|.:.|                             ..||||||
Yeast  1245 KYWIRSEEYQDKLEEYKTKISQETQKVDLEDLPLPATRAFIHPSSVLFSTNSVNLEDAKLLSEVD 1309

  Fly  1171 -----NSQV-SVFQAPFLVFQEKVRTSAIYIRDCSMLPLIAMVLFAGS---DFKVELHDGDFLFL 1226
                 .|:: :|.:.||::|.....|:.:|:||.:....::::||.|:   |....:|...   :
Yeast  1310 GPISRQSKIPTVVKYPFVLFTTSQVTNKLYLRDLTPTTTLSLLLFGGAISYDIGGTIHSPG---I 1371

  Fly  1227 LESGWIILKAHDLETAEMVQCLRAEMIKLLEEKIRDP 1263
            :...|:.::.. .:...:::.||.::.:.:.:|:..|
Yeast  1372 VVDNWLPIRTW-CKNGVLIKELRTQLDEAIRKKLESP 1407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1582	NP_001285098.1	UBA_like_SF	123..154	CDD:304366	5/30 (17%)
		zf-CCCH	250..272	CDD:279036	2/21 (10%)
		RWD	<284..360	CDD:283440	13/77 (17%)
		HrpA	419..1206	CDD:224557	280/850 (33%)
		DEXDc	471..619	CDD:238005	75/147 (51%)
		HELICc	781..871	CDD:197757	46/89 (52%)
		HA2	948..1029	CDD:214852	28/85 (33%)
		OB_NTP_bind	1070..1212	CDD:285018	43/195 (22%)
YLR419W	NP_013523.3	UBA_YLR419W_like	369..409	CDD:270457	8/41 (20%)
		RWD	426..528	CDD:399058	27/199 (14%)
		HrpA	563..1428	CDD:224557	290/917 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I1030
eggNOG	1	0.900	-	-		E1_COG1643
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I301
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000258
OrthoInspector	1	1.000	-	-		otm46732
orthoMCL	1	0.900	-	-		OOG6_100595
Panther	1	1.100	-	-	LDO	PTHR18934
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1595
SonicParanoid	1	1.000	-	-		X384
TreeFam	1	0.960	-	-
	12	11.850